ライフサイエンスコーパス: muscarinic acetylcholine receptor

1 oding potassium voltage-gated channels and a muscarinic acetylcholine receptor.

2 volved in the recycling of the M4 subtype of muscarinic acetylcholine receptor.

3 of the inactive and active state of the M(3) muscarinic acetylcholine receptor.

4 402-421 in transmembrane helix 7 of the M(1) muscarinic acetylcholine receptor.

5 beta2 adrenergic receptor (hbeta2AR) and M2 muscarinic acetylcholine receptor.

6 ulated with type 1 protease activated and M1 muscarinic acetylcholine receptors.

7 etabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors.

8 ies of cysteine (Cys)-substituted mutant M 3 muscarinic acetylcholine receptors.

9 HVC activity and was attenuated by blocking muscarinic acetylcholine receptors.

10 a series of cysteine-substituted mutant M(3) muscarinic acetylcholine receptors.

11 er reaction and are allosteric modulators at muscarinic acetylcholine receptors.

12 d which is inhibited following activation of muscarinic acetylcholine receptors.

13 lated, and only weakly inhibited, through M1 muscarinic acetylcholine receptors.

14 phenotype can be rescued by an antagonist of muscarinic acetylcholine receptors.

15 ergic G protein-coupled receptors, including muscarinic acetylcholine receptors.

16 y acetylcholine acting on both nicotinic and muscarinic acetylcholine receptors.

17 y changes in glycolysis and by activation of muscarinic acetylcholine receptors.

18 while enhancing myelination by deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte p

19 n upon stimulation with nafenopin, including muscarinic acetylcholine receptor 3, intermediate filame

20 , we find that the Chrm4 transcript encoding muscarinic acetylcholine receptor 4 (M4) is excessively

21 We and others have investigated muscarinic acetylcholine receptor 4 (M4) positive allost

22 nergic, dopaminergic D3 and D4 receptors and muscarinic acetylcholine receptor 4, the receptor tyrosi

23 eviously undisclosed antagonists of the M(2) muscarinic acetylcholine receptor, a G-protein coupled r

24 Herein we address these topics for the M1 muscarinic acetylcholine receptor, a key molecular targe

25 To address this issue, we used the M(3) muscarinic acetylcholine receptor, a prototypical class

26 ting to their active state, we used the M(3) muscarinic acetylcholine receptor, a prototypical class

27 By applying this method to the M(2) muscarinic acetylcholine receptor, a prototypical GPCR,

28 ces, we show that endogenous Galphaq-coupled muscarinic acetylcholine receptors activate PKA.

29 HEK 293 cells was induced via recombinant M2 muscarinic acetylcholine receptors activated by carbacho

30 Acetylcholine binding to muscarinic acetylcholine receptors activates G-proteins,

31 omain 3 (TM3) plays a crucial role mediating muscarinic acetylcholine receptor activation by acetylch

32 e rat dentate gyrus to examine the effect of muscarinic acetylcholine receptor activation on the intr

33 on the unknown transduction pathway linking muscarinic acetylcholine receptor activation to M-channe

34 rom intracellular stores and triggered by M1 muscarinic acetylcholine receptor activation was critica

35 both pharmacologic blockade of M-current and muscarinic acetylcholine receptor activation.

36 Disruption of NAc muscarinic acetylcholine receptor activity attenuated, w

37 ese results propose a new mechanism by which muscarinic acetylcholine receptors affect cognition and

38 ble toolbox derivatives of the highly potent muscarinic acetylcholine receptor agonist iperoxo.

39 bath application of 3 mum carbachol (CCh), a muscarinic acetylcholine receptor agonist, reduces evoke

40 with oxotremorine-M (Oxo-M), a nonselective muscarinic acetylcholine receptor agonist.

41 aperitoneal administration of pilocarpine, a muscarinic acetylcholine receptor agonist.

42 aperitoneal administration of pilocarpine, a muscarinic acetylcholine receptor agonist.

