ライフサイエンスコーパス: mucoid

1 sing AlgB.D59N or H-AlgB delta1-145 remained mucoid.

2 lony morphology and phenotype referred to as mucoid.

3 s in cystic fibrosis patients are frequently mucoid.

4 ved on solid culture media is referred to as mucoid.

5 monas aeruginosa (PA) as either nonmucoid or mucoid.

6 se-negative lasB::Cm knock-out mutant in the mucoid 8821 background was constructed, and it showed a

7 aeruginosa from cystic fibrosis patients are mucoid (alginate producing) yet lack flagella.

8 Developing biofilms of the mucoid (alginate-producing) cystic fibrosis pulmonary is

9 s in Pseudomonas aeruginosa, are elevated in mucoid, alginate-producing bacteria and in response to i

10 ranscribed in response to iron limitation in mucoid, alginate-producing bacteria.

11 We demonstrate that a mucoid, alginate-producing strain of Pseudomonas aerugin

12 The resulting strain was non-mucoid and exhibited no detectable algD transcription.

13 A dominant mucoid and hypermutator mutL lineage was replaced after

14 To detect spontaneous mutations in csrRS, mucoid and large colony variants of M1 strain MGAS166 we

15 e &gland, brain, muscle, immune, metabolism, mucoid and nerve conduction.

16 ate that elastase, when overproduced in both mucoid and non-mucoid cells, stimulates alginate synthes

17 serotype A), the switching occurred between mucoid and nonmucoid colonies.

18 imary clinical B. pseudomallei isolates with mucoid and nonmucoid colony morphologies from the same s

19 table for all of the agents tested, for both mucoid and nonmucoid isolates.

20 fibrosis pulmonary isolate FRD1, as well as mucoid and nonmucoid mutant strains, were monitored by A

21 s associated with ARF in the SLC region, 964 mucoid and nonmucoid pharyngeal isolates recovered in SL

22 t in addition to being intracellular in both mucoid and nonmucoid Pseudomonas aeruginosa, Ndk is also

23 found to promote phagocytic killing of both mucoid and nonmucoid strains as well as protection again

24 As expected, a rocA mutant is mucoid and produces more transcript from the has promote

25 be difficult because the organisms are often mucoid and slow growing.

26 study, we observed that in CF isolates, the mucoid and the nonmotile phenotypes occur predominantly

27 robial susceptibilities of 48 CF strains (25 mucoid) and 50 non-CF strains to 12 anti-Pseudomonas age

28 ny size (large, medium, and small) and their mucoid appearance on blood agar.

29 sed HCN production in an alginate-producing (mucoid) background.

30 ious reports of increased algR expression in mucoid backgrounds, and RpoS additionally plays a role i

31 also are cotranscribed in both nonmucoid and mucoid backgrounds.

32 More importantly, HNO2 killed mucoid bacteria (a) in anaerobic biofilms; (b) in vitro

33 Here we show that mucoid bacteria perish during anaerobic exposure to 15 m

34 Increased proportions of mucoid bacteria were isolated during exacerbations occur

35 bits and elicited opsonic antibodies against mucoid but not nonmucoid P. aeruginosa, but nonetheless

36 X-treated mice also had dramatically reduced mucoid cell hyperplasia, and airway responsiveness retur

37 peribronchial eosinophilic infiltration and mucoid cell hyperplasia.

38 -kDa Ndk-Scs complex specifically present in mucoid cell predominantly synthesizes GTP and UTP but no

39 omplex media but is greatly reduced when the mucoid cells are grown in mineral salts media or in pres

40 osa is greatly reduced in alginate-secreting mucoid cells isolated from the lungs of cystic fibrosis

41 In mucoid cells of P. aeruginosa, Ndk is also known to exis

42 22) P. aeruginosa strains were compared, the mucoid cells were cleared several-fold less efficiently

43 se, when overproduced in both mucoid and non-mucoid cells, stimulates alginate synthesis.

44 In contrast, Scnn1b-Tg mice infected with a mucoid CF isolate carried high bacterial burdens, produc

45 We sequenced algK from the mucoid CF isolate FRD1 and expressed it in Escherichia c

46 otype of an DeltaalgL mutation in the highly mucoid CF isolate FRD1.

47 algZ deletion mutant was constructed in the mucoid CF isolate FRD1.

