ライフサイエンスコーパス: multiple gene

1 es in methylation regulate the expression of multiple genes.

2 of complex diseases involves alterations on multiple genes.

3 ifferential and opposing temporal control of multiple genes.

4 to be determined by the expression levels of multiple genes.

5 the other half correlate with expression of multiple genes.

6 nsitivity to TMZ and alters transcription of multiple genes.

7 translocates into the nucleus and regulates multiple genes.

8 by simultaneously altering the expression of multiple genes.

9 hancer to produce simultaneous activation at multiple genes.

10 but rather is a variable trait influenced by multiple genes.

11 ptations that require evolutionary change in multiple genes.

12 d DEX up-regulated mRNA expression levels of multiple genes.

13 chanisms between canonical Wnt signaling and multiple genes.

14 combining point mutations and exonic CNVs in multiple genes.

15 isualize and compare expression profiles for multiple genes.

16 -elements or by integrating information from multiple genes.

17 NA potentially regulating the expressions of multiple genes.

18 h integrative model scores were observed for multiple genes.

19 Among the predicted TUs, 44% have multiple genes.

20 all mapped reads, including those mapped to multiple genes.

21 activation, indicating the participation of multiple genes.

22 cetylation, and altered expression levels of multiple genes.

23 ex phenotypes that arise from the actions of multiple genes.

24 , arising from the action and interaction of multiple genes.

25 hiatric disorder with aberrant expression of multiple genes.

26 and lungs of mice though facile knockout of multiple genes.

27 scription factor that controls expression of multiple genes.

28 ally concerted transcriptional regulation of multiple genes.

29 essential role in coordinated expression of multiple genes.

30 utation (50%) and 29 cases with mutations in multiple genes (23%).

31 e minimal 10-gene cluster may have undergone multiple gene acquisitions or losses and possibly horizo

32 ction in situ and is adaptable for targeting multiple genes across model organisms.

33 Here we show that risk alleles spanning multiple genes across the 10q24.32 schizophrenia-related

34 station, with a suspected etiology involving multiple gene and environmental interactions.

35 limination of Kmo in mice is associated with multiple gene and functional alterations that appear to

36 upon multifactorial processes that regulate multiple gene and protein pathways, including those invo

37 This strategy obviates the need to regulate multiple genes and decreases the genetic load required f

38 truction resulting from interactions between multiple genes and multiple environmental exposures.

39 ADHD is highly heritable and multifactorial; multiple genes and non-inherited factors contribute to t

40 are driven by diverse alterations affecting multiple genes and pathways.

41 networks through coordinated changes across multiple genes and pathways.

42 sis of asthma is a complex process involving multiple genes and pathways.

43 Simultaneous delivery of multiple genes and proteins (e.g., transcription factors

44 ricted HSV-1 epitope specificities expressed multiple genes and proteins associated to major T cell e

45 Silencers also act at multiple genes, and at the level of chromosomal domains

46 All of them affect multiple genes (apart from NRXN1) and cause substantial

47 Pathogenic variants (PVs) in multiple genes are known to increase the risk of early-o

48 Although multiple genes are likely involved in the genesis of HAP

49 el sequencing allows simultaneous testing of multiple genes associated with cancer susceptibility.

50 ockdown in RCC cell influenced expression of multiple genes associated with cell adhesion, among whic

51 1 alterations in B-ALL leads to induction of multiple genes associated with proliferation and treatme

52 Similarly, multiple genes associated with rare genetic mutations in

53 ible factor that upregulate transcription of multiple genes associated with the response to hypoxia,

54 Activin A orchestrated the expression of multiple genes associated with the TFH program, independ

55 dons under stress conditions, was covered by multiple genes belonging to the Elongator (e.g. ELP3) an

56 Multiple genes (C11orf30/EMSY, SKAP1, and CTNNA3) identi

57 yses of circulating isolates have shown that multiple genes can be recombined from human, avian, and

58 We identified multiple gene clusters with changes that correlate with

59 FL metabolism is a complex process involving multiple gene clusters, that produce a more diverse meta

60 he species barrier to infect mammals despite multiple genes conferring adaptation and replication of

61 L) are driven by genomic events that disrupt multiple genes controlling hematopoiesis.

62 2/Osx1 checkpoint and thus do not upregulate multiple genes controlling mineral metabolism in osteobl

63 the one hand, the evidence that variants in multiple genes converge to generate one clinical phenoty

64 bilistic promoter occupancy, the presence of multiple gene copies, and cell-to-cell variability.

