ライフサイエンスコーパス: mucus layer

1 difficile and F nucleatum in the intestinal mucus layer.

2 wim through and colonize the viscous gastric mucus layer.

3 oxygen available to bacteria growing at the mucus layer.

4 study the interaction of pathogens with the mucus layer.

5 and limiting the association of VRE with the mucus layer.

6 ng the protection provided by the intestinal mucus layer.

7 ersistence of H. pylori in the human gastric mucus layer.

8 the mucosal lining, and the thickness of the mucus layer.

9 ir as well as drug molecule transport in the mucus layer.

10 anded A. muciniphila and thinned the colonic mucus layer.

11 expression and invade the intestine's inner mucus layer.

12 enable the bacteria to penetrate the gastric mucus layer.

13 in Mucin-2 (MUC2) forms the protective colon mucus layer.

14 de and generate fluid flow, and an overlying mucus layer.

15 rial infections is the protective intestinal mucus layer.

16 ariants, which may reduce penetration of the mucus layer.

17 of effector proteins through the intestinal mucus layer.

18 n antimicrobial peptides and more penetrable mucus layer.

19 community, concomitant with depletion of the mucus layer.

20 ired, with a reduced ability to colonize the mucus layer.

21 mum, devoid of inner membranes embedded in a mucus layer.

22 tract are in intimate contact with the outer mucus layer.

23 at are secreted by epithelial cells into the mucus layer.

24 dvantage for penetrating the viscous stomach mucus layer.

25 tes enhanced the retention in the intestinal mucus layer.

26 lls and abundantly secreted into the surface mucus layer.

27 cin denaturation and microbial access to the mucus layer.

28 r subdiffusive virions to traverse through a mucus layer.

29 tiating the retention of bacteria within the mucus layer.

30 ucin-degrading bacterium that resides in the mucus layer.

31 the main components of the gastrointestinal mucus layer.

32 ost-adapted microbes that colonize or invade mucus layers.

33 host-adapted microbes that inhabit or attack mucus layers.

34 BoNTs is increased after crossing intestinal mucus layers.

35 encroachment into the normally sterile inner mucus layer, a central feature of gut inflammation, as w

36 an "expanded" rather than more concentrated mucus layer, a prediction confirmed by electron microsco

37 development of NEC: reducing bacteria in the mucus layer, administering probiotic treatment, and bloc

38 The host's conversion of MUC2 to the outer mucus layer allows bacteria to degrade the mucin glycans

39 d model of the glycocalyx layer, or adhesive mucus layer (AML), covered by mucus gel (luminal mucus l

40 It consists of microbiota, a mucus layer, an epithelial layer, and the immune system.

41 The intestinal mucus layer, an important element of epithelial protecti

42 between 042 and 042PicS258A in the lumen and mucus layer and adherent to tissue.

43 aomicron is a gut symbiont that inhabits the mucus layer and adheres to and metabolizes food particle

44 tion of mucin glycan chains constituting the mucus layer and also come from human milk oligosaccharid

45 eposition, the drug molecules diffuse in the mucus layer and are also subjected to mucociliary advect

46 ia and bacterial components can traverse the mucus layer and contact host cells.

47 These mice also had thinning of the colonic mucus layer and decreased levels of xylose in colonic lu

48 spirillum, leading to its exclusion from the mucus layer and disease remission.

49 tly improved permeability through intestinal mucus layer and epithelia.

50 7BL/6 mice wherein V. cholerae colonizes the mucus layer and forms microcolonies in the crypts of the

51 To create a model of the human intestinal mucus layer and gut microbiota, we used bioreactors inoc

52 lmo2776 mutant leads to a thinner intestinal mucus layer and higher Listeria loads both in the intest

53 ilm distribution, greater penetration of the mucus layer and increased colonization of the colonic ep

54 underscored by decreased thickness of the OE mucus layer and increased numbers of immune cells within

55 ta, Proteobacteria were present in the inner mucus layer and invaded mucosal tissues.

