ライフサイエンスコーパス: mucosal immunity

1 OPV-vaccinated individuals boosts intestinal mucosal immunity.

2 tion of IgA and IgM, which are important for mucosal immunity.

3 2, IFN, and TNFalpha, cytokines important in mucosal immunity.

4 this previously uncharacterized mechanism of mucosal immunity.

5 healthy fish, suggesting a potential role in mucosal immunity.

6 elp resolve unsettled paradigms of mammalian mucosal immunity.

7 immunity, plays the prevailing role in skin mucosal immunity.

8 influence the innate and adaptive phases of mucosal immunity.

9 mediated transcription of genes required for mucosal immunity.

10 tes are now emerging as important players in mucosal immunity.

11 ling and inductive sites that help establish mucosal immunity.

12 inst commensals are an integral component of mucosal immunity.

13 directly elicit or enhance pathogen-specific mucosal immunity.

14 d IL-22, a Th17-related cytokine critical in mucosal immunity.

15 ion, implicating IL-25 as a key component in mucosal immunity.

16 of NK-22 cells in promoting B-cell-mediated mucosal immunity.

17 ctions, the local microbiome composition and mucosal immunity.

18 interleukin-22 (IL-22), supporting a role in mucosal immunity.

19 oxO4 in the regulation of NF-kappaB-mediated mucosal immunity.

20 intestinal lamina propria play a key role in mucosal immunity.

21 reas both IL-17A and IL-17F are required for mucosal immunity.

22 rties highly suggestive of its regulation of mucosal immunity.

23 lasma cells (PCs) is a critical component of mucosal immunity.

24 ents and the use of FcRs in the induction of mucosal immunity.

25 tissue (NALT) or GALT, is thought to promote mucosal immunity.

26 n antigen uptake and subsequent induction of mucosal immunity.

27 rovide Ag-specific humoral and cell-mediated mucosal immunity.

28 per cells involved in autoimmune disease and mucosal immunity.

29 affect Ag delivery and the effectiveness of mucosal immunity.

30 y immunization facilitates the generation of mucosal immunity.

31 ogens is the induction of potent and durable mucosal immunity.

32 uggest a putative effector function in human mucosal immunity.

33 intestinal epithelial barriers and impaired mucosal immunity.

34 lation reverses PN-induced depression of gut mucosal immunity.

35 tical for GALT control mechanisms and intact mucosal immunity.

36 l mucosa, suggesting reconstitution of human mucosal immunity.

37 an immunomodulatory role that may impact on mucosal immunity.

38 PV potency may lead to even higher levels of mucosal immunity.

39 low in the maintenance of PP homeostasis and mucosal immunity.

40 tence of non-MAdCAM-1 mechanisms to preserve mucosal immunity.

41 antly impairs the generation of IgA-mediated mucosal immunity.

42 cells and thus might play a similar role in mucosal immunity.

43 ers mitochondrial pathways critical for lung mucosal immunity.

44 ens requires an effective adjuvant to induce mucosal immunity.

45 ntramuscular, or intrarectal route to induce mucosal immunity.

46 play an important role in the development of mucosal immunity.

47 pathogens and they play an important role in mucosal immunity.

48 ucosal immunity and/or the actively acquired mucosal immunity.

49 tranasally for the induction of systemic and mucosal immunity.

50 instead of i.v. maintains NT anti-influenza mucosal immunity.

51 K cells may participate in the regulation of mucosal immunity.

52 al secretions and plays an important role in mucosal immunity.

53 ting as both induction and effector site for mucosal immunity.

54 lls, rendering the metastases susceptible to mucosal immunity.

55 ing the potentially distinct consequences in mucosal immunity.

56 ceptor (AHR) and diet-derived AHR ligands in mucosal immunity.

57 heir GC responses may uniquely contribute to mucosal immunity.

58 l population that plays a front-line role in mucosal immunity.

59 ransient ablation of the microbiota restores mucosal immunity.

60 involvement of the enteric nervous system in mucosal immunity.

61 oader context of tissue compartment-specific mucosal immunity.

62 omes in nonhematopoietic cells contribute to mucosal immunity.

