ライフサイエンスコーパス: multivalent

1 ciation with scaffold proteins, including by multivalent A-kinase anchoring proteins (AKAPs) that bin

2 effective VAR2CSA-based vaccine may require multivalent activity.

3 The results imply that multivalent adhesin-based ETEC vaccines or prophylactics

4 re, we determined the host receptors for the multivalent adhesion molecule (MAM) from the gut commens

5 ads chemically coupled to a protein known as multivalent adhesion molecule 7, an adhesin which mediat

6 l sigma1 binding to alpha-SA favors a strong multivalent anchorage to JAM-A.

7 wo-ligand system composed of the predesigned multivalent and complementary terpyridine-based ligands

8 of the assembly of the KRAS-CRAF complex via multivalent and dynamic interactions between KRAS, CRAF

9 y, we demonstrate a method to build up rigid multivalent and multispecific scaffolds by exploiting th

10 nodes and trigger B cell activation through multivalent and oriented antigen display.

11 a model system of DNA-coated particles with multivalent and weak interactions that mimics ligand-rec

12 nd H5-con HA consensus genes in combination (multivalent) and compared to mice immunized with the tra

13 Here we show that multivalent anions such as oxalate, carbonate and sulfit

14 ect for the response bias, selected tethered multivalent antibodies and an IgG antibody (representing

15 and quantitating degradations accurately for multivalent antibodies by incorporating response bias co

16 pecific conjugation to create multispecific, multivalent antibodies of defined composition with retai

17 ution ligands by cross-linking pMHC or using multivalent antibodies to TCR.

18 agents of the allergic response, ensues when multivalent antigens bind to and cross-link the cells' r

19 e, has been shown to induce immunity against multivalent antigens, and can result in protein expressi

20 gating such assemblies, we characterized the multivalent association of the entire cognate binding do

21 r the development of viable electrolytes for multivalent batteries and, more generally, energy conver

22 e chemical design of materials for practical multivalent batteries.

23 on batteries, all-solid-state batteries, and multivalent batteries.

24 idal nanoparticles as substrates to create a multivalent bi-specific nanobioconjugate engager (mBiNE)

25 espite the development of extremely powerful multivalent binders of the Influenza virus and other vir

26 This study elucidates mechanisms of multivalent binding and establishes a framework for mode

27 We conceptualize multivalent binding as a protein-protein interaction net

28 applications of this framework, namely, how multivalent binding at the -35 and -10 sites can buffer

29 This interaction represents a multivalent binding event that is present in all the cur

30 To study the nature of such multivalent binding events, we fused a superfolder green

31 Multivalent binding interactions are commonly found thro

32 Nanoparticle assembly can be controlled by multivalent binding interactions between surface ligands

33 Multivalent binding interactions with the human ribosome

34 not only established a new method to dissect multivalent binding into actions of individual monovalen

35 Multivalent binding is essential to many biological proc

36 e client in a highly dynamic fashion using a multivalent binding mechanism that alters the folding pr

37 geometry of appropriate linkers for distinct multivalent binding modes.

38 The multivalent binding of the HA-sfGFP proteins was studied

39 Thus, the multivalent binding of TNRC6 enables cooperative binding

40 matching the spatial arrangement between the multivalent binding partners.

41 unction of the biophysical properties of the multivalent binding partners.

42 n kinase A anchoring protein 1 (dAKAP1) is a multivalent binding protein that targets protein kinase

43 Although multivalent binding to surfaces is an important tool in

44 their nuclear import, especially the role of multivalent binding to transport receptors via nuclear l

45 Cs through integration of dendrimer-mediated multivalent binding, a mixture of antibodies, and biomim

46 al approach to achieving this goal is to use multivalent binding, which often boosts the affinity bet

47 understand biological design strategies for multivalent binding.

48 dissociation in the selectivity of the weak multivalent binding.

49 fold on the presentation of receptors during multivalent binding.

50 y in biology and for the generation of novel multivalent biomaterials.

51 Multivalent biopolymers phase separate into membrane-les

52 ing, especially when the target is made from multivalent building blocks and/or under conditions of s

53 fficiently model dynamic reactions involving multivalent building blocks.

