ライフサイエンスコーパス: multilocus

1 ations and applied long-range haplotype- and multilocus allelic differentiation-based methods to dete

2 Here we used multilocus amplicon sequencing of eDNA to survey biodive

3 allows, thereby potentially allowing a true multilocus analysis for high-dimensional genomic data.

4 tly published approaches, making genome-wide multilocus analysis of longitudinal traits possible.

5 Here we report a multilocus analysis of nucleotide polymorphism and LD in

6 Exploratory linear mixed-effects multilocus analysis suggested that other functional vari

7 In contrast to standard methodology for multilocus analysis, which has focused on the dimension

8 Multilocus and whole-genome sequence analyses are becomi

9 We developed the Multilocus ANTIgenic Simulator (MANTIS) software package

10 Multilocus architecture is ancestral and maintained acro

11 We applied TREAT as a multilocus association test on >20 000 genes/regions in

12 on the dimension reduction of the data, our multilocus association-clustering test profits from the

13 aintenance of extensive polymorphism through multilocus balancing selection in a heterogeneous enviro

14 of diversity patterns and the generation of multilocus barcode reference libraries across whole ecos

15 of DNA sequencing continues to fall that our multilocus barcoding approach will eclipse existing sing

16 e, we could correctly identify species using multilocus barcoding method.

17 Multilocus coalescence analyses suggested that F. albici

18 ng of ancestral recombination graphs under a multilocus coalescent model.

19 Here, we infer multilocus coalescent trees from >1000 nuclear single-nu

20 Critically, the multilocus composite score revealed that those with a gr

21 th a greater number of these genotypes per a multilocus composite, show less responsivity of reward r

22 Here we use multilocus data and ecological niche models (ENMs) to te

23 ina amplicon sequencing approach to generate multilocus data from large collections of arthropods.

24 c studies based on single or, more commonly, multilocus data sets have helped resolve the placement o

25 because they can accommodate coalescence and multilocus data sets.

26 make an efficient use of information in the multilocus data.

27 A multilocus dataset was analyzed using maximum likelihood

28 Here, we analyze multilocus datasets of diverse arthropod communities, to

29 We present a minimal multilocus distance (MMD) method which rapidly deals wit

30 ishes and designed a three-step pipeline for multilocus DNA barcoding.

31 Multilocus DNA sequence data were used to assess the gen

32 e analyzed several sources of data including multilocus DNA sequence, climatic niche models and chrom

33 Imprinting defects can involve isolated or multilocus epigenetic changes that may have no evident g

34 Hence multilocus epistasis makes substantial contributions to

35 complex protein mixtures encoded by several multilocus gene families that function synergistically t

36 a novel Francisella species via 16S rRNA and multilocus gene sequence analysis.

37 The results suggest that the multilocus genetic composite is a more sensitive index o

38 ve effect of the 6 NOS1AP SNPs by means of a multilocus genetic risk score (GRS(NOS1AP)) uncovered a

39 We hypothesised that a multilocus genetic risk score could refine CHD predictio

40 A multilocus genetic risk score for BMI (GRS-BMI), calcula

41 We assessed genetic risk with a multilocus genetic risk score.

42 leotide polymorphisms (SNPs) and constructed multilocus genetic risk scores (GRSs) for each individua

43 We evaluated whether including multilocus genetic risk scores (GRSs) into the Framingha

44 A multilocus genetic score reflecting genetic variability

45 Multilocus genome-wide association studies (GWAS) have b

46 Principal component analysis, multilocus genotype assignment and interspecific heteroz

47 Modeling of phenotypes for multilocus genotype classes in the epistatic networks is

48 series of methods in population genetics use multilocus genotype data to assign individuals membershi

49 t process mixture model (DPM) for clustering multilocus genotype data.

50 In these models, the multilocus genotype is mapped to fitness in two steps.

51 bset of these polymorphic loci (9) and fewer multilocus genotypes (19), consistent with the dispersal

52 passing 5'UTR-Intron 1 of LRRTM3 that formed multilocus genotypes (MLG) with suggestive global associ

53 These clustered into 136 multilocus genotypes (MLGs), with 32% of MLGs recovered

54 Multilocus genotypes from 7 microsatellite loci suggeste

55 le in a relatedness analysis are a sample of multilocus genotypes from which both allele frequencies

56 Among the 19 multilocus genotypes identified in populations from the

57 ention to frequencies of locally most common multilocus genotypes in Floridian populations of the Man

58 Microsatellite multilocus genotypes of the pre-logging populations were

59 significantly correlated with the number of multilocus genotypes present.