63 pteronyssinus had no effect on offspring gut mucosal immunity.

64 ation suggests an important role for IRE1 in mucosal immunity.

65 thelial barrier plays a critical role in the mucosal immunity.

66 e sex work is associated with changes in the mucosal immunity.

67 Innate immune responses are critical for mucosal immunity.

68 tes that maintain the intestinal barrier and mucosal immunity.

69 e outside world and are at the front line of mucosal immunity.

70 known about the influence of asthma on host mucosal immunity.

71 or significantly enhanced human NoV-specific mucosal immunity.

72 studies of the role of specific cytokines in mucosal immunity.

73 We assessed the efficacy of IPV in boosting mucosal immunity.

74 d) vectors can stimulate adenovirus-specific mucosal immunity after replication, oral delivery of rep

75 these Ikaros-mutant mice conferred enhanced mucosal immunity against Citrobacter rodentium infection

76 to mediating autoimmunity, have key roles in mucosal immunity against extracellular pathogens.

77 )17 cells, which are essential for effective mucosal immunity against fungi.

78 over the role of enteric alpha-defensins in mucosal immunity against HIV-1 infection.

79 T-cells play an important role in promoting mucosal immunity against pathogens, but the mechanistic

80 s include a lack of information in humans on mucosal immunity against pneumococci and a lack of suita

81 g chemokine gradients that are essential for mucosal immunity against pulmonary bacterial pathogens.

82 Ab responses, which could provide protective mucosal immunity against Streptococcus pneumoniae infect

83 Studies directed at vaccine development and mucosal immunity against Streptococcus pyogenes would be

84 moniae, we hypothesized that ethanol impairs mucosal immunity against this pathogen by disrupting IL-

85 be critical in the development of long-term mucosal immunity against V. cholerae O1.

86 ets, limited immune activation and preserved mucosal immunity, all of which contribute to the avoidan

87 ous immunization was able to induce specific mucosal immunity and a more balanced T helper type 1 and

88 ulation has transformed our understanding of mucosal immunity and allergy.

89 mples can provide information about rates of mucosal immunity and allow estimation of the poliovirus

90 Significant downregulation of mucosal immunity and antioxidant pathways with increased

91 oducing CD4(+) helper T cells (Th17) mediate mucosal immunity and are involved in the pathogenesis of

92 hape the intestinal environment by affecting mucosal immunity and bacterial colonization.

93 hway in innate immune cells orchestrates gut mucosal immunity and commensal homeostasis by regulating

94 o unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pat

95 s is not sufficient per se to induce loss of mucosal immunity and disease progression during a primat

96 enhanced CD4(+) Th2-type, cytokine-mediated mucosal immunity and increased lymphoid-type dendritic c

97 Parenteral nutrition (PN) impairs mucosal immunity and increases the risk of infection in

98 , we examine the role of FoxO4 in intestinal mucosal immunity and inflammatory bowel disease (IBD).

99 n intestinal immune homeostasis by promoting mucosal immunity and limiting chronic inflammation.

100 icrobiome early in life imprint the host gut mucosal immunity and may play a critical role in precipi

101 a variety of host immune functions, such as mucosal immunity and oral tolerance.

102 mechanism by which ambient pollutants alter mucosal immunity and promote disorders such as asthma.

103 se molecules are critical factors for innate mucosal immunity and provide barrier protection.

104 Lack of enteral stimulation with PN impairs mucosal immunity and reduces IgA levels through depressi

105 cidating the impact of nutritional status on mucosal immunity and respiratory viral infection in infa

106 than inactivated vaccines by eliciting local mucosal immunity and systemic B cell- and T cell-mediate

107 Lactoferrin modulates mucosal immunity and targets mechanisms contributing to

108 investigated, and provocative insights into mucosal immunity and the enteric microbiota are now bein

109 nderstanding specialized aspects of acquired mucosal immunity and the importance of cross-talk betwee

110 hat has been implicated in the regulation of mucosal immunity and the pathogenesis of airway inflamma

111 substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bo

112 ew, we first sketch out our understanding of mucosal immunity and then compare the herpes simplex vir

113 needed tools to establish how CFTR regulates mucosal immunity and to test directly the effect of phar

114 semimature DCs that seem to locally regulate mucosal immunity and tolerance in a species lacking lymp

115 n regulating the homeostatic balance between mucosal immunity and tolerance, we have examined the exp

116 may provide new opportunities for enhancing mucosal immunity and treating autoimmune disease.