54 ecular assemblies is largely driven by weak, multivalent, but selective IDR-IDR interactions.

55 ly of multimeric rAb platforms that increase multivalent C1q binding and facilitate C1q activation.

56 target the siRNA to HER3+ tumors by forming multivalent capsid-like structures.

57 ectins are captured in the solution phase by multivalent capturing agents, released by competitive mo

58 Multivalent carbohydrate-based ligands were synthesized

59 Multivalent carbohydrate-lectin interactions at host-pat

60 Protein-induced PIP2 clustering and multivalent cation-induced PIP2 clustering are additive.

61 Multivalent cations alter DNA structure on the molecular

62 s presented here indicate that the effect of multivalent cations and of spermidine, in particular, on

63 We report that increased extracellular multivalent cations lead to increased heterochromatin le

64 We report that increased extracellular multivalent cations lead to increased heterochromatin le

65 Taken together, the use of multivalent cations represents a powerful strategy to al

66 Here, we examine the interactions of multivalent cations with these DNA bonds as a chemical a

67 PIP2 can form nanoscopic clusters bridged by multivalent cations.

68 of >60 degrees C relative to systems without multivalent cations.

69 Thus, PWWP2A is a novel H2A.Z-specific multivalent chromatin binder providing a surprising link

70 cleotides displayed on a nanoparticle form a multivalent complex with a long DNA target containing th

71 ble, limited success was reached for smaller multivalent compounds.

72 mologous chromosomes, which can form complex multivalent configurations at metaphase I, and in turn a

73 Until an affordable multivalent conjugate vaccine becomes available, the nee

74 astly different polymer conformations of the multivalent conjugates.

75 receptors and show that the stability of the multivalent connection increases with the number of bond

76 ath to increase the targeting selectivity of multivalent constructs.

77 these activities, identifying a key role for multivalent contacts through arginine's guanidinium ion.

78 nd that the BRD and an adjacent AT-hook make multivalent contacts with DNA, leading to robust affinit

79 s) to design small proteins that fold around multivalent cross-linkers.

80 structure can be defined by incorporating a multivalent cross-linking agent, and this approach has b

81 d to LuS-SpyTag or ferritin-SpyTag, enabling multivalent display of F trimers with prefusion antigeni

82 ne; 2) significantly enhanced cell uptake by multivalent display of KLA peptide brushes.

83 d platform, called nanoallergens that enable multivalent display of potential allergy epitopes for de

84 unlike biomolecular signaling, high density multivalent display of receptors is crucial for function

85 es the use of liposomal nanoparticles with a multivalent display of Siglec ligands.

86 Multivalent display on linear platforms is used by many

87 Synthetic supramolecular multivalent displays offer a matching approach for the m

88 matin fiber interacting with an ensemble of (multivalent) DNA-binding proteins able to switch between

89 rther assembled via streptavidin to form the multivalent DTP (SA-DTP).

90 0), TDP-43(11) and CELF1(12) assemble on the multivalent E-repeat element of Xist(7) and, via self-ag

91 s provides for the first time entry to study multivalent effects in dynamic 1D systems, of relevance

92 liar binding properties that only arise from multivalent effects.

93 the conserved well-folded PTP domain through multivalent electrostatic interactions and regulated by

94 ins associate with membranes through similar multivalent electrostatic interactions, without specific

95 ng protein, to form complexes with increased multivalent engagement of H3K9me2 and 3-modified chromat

96 btilis T-box-tRNA complexes, detailing their multivalent, exquisitely selective interactions.

97 Displaying antigens in a multivalent fashion on nanoparticles (NPs) is an establi

98 role of condensates in gene activation; the multivalent features of protein, RNA, and DNA that enabl

99 y can be increased by arraying immunogens in multivalent form on virus-like nanoparticles to enhance

100 erstand these interactions when occurring in multivalent form.

