ライフサイエンスコーパス: multiple

1 Macroscopic disease: Gastric lesions were multiple: 38%, single: 62%, submucosal: 13%, or ulcerate

2 Coordinating multiple activities of complex enzymes is critical for l

3 s of C(2) H(2) adsorption capacity following multiple adsorption-desorption cycles.

4 Col6a1(-/-) mice also displayed multiple airway changes, including increased branching (

5 ted the 3D-bioprinting technology to develop multiple all-inclusive high throughputs and customized o

6 tion should be allergen specific and include multiple allergen-specific mitigation strategies.

7 Deletion of Ccr2 in cancer cells resulted in multiple alterations associated with better immune contr

8 Full-length transcript analysis links multiple alternative splicing events together and allows

9 nitors, time-integrated instrumentation, and multiple analytical methods.

10 osed S. aureus, but also induce tolerance to multiple antibiotics.

11 und, BCH070, that inhibits asexual growth of multiple antimalarial-resistant strains of Plasmodium fa

12 PTB has multiple appalling sequelae, which require due attention

13 rimates, binocular disparity is processed in multiple areas of the visual cortex, with distinct contr

14 lid cancers subsequently preferentially lose multiple arms.

15 We also identify BST-2 genes in multiple avian species and show that they evolve rapidly

16 Our data analysis revealed that multiple biological processes including trehalose metabo

17 lenges and opportunities, and expertise from multiple biomedical and engineering fields will be neede

18 ter mortality) vegetation-type conversion in multiple biomes across the world (131 sites).

19 gh scanning of a single sensor chip on which multiple bioreactive areas have been created.

20 dly, the MG2G method can be used in studying multiple brain disorders and injuries, e.g., in Parkinso

21 The results suggest collaboration of multiple brain regions in control of multistep behavior,

22 ng SIV-infected rhesus macaques, we analyzed multiple brain regions through acute and chronic infecti

23 irected behavior requires the interaction of multiple brain regions.

24 these microtubules to subdivide the tip into multiple branches.

25 Yet, lncRNA LINP1 is over-expressed in multiple cancers and confers resistance to ionizing radi

26 e reader bromodomains, has shown promise for multiple cancers and neurodegenerative disease.

27 Dysregulation of MOF activity occurs in multiple cancers, including ovarian cancer, medulloblast

28 ist cell sedimentation, improve viability of multiple cell types, and enhance mechanical stability in

29 ssembly and disassembly of many molecules in multiple cellular compartments and their transport among

30 ation and batch-effect correction methods at multiple centers.

31 the workshop, students did a seven-question multiple-choice test about basic semiology and answered

32 to significantly improve their scores on the multiple-choice test.

33 population within the PVH that impinges upon multiple circuits to govern appetite.

34 s different levels of clinical expertise and multiple clinical workflows.

35 nt examination after baseline, adjusting for multiple colonoscopies within individuals.

36 Polyphenols affected multiple commensal bacterial groups and showed different

37 mmatory skin disease that is associated with multiple comorbidities and substantially diminishes pati

38 ividual enteropathogens after accounting for multiple comparisons.

39 of associations and Bonferroni corrected for multiple comparisons.

40 ly revealed that the niche is organized into multiple compartments for orchestrating stepwise adult s

41 rapeutic and medicinal properties related to multiple compounds, particularly Delta-9-tetrahydrocanna

42 cerous landscape in fallopian tubes contains multiple concurrent precursor lesions, including serous

43 ESI-IM-MS reveals the presence of multiple conformers for the dimer, tetramer, and hexamer

44 ted with CAKUTHED syndrome, characterized by multiple congenital defects including congenital heart d

45 all tissues, but to different degrees, with multiple cortical regions and neostriatum tending to hav

46 In vertebrates, multiple crb genes have been identified, but the differe

47 In parallel, we generated multiple CRISPR knockouts of the fly rrp4 gene.

48 MeLAD is searchable by multiple criteria, e.g. metalloenzyme name, ligand ident

49 vent simulations, were employed for sampling multiple cycles of LIV-BPSS clamshell-like conformationa

50 y 4 Th17 cells engrafted, induced release of multiple cytokines including IL6, IL17, MCP-1, and GM-CS

51 ng techniques for combining information from multiple data sources.