117 ld provide novel opportunities for enhancing mucosal immunity and treating intestinal inflammation.

118 ion of this niche, and many are important in mucosal immunity and vaccine development.

119 , and show an important association with CMV mucosal immunity and viral control.

120 at PRO 2000 has little deleterious effect on mucosal immunity and, if validated by clinical experienc

121 (IELs) are likely to play a key role in host mucosal immunity and, unlike other T cells, have been pr

122 ween SFB and the passively acquired maternal mucosal immunity and/or the actively acquired mucosal im

123 s that L-Sel is important for development of mucosal immunity, and absence of L-Sel is protective aga

124 stablish an intimate link between autophagy, mucosal immunity, and chronic inflammatory diseases.

125 thway in regulating intestinal inflammation, mucosal immunity, and commensal homeostasis.

126 phoid cells (ILCs) are critical mediators of mucosal immunity, and group 1 ILCs (ILC1 cells) and grou

127 an alternative pathway for the induction of mucosal immunity, and if the activity is evident in huma

128 cells involved in lymphoid tissue formation, mucosal immunity, and inflammation and (b) type 2 ILCs t

129 The role of cellular and humoral immunity, mucosal immunity, and other local factors in determining

130 lation pathway, anti-glycan immune response, mucosal immunity, antigen processing and presentation, a

131 timum strategies to elicit both systemic and mucosal immunity are critical for the development of vac

132 lymphocytes, IL-22 plays a critical role in mucosal immunity as well as in dysregulated inflammation

133 cantly to circulating natural antibodies and mucosal immunity as well as to immunoregulation.

134 DC play a critical role in the regulation of mucosal immunity, as well as the development of central

135 cytokines and the role they may play in gut mucosal immunity, as well as the emergence of new concep

136 parative estimates of humoral and intestinal mucosal immunity associated with different routine immun

137 ling pathway during oral infection, in which mucosal immunity assumes a predominant role, has not bee

138 piratory tract, an RSV vaccine should elicit mucosal immunity at upper and lower respiratory tracts i

139 hanisms by which Vitamin D and VDR influence mucosal immunity, bacterial infection, and inflammation.

140 amuscularly, it would be desirable to induce mucosal immunity by delivery through alternative routes.

141 Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effe

142 ions, and plays a significant role in normal mucosal immunity by modulating T cell activation and reg

143 en shown to be essential to induce effective mucosal immunity by non-replicating vaccines.

144 -4 response is required for the induction of mucosal immunity by oral QS-21 as adjuvant.

145 PN impairs innate mucosal immunity by suppressing luminal sPLA2 activity a

146 otential "Trojan horse" approach to modulate mucosal immunity by systemically immunizing with sFliC.

147 Impaired airway mucosal immunity can contribute to increased respiratory

148 The induced mucosal immunity can neutralize the pathogen on the muco

149 k of enteral stimulation creates a defect in mucosal immunity characterized by loss of IgA-mediated d

150 ificantly augmented VLP-induced systemic and mucosal immunity compared to the responses induced by lo

151 s host-microorganism interactions to control mucosal immunity, coordinate nutrient recycling and form

152 aeroallergen sensing in the early events of mucosal immunity could have greater benefit.

153 Mucosal immunity develops in the human fetal intestine b

154 rtant since it illustrates the importance of mucosal immunity for complete protection against CDI.

155 rface with the environment, which depends on mucosal immunity for protection against infectious agent

156 fected hepatoma cells we show that the human mucosal immunity gene, mucin-13 (MUC13), is strongly upr

157 ive responses systemically, the induction of mucosal immunity generally requires local Ag exposure.

