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1  which is filled with a dense and protective mucus plug.
2 al ascension across a dysfunctional cervical mucus plug.
3 topathology, obstructions were identified as mucus plugs.
4 helial biology that produce MUC5AC-dominated mucus plugs.
5 t intercrypt crevices, and absence of apical mucus plugs.
6  participants (37%) in the discovery set had mucus plugs.
7 goblet cells, circumscribed MUC5AC-dominated mucus plugs.
8 nt steroid sensitivity pathways and decrease mucus plugging.
9 itive T2-inflammation associated with severe mucus plugging.
10  from airway inflammation, bronchospasm, and mucus plugging.
11 c target for airway diseases associated with mucus plugging.
12 nce in mice with AAD, resulting in increased mucus plugging.
13 e of barotrauma, hemodynamic instability, or mucus plugging.
14  AHR reversal is directly related to reduced mucus plugging.
15  a T2-driven proximalization associated with mucus plugging.
16 on of pathologic mucus which leads to airway mucus plugging.
17 ated airways and often airway thickening and mucus plugging.
18 e from uninfected mice with AAD demonstrated mucus plugging after 14 and 21 days of ovalbumin-aerosol
19 ntly type 2 airway immune responses and with mucus plugging, air trapping, and airway remodeling.
20 sputum MUC5AC expression and high scores for mucus plugging, air trapping, and other measures of airw
21 ing micro-CT and matched histology to assess mucus plugs, airway wall remodelling and mucus compositi
22                          In asthmatic lungs, mucus-plugged airways had thickened airway walls, narrow
23 flammation, and lung image-based measures of mucus plugging and airway remodeling.
24 aluation of lung sections revealed extensive mucus plugging and epithelial cell hypertrophy/hyperplas
25 e (COPD); however, the association of airway mucus plugging and mortality in patients with COPD is un
26 gether with decreases in pulmonary function, mucus plugging and oxygen consumption by host neutrophil
27  of airway hyperresponsiveness and to assess mucus plugging and remodelling as wall thickening with i
28 that is fraught with complications including mucus plugging and tracheoesophageal fistula.
29 alities in lung morphology, including airway mucus plugging and wall thickening, in adolescent and ad
30 in Results: Among 400 smokers, 229 (57%) had mucus plugs and 207 (52%) had emphysema, and subgroups c
31  of airway remodeling and contributes to the mucus plugs and airflow obstruction associated with seve
32 trum of mucus pathophysiology contributes to mucus plugs and chronic bronchitis symptoms.
33             Rationale: The relative roles of mucus plugs and emphysema in mechanisms of airflow limit
34 bjectives: To relate image-based measures of mucus plugs and emphysema to measures of airflow obstruc
35                     The relationship between mucus plugs and spatially overlapping ventilation abnorm
36 h osteochondral destruction, bronchiectasis, mucus plugging, and a pulmonary nodule.
37 ll as MRI-defined airway wall abnormalities, mucus plugging, and abnormal lung perfusion in infants a
38 on have been shown to improve lung function, mucus plugging, and airway structural changes that can e
39                      Scores for trapped air, mucus plugging, and bronchial wall thickening improved s
40  MUC5AC is the secretory mucin implicated in mucus plugging, and MUC5AC gene expression has been asso
41 ed bronchial wall thickening/bronchiectasis, mucus plugging, and perfusion deficits from the first ye
42 goblet cell hyperplasia; hyper IgE syndrome; mucus plugging; and extensive inducible BALT.
43 flecting decreased formation of asphyxiating mucus plugs; and 3) in Scnn1b-Tg mice, neutrophilia, muc
44                  Objectives: To determine if mucus plugs are a persistent asthma phenotype and if cha
45                                   In asthma, mucus plugs are a prominent and spatially heterogeneous
46    Conclusions: Computed tomography-detected mucus plugs are associated with an increased risk for fu
47                                      Whether mucus plugs are associated with prospective exacerbation
48                                       Airway mucus plugs are common in patients with chronic obstruct
49 < 0.001).Conclusions: Symptomatically silent mucus plugs are highly prevalent in smokers and independ
50 of disease heterogeneity, including regional mucus plugging associated with abnormal lung perfusion i
51                            Conclusion Airway mucus plugging at CT was associated with reduced ventila
52                                    Segmental mucus plugs at CT were scored by two readers, with segme
53 ace enlargement, but had no effect on airway mucus plugging, bacterial infection, or pulmonary mortal
54                                    We scored mucus plugging based on the number of lung segments with
55 ailure, ventilation failure, barotraumas, or mucus plugging between treatment groups.