60 s of clonal evolutionary relationships among multilocus genotypes with the eBURST algorithm and analy

61 terranean possess 16 polymorphic loci and 37 multilocus genotypes.

62 al discriminative/predictive capability of 4 multilocus GRSs for incident CHD among subjects of Europ

63 e regression with empirical Bayes to perform multilocus GWAS under polygenic background control.

64 igh-throughput machine learning approach for multilocus GWAS using longitudinal traits by coupling Em

65 constructing the pfcrt-pfmdr1-pfdhfr-pfdhps multilocus haplotypes, we found that the alleles at thes

66 se familial biparental hydatidiform mole and multilocus imprinting disturbance, respectively.

67 5 in five mothers of individuals affected by multilocus imprinting disturbance.

68 od of this phenomenon (referred to herein as multilocus inherited neoplasia alleles syndrome [MINAS])

69 cores weighted by the T2D log odds ratio and multilocus kernel tests also indicated a significant rel

70 In using multilocus linkage disequilibrium (LD) to infer recombin

71 The absence of multilocus linkage disequilibrium and the high proportio

72 We concluded that LOS is a multilocus LOI syndrome, as is BWS.

73 digree of a sample of individuals from their multilocus marker genotypes.

74 p and parentage among individuals from their multilocus marker genotypes.

75 ratio in gametophyte plants (ramets) and in multilocus microsatellite genotypes (genets).

76 ly fixed for a single clone as determined by multilocus microsatellite genotyping.

77 Multilocus mixed model analysis confirmed the advantage

78 traits that were stable over 2 years using a multilocus mixed model as a general method for mapping c

79 ed by implementing rank transformation and a multilocus mixed model to map alleles controlling 20 ele

80 chromosome were included simultaneously in a multilocus model and least angle regression was used to

81 However, implementation of multilocus model in GWAS is still difficult.

82 The selected SNPs in multilocus model were further detected for their associa

83 olecular Inc., Des Plaines, IL) incorporates multilocus PCR and electrospray ionization-mass spectrom

84 Multilocus phylogenetic analyses showed that MRE form a

85 f Schizophyllum from the United States using multilocus phylogenetic analysis and their in vitro susc

86 Based on multilocus phylogenetic analysis, YSLV6 shows a close ev

87 A multilocus phylogenetic study was carried out to assess

88 Despite progress based on multilocus, phylogenetic studies of the palms (order Are

89 these issues, we first provide a snapshot of multilocus phylogeographic studies across the Carpentari

90 ious theory suggests that the conditions for multilocus polymorphism are restrictive.

91 mulations indicated that phylogeographic and multilocus population-level sampling both could differen

92 ective longitudinal study, we investigated a multilocus profile of genetic risk derived from publishe

93 , modeling epistatic relationships and using multilocus profiles.

94 for quantitative traits utilizing a range of multilocus quantitative genetic models and gene frequenc

95 andom-SNP-effect mixed linear model and fast multilocus random-SNP-effect EMMA methods had almost equ

96 pLARmEB, multilocus random-SNP-effect mixed linear model and fast

97 n allows accommodation of the duplication of multilocus region 34 protein (Dom34)-dependent ribosome

98 explore a more general class of models with multilocus seasonally fluctuating selection in diploids.

99 cterization of a subset of horse isolates by multilocus sequence analysis (MLSA) and 16S rRNA gene se

100 Although multilocus sequence analysis (MLSA) is considered the go

101 C. difficile genotypes were determined by multilocus sequence analysis and PCR ribotyping; sequenc

102 osis of Nocardia species was performed using multilocus sequence analysis of gyrase B of the beta sub

103 ized morphologically and molecularly using a multilocus sequence analysis that included the internal

104 o classify isolates into distinct species, a multilocus sequence analysis using rpoB and internal tra

105 Multilocus sequence data collected from a subset of 128

106 3 international clonal complexes, belongs to multilocus sequence type (MLST) 10, and is most closely

107 and repetitive extragenic palindromic-PCR), multilocus sequence type (MLST) analysis, and WGS on 148

108 m 0.02 to 4.865 mug/ml and correlated with a multilocus sequence type (MLST) clonal complex associate

109 ryptococcus neoformans strains with the same multilocus sequence type (MLST).