158 also resisted DIO, demonstrating that intact mucosal immunity guides diet-induced changes to the micr

159 changed that concept as our understanding of mucosal immunity has evolved and as we have come to unde

160 Dendritic cells (DCs) that orchestrate mucosal immunity have been studied in mice.

161 ambda (IFN-lambda) is a central regulator of mucosal immunity; however, its signaling specificity rel

162 bile toxin (LT) are powerful manipulators of mucosal immunity; however, past clinical trials identifi

163 In addition to enhancing mucosal immunity, IgD class-switched B cells enter the c

164 nal APCs in the induction and maintenance of mucosal immunity implicates SIRPalpha(+) antigen-present

165 nd flagellin on stimulation of antibacterial mucosal immunity in a lethal murine Pseudomonas aerugino

166 ted antimicrobial peptide (CRAMP), to innate mucosal immunity in a mouse model of Gram-negative pneum

167 To better delineate the role of mucosal immunity in colorectal cancer, we evaluated the

168 y assays can serve as markers of humoral and mucosal immunity in future trials of BCG and newer atten

169 The role of mucosal immunity in human papillomavirus (HPV)-related c

170 amined the degree and duration of intestinal mucosal immunity in India by measuring the prevalence of

171 These data highlight the importance of mucosal immunity in mediating optimal protection against

172 that the vaccine induced robust systemic and mucosal immunity in mice.

173 icantly enhances antipoliovirus systemic and mucosal immunity in mice.

174 ons of the respiratory microbiome and of the mucosal immunity in patients admitted to hospital, and e

175 is of the respiratory microbiome and altered mucosal immunity in patients with critical illness holds

176 d transmission, suggesting the importance of mucosal immunity in preventing influenza virus transmiss

177 he current information regarding the role of mucosal immunity in prevention of HIV transmission and d

178 There is a role for the measurement of mucosal immunity in response to candidate vaccines and,

179 itis, underscoring the critical role of host mucosal immunity in shaping the microbiota.

180 Nevertheless, induction of mucosal immunity in such a manner would be an attractive

181 pment, and recent evidence implies a role in mucosal immunity in the adult.

182 Here, an overview of mucosal immunity in the context of cancer and mucosal ca

183 Uncontrolled mucosal immunity in the gastrointestinal tract of humans

184 nal inflammation, commensal homeostasis, and mucosal immunity in the gut are unclear.

185 Mucosal immunity in the lung and intestine is controlled

186 s an important contributor to effective host mucosal immunity in the lung in response to Gram-negativ

187 al immune responses, but how this applies to mucosal immunity in the lung is not clear.

188 ell responses may be prevalent in modulating mucosal immunity in the lungs, Th1 cell responses contri

189 with Escherichia coli; however, its role in mucosal immunity in the respiratory tract is unknown.

190 To investigate how MAIT cells contribute to mucosal immunity in vivo, we used a murine model of pulm

191 IgA (sIgA), the primary effector molecule of mucosal immunity, in mice with homozygous neural crest c

192 s a host advantage by providing heterologous mucosal immunity independent of serotype-specific antibo

193 There have been no studies related to the mucosal immunity induced against this orally acquired pa

194 The mucosal immunity induced by OPV in India varies by locat

195 Studies of mucosal immunity induced by oral poliovirus (OPV) or ina

196 fecal-oral transmission relies on intestinal mucosal immunity induced by oral poliovirus vaccine (OPV

197 Mucosal immunity induced by oral poliovirus vaccine (OPV

198 ia, has raised questions about the degree of mucosal immunity induced by oral poliovirus vaccine (OPV

199 tor (SLPI), an anti-inflammatory mediator of mucosal immunity, inhibits human immunodeficiency virus

200 inpoint HVEM as an important orchestrator of mucosal immunity, integrating signals from innate lympho

201 hese genes included genes involved in innate mucosal immunity, intracellular signaling, and cellular

202 ciated with intestinal barrier functions and mucosal immunity involved in microbiome homeostasis.

203 ost deadly in the pneumonic form; therefore, mucosal immunity is an important first line of defense a

204 A critical step in the induction of adaptive mucosal immunity is antigen transcytosis, in which lumin

205 This defect in mucosal immunity is associated with eosinophilic, Th2-re

206 Mucosal immunity is considered important for protection

207 The induction of mucosal immunity is crucial in controlling viral replica

208 against paralytic disease, but its effect on mucosal immunity is debated.

