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1 press the neural crest marker p75 and become multipotent.
2 tors in the injured retina are intrinsically multipotent.
3 actility (seeded on 2 mum gratings) remained multipotent.
4 ges, a large fraction of the progenitors are multipotent.
5 that individual neural crest precursors are multipotent.
6 hat at the population level Cux2(+) RGCs are multipotent.
8 lymers are used to deliver minicircle DNA to multipotent adipose derived stem cells (ADSCs) and astro
12 n the groups (64 [99%] of 65 patients in the multipotent adult progenitor cell group vs 59 [97%] of 6
13 score of 8-20 to treatment with intravenous multipotent adult progenitor cells (400 million or 1200
16 ations consisted of 65 patients who received multipotent adult progenitor cells and 61 patients who r
17 tients were randomly assigned (67 to receive multipotent adult progenitor cells and 62 to receive pla
19 rolled, dose-escalation trial of intravenous multipotent adult progenitor cells in 33 centres in the
20 ved at 90 days in neurological outcomes with multipotent adult progenitor cells treatment, further cl
22 t, well-tolerated, and safest single dose of multipotent adult progenitor cells, and if they were eff
23 potent murine cells spontaneously convert to multipotent adult spermatogonial-derived stem cells (MAS
26 tted cells are molecularly distinct, whereas multipotent and bipotent progenitors do not exhibit diff
28 stem cell, endothelial cell, monocyte), were multipotent and could differentiate into macrophage-like
29 ic stem cells and their differentiation into multipotent and downstream lymphoid-biased progenitors.
31 derived hematopoietic stem cells that remain multipotent and give rise to a variety of lineage-specif
33 ve also uncovered the presence of a range of multipotent and lineage-restricted progenitor cells in t
34 ude that pro-centrioles/pro-basal bodies are multipotent and not committed to form either a 9+2 or 9+
37 Results: We found that basal cells included multipotent and secretory primed subsets in control adul
39 onal and population levels Fezf2(+) RGCs are multipotent and that at the population level Cux2(+) RGC
40 ad, only two progenitor classes predominate, multipotent and unipotent, with Er-Mk lineages emerging
44 stem cell-like ability to self-renew and the multipotent capacity to reconstitute the entire spectrum
45 induced pluripotent stem cell (iPSC)-derived multipotent cardiac progenitor (MCPs) cells and, in para
47 ese findings support ex vivo fucosylation of multipotent CD34(+) CB cells as a clinically feasible me
49 evelopment, the glycoprotein 2 (GP2) marks a multipotent cell population that will differentiate into
51 Normalized Nrf2/Keap1 signaling restores multipotent cell properties in dBMSCs through Sox2 expre
52 eneration through paracrine effects and as a multipotent cell source, and has received recent attenti
53 duced cell plasticity occurs via a transient multipotent cell state and that concomitant exposure to
54 both the sequence of lineage choices made by multipotent cells and to identify the genes influencing
56 in the early embryo from Brachyury-positive multipotent cells in the posterior-proximal region of th
57 we examined if the epicardium that contains multipotent cells is involved in this remodeling process
58 ralleled resolution and how the landscape of multipotent cells may be rather devoid of discrete struc
60 Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are emerging as the most promisin
63 lexity of gene regulatory networks that lead multipotent cells to acquire different cell fates makes
64 possess a population of highly proliferative multipotent cells with in vitro multilineage differentia
65 ocrine-selective transcription in epithelial multipotent cells, nascent endocrine progenitors, and di
70 Cs derived from PDL and gingiva demonstrated multipotent characteristics, suggesting new therapeutic
73 n profiles of human cardiac derivatives from multipotent CPCs to intermediates and mature cardiac cel