56 ual intercourse, allows virions to cross the mucus layer and reach the epithelium in a short timefram

57 ving evolved traits to invade the epithelial mucus layer and reside deep within the intestinal tissue

58 The bacteria stay close to the mucus layer and respond in a microenvironment-specific m

59 a are physically separated from villi by the mucus layer and their numbers controlled by mucus-embedd

60 ound in mucin, a component of the intestinal mucus layer and thus one of the prime adherence targets

61 ntraluminal digestive enzymes, the unstirred mucus layer, and a systemic ischemic-reperfusion injury.

62 robial peptide production, maturation of the mucus layer, and improved barrier function.

63 We investigated the roles of the intestinal mucus layer, and in particular Muc2, in development of e

64 ith VacA, including reduction of the gastric mucus layer, and increased vacuolation of parietal cells

65 O-glycosylation of mucin2, destabilizes the mucus layer, and increases intestinal permeability.

66 eristalsis, fluid wash-out, viscosity of the mucus layer, and pH.

67 The intestinal mucus layer appears to function as a defensive barrier l

68 d barrier properties of the adherent gastric mucus layer are normally maintained by building-block st

69 achieved in part by the presence of a dense mucus layer at the epithelial surface and by the product

70 nteractions among the intestinal microbiota, mucus layer, bile acids, and mucosal immune responses, r

71 ity or the thickness of the small-intestinal mucus layer but, in contrast to P9 wild-type pups, enabl

72 Entamoeba histolytica (Eh) colonizes the mucus layer by binding of the parasite's surface galacto

73 Regulation of the intestinal mucus layer by goblet cells is important for preventing

74 r less than 40 nm are able to pass through a mucus layer by passive Brownian motion.

75 s capable of dissolving the inner protective mucus layer by specific cleavages in the MUC2 mucin and

76 sorption, and were observed to move with the mucus layer by the action of mucociliary transport.

77 The mucus layer coating the airways is constantly moved alon

78 in that forms the scaffold of the intestinal mucus layer coating the epithelium and separates the lum

79 The mucus layer coating the pulmonary airways is moved along

80 A mucus layer coats the gastrointestinal tract and serves

81 s on the relative mucin concentration of the mucus layer compared with that of the periciliary layer;

82 rentiated colonoids, which produce an intact mucus layer comprised of the secreted mucin MUC2, reveal

83 stent intestinal colonization, and the cecal mucus layer contained high concentrations of MRSA.

84 The mucus layer covering the gastrointestinal (GI) epitheliu

85 The mucus layer covering the gastrointestinal tract is the f

86 rticularly true when pathogens encounter the mucus layer covering the respiratory tract.

87 eature low diversity and colonization by gut mucus layer-degrading species, such as Bacteroides, Akke

88 ; and CF secretion osmotic pressures predict mucus layer-dependent osmotic compression of the pericil

89 )-induced hepatic dysfunction and intestinal mucus layer depletion with a focus on antioxidant and an

90 obes may affect goblet cell dynamics and the mucus layer directly via the local release of bioactive

91 y limit its efficacy against microbes in the mucus layer, e.g. Escherichia coli.

92 By regulating assembly of the colon mucus layer, ERN2 further shaped the composition of the

93 n in the colonic mucosa was mirrorred in the mucus layer fecal colonocytes isolated from AOM rat stoo

94 The potential positive role of the mucus layer for cellular uptake and the fate of the colo

95 s from IDO1-TG mice were 2-fold thicker than mucus layers from control mice, with increased proportio

96 Intestinal mucus layers from IDO1-TG mice were 2-fold thicker than

97 monosaccharide constituent of the intestinal mucus layer, functions as an important nutrient and a ke

98 dent microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of whi

99 Defects in the mucus layer have been linked to metabolic diseases, but

100 pure frictional coupling with the overlying mucus layer; hence, ciliary mixing most likely accelerat

101 The inner mucus layer (IML) is a critical barrier that protects th

102 pylori's ability to bore into the protective mucus layer in a corkscrew-like motion, thereby enhancin

103 er pylori persists deep in the human gastric mucus layer in a harsh, nutrient-poor environment.

104 ve within the microaerophilic surface of the mucus layer in CF lungs.

105 to why/how MUC5AC forms a static, "tethered" mucus layer in chronic muco-obstructive lung diseases.

106 fails to explain the formation of a distinct mucus layer in health or why mucus clearance fails in di

107 nificantly prevented thinning of the colonic mucus layer in meropenem-treated mice.