43 study we have generated mice lacking the M1 muscarinic acetylcholine receptor and examined the effec

44 evaluating the binding sites of both the M2 muscarinic acetylcholine receptor and the D2 dopamine re

45 limiting the active conformation of the M(2) muscarinic acetylcholine receptor and thereby regulate s

46 ptor (LGR7), G-proteins (Galpha(q/11/o/13)), muscarinic acetylcholine receptor and vanilloid (TRPV1)

47 ure activation of recombinant and endogenous muscarinic acetylcholine receptors and activation of rec

48 ovary (CHO) cells stably transfected with M1 muscarinic acetylcholine receptors and currents were rec

49 an M(2)-selective competitive antagonist of muscarinic acetylcholine receptors and exhibits alloster

50 ugh a slowly activating pathway linked to M1 muscarinic acetylcholine receptors and Galphaq/11 protei

51 ular solution, indicating the involvement of muscarinic acetylcholine receptors and InsP(3)-sensitive

52 mechanism describing the interaction of M(2) muscarinic acetylcholine receptors and the guanine nucle

53 Dysfunction of muscarinic acetylcholine receptors and their downstream

54 amine receptors, 5-HT (serotonin) receptors, muscarinic acetylcholine receptor, and adrenergic recept

55 .5 +/- 8.5% of controls), insensitive to the muscarinic acetylcholine receptor antagonist atropine (1

56 Following treatment with the muscarinic acetylcholine receptor antagonist biperiden,

57 Scopolamine (hyoscine) is a muscarinic acetylcholine receptor antagonist that has tr

58 demonstrate that scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces r

59 ve revealed that scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces r

60 el tropane derivatives were characterized as muscarinic acetylcholine receptor antagonists (mAChRs).

61 Muscarinic acetylcholine receptor antagonists are widely

62 studies show that systemic administration of muscarinic acetylcholine receptor antagonists selectivel

63 piperazines was discovered as highly potent muscarinic acetylcholine receptor antagonists via high t

64 l quaternary ammonium salts as highly potent muscarinic acetylcholine receptor antagonists with excel

65 waves, MC calcium transients were blocked by muscarinic acetylcholine receptor antagonists, whereas d

66 structurally and physicochemically distinct muscarinic acetylcholine receptor antagonists.

67 Compounds acting at both nicotinic and muscarinic acetylcholine receptors appear to have antino

68 Muscarinic acetylcholine receptors are G protein-coupled

69 Muscarinic acetylcholine receptors are G-protein-coupled

70 M1 muscarinic acetylcholine receptors are highly expressed

71 rhelical constraint contacts, using the M(1) muscarinic acetylcholine receptor as a model.

72 Among these, we identified CHRM3, a M3R muscarinic acetylcholine receptor, as being restricted t

73 ous work has demonstrated that activation of muscarinic acetylcholine receptors at the lizard neuromu

74 rs (mGluRs, alpha1 adrenergic receptors, and muscarinic acetylcholine receptors), attained by superfu

75 um anti-Ro/SSA, anti-La/SSB, and anti-type 3 muscarinic acetylcholine receptor autoantibodies or in t

76 These results indicate a reduction in muscarinic acetylcholine receptor availability in vivo i

77 her syndrome was due to autoimmunity against muscarinic acetylcholine receptors, blocking their activ

78 It is concluded that muscarine acts on M3 muscarinic acetylcholine receptors both to inhibit IK(SO

79 is implicated in reward, whereas blockade of muscarinic acetylcholine receptors by scopolamine suppre

80 protein-coupled receptors, including the M3 muscarinic acetylcholine receptor, can form homo-oligome

81 Muscarinic acetylcholine receptors comprise a family of

82 Previous studies have shown that muscarinic acetylcholine receptors evoke both inhibition

83 In HEK293 cells, activation of the M1 muscarinic acetylcholine receptor evokes tyrosine phosph

84 CRT attenuated the increased M2 subtype of muscarinic acetylcholine receptor expression and Galphai

85 The patches are matched to a pattern of M2 muscarinic acetylcholine receptor expression at fixed lo

86 Galphai coupling and enhanced M3 subtype of muscarinic acetylcholine receptor expression in associat

87 /AL border coincides with a change in type 2 muscarinic acetylcholine receptor expression in layer 4