101 es of synaptic partner switching, leading to multivalent formation, and found potential defects in th

102 After vaccination with a multivalent GI.1 and GII.4c norovirus virus-like particl

103 o that the blockade of this receptor through multivalent glycoconjugates supposes a promising biologi

104 y of densely functionalized homo- and hetero-multivalent glycomimetics comprising aldehyde, amine, an

105 demonstrate that binding of G6b-B to HS and multivalent heparin inhibits platelet and megakaryocyte

106 to assess the safety and immunogenicity of a multivalent HIV vaccine including either DNA or NYVAC ve

107 rap (NT) to capture various biomolecules via multivalent, hybrid and synergistic interactions.

108 ysiological high-affinity conditions using a multivalent immunogen, rare VRC01-class B cells successf

109 optimized MORF3 mice, with a membrane-bound multivalent immunoreporter, confer Cre-dependent sparse

110 and lymphoid tissues, and they can be highly multivalent, improving their engagement with the immune

111 Multivalent influenza vaccine products provide protectio

112 Several studies have focused on oligomeric multivalent inhibitors and how changing parameters such

113 ptimizing the structure and effectiveness of multivalent inhibitors as well as be useful to understan

114 targeting multiple adjacent sites to create multivalent inhibitors may be effective for some protein

115 acing, which are critical to design specific multivalent inhibitors.

116 is strong interaction can be attributed to a multivalent interaction between the biosensor and the he

117 Herein, the multivalent interaction of norovirus-like particles (nor

118 how that the CPC binds nucleosomes through a multivalent interaction predominantly involving Borealin

119 ggests that SIM and other SMRs likely have a multivalent interaction with CYC/CDK complexes.

120 eport a peptide-based sensor that involves a multivalent interaction with L-ascorbate 6-phosphate lac

121 a pair of parallel-aligned DNAs to propose a multivalent interaction-mediated cluster model to accoun

122 exes have now unveiled the atomic details of multivalent interactions among eFGF, FGFR, and Klotho.

123 id phase separation, which arises from weak, multivalent interactions among proteins and nucleic acid

124 e phase separated polymers assembled through multivalent interactions among the three proteins.

125 olecular clusters are assembled through weak multivalent interactions and are platforms for cellular

126 e of signaling systems that assemble through multivalent interactions and drive nonequilibrium output

127 Our results support the model that multivalent interactions between APC and Axin drives the

128 xes are determined, in part, by a network of multivalent interactions between Ena/VASP proteins, EVH1

129 mer core by Swi6 increases opportunities for multivalent interactions between nucleosomes, thereby pr

130 , as they can directly weaken or enhance the multivalent interactions between phase-separating macrom

131 el for TREX complex function that depends on multivalent interactions between proteins and mRNA.

132 Our studies illustrate how multivalent interactions between proteins at the plasma

133 Fundamental studies into multivalent interactions between such linear, 1D materia

134 e Influenza A virus onto host cells involves multivalent interactions between virus surface hemagglut

135 ed by surface plasmon resonance experiments, multivalent interactions can generate several noncanonic

136 Together, multivalent interactions couple productive binding to ef

137 Here, we estimate that multivalent interactions for WT Syk improve cis-oriented

138 onformational rearrangements and heterotypic multivalent interactions may be a general principle unde

139 The multivalent interactions necessary for liquid-liquid pha

140 fluenza A virus infects target cells through multivalent interactions of its major spike proteins, he

141 derstanding of how MHC clustering influences multivalent interactions of pMHC ligands with CD8 and TC

142 The resulting multivalent interactions provide high DENV-binding avidi

143 Many condensates appear to form through multivalent interactions that drive liquid-liquid phase

144 pport a model in which FUS LC forms dynamic, multivalent interactions via multiple residue types and

145 nstruct tailor-made probes for interrogating multivalent interactions with angstromngstrom precision.

146 otein has four binding sites, which leads to multivalent interactions with membrane-anchored ligands

147 miscuous binding, and topologies that enable multivalent interactions) support the stability of and a

148 ternalization into the host cells occurs via multivalent interactions, in which a single virus binds

149 ction to dictate the thermodynamics of their multivalent interactions, resulting in emergent bundling

150 zing competitive binding kinetics to analyze multivalent interactions, which has remained difficult t

151 ity; ChIA-Drop also reveals promoter-centred multivalent interactions, which provide topological insi

152 ation is driven by the cumulative effects of multivalent interactions.