65 on over the mRNA lifetime, contribution from multiple gene copies, and mixing of cells from different

66 were compared for parasites with single vs. multiple gene copies, only amodiaquine and piperaquine r

67 A molecular approach using multiple genes, coupled with morphological and chromosom

68 vity improves endothelial function, controls multiple genes critical for inflammation, and prevents a

69 developmental disorders arise from single or multiple gene defects.

70 The success of each multiple-gene deletion attempt could only be partially p

71 The 18 successful multiple-gene deletions ranged in size from 21 to 183 kb

72 -based trans-splicing system is adaptable to multiple gene delivery systems, and it presents new oppo

73 l RNA polymerase-associated contacts involve multiple genes displaying similar expression levels.

74 vectors to target single (Mecp2) as well as multiple genes (Dnmt1, Dnmt3a and Dnmt3b) in the adult m

75 Using multiple gene-edited cell lines and patient-derived samp

76 SORT is compatible with multiple gene editing techniques, including mRNA, Cas9 m

77 ion of well-known sugar-responsive genes and multiple genes encoded by the plastid, on the one hand,

78 The organism possesses multiple genes encoding autotransporter proteins, which

79 Multicellular organisms have multiple genes encoding calponins and calponin-related p

80 Multiple genes encoding key regulators of axonal develop

81 ccompanied by the differential expression of multiple genes encoding small molecule-modifying enzymes

82 ion of many of these target genes, including multiple genes encoding transcription factors and severa

83 the green alga Chlamydomonas reinhardtii has multiple genes encoding type 2 DGATs (DGTTs).

84 Multiple genes/enzymes that play a role in DNA and histo

85 of potential significance (P<10(-4)) involve multiple genes expressed in the brain, including GRIN2B,

86 tional consideration of such features (e.g., multiple gene expression and anatomical parameters) is i

87 We identified multiple gene expression and DNAm levels in fetal brain

88 In conclusion, multiple gene expression associations with MDD were iden

89 and, finally, to perform a meta-analysis of multiple gene expression data sets.

90 rules to facilitate integrative modeling of multiple gene expression data.

91 ethods, this approach focused on integrating multiple gene expression datasets across platforms in or

92 f previously obtained gene signatures across multiple gene expression datasets.

93 e number of circuit structures able to drive multiple gene expression patterns decreases rapidly with

94 Despite multiple gene expression studies becoming available, the

95 ay and NGS technology, LA analysis combining multiple gene expression studies can provide more accura

96 However, multiple gene expression studies comparing wild-type and

97 hrough multiple tandem duplication events in multiple gene families.

98 s technology for the simultaneous editing of multiple genes (five genes or more) after a single trans

99 werful and highly efficient tool, to deliver multiple genes for a wide range of applications in prima

100 l criteria alone, to simultaneous testing of multiple genes for cancer-associated variants.

101 the creation of loss-of-function mutants of multiple genes from different gene families.

102 fication test that can quantitatively detect multiple genes from different pathogens.