88 ic receptor is the most recent member of the muscarinic acetylcholine receptor family (M(1)-M(5)) to

89 Members of the muscarinic acetylcholine receptor family are thought to

90 The muscarinic acetylcholine receptor family exemplifies the

91 mine (NMS) bind to the binding pocket of the muscarinic acetylcholine receptor formed by transmembran

92 Postsynaptically, the muscarinic acetylcholine receptor GAR-3 acts in RIA to c

93 resynaptic signaling pathway composed of the muscarinic acetylcholine receptor GAR-3, the heterotrime

94 amined the interaction of REST with the M(4) muscarinic acetylcholine receptor gene.

95 ric modulators (PAMs) of the M(1) subtype of muscarinic acetylcholine receptor have emerged as an exc

96 uggest that selective activators of the M(4) muscarinic acetylcholine receptor have potential as a no

97 Muscarinic acetylcholine receptors have been implicated

98 is known about the physiological function of muscarinic acetylcholine receptors in learning in adult

99 Here, we describe a role for central muscarinic acetylcholine receptors in the activation of

100 This strongly suggests a role of muscarinic acetylcholine receptors in the generalized se

101 ity, which we tentatively have called MARIA (muscarinic acetylcholine receptor-inducing activity) is

102 The drug scopolamine was used to block muscarinic acetylcholine receptors involved in working m

103 The muscarinic acetylcholine receptor is an important modula

104 The M5 muscarinic acetylcholine receptor is suggested to be a p

105 acterized GPCRs coupled to either G(q) (M(1) muscarinic acetylcholine receptor (M(1)AchR) and P2y(1)

106 on) address this question in relation to the muscarinic acetylcholine receptor (M(1)AchR) and the B(2

107 he regulation of endogenously expressed M(3) muscarinic acetylcholine receptor (M(3) mAChR).

108 lar location of NKCC1, Na(+)-K(+)-ATPase, M3 muscarinic acetylcholine receptor (M(3)AChR) and lysosom

109 e prospectively apply our model to the human muscarinic acetylcholine receptor M1, finding four exper

110 itive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (M1 mAChR) are a promi

111 sed biosensor to detect activation of the M1 muscarinic acetylcholine receptor (M1 mAChR) in vitro an

112 acetylcholine receptors, particularly the M1 muscarinic acetylcholine receptor (M1 mAChR), which was

113 1)-coupled receptors - prototypically the M1 muscarinic acetylcholine receptor (M1-mAChR).

114 an be recapitulated with blockade of M1-type muscarinic acetylcholine receptors (M1-AChR); however, t

115 Galphaq-coupled receptors, including the M1 muscarinic acetylcholine receptor (M1R), and opposes the

116 consistent with beta-arrestin binding to M1 muscarinic acetylcholine receptors (M1Rs) in two differe

117 tween polymorphisms in the gene encoding the muscarinic acetylcholine receptor M2 (CHRM2) and EROs.

118 hisms genotyped across a candidate gene, the muscarinic acetylcholine receptor M2 gene (CHRM2).

119 typically express somatostatin, VIP, or the muscarinic acetylcholine receptor M2.

120 stence of a second allosteric site on the M2 muscarinic acetylcholine receptor (M2 mAChR).

121 for several allosteric modulators of the M2 muscarinic acetylcholine receptor (M2 receptor), a proto

122 G betagamma), and efficiently translate M(2) muscarinic acetylcholine receptor (M2R) activation into

123 The M2 muscarinic acetylcholine receptor (M2R) is a prototypica

124 Following m2-muscarinic acetylcholine receptor (M2R) stimulation, KAC

125 The M2 muscarinic acetylcholine receptor (M2R) was found to exh

126 We here describe a muscarinic acetylcholine receptor M3 (CHRM3) (1q41-q44)

127 Human acini preferentially expressed the muscarinic acetylcholine receptor M3 and maintained phys

128 gical interventions, we demonstrate that the muscarinic acetylcholine receptor M3 mediates these acti

129 ed inflammatory cytokines and decreased M3R (Muscarinic Acetylcholine receptor M3) and AQP5 (Aquapori

130 major role in the regulation of the human M3 muscarinic acetylcholine receptor (M3 mAChR) in the huma

131 n and lung function regulated through the M3-muscarinic acetylcholine receptor (M3-mAChR).