48 the secretion is triggered primarily in the mucoid CF isolate of strain 8821M (or in strain FRD1) bu

49 A typical mucoid CF isolate, FRD1, and its isogenic mutants were t

50 The overall frequency of mucA alterations in mucoid CF isolates was 84%.

51 The mucA22 allele is common in mucoid CF isolates.

52 90% reduction in alginate production in the mucoid, CF isolate, P. aeruginosa FRD1.

53 ariner transposon library using CF149, a non-mucoid clinical isolate with a misssense mutation in alg

54 r, the average amount of cyanide produced by mucoid clinical isolates was 4.7 +/- 0.85 micromol of HC

55 increase in bacterial hyaluronan production (mucoid colonies 200 mug per CFU and no detectable capsul

56 tified as csrR, caused the strain to produce mucoid colonies and to increase transcription of hasA, t

57 ive ("flesh-eating") infection often grow as mucoid colonies on primary culture but lose this colony

58 no detectable capsule production in the non-mucoid colonies).

59 between small, dry, compact and larger, more mucoid colonies.

60 ooth colony (SM) switches to a more virulent mucoid colony (MC) variant.

61 23.7%) isolates lacked the typical button or mucoid colony appearance of S. pneumoniae.

62 syrA was identified by its ability to confer mucoid colony morphology and by its ability to suppress

63 solates from these patients typically have a mucoid colony morphology due to overproduction of the ex

64 3 produced a transconjugant that exhibited a mucoid colony morphology, reflecting increased hyaluroni

65 the exopolysaccharide alginate resulting in mucoid colony morphology.

66 The hldD, hldE, and waaF mutants exhibited a mucoid colony phenotype due to production of a colanic a

67 Organisms with a mucoid colony phenotype when grown on blood agar plates

68 lymer poly-gamma-glutamate (PGA) to confer a mucoid colony phenotype.

69 a usually undergoes a phenotypic switch to a mucoid colony, which is characterized by the overproduct

70 h cells from smooth-colony variants (SM) and mucoid-colony variants (MC) arising from phenotypic swit

71 These results suggest that mucoid conversion and inhibition of invasive virulence d

72 However, the mucoid conversion can occur in wt mucA strains via the d

73 These observations suggested that mucoid conversion in CF may be driven by a selection for

74 that reducing activity of RpoD is linked to mucoid conversion in CF149.

75 omoter caused the overexpression of MucE and mucoid conversion in P. aeruginosa strains PAO1 and PA14

76 ion of the exopolysaccharide alginate causes mucoid conversion in Pseudomonas aeruginosa and is a poo

77 coid isolation, increased exacerbations, and mucoid conversion in vivo.

78 Mucoid conversion is indicative of overproduction of a c

79 In this study we hypothesized that mucoid conversion may be part of a larger response that

80 Estradiol and estriol induced mucoid conversion of P. aeruginosa in women with cystic

81 th cystic fibrosis are at increased risk for mucoid conversion of Pseudomonas aeruginosa, which contr

82 e C terminus of MucE (WVF) were required for mucoid conversion via two predicted proteases AlgW (DegS

83 Thus, even though dsbA is coregulated with mucoid conversion, it was not required for alginate prod

84 n cystic fibrosis patients typically undergo mucoid conversion.

85 order to identify protein levels enhanced by mucoid conversion.

86 factor MucA is a well-accepted mechanism for mucoid conversion.

87 ationic polypeptide-depleted fluid against a mucoid cystic fibrosis isolate of P. aeruginosa.

88 we tested wild-type strains PAO1, PA14, the mucoid cystic fibrosis isolate, FRD1 (mucA22+), and the

89 show here that a null mutation in kinB in a mucoid cystic fibrosis isolate, P. aeruginosa FRD1, did

90 structure of microvessel walls, formation of mucoid cysts initiated in the proximity of damaged micro

91 The severity of mucoid degeneration and chondroid metaplasia in the ACL

92 ar appearance, pronounced vacuolization, and mucoid degeneration, appearing as Wallerian degeneration

93 e found that P. aeruginosa strain PAO1 and a mucoid derivative of strain PAO1 each grew at dissolved

94 large fraction of P. aeruginosa CF isolates mucoid, did not abrogate AlgU-MucA interactions, althoug

95 iants of Cryptococcus neoformans (smooth and mucoid) differed in their abilities to promote increased

96 ns associated with cystic fibrosis are often mucoid due to the copious production of alginate, an exo

97 lon mutants are also mucoid, due to the stabilization of another Lon substrat

98 In addition, two mucoid E. faecalis isolates from patients with chronic u

99 r (TNF)-alpha, a proinflammatory cytokine in mucoid effusion, markedly increased Muc2 mucin mRNA expr

100 The mucoid exopolysaccharide (MEP) from P. aeruginosa has be

101 he opsonic antibody activity specific to the mucoid exopolysaccharide (MEP) surface antigen.