110 States and Canada between 1992 and 2013 were multilocus sequence type (ST) 1.

111 umoniae, most notably isolates classified as multilocus sequence type (ST) 258, have emerged as an im

112 al and spatial diverse S. aureus isolates of multilocus sequence type (ST) 8 to reconstruct the molec

113 moniae is primarily associated with a single multilocus sequence type (ST), ST258, and its related va

114 of the E coli genome showed it to belong to multilocus sequence type 131 (ST131).

115 All MRSA belonged to multilocus sequence type 239 (ST 239).

116 Klebsiella pneumoniae strains classified as multilocus sequence type 258 (ST258) are among the most

117 var Typhimurium (45% [116/258] of which were multilocus sequence type 313).

118 nella enterica serovar Typhimurium strain of multilocus sequence type 313, the predominant genotype c

119 Sequencing of a multilocus sequence type 95 (ST95) serogroup O1 strain p

120 he property's groundwater supply matched the multilocus sequence type of the clinical isolates.

121 Genotype (multilocus sequence type) and fluoroquinolone susceptibi

122 rocessed fastq folders to determine species, multilocus sequence type, the presence of a mec gene, an

123 arches) were used to determine stx subtypes, multilocus sequence types (15 loci), and the presence of

124 of strains representing different serotypes, multilocus sequence types (MLST), and sites of clinical

125 s performed to produce a phylogeny, identify multilocus sequence types (MLST), multiantigen sequence

126 erformed to produce a phylogeny and identify multilocus sequence types (MLST), N. gonorrhoeae multian

127 e of 28 E. faecalis isolates representing 24 multilocus sequence types (MLSTs), including human comme

128 5 USA500 isolates yielded 3 spa types and 2 multilocus sequence types (MLSTs).

129 We screened the collection for multilocus sequence types (STs) and for host specific re

130 rkholderia pseudomallei isolates with shared multilocus sequence types (STs) have not been isolated f

131 Previously, Bayesian clustering of 437 multilocus sequence types (STs) in the international dat

132 Studies have indicated that some multilocus sequence types (STs) of GBS are more likely t

133 Serotypes and multilocus sequence types (STs) were extracted from the

134 h chronic melioidosis demonstrated identical multilocus sequence types (STs).

135 ins representing epidemiologically important multilocus sequence types ST131, ST73, and ST95 and non-

136 ote, only four isolates (7%) of the 56 whose multilocus sequence types were determined were found to

137 ally, the software identifies a cluster of 9 multilocus sequence types with abnormally high 'virulenc

138 metronidazole resistance were similar in all multilocus sequence types.

139 did whole genome sequencing and core genome multilocus sequence typing (1546 loci) on serogroup W di

140 ing Ridom SeqSphere software for core genome multilocus sequence typing (cgMLST) analysis of whole-ge

141 Core genome multilocus sequence typing (cgMLST) and high-quality sin

142 strategies were used to generate core genome multilocus sequence typing (cgMLST) data.

143 ere, we describe a refinement to core genome multilocus sequence typing (cgMLST) in which alleles at

144 we proposed the development of a core genome multilocus sequence typing (cgMLST) scheme for M. gallis

145 We describe the creation of a core genome multilocus sequence typing (cgMLST) scheme to provide a

146 Based on core genome multilocus sequence typing (cgMLST), isolates from linea

147 es and in three European countries presented multilocus sequence typing (MLST) alleles, sequence type

148 lecular characterization was performed using multilocus sequence typing (MLST) alongside traditional

149 he specificity and sensitivity inferred from multilocus sequence typing (MLST) and genome-wide SNP-ba

150 ecular epidemiology of CR-KP infections with Multilocus sequence typing (MLST) and Matrix-assisted la

151 he same patient were molecularly typed using multilocus sequence typing (MLST) and multispacer sequen