74 hage colony-stimulating factor (GM-CSF) is a multipotent cytokine that prompts the proliferation of b
75 om exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory propert
78 ing of the epigenetic programs necessary for multipotent differentiation of MSCs that may prove benef
79 genomic stability and the ability to undergo multipotent differentiation to the specific epithelia fr
80 ages and yet capable of self-replication and multipotent differentiation, being able to differentiate
82 ives and their pharmacological evaluation as multipotent drugs for the treatment of Alzheimer's disea
84 Neural crest cells (NCCs) are migratory, multipotent embryonic cells that are unique to vertebrat
85 dels can be developed in situ from different multipotent embryonic cerebellar progenitor cells via co
87 y, mice with loss of both Sin3a and Sin3b in multipotent embryonic pancreatic progenitors had signifi
90 romote the differentiation of these putative multipotent etv2 progenitor cells into skeletal muscle c
91 eveal the births of larval astrocytes from a multipotent glial lineage, their allocation to reproduci
92 antage of cells conditionally blocked at the multipotent haematopoietic progenitor stage to develop a
93 Here, we employed a cellular model of murine multipotent haematopoietic progenitors (Hoxb8-FL) to kno
95 to support the maintenance and expansion of multipotent hematopoietic cells, i.e. hematopoietic stem
96 x/flox):Scl-Cre-ER(T)) and demonstrated that multipotent hematopoietic colonies form despite the abse
97 ne receptor CCR9 controls the immigration of multipotent hematopoietic progenitor cells into the thym
98 ents diagnosed with BCR-ABL1-positive ALL, a multipotent hematopoietic progenitor is affected by the
99 iver mutation in a bone marrow (BM)-resident multipotent hematopoietic progenitor, while low-risk, MS
103 poses a hierarchy in which a small number of multipotent hematopoietic stem cells (HSCs) maintain all
105 nto immunocompromised mice the percentage of multipotent HSPCs within the engrafted HSPC population w
109 le scaffolds capable of supporting growth of multipotent human bone marrow mesenchymal stem cells (hM
112 dipose-derived stromal/stem cells (ASCs) are multipotent in nature that can be differentiated into va
113 scribe a protocol to generate expandable and multipotent induced cardiac progenitor cells (iCPCs) fro
114 use green fluorescent protein (GFP)-positive multipotent induced pluripotent stem cell (iPSC)-derived
115 After in vitro enzymatic inhibition assays, multipotent inhibitors showing potencies in the nanomola
118 man hematopoietic system, rare self-renewing multipotent long-term hematopoietic stem cells (LT-HSCs)
119 onal pioneering during B cell programming of multipotent lymphoid progenitors by restricting chromati
121 memory formation depends on elucidating how multipotent memory precursor (MP) cells maintain develop
122 ess and application of mechanical stretch to multipotent mesenchymal cells stimulated the nuclear tra
128 ation consisting of mature white adipocytes, multipotent mesenchymal stem cells, committed progenitor
130 llicular thyroid cancers and the presence of multipotent mesenchymal stem/stromal cells (MSCs) in non
131 imum (estimate+/-SE, 0.01+/-0.002; P<0.001), multipotent mesenchymal stromal cell colony maximum (est
134 ce, we demonstrate expression exclusively in multipotent mesenchymal stromal cells (MSCs) in the bone
135 on is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery
138 omprise the head and face are derived from a multipotent migratory progenitor cell population called
140 (ESC)-based model yields high proportions of multipotent NC cells (expressing SOX10, PAX7 and TFAP2A)
143 ion of the GRN underlying development of the multipotent neural crest (NC) embryonic cell population.
145 ved skilled forelimb function after grafting multipotent neural progenitor cells into sites of SCI.
147 berant Wnt responses, that induce some early multipotent NKX2-1(+) progenitors to lose lung fate.