52 To this end, it is important to exploit multiple data streams that are becoming abundantly avail

53 multi-omic case-control studies that measure multiple data types in the same set of samples.

54 d more consistent spatial information across multiple days than other neurons.

55 CORE allows long-term optical recording over multiple days.

56 e use of LSD1 inhibitors in the treatment of multiple different malignancies, including AML.

57 Multiple differentially expressed gene clusters in pathw

58 TEC compartment are heterogenous and include multiple differentiated cell states.

59 pha-Hydroxylated BAs (12HBAs) are altered in multiple disease settings, but the consequences of 12HBA

60 offers a novel approach to the treatment of multiple diseases.

61 opmental plasticity allows genomes to encode multiple distinct phenotypes that can be differentially

62 We also found that many RBPs can bind to multiple distinctly different motifs.

63 stantial minority of patients are exposed to multiple DMARDs without necessarily benefitting from the

64 establishing long-range interactions between multiple dopants or defects is challenging(13,14).

65 growth potential endowed by accumulation of multiple drivers.

66 d, the model is biologically validated using multiple electrophysiological recordings.

67 say is capable of simultaneously quantifying multiple endogenous compounds, including IBC, thiamine,

68 tion (-31.0%), and combinations of available multiple environmental change factors (-14.5%), the exte

69 ce [currently disturbed]) and in response to multiple environmental change factors (warming, elevated

70 cterium and genes conditionally essential in multiple environments - abscess formation; epithelial co

71 cells consistently responded to cues across multiple environments.

72 s one of these environmental chemicals, with multiple epidemiology studies supporting its association

73 Multiple evanescent white dot syndrome is a rare self-li

74 A theoretical analysis reveals multiple evolutionary stable network structures that dep

75 Multiple factors associate directly with CMG, including

76 However, how the binding of multiple factors at any given locus is coordinated has b

77 to as intrinsic and extrinsic) triggered by multiple factors, including cellular stress, DNA damage

78 use a compatibility assessment that includes multiple factors, like spatial and temporal indicators.

79 should become increasingly predictable over multiple fire cycles, as boundaries are progressively sh

80 Here, we study how these multiple FLC paralogues determine vernalization requirem

81 Four other animals presented with multiple foci of ectopic calcification within the walls

82 e structure also revealed the arrangement of multiple forms of alpha- and beta-polypeptides in an ind

83 noscale, imparting wood-based materials with multiple functions for a range of emerging applications.

84 al Sox10 deficiencies to show that Sox10 has multiple functions in the developing mammary gland.

85 ility distribution, effectively representing multiple future outcomes simultaneously and in parallel.

86 Multiple G protein-coupled receptors (GPCRs) are targets

87 perturbations affecting the step length over multiple gait cycles.

88 Despite multiple gene expression studies becoming available, the

89 to environmental nitrogen supply, affecting multiple gene regulatory processes including genome-wide

90 mpanying telomere fusions, and propagate for multiple generations.

91 ally slows expansion across a landscape over multiple generations.

92 mbly algorithms do not apply when assembling multiple genomes at varying levels of abundance.

93 Multiple genotypes were found in three (8%) of those whe

94 s global implementation based on analysis of multiple geopolitical datasets.

95 ish sc-FLCCS, we first engineered and tested multiple green fluorescent protein (GFP)-like fluorescen

96 tor of skin cancer risk has been proposed by multiple groups.

97 Inhibition of multiple growth factor pathways may postpone resistance

98 its in vitro neutralization activity against multiple H1N1 and H5N1 strains.

99 We showed that multiple histological samples per patient is necessary t

100 ilevel dynamic representations of rhythms of multiple homeostatic regulatory systems.

101 ng, recombination and correct segregation of multiple homologous chromosomes, which can form complex

102 this work leverages the genetic diversity of multiple human cell lines to highlight viral determinant

103 There is a need for reference genomes from multiple human populations to avoid potential biases.

104 correlates with an immunosuppressive TME in multiple human tumors.