152 MRSA isolates were further genotyped using multilocus sequence typing (MLST) and pulsed-field gel e

153 virulence-associated genes were analyzed by multilocus sequence typing (MLST) and sequence analysis

154 Characterization of PVL-MSSA isolates by multilocus sequence typing (MLST) and spa typing in this

155 The data for these isolates included multilocus sequence typing (MLST) and staphylococcal pro

156 genotyping approaches: gyrB gene sequencing, multilocus sequence typing (MLST) and whole genome clust

157 ere tested for antimicrobial susceptibility, Multilocus Sequence Typing (MLST) and Whole Genome Seque

158 discriminatory power was compared to that of multilocus sequence typing (MLST) and whole-genome optic

159 terizes B. hampsonii using a newly developed multilocus sequence typing (MLST) approach and elucidate

160 sZ, gltA, groEL, ribC, and rpoB), applying a multilocus sequence typing (MLST) approach.

161 Serotyping and multilocus sequence typing (MLST) are primary methods to

162 and refrigeration, predominantly belonged to multilocus sequence typing (MLST) clonal complex (CC)-21

163 Multilocus sequence typing (MLST) confirmed the strains

164 Although multilocus sequence typing (MLST) currently represents t

165 Multilocus sequence typing (MLST) data demonstrated that

166 nalysis of the population structure based on multilocus sequence typing (MLST) data derived from the

167 A multilocus sequence typing (MLST) database for V. paraha

168 Multilocus sequence typing (MLST) demonstrated 21 known

169 Comparison between WGS and multilocus sequence typing (MLST) identified major discr

170 he 16S-23S rRNA intergenic spacer region and multilocus sequence typing (MLST) indicated a predominan

171 Multilocus sequence typing (MLST) is the gold standard g

172 capsular biosynthetic loci, and 8 targeting multilocus sequence typing (MLST) loci were employed for

173 We performed multilocus sequence typing (MLST) on all isolates and se

174 A multilocus sequence typing (MLST) scheme for M. pneumoni

175 of the genetic diversity of this pathogen, a multilocus sequence typing (MLST) scheme was developed a

176 In this study, we introduce a multilocus sequence typing (MLST) scheme, comprised of s

177 e identified and used to develop an expanded multilocus sequence typing (MLST) scheme.

178 Two multilocus sequence typing (MLST) schemes have been deve

179 d 167 isolates into 39 groups and subsequent multilocus sequence typing (MLST) separated a subset of

180 clades are assigned to ST131 by the Achtman multilocus sequence typing (MLST) system and a screening

181 Here, we used multilocus sequence typing (MLST) to compare the molecul

182 Multilocus sequence typing (MLST) was able to accurately

183 Nested multilocus sequence typing (MLST) was employed for case

184 pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST) were performed.

185 ing pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and clustered regular

186 notyped by pulsed field gel electrophoresis, multilocus sequence typing (MLST), and molecular capsule

187 riable number tandem repeat analysis (MLVA), multilocus sequence typing (MLST), and pertactin gene (p

188 ing pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and serotyping.

189 The isolates underwent multilocus sequence typing (MLST), as well as assays for

190 of sequence-based typing approaches, such as multilocus sequence typing (MLST), by substantially incr

191 Sequence-based typing (SBT), analogous to multilocus sequence typing (MLST), is the current "gold

192 -field gel electrophoresis (PFGE) and 7-gene multilocus sequence typing (MLST), provided limited reso

193 during 2002 to 2008 in Great Britain, using multilocus sequence typing (MLST), pulsed-field gel elec

194 lution antimicrobial susceptibility testing, multilocus sequence typing (MLST), spa typing, SCCmec ty

195 2016 with the isolates confirmed as ST398 by multilocus sequence typing (MLST), which prompted retros

196 genomic clades of Bp, largely congruent with multilocus sequence typing (MLST).

197 onsistent with genomotypes assigned by using multilocus sequence typing (MLST).

198 Selected isolates were subjected to multilocus sequence typing (MLST).

199 in China, Sweden, and Egypt were subtyped by multilocus sequence typing (MLST).

200 y repetitive sequence-based PCR (repPCR) and multilocus sequence typing (MLST).

201 ism analysis (RFLP), PCR fingerprinting, and multilocus sequence typing (MLST).