103 ositive T cells and its capacity to suppress multiple genes from the transforming growth factor-beta

104 ent strategies for simultaneous detection of multiple gene fusions are limited by tedious and prolong

105 Serum response factor (SRF) controls multiple genes governing adhesion and migration, mainly

106 Among 21 candidate genes, we identified multiple genes (gp130, CCL4, TNFalpha, SH2D1B, CAV1, aty

107 e variation and that patterns of single- and multiple-gene haplotypes exhibit strong geographical str

108 Exome sequencing studies have identified multiple genes harboring de novo loss-of-function (LoF)

109 Genetic mutations in multiple genes have been associated with the development

110 Multiple genes have been identified that affect plumage

111 The heritability of autism is high and multiple genes have been implicated as causal.

112 To date, multiple genes have been implicated in single-gene hered

113 Over the last 25 years, multiple genes have been reported to cause this conditio

114 Multiple genes have been shown to contribute to the risk

115 C. elegans from hypoxic stress, we isolated multiple genes impacting protein synthesis: a ribosomal

116 els of miR-34a, which is predicted to target multiple genes implicated as genetic risk factors for BD

117 regulatory hub by physical interactions with multiple genes important for prostate carcinogenesis.

118 s potentially facilitating the expression of multiple genes important in the innate immune response t

119 on of a single promoter for co-regulation of multiple genes in a crop plant.

120 an neurons to rapidly assay the functions of multiple genes in a disease-relevant context, assess pot

121 When multiple genes in a pathway were considered together, a

122 sequencing, it is now affordable to examine multiple genes in a single disease-targeted clinical tes

123 Cloning of multiple genes in a single vector has greatly facilitate

124 enetic Wnt dysregulation (high tone) express multiple genes in common with colon cancer, including Le

125 However, expression of multiple genes in concert is often needed to ensure surv

126 re the potential to affect the expression of multiple genes in its genomic vicinity.

127 als a role for tissue-specific expression of multiple genes in longevity.

128 eading to altered pathogenic deregulation of multiple genes in muscles.

129 Detailed molecular studies have identified multiple genes in MYXV that are critical for virulence,

130 genes (SpCas9) can be used to edit single or multiple genes in replicating eukaryotic cells, resultin

131 action (qPCR) approaches enable profiling of multiple genes in single cells, bringing new insights to

132 Conclusion: Alcohol affects multiple genes in the autophagy pathway and impairs auto

133 hitecture 1 (IPA1), which directly regulates multiple genes in the GA pathway.

134 TNBC cells in suspension upregulated multiple genes in the kynurenine pathway of tryptophan c

135 which subsequently induces the expression of multiple genes in the nucleus.

136 of a critical effector gene, is shared with multiple genes in the p53 pathway.

137 ology and induce epigenetic modifications at multiple genes in the same cell.

138 We observed that the expression of multiple genes in the vicinity of any single CKD risk al

139 Supergene regions maintain alleles of multiple genes in tight linkage through suppressed recom

140 ions following acute UVB radiation affecting multiple genes including HRNR, TRIOBP, KCNJ12, and KMT2C

141 ted scratches showed increased expression of multiple genes including the chemokine CXCL2 and its rec

142 led that indole influenced the expression of multiple genes including the emhABC operon encoding a ma

143 s as a transcriptional regulator controlling multiple genes including the general stress response reg

144 Tfap2alpha in turn activates multiple genes including the protocadherin pcdh8l (PCNS)

145 p sequencing identified aberrant splicing of multiple genes including those encoding myofibrillar and

146 es and mice in vivo, producing PTC repair in multiple genes, including disease causing mutations with

147 sed IL-6- and TGF-beta-induced expression of multiple genes, including HIF-1alpha and PAI-1, in AECs.

148 rrant methylation and expression patterns of multiple genes, including Igf1r and Nr4a2, which are inv

149 typhi A are characterized by inactivation of multiple genes, including in the flagellum-chemotaxis pa

150 ncing analysis, influences the expression of multiple genes, including many involved in cell wall hom

151 erties identified differential expression in multiple genes, including MYC, as potentially affecting

152 uencing identified UV-signature mutations in multiple genes, including NOTCH1-3 in the epidermis and

153 CpG sites in multiple genes, including novel findings and results pre

154 ray analysis revealed age-related changes in multiple genes, including some with roles in proliferati

155 lar atrophic processes via the regulation of multiple genes, including the muscle atrophy gene Trim63

156 with reduced damage-responsive expression of multiple genes, including the WNT genes wingless (wg) an

157 specific regulatory changes are uncovered in multiple genes, including those associated with language

158 sion to the blastema overcomes repression of multiple genes, including wg, and restores cellular resp

159 ey B cell transcription factors and affected multiple genes involved in B cell biology.