149 or the existence of a sortable population of multipotent non-epithelial cells in the adult pancreas t
150 oma function in vivo, which is mediated by a multipotent NT5E(+) (CD73)(+) ENG(-) (CD105)(-) LY6A(+)
151 monstrates that BMI1 is expressed in vivo by multipotent OE progenitors, validating our culture model
152 s do not require transit through a requisite multipotent or bipotent megakaryocyte-erythrocyte progen
153 ells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only spec
154 n of nuclear peripheral heterochromatin as a multipotent P19 cell adopts either a neural or a cardiac
155 just the Swi/Snf Brg1 ATPase subunit reduced multipotent pancreatic progenitor cell proliferation and
156 Notch signaling controls proliferation of multipotent pancreatic progenitor cells (MPCs) and their
160 NMP-like cells in vitro initially produce a multipotent population that, in addition to NMPs, genera
161 hich have been proposed to arise either from multipotent precursor cells or pools of heterogeneous, r
162 l checkpoints that dictate the commitment of multipotent precursors to the T cell lineage and their s
163 transition from naive/primed pluripotency to multipotent primary neural progenitor cells (NPCs).
164 ing of changes with age in the heterogeneous multipotent progenitor (MPP) cell compartment, which is
165 surrounding genes specifically expressed in multipotent progenitor (MPP) cells and HSCs (P <= 3.5 x
166 rease in hematopoietic stem cells (HSCs) and multipotent progenitor (MPP) cells in conditional Runx1-
167 regeneration involving the remodeling of the multipotent progenitor (MPP) compartment downstream of h
169 CL12, but whether a separate niche instructs multipotent progenitor (MPP) differentiation remains unc
170 nalyses suggest that LumP and PrU cells have multipotent progenitor activity in organoid formation an
174 of JMML using mice that express KrasG12D in multipotent progenitor cells (Flt3Cre+ KrasG12D mice).
176 roles in the migration and specification of multipotent progenitor cells at the onset of cardiogenes
177 capacity to predict and control when and how multipotent progenitor cells commit to the desired cell
178 e of differentiated tissue-specific stem and multipotent progenitor cells for regenerative medicine a
180 , the biological secretome of Amnion-derived Multipotent Progenitor cells, contains multiple anti-inf
181 their order; the final mutations occur in a multipotent progenitor derived from the preleukemic HSC
184 epithelium of the branching mouse lung is a multipotent progenitor pool that self-renews and produce
189 olecular network wiring helps to establish a multipotent progenitor state, with experimental approach
190 by modulating transcription, thus impacting multipotent progenitor states and subsequent fate choice
191 ey transit into short-term self-renewing and multipotent progenitor states, with the first major line
193 erentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly de
195 wounding increases myeloid lineage-committed multipotent progenitors (MPP3 subset) and Mo in bone mar
196 ction, lineage specification at the level of multipotent progenitors (MPPs) remains poorly understood
197 s of the composition of HSCs and HSC-derived multipotent progenitors (MPPs) revealed a significantly
198 cells (HSCs), short-term HSCs (ST-HSCs), and multipotent progenitors (MPPs) were all significantly re
202 ubsets of these cells can differentiate from multipotent progenitors and committed T cell precursors
203 mouse young adult and old adult mouse HSCs, multipotent progenitors and oligopotent progenitors; 12
204 homed HSCs in bone marrow and spleen became multipotent progenitors and, occasionally, some HSCs gav
206 ensure precision in lineage specification as multipotent progenitors become restricted in cell fate.