102 than those involved in the production of the mucoid exopolysaccharide alginate, are turned on during

103 aboration of the extracellular, O-acetylated mucoid exopolysaccharide, or alginate, is a major microb

104 upon the conversion of P. aeruginosa to the mucoid, exopolysaccharide alginate-overproducing phenoty

105 The conversion to mucoid, exopolysaccharide alginate-overproducing phenoty

106 Similar experiments were performed with mucoid films collected from the inferior conjunctival fo

107 ular surface in DED patients and abundant in mucoid films.

108 use conversion from a typical nonmucoid to a mucoid form in the CF lung.

109 Among these mucoid forms, the 'houses' of larvaceans are marvels of

110 ix to eight times as intense as those of the mucoid FRD1 parent strain.

111 he algT-mucABCD operon, MucD was detected in mucoid (FRD1) and nonmucoid (PAO1) parental strains and

112 Four mucoid fur mutants produced 1.7- to 2.6-fold-greater fum

113 ignal intensities and the so-called inverted mucoid impaction signal (IMIS) sign was qualitatively an

114 This type of mucoid induction requires the alternate sigma factor Rpo

115 wild-type mice challenged with an LPS-rough mucoid isolate of P. aeruginosa lacking the CFTR ligand.

116 In some instances, mucoid isolates of P. aeruginosa were recovered from lun

117 Mucoid isolates were more likely to be hypermutators.

118 ratory strains and early lung colonizing non-mucoid isolates with a wt mucA.

119 However, for mucoid isolates, correlation coefficients (r values) for

120 show greater expression of the gene than do mucoid isolates.

121 they were significantly less effective with mucoid isolates.

122 tro and were associated with selectivity for mucoid isolation, increased exacerbations, and mucoid co

123 y and proteomic analyses were performed on a mucoid kinB mutant and an isogenic nonmucoid kinB rpoN d

124 ction from laboratory isolates revealed that mucoid laboratory strains made sevenfold more HCN than t

125 gulated using isogenic S. aureus MN8 and MN8 mucoid (MN8m) strains, the latter of which constitutivel

126 atients with cystic fibrosis often display a mucoid morphology due to high levels of expression of th

127 re to estradiol, P. aeruginosa adopted early mucoid morphology, whereas short-term exposure inhibited

128 romoter of rpoH was found to be activated in mucoid mucA mutants.

129 Alginate production in mucoid (MucA-defective) Pseudomonas aeruginosa is depend

130 Mucoid, mucA mutant Pseudomonas aeruginosa cause chronic

131 When isogenic nonmucoid (mucA+) and mucoid (mucA22) P. aeruginosa strains were compared, the

132 However, inactivation of algZ in a mucoid mutant P. aeruginosa strain, which had AlgU freed

133 Compared with MGAS166, these mucoid mutants are more hemolytic and cause significantl

134 Three mucoid mutants were identified with transposon insertion

135 ts showed that ectopic expression of FleQ in mucoid, nonmotile CF isolates restored flagellum biosynt

136 that AlgT inhibits flagellum biosynthesis in mucoid, nonmotile P. aeruginosa cystic fibrosis isolates

137 a repressor of fleQ, we mutated amrZ in the mucoid, nonmotile P. aeruginosa strain FRD1.

138 ntation of the mutant with amrZ restored the mucoid, nonmotile phenotype.

139 he cystic fibrosis lung frequently display a mucoid, nonmotile phenotype.

140 ibits lawn bordering and roaming behavior on mucoid nonpathogenic bacteria and loss of pathogen avoid

141 charge was frequent or very frequent in 85%, mucoid or mucopurulent in 90%, and moderate to severe in

142 hose in desert tortoises and include serous, mucoid, or purulent discharge from the nares, excessive

143 Mucoid otitis media (MOM) is characterized by viscous fl

144 CF cells sequentially infected with mucoid P. aeruginosa (MPA) and RV showed lower levels of

145 tor was also associated with reduced odds of mucoid P. aeruginosa (OR, 0.77; P = .013) and Aspergillu

146 ction chromatography of the crude extract of mucoid P. aeruginosa 8821, a CF isolate.

147 nse of cystic fibrosis and wild-type mice to mucoid P. aeruginosa administered by insufflation.