160 This leads to the enhanced translation of multiple genes involved in Ca(2+) regulation and to incr

161 aled the upregulation in the myb59 mutant of multiple genes involved in calcium (Ca) homeostasis and

162 tion factor that regulates the expression of multiple genes involved in cell growth, viability and ti

163 s and discovered epigenetic dysregulation of multiple genes involved in cell migration, including mem

164 is, qRT-PCR confirmed that the expression of multiple genes involved in cilia biogenesis was signific

165 Moreover we identify multiple genes involved in endocytosis and intracellular

166 isms have been identified, notably including multiple genes involved in epithelial function/secretion

167 ling of the kidney translatome revealed that multiple genes involved in formation of the initiation c

168 Mutations in multiple genes involved in homology-directed repair (HDR

169 RAMP) mice resulted in a strong induction of multiple genes involved in inflammatory responses and mo

170 Additionally, multiple genes involved in maintaining the mitotic cell

171 Axud1 loss leads to downregulation of multiple genes involved in neural crest specification, s

172 arvation responses, such as up-regulation of multiple genes involved in Pi uptake and solubilization,

173 In Arabidopsis thaliana, multiple genes involved in shoot apical meristem (SAM) t

174 sion levels and/or gene number expansion for multiple genes involved in stress responses and the bios

175 d that overexpression of miR-450a suppressed multiple genes involved in the epithelial-to-mesenchymal

176 demonstrated that SRSF2 governs splicing of multiple genes involved in the stress-induced cell death

177 RNA sequencing and microarrays, we show that multiple genes involved in various steps of mRNA process

178 othelial cells (BMECs) changes expression of multiple genes involved in vascular development.

179 These multiple gene knockdowns will not only increase the effi

180 ors are optimized to create either single or multiple gene knockouts and large chromosomal deletions.

181 We uncovered multiple genes known to be involved in p53 and Rb regula

182 of gene-level influences, and we identified multiple gene level variables associated with splicing r

183 ing variants may increase risk for COPD, but multiple genes likely contribute to COPD susceptibility.

184 number of populations is small and there are multiple gene lineages from each population.

185 Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD),

186 nalysis showed that FGF2 treatment regulated multiple genes linked to cell division, and that the mRN

187 GS) technologies facilitate the screening of multiple genes linked to neurodegenerative dementia, but

188 isons of the two RNP delivery methods across multiple gene loci and conclude that electroporation com

189 ecific single-base mutations are achieved in multiple gene loci.

190 rm supports the rapid, arrayed generation of multiple gene manipulations and is widely adaptable acro

191 We hypothesize that the combination of multiple genes may generate biomarkers with prognostic p

192 entified three genetic components comprising multiple genes mediating ERP subcomponent abnormalities

193 MemorySeq revealed multiple gene modules that expressed together in rare ce

194 ary being related to secretory function, and multiple genes more highly expressed in the female pitui

195 uitary as compared to the hypothalamus, with multiple genes more highly expressed in the male pituita

196 evident in familial ALS phenotypes linked to multiple gene mutations including the TDP-43 gene coding

197 with reduced damage-responsive expression of multiple genes needed for regeneration.

198 We show that KLF6 transactivates multiple genes negatively controlling the NF-kappaB path

199 omputational methods that enable analysis of multiple gene networks, each of which exhibits different

200 nal analysis of GM corn containing traits of multiple genes (NK603, MON88017xMON810 and MON89034xMON8

201 rophic forms downregulated the expression of multiple genes normally associated with the response to

202 The T2D enrichment signal was largely due to multiple genes of modest effects (P = 4 x 10(-4), after

203 d that VO2 max trainability is influenced by multiple genes of small effects, but these findings stil

204 that the paper-based sensor cam distinguish multiple genes of the genomic DNA extracted from Escheri

205 antitative PCR (MSRE-qPCR) and observed that multiple genes of the IL-12/IFN-gamma signaling pathway

206 MicroRNAs (miRNAs) regulate multiple genes, often within the same pathway, fine-tuni

207 It becomes routine to utilize multiple genes on mitogenome or the entire mitogenomes t

208 ation where a protein can be associated with multiple gene ontology terms as its labels.