202 by using polymerase chain reaction (PCR) and multilocus sequence typing (MLST).

203 solates causing meningitis were genotyped by multilocus sequence typing (MLST).

204 Selected strains were evaluated by multilocus sequence typing (MLST).

205 raditional method of amplicon sequencing for multilocus sequence typing (MLST).

206 ups within clonal groups defined by standard multilocus sequence typing (MLST).

207 sive) from 2011 to 2014 was characterized by multilocus sequence typing (MLST).

208 Ribosomal multilocus sequence typing (rMLST) using ribosomal prote

209 lectrophoresis (PFGE); however, conventional multilocus sequence typing (targeting 6 conserved loci)

210 are, and environmental data and whole-genome multilocus sequence typing (wgMLST) of clinical and envi

211 icd allele 96 and gyrB allele 87, two of the multilocus sequence typing alleles that define ST648; an

212 restriction fragment length polymorphism and multilocus sequence typing analysis.

213 valuation of genotypic (gene comparisons and multilocus sequence typing and analysis), genomic (dDDH,

214 pes (sequence types [ST]) were defined using multilocus sequence typing and assigned to a clonal comp

215 borrelial DNA in ticks were characterized by multilocus sequence typing and by sequencing five other

216 BLEC by pulsed-field gel electrophoresis and multilocus sequence typing and identified their blaESBL

217 cell lymphoma, which was identified both by multilocus sequence typing and matrix-assisted laser des

218 Isolates underwent multilocus sequence typing and PCR sequencing of the wzi

219 latedness of the isolates was assessed using multilocus sequence typing and phylogenetic analyses.

220 sely related porA sequences was confirmed by multilocus sequence typing and pulsed-field gel electrop

221 Whole-genome multilocus sequence typing and single nucleotide polymor

222 DNA uptake sequence signatures, metagenomic multilocus sequence typing and strain-specific marker ge

223 he developed assays and a recently developed multilocus sequence typing assay showed congruent typing

224 We show that emm typing and multilocus sequence typing can be achieved rapidly and e

225 e patients, belonged to the same core-genome multilocus sequence typing cluster with no more than 4 a

226 Serotype and multilocus sequence typing data for 426 pneumococci date

227 ce types and showed improved congruence with multilocus sequence typing data.

228 Multilocus sequence typing effectively distinguished 82

229 We compared Xpert C. difficile/Epi to multilocus sequence typing for identification of C. diff

230 ST17) were identified for the first time by multilocus sequence typing in an area where bathing had

231 Multilocus sequence typing indicates that C. difficile s

232 hole-genome sequencing was used to determine multilocus sequence typing information and identify gene

233 A multilocus sequence typing method was also established f

234 Multilocus sequence typing of Borrelia hermsii isolates

235 Multilocus sequence typing of multiple isolates from the

236 analysis of PCR amplified16S rRNA genes, and multilocus sequence typing of three housekeeping genes c

237 s were serotyped; susceptibility testing and multilocus sequence typing on Salmonella enterica serova

238 s of clinical M. abscessus isolates utilized multilocus sequence typing or pulsed-field gel electroph

239 We have created the first multilocus sequence typing scheme (MLST) for P. larvae,

240 These were organized into a core genome multilocus sequence typing scheme (N gonorrhoeae cgMLST

241 ity within the species based on the existing multilocus sequence typing scheme.

242 ation showed that the arcC genes used in the multilocus sequence typing schemes of these two species

243 perior accuracy and performance for standard multilocus sequence typing schemes, along with larger ge

244 Multilocus sequence typing showed various clades, with m

245 e development and evaluation of an effective multilocus sequence typing strategy for M. xenopi.

246 in the South Pacific - for Wolbachia, using multilocus sequence typing to characterize bacterial str

247 We used multilocus sequence typing utilizing eight chromosomally

248 Multilocus sequence typing was successfully completed on

249 electrophoresis) patterns and the same MLST (multilocus sequence typing) sequence type (ST-1068) rega

250 action, pulse-field gel electrophoresis, and multilocus sequence typing).