108 niphila and additionally thinned the colonic mucus layer in mice.

109 idase-mediated degradation of the protective mucus layer in the cervicovaginal environment.

110 susceptibility and highlight the role of the mucus layer in the development of CD.

111 pathogen E. coli K1 to enter the compromised mucus layer in the distal small intestine prior to syste

112 C2, which allows us to study the role of the mucus layer in the infection by human intestinal pathoge

113 A dense mucus layer in the large intestine prevents inflammation

114 H. felis colonized the mucus layer in the stomachs of Duoxa(-/-) mice to a grea

115 g human intestinal cells and their overlying mucus layer in vitro would thus enable the investigation

116 cells were mostly trapped within the surface mucus layer in WT mice.

117 y member of communities in the outer (loose) mucus layer, in the cecum and colon, starting at day 1 p

118 down mice (Rab7(KD)) displayed a compromised mucus layer, increased microbial permeability, and deple

119 The intestinal mucus layer is a physical barrier separating the tremend

120 med that Siglec-8 ligand on the human airway mucus layer is an isoform of DMBT1 carrying O-linked sia

121 The gastrointestinal mucus layer is colonized by a dense community of microbe

122 al irritants is enhanced when the protective mucus layer is compromised.

123 calization of the specific pathobiont in the mucus layer is critical for disease development, which i

124 The mucus layer is critical in limiting contact between host

125 ypothesis that growth of MRSA in the colonic mucus layer is required for establishment of intestinal

126 The dynamic nature of the mucus layer is shown.

127 as analyzed, considering that the intestinal mucus layer is the first defense against enteric pathoge

128 ization of a select group of bacteria to the mucus layer, ITLN1 modifies this critical barrier.

129 crypt regeneration, and also replenished the mucus layer, leading to amelioration of C. rodentium- an

130 ncreased encroachment of bacteria into inner mucus layers, low-grade gut inflammation, and a dramatic

131 s comprehensive insight into the dynamics of mucus layer maturation upon bacterial colonization of ge

132 The ASL comprises a superficial mucus layer (ML) overlying a periciliary fluid layer (PC

133 of functions in pathogen resistance such as mucus layer modifications and hydration, tight junction

134 of particular H. pylori strains in specific mucus layer niches.

135 The viscoelastic mucus layer of gastrointestinal tracts is a host defense

136 the major Siglec-8 sialoglycan ligand on the mucus layer of human airways.

137 ETEC is adapted to specifically degrade the mucus layer of its human host.

138 LipoLLA penetrated the mucus layer of mouse stomach, and a significant portion

139 duction and infiltrated the protective inner mucus layer of the colon.

140 The thick mucus layer of the gut provides a barrier to infiltratio

141 EA both bound to a receptor localized in the mucus layer of the murine cecum.

142 at the fluorescent markers can penetrate the mucus layer of the small intestine at low acoustic power

143 ty member of mixed bacterial biofilms in the mucus layer of the streptomycin-treated mouse intestine.

144 of solid fecal sections showed a continuous mucus layer of varying thickness along human fecal secti

145 e 1 pili (T1P) bound throughout the secreted mucus layers of the colon and to epithelial cells in mou

146 eing washed off by the continuously secreted mucus layers of the colon.

147 The sputum (mucus) layer of the cystic fibrosis (CF) lung is a compl

148 luids, including in vitro navigation through mucus layers on biologically relevant three-dimensional

149 ed fluid secretion mechanically disrupts the mucus layer or that toxins interfere with innate mucosal

150 ing reduced E-cadherin expression, perturbed mucus layer organization, and infiltration of bacteria i

151 ter layer and the physical resistance of the mucus layer particularly affect bioavailability of, espe

152 f-renewing replica of human 3D crypts with a mucus layer patterned in the X-Y-Z dimensions.