207 rm, but the chromatin landscapes that govern multipotent progenitors competence and early fate choice
208 ferentiation recapitulates the generation of multipotent progenitors during embryonic development, wh
211 We further show that adenosine increased multipotent progenitors in a mouse embryonic stem cell c
212 ecific progenitors, we identify bipotent and multipotent progenitors in ducts and TDLUs, respectively
213 yelopoiesis caused by epigenetic rewiring of multipotent progenitors in the bone marrow, which overco
214 sion between endocrine and exocrine fates of multipotent progenitors in the developing pancreas, and
218 or 1 complex (Paf1C) is required to maintain multipotent progenitors of the neural crest (NC) lineage
222 ferentiation of lineage-committed cells from multipotent progenitors requires the establishment of ac
223 forming haematopoietic stem cells (HSCs) and multipotent progenitors results in more aggressive AML t
225 layer was damaged, MG respond by generating multipotent progenitors that migrate to all nuclear laye
226 nation of key transcription factors (TFs) in multipotent progenitors that transition them away from o
227 6 deficiency increased the ratio of Flt3(hi) multipotent progenitors to CD150(+) stem cells in the mo
231 urvived up to a year and showed expansion of multipotent progenitors, aberrant lymphopoiesis and thro
232 tors, including hematopoietic stem cells and multipotent progenitors, and increases the frequency of
233 es, implying that cells in the CE domain are multipotent progenitors, and suggesting that an asymmetr
234 egulated in SDS hematopoietic stem cells and multipotent progenitors, but not in lineage-committed pr
235 GM-CSF-receptor is increased on HSCs and multipotent progenitors, favoring a striking increase in
236 ation and differentiation of tissue-specific multipotent progenitors, lineage-specific transcriptiona
237 show cell biological features different from multipotent progenitors, raising the possibility that an
238 first major lineage commitment occurring in multipotent progenitors, thus giving rise to progenitors
239 ls (EpiSCs) are an effective source of these multipotent progenitors, which are further differentiate
248 differentiated cells to dedifferentiate into multipotent proliferative cells with the capacity to reg
249 adult sheath tissues possess clonogenic and multipotent properties comparable to those of stem/proge
250 diate progenitors (IPs) are derived from the multipotent radial glia (RGs) and serve as the direct pr
251 teraction in the regulation of Six2-positive multipotent renal progenitor cells and formation of the
253 es, retinal ganglion cells (RGCs) arise from multipotent retinal progenitor cells (RPCs), and their f
256 ows that, whereas the prostate develops from multipotent SCs, only unipotent SCs mediate mammary glan
260 ed stem cell-like cells (iMuSCs) displayed a multipotent state with sensitiveness and strong migratio
261 maintains eye field neural progenitors in a multipotent state; then, in combination with Pax6, Tbx3
264 ither frozen, nor fresh hAFSCs cultivated in multipotent stem cell culture conditions expressed OCT4A
267 aryocyte differentiation apparent from early multipotent stem cells in myelofibrosis and associated a
268 e of soluble cues directs differentiation of multipotent stem cells into discrete populations of spec
270 t population of central nervous system (CNS) multipotent stem cells known as oligodendrocyte progenit
273 rise via a hierarchical scheme starting with multipotent stem cells that become increasingly restrict
274 e neural crest is an embryonic population of multipotent stem cells that form numerous defining featu
275 opoietic stem cells (HSCs) are self-renewing multipotent stem cells that generate mature blood lineag
276 ne neural progenitor cells (NPCs), which are multipotent stem cells that give rise to cells in the ce
277 C-MSCs), originating in Wharton's jelly, are multipotent stem cells that home to damaged tissues and
279 vital for the differentiation of ES cells to multipotent stem cells, little is known regarding the ro
281 y gland evokes cell dedifferentiation into a multipotent stem-like state, suggesting this to be a mec
282 mouse of a previously unknown population of multipotent stem/progenitor cells that are capable of no
283 neuronal precursors to dedifferentiate into multipotent stem/progenitor cells that contribute signif
284 ation and maintenance of bone marrow-derived multipotent stromal cells (BMSCs) that contribute to wou
285 silencing SMS in human bone marrow - derived multipotent stromal cells (MSCs) derived from healthy do
286 Transplantation of mesenchymal stem cells/multipotent stromal cells (MSCs) has been proposed to au
287 identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reserv
289 arrow stromal cells (BMSCs), a major type of multipotent stromal cells, produces pain relief (antihyp
290 ective differentiation of naive T cells into multipotent T cells is of great interest clinically for
293 the current view of endogenous pericytes as multipotent tissue-resident progenitors and suggest that
294 o function as mesenchymal stem cells (MSCs), multipotent tissue-resident progenitors with great poten
295 ults in differential fate acquisition in the multipotent trophectoderm leading to the formation of a
297 m-like cells represent poorly differentiated multipotent tumor-propagating cells that contribute disp
298 animal stem cell niches, maintain a pool of multipotent, undifferentiated cells that divide and diff
299 -Ras-Raf-ERK cascade initiates patterning of multipotent vulval precursor cells (VPCs) of Caenorhabdi