209 cosal surfaces is the natural route by which mucosal immunity is generated, as peripheral antigen del

210 Inducing humoral, cellular and mucosal immunity is likely to improve the effectiveness

211 However, the role of HIF signaling in colon mucosal immunity is not known.

212 Loss of upper respiratory tract mucosal immunity is not related to serum Ab, because 10

213 Mucosal immunity is poorly activated after systemic immu

214 n, and demonstrates that a component of host mucosal immunity is reprogrammed during the progression

215 l proposes that the fundamental mechanism of mucosal immunity is subdiffusion resulting from adherenc

216 A key to effective mucosal immunity is the capacity for antigens administer

217 Mucosal immunity is thought to wane over time but the ra

218 ssociated lymphocytes, but their function in mucosal immunity is unclear.

219 A HIV vaccine that provides mucosal immunity is urgently needed.

220 n epithelial cells and important in skin and mucosal immunity, is pseudogenized in all African and As

221 al adjuvants that induce both parenteral and mucosal immunity may be a better way to assess oral tole

222 Previous work had suggested that mucosal immunity may be affected by the stage of the est

223 Therefore, mucosal immunity may be critical to control both initial

224 the hypothesis that preexisting humoral and mucosal immunity may influence viral recovery and immune

225 , IgA antibody, which plays pivotal roles in mucosal immunity, might efficiently prevent HIV infectio

226 amebiasis subunit vaccine designed to elicit mucosal immunity mimicking that of humans cured of ALA.

227 es an important tool for detailed studies of mucosal immunity necessary for the development of mucosa

228 Initiation of adaptive mucosal immunity occurs in organized mucosal lymphoid ti

229 geal-associated lymphoreticular tissue-based mucosal immunity offers an attractive possibility to pro

230 lt3 ligand (FL) for its potential to enhance mucosal immunity or tolerance.

231 No vaccine to boost mucosal immunity, or as a therapeutic, has yet been deve

232 A myriad of interacting mechanisms of mucosal immunity permit the gut to corral the microbiota

233 Thus, underlying CMV infection can alter mucosal immunity, potentially increasing the tendency of

234 eminal contributions include regional innate mucosal immunity, prevention of SIV infection in macaque

235 reinstating mucosal architecture, improving mucosal immunity, promoting beneficial bacteria, and dow

236 ling, p53 may act as a negative regulator of mucosal immunity, promoting immunological tolerance by p

237 G crosses epithelial barriers to function in mucosal immunity remains unknown.

238 Mucosal immunity remodeled with increased in anti-inflam

239 ring the acute phase of infection, antiviral mucosal immunity restricts viral replication in the prim

240 Preceding mucosal infection induces mucosal immunity, resulting in at least 50-fold reductio

241 ry immunological defect or from dysregulated mucosal immunity secondary to intrinsic, nonhematopoieti

242 accines that induce high levels of effective mucosal immunity should impact viral replication rate an

243 elial transition, glycoprotein biosynthesis, mucosal immunity, signaling, and endocytic and neural re

244 to support intestinal homeostasis and shape mucosal immunity, similarly to commensal bacteria.

245 Genetic and mucosal immunity strongly influence the composition and

246 V) is believed to induce significantly lower mucosal immunity than oral poliovirus vaccine (OPV).

247 seasonal in India and results in intestinal mucosal immunity that appears to wane significantly with

248 HIV-1; this approach could elicit persistent mucosal immunity that may prevent HIV-1/SIV(mac251) infe

249 ic Ig receptor (pIgR) is a central player in mucosal immunity that mediates the delivery of polymeric

250 temic immunity it has potential to stimulate mucosal immunity through antigen-processing by the gut-a

251 e have shown that each is critical to intact mucosal immunity through effects on lymphocyte homing, I

252 Therefore, enhancing mucosal immunity through vaccines-strengthening that fir

253 In the field of oral mucosal immunity, through the study of patients with sel

254 n, although attractive, is poor for inducing mucosal immunity, thus limiting its protective value aga

255 Finally, evidence was found of acquired mucosal immunity to amebiasis in Bangladeshi children, o

256 d CD161(hi)CD8alpha(+) T cells contribute to mucosal immunity to bacteria and yeast.