105 highly reusable coalescence mergers (binary, multiple, hybrids) are given, and we illustrate their po

106 ation of motor behavior by DA neurons within multiple hypothalamic nuclei and elucidate a novel funct

107 We further show that multiple immune cell populations contain lineage-labeled

108 n IRF5 genetic risk variants associated with multiple immune-mediated diseases are a major determinan

109 eficiency leads to compromised expression of multiple immune-response-related genes.

110 If not available, multiple immunosuppressive regimens have been used with

111 are presented along with its application to multiple in vitro and in vivo studies across species.

112 e species differences in susceptibility with multiple in-depth structural analyses to identify key AC

113 are enriched in 'public' clonotypes found in multiple individuals, indicating strong selection of B c

114 esponse is cumulative and aberrant as, after multiple infections, the epithelium was markedly thicken

115 (AD) is a complex inflammatory disorder with multiple interactions between genetic, immune and extern

116 rectifier potassium channel (Kir) Kir2.2 has multiple interactions with plasma membrane lipids: Phosp

117 yme, such as a nucleotide hydrolysis site or multiple intermediate conformations.

118 We estimate uncertainties using multiple interpolation methods, finding convergent resul

119 its' response to modifications in single and multiple intrinsic conductances in the individual neuron

120 nse (FPIR) is associated with positivity for multiple islet autoantibodies, irrespective of class II

121 Travel history revealed multiple journeys to tropic and subtropic regions during

122 Multiple kinases converge on the transcription factor cA

123 ulting in osmotic stress; no accumulation of multiple kinetoplasts and/or nuclei was detected.

124 n of architectured electrodes often involves multiple laborious steps that are not directly scalable

125 , Ecologic Femi+ vaginal capsule (containing multiple Lactobacillus and one Bifidobacterium species),

126 Second, we quantitatively test model against multiple leaf gas-exchange datasets.

127 Using multiple length scale imaging and computational analysis

128 The corroborative evidence from multiple levels including molecular, brain, and behavior

129 e-dimensional organization of chromosomes at multiple levels, including compartments(1) and topologic

130 that are regulated in this way often contain multiple ligand binding sites or modification sites, whi

131 ediated TRPV1 activation gating, and reveals multiple ligand-channel interactions that stabilize this

132 rong broadband (full visible range) lossless multiple light scattering events, enabled by a highly po

133 ntrol of isomerization of a receptor bearing multiple light-switchable subunits in a confined space i

134 R inhibitor therapy and psoas muscle area on multiple linear mixed-effect modeling (P = .055); howeve

135 Our multiple linear regression model explained 61.1% of the

136 Multiple linear regressions, conducted separately for CN

137 Combining multiple lines of evidence, including radiocarbon dating

138 Here, we show that multiple linked but recombining loci underlie cryptic co

139 Air samples were collected from multiple locations in the school, two days per week, thr

140 Multiple logistic regression was performed on demographi

141 data and then fed the selected variables to multiple machine learning models.

142 ings highlight the importance of considering multiple maternal features when assessing variation in m

143 Multiple mating by females is common and often driven by

144 ally when processing trace samples and where multiple measurements are desired.

145 nomaterials may induce neurotoxicity through multiple mechanisms including the oxidative stress, DNA

146 Our results suggest that multiple mechanisms may have emerged during evolution to

147 Our data indicate that multiple members of the CslF/H family fulfil important f

148 The escalating problem of obesity and its multiple metabolic and cardiovascular complications thre

149 SONATA is used in multiple modeling and visualization tools, and we also p

150 mework that will distill the currently known multiple models of collaboration.

151 architectures, our data provide evidence of multiple modes of organization in prokaryotic chromosome

152 in health and disease through integration of multiple molecular datasets and pathway annotations.