153 y disordered region that phase-separates via multivalent interactions.

154 precise molecular assemblies to investigate multivalent interactions.

155 The rapidly expanding field of nonaqueous multivalent intercalation batteries offers a promising w

156 ase3-FBXL2-SKP1 complex reveals an extensive multivalent interface specifically formed between the le

157 Liquid-liquid phase separation of multivalent intrinsically disordered protein-RNA complex

158 co interacts with the N terminus of CsoS2, a multivalent, intrinsically disordered protein.

159 hich diminish drastically in the presence of multivalent ions at concentrations as low as 0.1 mM, zwi

160 wear is demonstrated to be triggered by the multivalent ions bridging the polymer chains and dehydra

161 We established that using multivalent ions in a net negatively charged globular pr

162 ations that show a preferential insertion of multivalent ions into titanium vacancies, allowing a muc

163 or sodium ions, the reversible insertion of multivalent ions such as Mg(2+) and Al(3+) into electrod

164 as low as ~10(-3) at such concentrations of multivalent ions up to intermediate normal loads.

165 onic bottlebrush polymers in the presence of multivalent ions using the surface force apparatus.

166 disordered proteins by low concentrations of multivalent ions--may be a control mechanism utilized by

167 d polyelectrolyte brushes in the presence of multivalent ions.

168 ity as drivers of in-register binding in the multivalent LC8-IDP complex assembly and the degree of c

169 Multivalent lectin-glycan interactions are widespread in

170 glycans are powerful mechanistic probes for multivalent lectin-glycan interactions.

171 To overcome the unexpected obstacle, the multivalent ligand design along with spontaneous heterol

172 asingly using nucleic acid architectures for multivalent ligand presentation to unravel the mechanism

173 Conjugates of these multivalent ligands with auristatin and saporin toxins a

174 caffolds provide easy access to libraries of multivalent ligands with tunable affinities.

175 d a series of complementary DNA-duplex-based multivalent ligands, also with appended short oligonucle

176 lso be used for nonlectin proteins that bind multivalent ligands.

177 alently cross-linked complexes with specific multivalent ligands.

178 In this work we interfaced two synthetic multivalent linear nanoplatforms based on a dynamic supr

179 Overall, multivalent lipid binding by the Slp-4 C2A domain provid

180 patiotemporally actuated organelles based on multivalent low-affinity interactions.

181 SN22 is an effective and curative multivalent macromolecular agent in multiple solid tumor

182 This position provides a multivalent mechanism for interaction of the RIIbeta hol

183 An effective low-cost multivalent meningococcal conjugate vaccine could help f

184 ration for the anticipated introduction of a multivalent meningococcal conjugate vaccine within Afric

185 Affordable multivalent meningococcal conjugate vaccines are being d

186 serogroups may continue to occur; effective multivalent meningococcal conjugate vaccines could impro

187 hich allows for engineering such a selective multivalent metal ion binding site into target macromole

188 en contained only traces of Ca(2+) and other multivalent metal ions.

189 configurations include alkali (Li/Na/K) and multivalent (Mg, Zn)-based electrolytes for conventional

190 This multivalent mode of binding was further strengthened by

191 ase binding sites and develop what we call a multivalent model that incorporates this effect and can

192 ortance of protein kinase regulation through multivalent modification of the activation segment.

193 ectors either alone or in combination with a multivalent modified vaccinia Ankara (MVA) Ebola vaccine

194 asured binding interactions among three core multivalent molecular components necessary for such asse

195 n mRNA, thereby aiding the assembly of large multivalent mRNP granules that are PBs.

196 The structure-based design of multivalent nanomaterials, involving modulation of nanos

197 cine design, antigens are often arrayed in a multivalent nanoparticle form, but in vivo mechanisms un

198 is for interpreting immune responses to this multivalent nanoparticle immunogen.