132 ts, CCK-8 and gastrin, and an agonist for m3 muscarinic acetylcholine receptors (m3 AchR), carbachol.

133 We previously reported that type 3 muscarinic acetylcholine receptors (M3-Rs) physically in

134 levels of AuAbs to desmocollin 3 (Dsc3), M3 muscarinic acetylcholine receptor (M3AR), and secretory

135 f family A GPCR dimers, we used the rat M(3) muscarinic acetylcholine receptor (M3R) as a model syste

136 (SMG), production of antinuclear and anti-M3 muscarinic acetylcholine receptor (M3R) autoantibodies a

137 The M muscarinic acetylcholine receptor (M3R) regulates many f

138 d light on this issue, we have used the M(3) muscarinic acetylcholine receptor (M3R), a prototypic cl

139 ionally critical amino acids in the rat M(3) muscarinic acetylcholine receptor (M3R), a prototypic cl

140 To address this issue, we used the M(3) muscarinic acetylcholine receptor (M3R), a prototypic cl

141 , can inhibit signal transduction via the M3 muscarinic acetylcholine receptor (M3R).

142 that autoantibodies reactive with the type 3 muscarinic acetylcholine receptors (M3Rs) expressed on s

143 L to modulate the activity of beta-cell M(3) muscarinic acetylcholine receptors (M3Rs), which play an

144 reward, potentially mediated through the M5 muscarinic acetylcholine receptor (M5R).

145 the phosphorylation and regulation of the M3 muscarinic acetylcholine receptor (mACh) endogenously ex

146 itive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (mAChR) achieve exquis

147 Here we show that muscarinic acetylcholine receptor (mAChR) activation als

148 ation of vestibular afferents is mediated by muscarinic acetylcholine receptor (mAChR) activation and

149 Muscarinic acetylcholine receptor (mAChR) activation in

150 e identity of signaling elements that couple muscarinic acetylcholine receptor (mAChR) activation to

151 on populations are differentially engaged by muscarinic acetylcholine receptor (mAChR) activation.

152 mulating evidence suggests that selective M4 muscarinic acetylcholine receptor (mAChR) activators may

153 Nanoinjections of the muscarinic acetylcholine receptor (mAChR) agonist, oxotr

154 ) protein-coupled receptors such as the M(2) muscarinic acetylcholine receptor (mAChR) and A(1) adeno

155 fibers, we investigated the function of the muscarinic acetylcholine receptor (mAchR) and G(alpha)q.

156 The abilities of the M(3) muscarinic acetylcholine receptor (mAChR) and Rac1 to re

157 series of novel 1,4-dioxane analogues of the muscarinic acetylcholine receptor (mAChR) antagonist 2 w

158 X-198321) is a single molecule composed of a muscarinic acetylcholine receptor (mAChR) antagonist moi

159 Muscarinic acetylcholine receptor (mAChR) blockade by sc

160 The activation of the muscarinic acetylcholine receptor (mAChR) family, consis

161 Phosphorylation of the M(2) muscarinic acetylcholine receptor (mAChR) has been shown

162 pe-selective allosteric modulators of the M5 muscarinic acetylcholine receptor (mAChR) have been desc

163 t deficits in signaling of the M1 subtype of muscarinic acetylcholine receptor (mAChR) in the prefron

164 ue, we have found that the density of atrial muscarinic acetylcholine receptor (mAChR) increases with

165 siccating environmental stress with systemic muscarinic acetylcholine receptor (mAChR) inhibition.