153 h AD, much like people with cancer, may have multiple molecular drivers of an otherwise common phenot

154 MT phenotypes and indicate that EMT involves multiple molecular programs.

155 Here, we use multiple mouse models to investigate in vivo consequence

156 We used multiple mouse models to investigate the mechanisms of N

157 ome (MDS) is significantly increased in both multiple myeloma (MM) and monoclonal gammopathy of undet

158 utside the bone marrow (BM) in patients with multiple myeloma (MM).

159 8 was validated in several Ewing sarcoma and multiple myeloma cell lines.

160 ine xenograft model using CD38-positive OPM2 multiple myeloma cells was used to evaluate CD38-specifi

161 otherapy in patients with heavily pretreated multiple myeloma in the GEN501 and SIRIUS studies.

162 novel therapeutic approach for treatment of multiple myeloma.

163 Here we report that multiple MYO7A isoforms are expressed in the mouse cochl

164 Consequently, multiple Na(V)1.7-specific and Na(V)1.8-specific blocker

165 entations, information is distributed across multiple neurons.

166 a Bayesian approach (BeviMed(4)) identified multiple new candidate PID-associated genes, including I

167 consider mechanisms by which the activity of multiple niche cell types may be coordinated to communic

168 de a collection of literature which utilizes multiple noncovalent interactions like H-bonding, solven

169 abolic syndrome, as RXR heterodimerizes with multiple nuclear receptors that regulate genes involved

170 pared binding sites of TRAMP components with multiple nuclear RNA binding proteins, revealing prefere

171 GP340 and SALSA), a large glycoprotein with multiple O-glycosylation repeats.

172 y be especially sensitive to the presence of multiple objects.

173 Here we use multiple observational platforms and an eddy-resolving o

174 odeling to account for the nesting effect of multiple observations within residents and to test for p

175 of the limit cycles becomes an integer n > 1 multiple of the driving period.

176 y additional AF-related genes by integrating multiple omics data.

177 TiPARP as a negative-feedback regulator for multiple oncogenic transcription factors, provides insig

178 This new episteme brings multiple opportunities to rethink approaches to sustaini

179 ure, acute respiratory distress syndrome, or multiple organ dysfunction; and direct tissue injury (n

180 tumor suppressor and has beneficial roles in multiple organs.

181 also no less complex than those observed for multiple other of the 56 cross feeding interactions we s

182 cles in microfluidic systems flowing through multiple outlet channels are typically conducted off-lin

183 Switching from single column to multiple parallel columns with different selectivity enh

184 (for example, Lychnis flos-cuculi) harboured multiple parasite species whilst others (for example, Ly

185 Multiple pathogens affect mitochondria dynamics and func

186 Multiple pathophysiological mechanisms with the potentia

187 o kinetochores in budding yeast depends upon multiple pathways, including the Bub1-Bub3 pathway.

188 Data from multiple phosphoproteomic data sets are provided as web-

189 udy of THF-doped riverine DOM using infrared multiple photon dissociation (IRMPD).

190 Multiple phylogenetic studies of HIV in sub-Saharan Afri

191 When combining multiple pieces of evidence from many different sources,

192 predictive value of trans-ethnic variants in multiple populations and compared genetic architecture a

193 ing DCs for sets of sequences that covary at multiple positions dramatically increases the difficulty

194 idue-level ensemble error classifications at multiple predefined error thresholds, and then combines

195 Multiple predisposing factors (for example, pre-existing

196 -effects Cox regression models adjusting for multiple pregnancies per individual.

197 safe and well tolerated in patients for whom multiple previous standard-of-care preventive treatments

198 stress that has been demonstrated to govern multiple pro-tumoural attributes in the cancer cell whil

199 ossess activity against numerous viruses via multiple proposed mechanisms.

200 verged upon a common swimming strategy using multiple propulsors coordinated as metachronal waves.

201 ology approaches, to obtain atomic models of multiple protein complexes implicated in intraerythrocyt

202 ffinities of PBD-peptide interactions across multiple protein families.