199 Dendrimers are branched, multivalent nanoparticles with a well-defined structure

200 The combination of these two multivalent nanoplatforms provides for the first time en

201 The resulting multivalent nanotoxoids are capable of delivering virule

202 ge of the current vaccine approach is mvPC's multivalent nature (recognizing multiple-epitopes), whic

203 This initial attachment is of a multivalent nature, i.e., it requires the establishment

204 We bioengineered multivalent Nb constructs that achieved ultrahigh neutra

205 These areas include DNA/RNA nanotechnology, multivalent nucleic acid nanostructures, and nucleic aci

206 In this review, we discuss multivalent nucleic acid-ligand conjugates in the contex

207 l molecular complexes and interactions among multivalent or multistate molecules.

208 er manner to any of the available sites on a multivalent partner.

209 We found that a multivalent peptide construct featuring four lysine-alan

210 The new multivalent-permeable Fuji T1 is able to transport dival

211 re, we quantitatively analyze the effects of multivalent phosphorylation of LAT by reconstituting the

212 tile platform described here thus allows for multivalent plug-and-play presentation on self-assemblin

213 granule protein FUS (fused in sarcoma) to a multivalent poly-Src homology 3 (SH3) domain protein tha

214 Multivalent polyions can undergo complex coacervation, p

215 Structure-function relationships for multivalent polymer scaffolds are highly complex due to

216 this work, we will examine the binding of a multivalent polymer to a small target.

217 peptide as the model system, here we report multivalent polymer-peptide conjugates (mPPCs) that disa

218 Here, we developed a multivalent, polymer-based prodrug of a structurally opt

219 SN22 administered as a multivalent polymeric prodrug resulted in increased and

220 The architecture of multivalent polymers exerts an amplified interaction bet

221 Multivalent polymers have shown promise as inhibitors of

222 Designing multivalent polymers to bind to viruses and toxic protei

223 udies of how larger structural parameters of multivalent polymers, such as degree of polymerization,

224 olymerization affects the binding avidity of multivalent polymers.

225 The multivalent presentation of specific carbohydrates by us

226 discovery to design a novel vaccine based on multivalent presentation of the identified minimal epito

227 Multivalent presentation of viral glycoproteins can subs

228 those elicited by the ST-5 CPS component in multivalent Prevnar13.

229 Phase separation of multivalent protein and RNA molecules underlies the biog

230 ng HNRNPD and HNRNPDL, which are involved in multivalent protein assemblies and phase separation.

231 Our data demonstrate how multivalent protein-protein and protein-lipid interactio

232 simulates binding kinetics and equilibria of multivalent protein-protein interactions as a function o

233 factors form concentrated hubs in cells via multivalent protein-protein interactions, often mediated

234 SGs arise by multivalent protein-protein, protein-RNA, and RNA-RNA in

235 vealed critical roles of position-dependent, multivalent protein-RNA interactions that direct splicin

236 nule formation, consistent with models where multivalent protein:RNA and protein:protein contacts for

237 , domain-domain interactions, and binding to multivalent proteins all contribute to cluster formation

238 ons of multicomponent mixtures comprising of multivalent proteins and RNA molecules.

239 Phase transitions of linear multivalent proteins control the reversible formation of

240 e explore formation of prototypical MOs from multivalent proteins on various time and length scales a

241 A system-spanning network encompassing all multivalent proteins was only observed at high concentra

242 lows us to simulate thousands of interacting multivalent proteins, we investigate the physical parame

243 prising of coarse-grained representations of multivalent proteins.

244 ized by reversible physical crosslinks among multivalent proteins.

245 SSI using simulations of linear and branched multivalent proteins.

246 taneous phase transitions that are driven by multivalent proteins.

247 ered linkers influences phase transitions of multivalent proteins.

248 apid and reversible condensation of numerous multivalent proteins.

249 l surfaces or artificial surfaces displaying multivalent recognition motifs-within a layer of polymer

250 together using molecular linkers to create a multivalent recombinant protein against Candida albicans

251 r complex when bound to an IDP domain of the multivalent regulatory protein ASCIZ.