148 ntion of active elastase in the periplasm of mucoid P. aeruginosa and its role in the generation of t

149 sponse regulators activate alginate genes in mucoid P. aeruginosa appears not to be mediated by conve

150 l therapeutics directed against biofilms and mucoid P. aeruginosa are being developed.

151 it may play an important role in protecting mucoid P. aeruginosa biofilm bacteria from the human imm

152 ture and extracellular matrix composition of mucoid P. aeruginosa biofilms, through increased express

153 Thus mucoid P. aeruginosa cells elaborate enzymes that modula

154 creted into the extracellular environment by mucoid P. aeruginosa cells.

155 identified a protein(s), AlgZ, expressed in mucoid P. aeruginosa CF isolates that specifically bound

156 The calcium-induced extracellular matrix of mucoid P. aeruginosa consists primarily of the virulence

157 o the important clinical goal of eradicating mucoid P. aeruginosa from the CF airways.

158 investigated mechanisms of the emergence of mucoid P. aeruginosa in CF by analyzing the status of mu

159 The emergence of mucoid P. aeruginosa in CF is associated with increased

160 The emergence of mucoid P. aeruginosa in CF is associated with respirator

161 ing to the morbidity and mortality caused by mucoid P. aeruginosa in CF.

162 ung infections could not be established with mucoid P. aeruginosa in either cystic fibrosis or wild-t

163 fection, chronic P. aeruginosa infection and mucoid P. aeruginosa in individuals with cystic fibrosis

164 on of antibodies mediated opsonic killing of mucoid P. aeruginosa in vitro.

165 Indeed, chronic infection of the lung by mucoid P. aeruginosa is a major cause of morbidity and m

166 A mutation in the algR2 gene of mucoid P. aeruginosa is known to exhibit a nonmucoid (no

167 hesis by laboratory and clinical isolates of mucoid P. aeruginosa is necessary and sufficient to atte

168 airway epithelia to the stimuli presented by mucoid P. aeruginosa is not proinflammatory and, hence,

169 lyzing the status of mucA in a collection of mucoid P. aeruginosa isolates from 53 CF patients.

170 Comparison of paired nonmucoid and mucoid P. aeruginosa isolates from three CF patients ind

171 Interestingly, mucoid P. aeruginosa isolates from urinary tract infecti

172 enance of biofilms produced by nonmucoid and mucoid P. aeruginosa isolates.

173 rogated AIgU-dependent rpoH transcription in mucoid P. aeruginosa laboratory isolates and CF isolates

174 pared with wild-type controls in the face of mucoid P. aeruginosa lung infection.

175 in CF is the result of a global induction in mucoid P. aeruginosa of lipoproteins that act as proinfl

176 Our data indicate that (i) mucoid P. aeruginosa regardless of their origin (laborat

177 Transcriptional profiling analyses comparing mucoid P. aeruginosa strains to their isogenic algR dele

178 tibility testing of CF strains, particularly mucoid P. aeruginosa strains, is unknown.

179 ere similar in mice exposed to nonmucoid and mucoid P. aeruginosa throughout the infection.

180 tion of alginate maximizes the resistance of mucoid P. aeruginosa to antibody-independent opsonic kil

181 te plays an important role in the ability of mucoid P. aeruginosa to form biofilms and to resist comp

182 is the molecular basis for the resistance of mucoid P. aeruginosa to normally nonopsonic but alginate

183 ds or beads containing a clinical isolate of mucoid P. aeruginosa were instilled in the right lung of

184 We have previously reported that in mucoid P. aeruginosa, an intracellular protease cleaves

185 The recognition of genes induced in mucoid P. aeruginosa, other than those associated with a

186 ng that AlgR activates hcnA transcription in mucoid P. aeruginosa.

187 lobal responses to infection with motile and mucoid P. aeruginosa.

188 when the bulk of alginate is synthesized by mucoid P. aeruginosa.

189 Elastase is secreted in non-mucoid P. aeruginosa.

190 patients, encounters alginate elaborated by mucoid P. aeruginosa.