203 The aspect of multiple protein isoforms is also considered in the sele

204 The IGF1/Igf1 gene encodes multiple protein isoforms that differ in tissue expressi

205 equent origin activation is under control of multiple protein kinases that either promote or inhibit

206 We established a biomarker signature and multiple protein ratios that differentiate Parkinson's d

207 ortantly, our methodology is compatible with multiple proteins (e.g. BSA, HSA, GOx, beta-galactosidas

208 ia, as well as serologic evidence for HPG in multiple pteropid bat species, while phylogenetic analys

209 ession of SNX19 transcript features that tag multiple rare classes of SNX19 transcripts, whereas they

210 solation by 2D-LC, and targeted detection by multiple reaction monitoring (MRM).

211 We employed a high-throughput scheduled multiple-reaction monitoring (MRM)-based targeted proteo

212 ond enzyme (designated CsGA1ox/ds) performed multiple reactions, including 1beta-oxidation and 9,11-d

213 tegration of extracellular signaling through multiple receptors, including the T-cell receptor (TCR),

214 paves the way to explore transient states in multiple redox-center containing proteins (homo and hete

215 hod to characterize elusive intermediates in multiple redox-centre containing proteins.

216 ller than the number of markers, a penalized multiple regression method can be adopted by fitting all

217 ing SDCP-MS and AIDP-Wb, we rapidly identify multiple regulatory factors that specifically bind in an

218 Multiple regulatory mechanisms have been identified empl

219 ask-remapping paradigm, where subjects solve multiple reinforcement learning (RL) problems differing

220 at the nexus of the regulatory pathways for multiple renal transport processes.

221 There have been multiple reports in recent years illustrating bee popula

222 Multiple researchers have recently reported a linear rel

223 stance mechanism, and the plasticity between multiple resistance mechanisms could restrict the effect

224 s and strategies to mitigate the extreme and multiple resistance provided by these mechanisms are req

225 utilizing this material to sensitize a blue multiple-resonance TADF emitter, the corresponding devic

226 a prognostic index (PIUKALL) that integrates multiple risk factors and uses continuous data.

227 n explanatory diet trial and for a pragmatic multiple risk-factor intervention, one designed by Insti

228 s suggest that Gag-RNA interactions occur at multiple RNA sites during genome packaging; furthermore,

229 e imaging methods can be parallelized across multiple samples to increase throughput.

230 Indeed, multiple SAS subfamilies are encoded in widespread conse

231 l ordering of inorganic building blocks over multiple scales.

232 eronegative with unknown MOG-Ab-serostatus), multiple sclerosis (MS) (n=69), optic neuritis (n=5) and

233 + inner plexiform layer (GCIPL) thinning in multiple sclerosis (MS) attributable to normal aging inc

234 nal loss, which are pathological features of multiple sclerosis (MS), the most common disabling neuro

235 of T cell-mediated autoimmunity that mimics multiple sclerosis (MS).

236 r comorbidities have a deleterious impact on multiple sclerosis clinical outcomes but it is unclear w

237 brain slices of 23 patients with progressive multiple sclerosis directly after autopsy, at 3 T, using

238 Currently, studying mitochondrial changes in multiple sclerosis is hampered by a paucity of non-invas

239 The identification of progression in multiple sclerosis is typically retrospective.

240 or of cerebral small vessel disease or worse multiple sclerosis pathology.

241 t for spasticity in stroke, brain injury and multiple sclerosis patients, who are often undergoing co

242 ) Programme, an MRC and NIHR partnership, UK Multiple Sclerosis Society, and US National Multiple Scl

243 Multiple Sclerosis Society, and US National Multiple Sclerosis Society.

244 -approved immunomodulatory drug for treating multiple sclerosis, is an agonist of sphingosine-1-phosp

245 ng to CNS pathology in EAE and, potentially, multiple sclerosis.

246 encephalomyelitis (EAE), an animal model of multiple sclerosis.

247 imer's disease, autism spectrum disorder and multiple sclerosis.

248 ly beneficial in autoimmune diseases such as multiple sclerosis.

249 cell depletion and by the identification of multiple self-antigens that promote B cell expansion.

250 eference in social perception is evident for multiple sensory modalities and in many species.

251 onstrate that shell strength is derived from multiple shape parameters.