252 ort here an unexpected role for the polymer: multivalent, reversible, and adaptive binding to protein

253 pproach to improve molecular buffering using multivalent ring-chain systems.

254 Multivalent RNA binding stimulates higher-order assembly

255 Therefore, we designed a new multivalent RNA nanoparticle harboring three copies of h

256 emonstrates the potential of the rubber-like multivalent RNA nanoparticles to conquest the liver canc

257 Here, we test the possibility that the multivalent RNA-binding nucleocapsid protein (N) from se

258 nsates and discrete 15-nm particles based on multivalent RNA-protein and protein-protein interactions

259 the components, timing, and kinetics of the multivalent role of ubiquitin signals in control of ampl

260 An optimal designed multivalent SA receptor showed a higher binding stabilit

261 a promising strategy for the development of multivalent Salmonella vaccines.

262 h the membrane whereas R.RKTR forms specific multivalent salt bridges with PA.

263 Polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins,

264 neuronal compartment organized by the large multivalent scaffold protein mAKAPalpha promotes neurona

265 This behavior boosts Q beyond that of any multivalent scaffold system.

266 power in protomer concentration than for any multivalent scaffold.

267 um and discrete setting, and compare it with multivalent scaffolds with fixed number of binding sites

268 y central roles in establishment of a robust multivalent SH3 domain-PRM network in vivo, giving actin

269 -95, thus resulting in a highly specific and multivalent stargazin/PSD-95 complex.

270 ificantly more force stable than commercial, multivalent streptavidin.

271 In the next section, multivalent structures such as glycoclusters and glycode

272 the possibility that condensates assemble on multivalent surfaces such as DNA, microtubules, or lipid

273 This establishes multivalent, synergistic H3-tail binding causing distinc

274 ependent (Type 1) Ags, but Ab responses to a multivalent T-independent (Type 2) Ag were impaired, a s

275 a rotating magnetic field and stabilized by multivalent target molecules.

276 s of this approach in the context of soluble multivalent targeting scaffolds has yet to be undertaken

277 longer polymers increase binding avidity to multivalent targets but reach a limit in binding avidity

278 a homogeneous biosensor for the detection of multivalent targets by combination of magnetic nanoparti

279 to determine stability profiles for the same multivalent tethered antibody formats from both in vitro

280 In the case of engineered multivalent tethered antibody formats, proteolysis or de

281 For the multivalent tethered antibody molecules selected, an ~30

282 ion of specific structured (TF-DNA) and weak multivalent (TF-coactivator) interactions allows for con

283 of the plant-derived recombinant enzyme as a multivalent therapeutic.

284 a binding that we simulate to be strong and multivalent to the VAL repeating units, generating force

285 in as a component of an anti-virulence based multivalent toxoid vaccine against S. aureus disease.

286 Eukaryotic genes are regulated by multivalent transcription factor complexes.

287 ral and functional properties for a range of multivalent transition metal oxides.

288 f competition in a ring-chain equilibrium of multivalent ureidopyrimidinone monomers and a monovalent

289 r understanding of how to use Env trimers in multivalent vaccination regimens and the immunogenicity

290 s that would constitute a broadly protective multivalent vaccine against Strep A isolates.

291 will be needed to define the efficacy of the multivalent vaccine candidate to protect against lethal

292 a potential Virus Like Particle (VLP) based multivalent vaccine candidate to target these diseases b

293 se 87% of NTS belonged to only 4 serovars, a multivalent vaccine may be an effective strategy to redu

294 nfants with maternally derived antibodies, a multivalent vaccine might also serve to reduce fetal and

295 Thus, a multivalent vaccine that targets all four viruses would

296 The development of multivalent vaccines is an attractive methodology for th

297 rter DNA ligand-receptor pairs, proving that multivalent weak interactions lead to enhanced selectivi

298 re accompanied by a substantial frequency of multivalents, which varied by variety and by chromosome

299 the literature, the molecular mechanisms of multivalent WW domain-PPXY assemblies are still poorly u

300 interconverting conformers may be common in multivalent WW domain-PPXY interactions to promote the a