56                                              Mucus plugging can worsen asthma control, lead to reduce
57 erized by lung eosinophilia, remodeling, and mucus plugging, controlled by adaptive Th2 effector cell
58  disease was believed to arise from abnormal mucus plugging exocrine ducts.
59                                              Mucus plug formation and chronic bronchitis are manifest
60  pneumothorax development in one patient and mucus plug formation in one patient.
61                   Here, we demonstrated that mucus plugs from individuals with fatal asthma are heter
62                          Segments containing mucus plugs had a median segmental VDP of 25.9% (25th-75
63                Participants with one or more mucus plugs had a median whole-lung VDP of 11.1% (25th-7
64 ssion patterns are linked to the presence of mucus plugs, highlighting biological pathways involved i
65 ng based on the number of lung segments with mucus plugs identified on chest computed tomography scan
66                                 Conclusions: Mucus plugs identify a persistent asthma phenotype, and
67 c variations that may underlie propensity to mucus plugging in asthma and could be important in targe
68 tasis and likely represents a major cause of mucus plugging in asthma.
69  may serve to identify occult central airway mucus plugging in the ventilated asthmatic patient.
70 95% CI, 50.7%-57.4%) in participants who had mucus plugs in 0, 1 to 2, and 3 or more lung segments, r
71 53 (21.8%), and 825 (18.9%) participants had mucus plugs in 0, 1 to 2, and 3 or more lung segments, r
72                              The presence of mucus plugs in 1 to 2 vs 0 and 3 or more vs 0 lung segme
73                            Background Airway mucus plugs in asthma are associated with exacerbation f
74 r luminal O(2), airway epithelia surrounding mucus plugs in chronic obstructive pulmonary disease (CO
75       Rationale: Cross-sectional analysis of mucus plugs in computed tomography (CT) lung scans in th
76  target for mucin depolymerization to remove mucus plugs in COPD and other lung pathologies.
77 airflow over time supports a causal role for mucus plugs in mechanisms of airflow obstruction in asth
78 ciated with protection from the formation of mucus plugs in T2-high asthma.
79 , accidental extubation, desaturation and/or mucus plugging/inhalation, hypotension and/or arrhythmia
80  foreign bodies, virus infection, tumors, or mucus plugs intrinsic to airway disease, including cysti
81 ary lesions (k = 1.00), effusion (k = 0.64), mucus plug (k = 0.68), and solid scattered nodularity (k
82 hyperpolarized helium 3 MRI, suggesting that mucus plugging may be an important cause of ventilation
83 electasis/consolidation, BE with and without mucus plugging (MP), airway wall thickening, MP, ground-
84 ever, some features are different, including mucus plugging, mucus "tethering" to goblet cells, plasm
85                  In in vivo models of airway mucus plugs, neutrophil migration was inhibited by thick
86 lbumin-aerosol challenge, with resolution of mucus plugging occurring by 42 days.
87 tent asthma phenotype, and susceptibility to mucus plugs occurs at the subject and the bronchopulmona
88 act infection can result in inflammation and mucus plugging of airways.
89 t represent a protective strategy to prevent mucus plugging of distal airways and thus impaired venti
90 f partially dispersed Paneth granules in the mucus plugs of CF mouse intestinal crypts, and this mucu
91 use mortality compared with patients without mucus plugging on chest CT scans.
92   Objective: To examine associations between mucus plugs on chest computed tomography (CT) and future
93                          Radiologists scored mucus plugs on CT lung images, and imaging software auto
94 n alone is not sufficient to trigger luminal mucus plugging or airways inflammation/goblet cell hyper
95 n adult Scnn1b-Tg mice, but did not decrease mucus plugging or neutrophilia.