166 Activation of the M1 muscarinic acetylcholine receptor (mAChR) is a prospecti

167 Here, the extracellular vestibule of the M2 muscarinic acetylcholine receptor (mAChR) is targeted fo

168 rallel synthesis effort identified the first muscarinic acetylcholine receptor (mAChR) negative allos

169 es alpha activity when the actions of either muscarinic acetylcholine receptor (mAChR) or metabotropi

170 Novel bitopic hybrids, based on the M1/M4 muscarinic acetylcholine receptor (mAChR) orthosteric ag

171 The M(1) muscarinic acetylcholine receptor (mAChR) plays an impor

172 M(1) muscarinic acetylcholine receptor (mAChR) positive allos

173 In this study, we characterized a muscarinic acetylcholine receptor (mAChR) potentiator, L

174 We demonstrate that a G alpha(q)-coupled muscarinic acetylcholine receptor (mAChR) signaling path

175 We have studied the effects of m1 muscarinic acetylcholine receptor (mAChR) stimulation, w

176 positive allosteric modulation (PAM) of the muscarinic acetylcholine receptor (mAChR) subtype 5 (M5)

177 Identification of the specific muscarinic acetylcholine receptor (mAChR) subtype(s) med

178 The generation of muscarinic acetylcholine receptor (mAChR) subtype-select

179 Identification of the specific muscarinic acetylcholine receptor (mAChR) subtypes media

180 77-LH-28-1 are selective agonists of the M1 muscarinic acetylcholine receptor (mAChR) that may gain

181 Selective activation of the M1 muscarinic acetylcholine receptor (mAChR) via a positive

182 Muscarinic acetylcholine receptor (mAChR), a member of t

183 sitive allosteric modulator (PAM) for the M1 muscarinic acetylcholine receptor (mAChR), but it posses

184 t manner, some receptors, including the M(2) muscarinic acetylcholine receptor (mAChR), can also exhi

185 We previously reported a form of muscarinic acetylcholine receptor (mAChR)-dependent long

186 tive positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR).

187 osteric modulator of acetylcholine at the M1 muscarinic acetylcholine receptor (mAChR).

188 a strict, two-state MWC mechanism at the M1 muscarinic acetylcholine receptor (mAChR).

189 nction in part by signaling through the M(1) muscarinic acetylcholine receptor (mAChR).

190 the interactions of arrestins with the M(2) muscarinic acetylcholine receptor (mAChR).

191 Genetic studies further indicate that muscarinic acetylcholine receptor (mAchR)/Galphao signal

192 Muscarinic acetylcholine receptors (mAChR) are G protein

193 2) purinergic receptors and transfected M(3) muscarinic acetylcholine receptors (mAChR) in Chinese ha

194 Muscarinic acetylcholine receptors (mAChR) in the centra

195 Muscarinic acetylcholine receptors (mAChR) play importan

196 eceptors (AR) in BF; and AC5/6, beta1-AR, M4-muscarinic acetylcholine receptors (mAChR), mu-opioid re

197 etabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors (mAChR).

198 tory learning in adult flies requires type A muscarinic acetylcholine receptors (mAChR-A), particular

199 this study we showed that stimulation of M1 muscarinic acetylcholine receptors (mAChRs) activates en

200 The activation and blockade of muscarinic acetylcholine receptors (mAChRs) affects reti

201 The M3 and M2 muscarinic acetylcholine receptors (mAChRs) and beta-2-a

202 EPF is enabled by the activation of muscarinic acetylcholine receptors (mAChRs) and is trigg

203 duced by mamba snakes that primarily bind to muscarinic acetylcholine receptors (MAChRs) and modulate

204 Although muscarinic acetylcholine receptors (mAChRs) and NMDA rec

205 It has long been recognized that muscarinic acetylcholine receptors (mAChRs) are crucial

206 s to determine the extent to which m1 and m2 muscarinic acetylcholine receptors (mAChRs) are expresse

207 cotinic acetylcholine receptors (nAChRs) and muscarinic acetylcholine receptors (mAChRs) are expresse

208 Muscarinic acetylcholine receptors (mAChRs) are known to

209 Muscarinic acetylcholine receptors (mAChRs) are known to

210 Muscarinic acetylcholine receptors (mAChRs) are widely e

211 Stimulation of muscarinic acetylcholine receptors (mAChRs) by elevated

212 Muscarinic acetylcholine receptors (mAChRs) can be diffe

213 The 2nd outer loop (o2) of muscarinic acetylcholine receptors (mAChRs) contains a h

214 re, we show that physiological activation of muscarinic acetylcholine receptors (mAChRs) controls the