251 Isolates were characterised by serotyping, multilocus sequence typing, and antimicrobial susceptibi

252 chain reaction, phylogeny was assigned using multilocus sequence typing, and clonal relatedness was e

253 ase genes, pulsed-field gel electrophoresis, multilocus sequence typing, and plasmid analysis were pe

254 typing by pulsed-field gel electrophoresis, multilocus sequence typing, and WGS.

255 Using serotyping, multilocus sequence typing, and whole-genome sequencing

256 Whole-genome sequencing was used to perform multilocus sequence typing, capsular typing, and identif

257 ere characterized by susceptibility testing, multilocus sequence typing, DiversiLab, and plasmid anal

258 Relatedness was assessed by multilocus sequence typing, fitness was evaluated by gro

259 brial adhesin gene: H subclone assignments), multilocus sequence typing, gyrA and parC sequence (fluo

260 iers, and blood cultures were analyzed using multilocus sequence typing, phylotyping, ESBL genes, pla

261 ics of the strains, which were determined by multilocus sequence typing, sap typing, and the presence

262 Using multilocus sequence typing, we investigated the genetic

263 mining of this enormous data set to create a multilocus sequence typing-based scheme that can identif

264 ptococcus pneumoniae, and isolates underwent multilocus sequence typing.

265 Meningococcal CCs were assessed by multilocus sequence typing.

266 pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing.

267 iverse and can be classified by serotype and multilocus sequence typing.

268 C. trachomatis samples were typed using multilocus sequence typing.

269 s from the same counties were compared using multilocus sequence typing.

270 to 2011, we identified 85 sequence types by multilocus sequence typing.

271 rsity of the isolates was investigated using multilocus sequence typing.

272 dom (approximately 600,000 people) underwent multilocus sequence typing.

273 KPC-KP isolates underwent multilocus sequence typing.

274 ers or skin lesions, and were examined using multilocus sequence typing.

275 n, partial sequencing of the groEL gene, and multilocus sequencing of 7 housekeeping genes confirmed

276 ive whole-genome sequencing with core genome multilocus sequencing typing (cgMLST) analysis for real-

277 e theoretical predictions was tested against multilocus simulations, with selection, recombination, a

278 A time-calibrated multilocus species tree revealed a pattern of Miocene an

279 erinary relevance within Fusarium Six of the multilocus STs within the FSSC (3+4-eee, 1-b, 12-a, 12-b

280 In addition, for multilocus traits, the multiplicity of alternative, func

281 Current whole-genome clustering and multilocus typing approaches do not fully exploit core a

282 To answer this question, we developed a multilocus typing assay based on high-throughput sequenc

283 y and genotypically characterized, including multilocus typing of five genes and whole-genome sequenc

284 Multilocus variable number of tandem repeats analysis (M

285 Pulsed-field gel electrophoresis (PFGE) and multilocus variable number tandem repeat analysis (MLVA)

286 ded pulsed-field gel electrophoresis (PFGE), multilocus variable number tandem repeat analysis (MLVA)

287 WGS also correlated well with multilocus variable-number tandem repeat analysis (MLVA)

288 enetic clusters that were directly linked to multilocus variable-number tandem repeat analysis (MLVA)

289 aphylococcal protein A (spa) typing and with multilocus variable-number tandem repeat analysis (MLVA)

290 his study, we evaluated a recently developed multilocus variable-number tandem-repeat (VNTR) analysis

291 inly performed through PCR-based methods and multilocus variable-number tandem-repeat (VNTR) analysis

292 f strains revealed cocirculation of multiple multilocus variable-number tandem-repeat analysis (MLVA)

293 genome sequencing and two PCR-based methods, multilocus variable-number tandem-repeat analysis (MLVA)

294 pes 1 [60%] and 2 [40%]) and seven different multilocus variable-number tandem-repeat analysis (MLVA)

295 No study to date has compared multilocus variable-number tandem-repeat analysis (MLVA)

296 In this study, multilocus variable-number tandem-repeat analysis (MLVA)

297 ed using the major adhesion protein (P1) and multilocus variable-number tandem-repeat analysis (MLVA)

298 that complex phenotypes can also arise from multilocus variation.

299 al susceptibility testing, P1 subtyping, and multilocus VNTR (variable-number tandem repeats) analysi

300 To address these issues, we developed a multilocus Wright-Fisher model of HIV dynamics with sele