257 Administration of IFN-gamma activated the mucosal immunity to C. rodentium infection by increasing

258 cal or stress response pathways intersect in mucosal immunity to dictate the response to pathogenic a

259 cine, will most likely not induce the needed mucosal immunity to efficiently protect the initial site

260 Th17 cells have been implicated in mucosal immunity to extracellular bacteria, and preserva

261 Mucosal immunity to gastrointestinal pathogens in early

262 haride (LPS) are the primary determinants of mucosal immunity to gram-negative enteric pathogens.

263 ave investigated the induction of protective mucosal immunity to human immunodeficiency virus type 1

264 sults indicate that bacteriophages can alter mucosal immunity to impact mammalian health.

265 gest that chIL-17RA has an important role in mucosal immunity to intestinal intracellular parasite in

266 memory in NALT that offers cross-protective mucosal immunity to not only H1N1 but also aH5N1 viruses

267 Mucosal immunity to reinfection with a highly virulent v

268 While mucosal immunity to ricin correlates with secretory immu

269 A are sufficient to confer both systemic and mucosal immunity to ricin.

270 ction of the upper respiratory tract or host mucosal immunity to RSV, recent literature suggests that

271 Induction of mucosal immunity to target this local, contained replica

272 isease (IBD) has been attributed to aberrant mucosal immunity to the intestinal microbiota.

273 suggest mechanisms involving trained innate mucosal immunity together with antigen-specific T cells,

274 their potential function and contribution to mucosal immunity, tolerance, and disease.

275 ent for IgA nephropathy targeting intestinal mucosal immunity upstream of disease manifestation.

276 , and the healthy adult nasal microbiota and mucosal immunity using an experimental human challenge m

277 that the salivary gland participates in oral mucosal immunity via generation of ectopic GCs, which fu

278 Vitamin D exerts a regulatory role over mucosal immunity via the vitamin D receptor (VDR).

279 actors remain the main drivers of protective mucosal immunity; virulence factor-deficient, like kille

280 the mechanisms responsible for induction of mucosal immunity vs tolerance are not yet fully delineat

281 Mucosal immunity was demonstrated by high levels of IgA

282 Our previous studies showed that mucosal immunity was impaired in 1-year-old mice that ha

283 The alpha-defensin-mediated innate mucosal immunity was maintained in PC throughout the cou

284 Mucosal immunity was measured by in-vitro neutralisation

285 ion of antigen-specific humoral and cellular mucosal immunity was not accompanied by a detectable inc

286 understand the effect of viral chemokines on mucosal immunity, we compared the affects of vMIP-II, I-

287 rther understanding of HIV-1-specific T-cell mucosal immunity, we established HIV-1-specific CD8(+) c

288 neutrophil activation and IgA antibodies in mucosal immunity, we hypothesized that FcR genetics and

289 ular mechanisms by which FoxO4 regulates the mucosal immunity were explored through immunologic and b

290 NA and HIV DNA copy numbers, and recovery of mucosal immunity were measured before and 9 months after

291 nutrition (PN) decreases GALT cell mass and mucosal immunity when compared with enteral feeding.

292 gans, including classical inductive sites of mucosal immunity, where they effectively stimulated B an

293 press IL-22, a T(H)17 cytokine important for mucosal immunity, whereas earlier and later stages of NK

294 Therefore, enhancing pulmonary mucosal immunity (which includes a combination of innate

295 Thus, 3SL directly modulates mucosal immunity, which increases susceptibility to coli

296 nature of antipneumococcal antibody-mediated mucosal immunity while informing vaccine development.

297 ts may augment luminal surveillance to boost mucosal immunity, while others may promote microbial acc

298 teronyssinus through breast milk affects gut mucosal immunity with long-term effects on IgE-mediated

299 Induction of mucosal immunity with vaccines is attractive for the imm

300 tive immunity against SARS-CoV-2 by inducing mucosal immunity within the respiratory system, a potent