191 isk factors, only respiratory infection with mucoid PA correlated significantly with bronchiectasis (

192 isolates were more likely to be infected by mucoid PA, and they showed a narrow T-cell epitope respo

193 cantly related to respiratory infection with mucoid PA; attempts to prevent bronchiectasis should inc

194 Disruption of dsbA in the mucoid PDO300 background did not affect alginate product

195 Overexpression of algW in PAO1 resulted in a mucoid phenotype and alginate production, even in the ab

196 tion of phpA was found to correlate with the mucoid phenotype and an increase in algD transcription i

197 system that, when inactivated, results in a mucoid phenotype and enhanced virulence in mouse infecti

198 biofilms and the selection of mutants with a mucoid phenotype are major adaptations that allow its pe

199 conversion of Pseudomonas aeruginosa to the mucoid phenotype coincides with the establishment of chr

200 ion of invasive virulence factors and have a mucoid phenotype due to the production of an alginate ca

201 The conversion to mucoid phenotype in Pseudomonas aeruginosa during chroni

202 The mucoid phenotype indicates alginate overproduction and i

203 The mucoid phenotype is due to abundant production of the hy

204 well-studied mechanism for transition to the mucoid phenotype is mutation of mucA, leading to loss of

205 regulator of both sigma(22) activity and the mucoid phenotype is the cognate anti-sigma factor MucA.

206 we demonstrated that in vivo switching to a mucoid phenotype occurred in two mice strains and was as

207 ere identified as positive regulators of the mucoid phenotype on PIAAMV.

208 Conversion of Pseudomonas aeruginosa to the mucoid phenotype plays a major role in the pathogenesis

209 The mucoid phenotype results from loss-of-function mutations

210 The alginate-overproducing (Alg(+)) mucoid phenotype seen in the CF isolates is extremely un

211 rity, and in the concomitant appearance of a mucoid phenotype that is reminiscent of cells in the ear

212 y have negative effects on expression of the mucoid phenotype under the conditions tested.

213 Reversion to the mucoid phenotype was associated with reversion of the mu

214 The algXDelta::Gm mutant was restored to the mucoid phenotype with wild-type P. aeruginosa algX provi

215 opolysaccharide abundance (contributing to a mucoid phenotype).

216 riant was experimentally proven to cause the mucoid phenotype, and corresponding resistance to phagoc

217 the host immune system, and conversion to a mucoid phenotype.

218 s, P. aeruginosa undergoes a conversion to a mucoid phenotype.

219 saccharide, alginate, giving these strains a mucoid phenotype.

220 ause alginate overproduction, resulting in a mucoid phenotype.

221 tic susceptibility, capsule composition, and mucoid phenotype.

222 lginate, an exopolysaccharide that confers a mucoid phenotype.

223 ss of O-antigen synthesis alternating with a mucoid phenotype.

224 kground was constructed, and it showed a non-mucoid phenotype.

225 classic feature of CF airway isolates is the mucoid phenotype.

226 P. aeruginosa strains PAO1 and PA14 are non-mucoid, producing minimal amounts of alginate.

227 enBank database with only weak similarity to mucoid protein sequences.

228 In conclusion, mucoid Pseudomonas adapted to the CF-lung remained able

229 [FEV(1)]) of the CFTR gene genotype, gender, mucoid Pseudomonas aeruginosa (MPA) infection status, pr

230 Mucoid Pseudomonas aeruginosa (n = 12; 15%) and nontuber

231 iated with chronic pulmonary infections with mucoid Pseudomonas aeruginosa (PA).

232 tics, tobramycin and ciprofloxacin, into non-mucoid Pseudomonas aeruginosa biofilms.

233 fficacy of azithromycin in a murine model of mucoid Pseudomonas aeruginosa endobronchial infection.

234 maintenance of chronic lung infections with mucoid Pseudomonas aeruginosa in patients with cystic fi

235 The exopolysaccharide alginate, produced by mucoid Pseudomonas aeruginosa in the lungs of cystic fib

236 tible to chronic pulmonary disease caused by mucoid Pseudomonas aeruginosa strains that overproduce t

237 In non-mucoid Pseudomonas aeruginosa strains, the Pel and Psl p

238 ciated with chronic pulmonary infection with mucoid Pseudomonas aeruginosa.

239 c bacteria and loss of pathogen avoidance on mucoid Pseudomonas aeruginosa.

240 tors in nontypeable, alginate overproducing (mucoid) Pseudomonas aeruginosa strains isolated from cys

241 we screened a transposon library in the non-mucoid reference strain PAO1, and identified a mutant th

242 were found to display phenotypes which were mucoid relative to the phenotype of the parental algB st

243 s been attributed to accumulation of viscous mucoid secretions in intrahepatic bile ducts.

244 hrough viscoelastic cervical mucus and other mucoid secretions to reach the site of fertilization.

245 By using a representative strain of the mucoid serotype 3 clone, rough phase variants with a div

246 ations were found to be strain specific: the mucoid strain 18A experienced mutations in alginate prod

247 ies from isogenic nonmucoid strain 4095a and mucoid strain 4095c were further investigated.