252 m cells and by influencing the activities of multiple signaling pathways that are known to regulate H

253 quantitative trait loci analyses identified multiple SNPs associated with expression levels of post-

254 In the replication cohorts, multiple SNPs in strong linkage disequilibrium with rs56

255 By integrating multiple sources of genetic and genomic data, we show th

256 Multiple spacer integration is a rare event which signif

257 complex morphologies that contain cells with multiple spacers.

258 erized by FT-FRAP through a nonlinear fit to multiple spatial harmonics of the fluorescence recovery.

259 cted historic propagules of Daphnia spanning multiple species and lakes in Wisconsin following the in

260 purified rhodopsin from mice indicated that multiple species can potentially contribute to the const

261 enon, we identified 18 novel RALF-likes from multiple species of RKNs and showed that two RALF-likes

262 Meal ingestion increases body temperature in multiple species, an effect that is blunted by obesity.

263 ombotic femoral veins and those who received multiple stents were characterized by the highest risk.

264 oduction of soy protein-based foods requires multiple-step, intensive processing and storage of soy i

265 tures, or site-specific methods that require multiple steps, introduction of mutations, or use of enz

266 Due to the complex multiple-steps protocols in data acquisition, extreme de

267 rocess to access chiral cyclopentane bearing multiple stereocenters with excellent enantioselectivity

268 ule modules, as is useful, for example, when multiple stimulus-action mappings must be retained and u

269 rties and of oxidative damage mechanisms for multiple strains in a species.

270 al decisions in plant immunity by modulating multiple stress-responsive processes in this quasi-organ

271 We also highlight that responses to multiple stressors may vary depending on the response co

272 e need to further investigate the impacts of multiple stressors on immune system development in early

273 ve oxygen species, suggesting involvement of multiple structural features or a nullified function of

274 tic interactions have been reproduced across multiple studies and many appear highly context-specific

275 tion, but because the opioid crisis includes multiple substances, the opioid specificity of intervent

276 Metamaterials assemble multiple subwavelength elements to create structures wit

277 buting to a behavioral phenotype that mimics multiple symptoms associated with schizophrenia.

278 ion with anti-PD1, SG7 slows tumor growth in multiple syngeneic mouse models.

279 e phenotypic model of TCR signaling in which multiple T cell responses share a common rate-limiting t

280 on how to establish tau positivity (T+) for multiple tau-imaging tracers in order to reach a consens

281 mical niches that enable the co-existence of multiple taxa that occupy the same apparent metabolic ni

282 t accounts for quantitative FLS variation at multiple taxonomic scales using case studies from temper

283 Animal populations face multiple threats induced by anthropogenic environmental

284 ions in evolution and occurred independently multiple times in algae, plants, animals, and fungi.

285 C(4) photosynthesis evolved multiple times independently from ancestral C(3) photosy

286 parasitoid wasps have evolved independently multiple times, but most of these systems remain largely

287 The multiple timescales observed in the pump-probe experimen

288 enes in single-cell RNA-sequencing data from multiple tissues from healthy human donors.

289 ulations, we analyzed the transcriptome from multiple tissues of two recently diverged Ficedula flyca

290 the polarity of ribosomes on mRNAs encoding multiple TMDs was disproportionately affected by RPLP1/2

291 This combinatorial study of multiple transgenes targeting primary metabolism thus of

292 actory LTM is optimal after spaced training, multiple trials of differential odor conditioning with r

293 ith worse survival outcomes in patients with multiple tumor types.

294 Studies have identified multiple types of chronic inflammation ranging from auto

295 dels are often informed by data sourced from multiple unrelated cell types (mosaic data) or from puri

296 However, the gut microbiomes of multiple unrelated healthy individuals as well as divers

297 Multiple upstream events activate the pathway, but how e

298 was able to identify EGFR-mutant patients in multiple validation sets with globally good accuracy, es

299 ter stacking expression system was stable in multiple vegetative propagations, demonstrating the feas

300 ciferase inhibition and autofluorescence via multiple wavelengths (red, blue, and green) and under va