209 Both tubulins are encoded by multiple genes or composed of different isotypes, which

210 By providing one or multiple genes or gene sets as input and specifying a ge

211 y controlled, and cell-specific silencing of multiple genes or pathways.

212 h as the ability to coordinate expression of multiple genes or to implement threshold crossing mechan

213 ied in this study shows the value of using a multiple-gene panel in pancreatic cancer.

214 by next-generation sequencing using a custom multiple-gene panel.

215 isk is evolving rapidly, with growing use of multiple-gene panels that can yield uncertain results.

216 T. sanguinis alters intestinal expression of multiple gene pathways, including those important for li

217 design and construct viable genomes lacking multiple genes, paving the way toward genome minimizatio

218 ated with schizophrenia and autism, spanning multiple genes possibly involved in synaptic neurotransm

219 high-quality gene models, this program runs multiple gene predictors, evaluates all predicted genes,

220 We found that multiple gene products of the latent locus localize to t

221 herefore, Ezh2 coordinates the repression of multiple gene programs in B lymphocytes and maintains th

222 Multiple genes/proteins involved in glycolysis/gluconeog

223 ription factor binding to the same motifs in multiple genes provided evidence for shared mechanisms g

224 ession, potentially driven by interaction of multiple genes rather than a dominant role of the major

225 ypoxia in animals involves the expression of multiple genes regulated by the alphabeta-hypoxia-induci

226 type C57BL/6 donors normalized expression of multiple genes regulating immune function and epithelial

227 Knockout of multiple genes regulating PI3K/mTOR signaling impacted t

228 The discovery of multiple genes regulating vesicular trafficking, cell su

229 three distinct temporal peaks demonstrating multiple gene regulation waves in LTAM.

230 rtionate number of SNPs in the gene encoding multiple gene regulator of group A Streptococcus (mga).

231 MgrA is a multiple-gene regulator that has been shown to activate

232 al (3D) organization of DNA is implicated in multiple gene regulatory mechanisms, but understanding t

233 might have evolved via concerted changes in multiple gene regulatory networks.

234 to environmental nitrogen supply, affecting multiple gene regulatory processes including genome-wide

235 r pore complex (NPC) have been implicated in multiple gene regulatory processes, but the underlying l

236 Transcriptome comparisons revealed that multiple genes related to carboxy-terminal domain (CTD)

237 astasis, as well as suppressed expression of multiple genes related to cell migration and microenviro

238 that does not change in number and expresses multiple genes related to lipid metabolism and lipid sig

239 ped the "NanoScript" platform by integrating multiple gene repression molecules with a nanoparticle.

240 the combination or synthesis of mutations in multiple genes results in cell death, provides a framewo

241 Multiple gene segment exchanges among and within subtype

242 genetically and functionally compatible with multiple gene segments from the 2009 pandemic influenza

243 ent eukaryotic genome projects have reported multiple gene sequences that were much more similar to h

244 However, these results suggest that multiple-gene sequencing may benefit appropriately selec

245 adult mice, allowing simultaneous editing of multiple gene sets in individual cells.

246 te that by identifying genes associated with multiple gene-sets, FCM clustering algorithm significant

247 ector options, particularly when delivery of multiple gene/shRNA combinations is required.

248 uding, but not limited to, the evaluation of multiple gene signatures for potential clinical use as c

249 Combinatorial RNAi technology and concurrent multiple gene silencing are expected to provide advanced

250 ual cells and measuring expression levels of multiple genes simultaneously from each cell.