153 The results show that the two mucus layers penetrate each other only marginally, and t

154 Pic degraded MUC2, it did not show improved mucus layer penetration or colonization of the colonic e

155 disease (IBD) are associated with a reduced mucus layer, potentially leading to dysbiosis associated

156 The mucus layer produced by highly stressed goblet cells for

157 ng mucins, which are major components of the mucus layer protecting many epithelial surfaces, are clu

158 The intestinal mucus layer protects the epithelium from noxious agents,

159 Human upper airway mucus layer proteins were recovered during presurgical n

160 The colonic mucus layer provides a potential niche for growth of VRE

161 The mucus layer provides an essential first host barrier to

162 These results suggest that the cecal mucus layer provides an important niche that facilitates

163 Removing the mucus layer reduced PCL transport by > 80%, to 4.8+/-0.6

164 y old) was characterized by a more permeable mucus layer relative to 21 day old pups, suggesting imma

165 The gastrointestinal mucus layer represents the last barrier between ingested

166 he cell monolayer and penetrated through the mucus layer secreted by the cells.

167 dent in the large intestine, where the inner mucus layer separates the numerous commensal bacteria fr

168 But virus also undergoes advection: as the mucus layer sitting atop the PCF is pushed along by the

169 s (IEC-Cosmc(-/y)) resulted in a compromised mucus layer, spontaneous microbe-dependent inflammation,

170 of T1D is associated with alterations of the mucus layer structure and loss of gut barrier integrity.

171 ral egress from the microvilli back into the mucus layer, supporting a model of virus dispersion thro

172 g A. muciniphila or propionate preserved the mucus layer, suppressed translocation of flagellin, redu

173 (ob/ob) mice have a defective inner colonic mucus layer that is characterized by increased penetrabi

174 , for example, is lined by a firmly adherent mucus layer that is typically devoid of bacteria, follow

175 something that is achieved by a dense inner mucus layer that lines the epithelial cells.

176 imarily as single cells dispersed within the mucus layer that overlies the mouse cecal epithelium.

177 All mucosae are characterized by an outer mucus layer that protects the underlying cells from phys

178 retion is essential for the formation of the mucus layer that protects the underlying epithelial cell

179 (1), suggesting that mechanisms exist in the mucus layer that regulate virulence.

180 epithelial surface is protected by an inner mucus layer that the commensal microflora cannot penetra

181 tected by a highly viscoelastic and adhesive mucus layer that traps most foreign particles, including

182 ay surface liquid (ASL) consisting of both a mucus layer that traps, kills, and inactivates bacteria

183 to the epithelial surface and the overlying mucus layer, the pneumococcus undergoes micro-invasion o

184 inal ITLN1 exhibited decreased inner colonic mucus layer thickness and closer apposition of A. mucini

185 tificial cilium with capacitance sensing for mucus layer thickness, offering unique self-calibration,

186 did not improve the metabolic profile or the mucus layer thickness.

187 oatings that allow them to rapidly penetrate mucus layers through openings in the mucus mesh at rates

188 an inability to pass through the intestinal mucus layer to directly contact the epithelium.

189 al cells creates an oxygen gradient from the mucus layer to the anaerobic lumen [L.

190 We show that larvae degrade mucus layers to access epithelial cells.

191 stribution of inert nanoparticles within the mucus layers using an efficient replica exchange Monte C

192 s layer (AML), covered by mucus gel (luminal mucus layer) using a polymer lattice model and stochasti

193 SARS-CoV-2 traverses the mucus layer, using motile cilia as tracks to access the

194 duct exteriorization whereas the role of the mucus layer was tested via the enteral administration of

195 ting this adaptation involved the intestinal mucus layer, we found that C. rodentium was able to cata

196 The changes in the inner mucus layer were microbiota and A. muciniphila dependent

197 ent, to optimize adhesion to the respiratory mucus layer when inhaled.

198 quired high concentrations of VRE within the mucus layer, whereas saline-treated mice did not.

199 l exhibited lower FAS levels and a decreased mucus layer, which could be restored with insulin treatm

200 lity to degrade host mucins and colonize the mucus layer, which involves removal of the terminal sial

201 ducts are normally transported to the airway mucus layer, which is lost during tissue preparation.

202 e show that the small intestine has a porous mucus layer, which permitted the uptake of MUC2 by antig

203 f interaction between COS and the intestinal mucus layer, which was associated with absorption benefi

204 ella propel bacteria through urine and along mucus layers, while type 1 fimbriae allow bacteria to ad

205 Zg16(-/-) mice have a distal colon mucus layer with normal thickness, but with bacteria clo

206 ubbles, cationic microbubbles mixed into the mucus layer, without epithelial absorption, and were obs