215 Gq-coupled, M1 muscarinic acetylcholine receptors (mAChRs) facilitate h

216 Activation of muscarinic acetylcholine receptors (mAChRs) has been sho

217 y transmission mediated, for example, by the muscarinic acetylcholine receptors (mAChRs) in relevant

218 Activation of muscarinic acetylcholine receptors (mAChRs) in the spina

219 Both GABA(B) and muscarinic acetylcholine receptors (mAChRs) influence hi

220 Stimulation of muscarinic acetylcholine receptors (mAChRs) inhibits noc

221 Activation of spinal muscarinic acetylcholine receptors (mAChRs) inhibits noc

222 Activation of striatal muscarinic acetylcholine receptors (mAChRs) is known to

223 gency and frequency, presumably by acting on muscarinic acetylcholine receptors (mAChRs) located in b

224 at subtype-selective activators of M(1)/M(4) muscarinic acetylcholine receptors (mAChRs) may offer a

225 elective antagonists of specific subtypes of muscarinic acetylcholine receptors (mAChRs) may provide

226 Activators of M(1) muscarinic acetylcholine receptors (mAChRs) may provide

227 M(1) muscarinic acetylcholine receptors (mAChRs) may represen

228 Muscarinic acetylcholine receptors (mAChRs) modulate syn

229 Spinal muscarinic acetylcholine receptors (mAChRs) play an impo

230 Muscarinic acetylcholine receptors (mAChRs) play an impo

231 Furthermore, inhibition of muscarinic acetylcholine receptors (mAChRs) reduced calc

232 Although muscarinic acetylcholine receptors (mAChRs) regulate pro

233 M(1) muscarinic acetylcholine receptors (mAChRs) represent a

234 cholinergic innervation from the septum, and muscarinic acetylcholine receptors (mAChRs) share some s

235 Activation of muscarinic acetylcholine receptors (mAChRs) significantl

236 etabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors (mAChRs) synergistica

237 rugs (DREADDs) are chemogenetically modified muscarinic acetylcholine receptors (mAChRs) that have mi

238 Activation of muscarinic acetylcholine receptors (mAChRs) with carbach

239 endent mechanisms, whereas others, like M(2) muscarinic acetylcholine receptors (mAChRs), are interna

240 We also characterized two types (A and B) of muscarinic acetylcholine receptors (mAChRs), which were

241 frontal cortex (PFC) and their modulation by muscarinic acetylcholine receptors (mAChRs).

242 mory formation are largely performed through muscarinic acetylcholine receptors (mAChRs).

243 G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs).

244 (123)I-iododexetimide is used for imaging muscarinic acetylcholine receptors (mAchRs).

245 receptors and allosterically interacts with muscarinic acetylcholine receptors (mAChRs).

246 ution of BK channels to control of M2- or M3-muscarinic acetylcholine receptor mediated airway smooth

247 CIH-induced HIF-alpha isoform imbalance via muscarinic acetylcholine receptor-mediated Ca(2+) influx

248 er suggests that GRK2 may selectively impair muscarinic acetylcholine receptor-mediated function in v

249 ts also potentiated both opioid receptor and muscarinic acetylcholine receptor-mediated stimulation o

250 luorescently labeled dibenzodiazepinone-type muscarinic acetylcholine receptor (MR) antagonists, incl

251 Muscarinic acetylcholine receptors (MRs), comprising fiv

252 This Mendelian disease caused by a muscarinic acetylcholine receptor mutation strikingly ph

253 Stimulation of muscarinic acetylcholine receptors on oligodendrocytes i

254 ly, signaling and function mediated by m2/m3 muscarinic acetylcholine receptors or prostaglandin E(2)

255 ere agonist binding follows hyperbolic (M(4) muscarinic acetylcholine receptors) or nonhyperbolic rel

256 when activated via either the endogenous M3 muscarinic acetylcholine receptor, or via coexpressed mG

257 lternative strategy is to selectively target muscarinic acetylcholine receptors, particularly the M1