248 whether these proteins were enhanced in the mucoid strain due to increased transcription.

249 genesis of nonmucoid algB derivatives of the mucoid strain FRD1 was employed.

250 gG activity, a mutant was constructed in the mucoid strain FRD1 with a defined non-polar deletion of

251 Herein we show that a highly mucoid strain of E. coli K-12 ligates CA repeats to a si

252 on the eradication of biofilms formed by the mucoid strain of Pseudomonas aeruginosa and investigated

253 FU of group B streptococci or 10(7) CFU of a mucoid strain of Pseudomonas aeruginosa by intratracheal

254 For mucoid strain P. aeruginosa FRD1, calcium addition (1.0

255 eatment with S-nitrosoglutathione, while the mucoid strain PAO578II showed no further upregulation ab

256 pted agar bead murine model using a clinical mucoid strain that demonstrates the key features of tran

257 teins that were clearly more abundant in the mucoid strain were observed.

258 However, the mucoid strains can revert to nonmucoidy in vitro through

259 Non-mucoid strains can use either Pel or Psl as the primary

260 tions are cleared but chronic infection with mucoid strains ensues in the majority of CF patients and

261 Here, we show that mucoid strains of bacteria that produce an exopolysaccha

262 In the presence of mucoid strains of bacteria, the C. elegans laboratory wi

263 However, certain clinical mucoid strains of P. aeruginosa have a wild-type (wt) mu

264 odies broadly cross-reactive to heterologous mucoid strains of P. aeruginosa.

265 an extracellular polysaccharide produced by mucoid strains of Pseudomonas aeruginosa that are typica

266 The second were the mucoid strains Smith diffuse and M, both of which encode

267 on resulted in suppression of mucoidy in all mucoid strains tested, indicating that sigma factor comp

268 ent promoter (PssrA ) was more active in non-mucoid strains than in isogenic mucoid variants.

269 l), is required for biofilm formation in non-mucoid strains that do not rely on alginate as the princ

270 uggests that the reduced CBC observed in the mucoid strains was due to masking of the collagen adhesi

271 ) of nonmucoid strains and 40% (24 of 60) of mucoid strains were definitively identified as Pseudomon

272 n were non-CF strains (P < 0.0001), although mucoid strains were not more likely to have serious disc

273 Mucoid strains with mucA mutations predominantly populat

274 enhanced or reduced formation of alginate in mucoid strains, respectively.

275 tL lineage was replaced after 11 days by non-mucoid strains.

276 ved from Pseudomonas lipoproteins induced in mucoid strains.

277 d the presence of mucA mutations only in the mucoid strains.

278 MAb-reactive (nonmucoid) and nonreactive (mucoid) strains from the same patient exhibited identica

279 onic acid capsule on highly encapsulated, or mucoid, strains.

280 In the midwaters of the ocean, mucoid structures are readily secreted by numerous anima

281 However, little is known about these mucoid structures owing to the challenges of observing t

282 Selection of both pre-existing non-mucoid subpopulations and of novel phenotypic traits sug

283 Similar to cells of the mucoid switch variant, all1Delta cells produced a larger

284 und to be downregulated in the hypervirulent mucoid switch variant, both during logarithmic growth an

285 mimicked the hypervirulent phenotype of the mucoid switch variant, which is characterized by decreas

286 hese mutants ranged from being only slightly mucoid to being indistinguishable from that of the origi

287 One of the particularly mucoid transposon mutants was chosen for further study.

288 erotype 19 gives rise to variants (the small mucoid variant [SMV] and the acapsular small-colony vari

289 Rats infected with the mucoid variant developed increased ICP, whereas rats inf

290 The large mucoid variant formed flat unstructured biofilms, failed

291 brain fungal burdens were comparable between mucoid variant- and smooth parent-infected rats.

292 cerebrospinal fluid (CSF) fungal burden for mucoid variant-infected rats, although brain fungal burd

293 intensity over the surfaces of the brains of mucoid variant-infected rats.

294 charide accumulated in the CSF and brains of mucoid variant-infected rats.

295 tic inflammatory response in the meninges of mucoid variant-infected rats.

296 Mucoid variants appeared at later biofilm developmental

297 Mucoid variants of the opportunistic pathogen Pseudomona

298 Low oxygen tension growth of mucoid variants readily selects for nonmucoid variants.

299 ctive in non-mucoid strains than in isogenic mucoid variants.

300 In contrast, the mucoid wild-type strain produced only polymerized uronic