251 dothelial cells in vivo by durably silencing multiple genes simultaneously, but efficient siRNA deliv

252 iautomatic imaging analysis, and it can test multiple genes simultaneously, gene-dosing effects and a

253 equence of the interaction and regulation of multiple genes simultaneously, therefore characterizing

254 To target multiple genes simultaneously, we established simple one

255 cluding zebrafish, and can be used to target multiple genes simultaneously.

256 gene as well as loci where TWAS prioritizes multiple genes, some likely to be non-causal, owing to s

257 he virus genome and phylogenetic analysis of multiple genes strongly suggested that this virus is a b

258 Brpf1 loss led to decreased transcription of multiple genes, such as Robo3 and Otx1, important for ne

259 l tissue and observe that in this condition, multiple genes switch their APA patterns, demonstrating

260 further demonstrated for several ASOs versus multiple gene targets.

261 ation of high-dimensional sequencing data of multiple gene targets.

262 overexpression, knock-down, and knock-out of multiple gene targets.

263 46-gene hotspot cancer panel assay allowing multiple gene testing from small diagnostic biopsies.

264 Growth is a complex trait influenced by multiple genes that act at different moments during the

265 l walls, and genetic studies have identified multiple genes that affect xylan formation.

266 hronically exposed skin contain mutations in multiple genes that are mutated in cutaneous squamous ce

267 Multiple genes that contribute to ExPEC fitness in mucus

268 ndividual fibroblasts showed deregulation of multiple genes that control development.

269 pe I interferons (IFNs) induce expression of multiple genes that control innate immune responses to i

270 disease characterized by the aberrations in multiple genes that drive pathogenesis and limit therape

271 able to achieve an editing rate of > 99% for multiple genes that functionalizes the phages for furthe

272 conclusion, DRMD is a complex phenotype with multiple genes that impact the probability of onset.

273 tic choriomeningitis virus (LCMV) identified multiple genes that regulated development of follicular

274 entiation by orchestrating the expression of multiple genes that show diversified expression profiles

275 Transcriptome analysis identified multiple genes that were deregulated by Trex2 loss after

276 ciency with transcriptional dysregulation of multiples genes, thereby leading to a neurodevelopmental

277 r developmental stage-specific expression of multiple genes through chromatin compaction at its targe

278 -wide association studies (GWAS) have linked multiple genes to ARDS.

279 ocations of autosomal genome regions causing multiple genes to become partially sex-linked.

280 inese hamster ovary (CHO) cell by disrupting multiple genes to eliminate HCPs.

281 Overall, our data annotated multiple genes to previously reported CKD-associated sin

282 this approach by deleting single (Ptch1) or multiple genes (Trp53, Pten, Nf1) in the mouse brain, re

283 Remarkably, 219 (14%) genes possessed multiple gene TSSs (gTSSs), and 84 genes exhibited tempe

284 a Simpson's paradox during overexpression of multiple genes: two competing proteins in single cells c

285 Because Pol II transcribes multiple gene types, its termination occurs in a variety

286 ncing identified numerous mutant clones with multiple genes under positive selection, including Notch

287 1 diabetes (T1D) involves the interaction of multiple gene variants, environmental factors, and immun

288 h PML-II contributes to the transcription of multiple genes via the association of its C-terminal dom

289 rognostic effects of genetic variants across multiple genes, we identify four gene modules associated

290 Multiple genes were associated with CM, but due to the c

291 an NK cell developmental subsets showed that multiple genes were dysregulated by IRF8 mutation.

292 eneous patterns of chromatin status spanning multiple genes were phased.

293 quality traits often requires pyramiding of multiple genes, which remains a major hurdle given vario

294 y number variation (CNV) affecting a gene or multiple genes will manifest as disease.

295 hown that, "modular markers," that integrate multiple genes with potential interactions can improve d

296 NA microarray analysis, and found to include multiple genes with putative association to the cell env

297 atory modules that coordinate the control of multiple genes with the same regulatory logic.

298 The simultaneous targeting of multiple genes within a pathway may enable miRNAs to mor

299 ella enterica pathogenicity and dependent on multiple genes within Salmonella pathogenicity island 1

300 sms occur through concerted relationships of multiple genes working in networks that are often repres