96 ter the overall permeability of the cervical mucus plug, our findings suggest that the latter mechani
97 ersistent asthma phenotype and if changes in mucus plugs over time associate with changes in lung fun
98  secretion, which formed a thick, protective mucus plug overlying the surface epithelium, entrapping
99  radiographic infiltrates, coughing up thick mucus plugs, peripheral and pulmonary eosinophilia, and
100 ogists generated mucus plug scores to assess mucus plug persistence over time.
101 thma Research Program (SARP)-3 showed a high mucus plug phenotype.
102 redicted; 36.2% female), 44.4% and 46.0% had mucus plugs, respectively.
103 icted FEV(1), and FVC stratified by baseline mucus plug score (high/low defined by score >=4/0-3.5, r
104            The association between change in mucus plug score and change in airflow over time support
105                                              Mucus plug score and emphysema percentage were independe
106                    The relationships between mucus plug score and lung function outcomes were stronge
107  Fewer dupilumab-receiving patients had high mucus plug score at Week 24 than at baseline (32.8% vs 6
108                 Associations between ordinal mucus plug score categories (0, 1-2, and >=3) and prospe
109                   Post hoc analyses included mucus plug score change from baseline, and patient propo
110                                The change in mucus plug score from baseline to Year 3 was significant
111 sults: In 164 participants, the mean (range) mucus plug score was similar at baseline and Year 3 (3.4
112                                   Changes in mucus plug score were analyzed in relation to changes in
113 moderate-to-severe asthma with high baseline mucus plug score, and increased the likelihood of achiev
114 nadjusted and adjusted relationships between mucus plug score, emphysema percentage, and lung functio
115        Assess dupilumab efficacy by baseline mucus plug score.
116 chieving FeNO <25 ppb regardless of baseline mucus plug score.
117 0.30 mL [0.01-0.59]; P = 0.0399) in the high-mucus-plug score subgroup.
118  likely to achieve FeNO <25 ppb in high-/low-mucus-plug score subgroups (odds ratio: 6.64; P = 0.003/
119 e To assess regional associations between CT mucus plugs scored by individual bronchopulmonary segmen
120                            Dupilumab reduced mucus plug scores and improved lung function in patients
121                Only 33% of smokers with high mucus plug scores had mucus symptoms.
122  SARP-3 participants, radiologists generated mucus plug scores to assess mucus plug persistence over
123               Compared with smokers with low mucus plug scores, those with high scores had worse COPD
124 bstruction, frequent exacerbations, and high mucus plug scores.
125 mental VDP of 18.9% (95% CI: 15.7, 22.2) for mucus-plugged segments versus 5.1% (95% CI: 3.3, 7.0) fo
126  reduced the airway eosinophil infiltration, mucus plugging, smooth muscle hyperplasia, and subepithe
127  segments with AT more frequently had airway mucus plugging than lung segments without AT (48% vs. 18
128 function and was more weakly associated with mucus plugs than that of epithelial-related genes.
129                                              Mucus plugs that completely occluded airways on chest CT
130   In participants with COPD, the presence of mucus plugs that obstructed medium- to large-sized airwa
131                    Relative to those without mucus plugs, the presence of 1-2 and >=3 mucus plugs was
132                            In MCMV/AAD mice, mucus plugging was observed after 7 days of ovalbumin-ae
133          In the distal lung, MUC5B-dominated mucus plugging was observed in 90% of subjects with COVI
134                  The presence of 1-2 and >=3 mucus plugs was also associated with increased risk for
135 out mucus plugs, the presence of 1-2 and >=3 mucus plugs was associated with increased risk (adjusted
136                                              Mucus plugs were comprised of 84% and 82% MUC5AC and 16%
137 ltiple types of obstruction characterized as mucus plugs were identified in smokers with emphysema an
138                                              Mucus plugs were observed in 49 total bronchopulmonary s
139                                     Methods: Mucus plugs were visually identified on baseline chest c
140 severe in those with airway eosinophilia and mucus plugging, whereas those who are obese have less se
141  from airway epithelial cells and subsequent mucus plugging, which serves as the focus for infections
142  from airway epithelial cells and subsequent mucus plugging, which serves as the focus for infections
143 nd 21% of transitional bronchioles contained mucus plugs, with a high coefficient of variation in the
144 ue to the resolution of CT, it is unknown if mucus plugs within the distal small airways (<2mm in dia

 
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