258 Additionally, blocking nicotinic, but not muscarinic, acetylcholine receptors prevents SCC-mediate

259 Activation of muscarinic acetylcholine receptors produces a significan

260 report that activation of the M4 subtype of muscarinic acetylcholine receptor reduces transmission a

261 Muscarinic acetylcholine receptors regulate the activity

262 The m4 subtype of muscarinic acetylcholine receptor regulates many physiol

263 Activation of the muscarinic acetylcholine receptors requires agonist bind

264 through an acetylcholine-gated channel and a muscarinic acetylcholine receptor, respectively.

265 Here I show that activation of muscarinic acetylcholine receptors results in waves of c

266 g pattern of geniculocortical inputs with M2 muscarinic acetylcholine receptor-rich patches in layer

267 tractile GPCRs, but selectively inhibited M3 muscarinic acetylcholine receptor signaling ( approximat

268 has important functions in both hippocampal muscarinic acetylcholine receptor signalling and in cort

269 agonist-bound, active state of the human M2 muscarinic acetylcholine receptor stabilized by a G-prot

270 otype previously used for the preparation of muscarinic acetylcholine receptor subtype 1 positive all

271 The rat muscarinic acetylcholine receptor subtype 3 was modified

272 nd functional assays using the wild-type rat muscarinic acetylcholine receptor subtype 3.

273 ubstantia nigra pars reticulata (SNr) act on muscarinic acetylcholine receptor subtype 4 (M4) to oppo

274 f the first positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M

275 Mice with targeted disruption of single muscarinic acetylcholine receptor subtype genes (M(1) to

276 t mutant mice that selectively lack the M(3) muscarinic acetylcholine receptor subtype in the brain (

277 the PET radiotracer (11)C-LSN3172176 for the muscarinic acetylcholine receptor subtype M1.

278 The muscarinic acetylcholine receptor subtype M3 (CHRM3) gen

279 We found that the muscarinic acetylcholine receptor subtype M3 (M3R) inter

280 ed from rat cortical neuroepithelium express muscarinic acetylcholine receptor subtype mRNAs.

281 gG reactivity in patients with PV toward the muscarinic acetylcholine receptor subtypes 3, 4, and 5 a

282 essed in HEK293 cells with each of the known muscarinic acetylcholine receptor subtypes.

283 tant versions of bovine rhodopsin and the M3 muscarinic acetylcholine receptor suggested that the cyt

284 diolabeled species from all five subtypes of muscarinic acetylcholine receptors, suggesting allosteri

285 tion of Gq-coupled receptors, such as the m1 muscarinic acetylcholine receptor, suppresses the M-curr

286 enous actuator ligand to activate a modified muscarinic acetylcholine receptor that is insensitive to

287 In cells expressing the M3 muscarinic acetylcholine receptor, the agonist carbachol

288 Among these is the M3 muscarinic acetylcholine receptor, the major muscarinic

289 Therefore, we coupled m2-muscarinic acetylcholine receptors to GIRK channels in X

290 We assessed the contribution of muscarinic acetylcholine receptors to motivated behaviou

291 c stimulation of the heart acts through M(2)-muscarinic acetylcholine receptors to regulate ion chann

292 imary and secondary Gi/o coupling, using the muscarinic acetylcholine receptor type 2 (M2R) as the pr

293 ex can inhibit Ca2+ mobilization elicited by muscarinic acetylcholine receptor type 3 (M3R), but not

294 CIN firing by CRF results in the activation muscarinic acetylcholine receptors type 5, which mediate

295 The M2 subtype of muscarinic acetylcholine receptors was upregulated in hu

296 ion depended on local activation of cortical muscarinic acetylcholine receptors, whereas the increase

297 CHRM3 encodes the M3 muscarinic acetylcholine receptor, which we show is pres

298 macotherapy with nonselective antagonists of muscarinic acetylcholine receptors, which have many unde

299 nous activation of metabotropic glutamate or muscarinic acetylcholine receptors with submaximal TBF u

300 Autoantibodies against the muscarinic acetylcholine receptors would provide a link