ライフサイエンスコーパス: muscle development

1 tion in mammals and plays important roles in muscle development.

2 showed that this gene is necessary for early muscle development.

3 in several stages of prenatal and postnatal muscle development.

4 DNA damage and apoptosis, impairing skeletal muscle development.

5 le maturation and maintenance than for early muscle development.

6 loping zebrafish to determine the effects on muscle development.

7 genes and plays a critical role in skeletal muscle development.

8 chicken embryos, little is known about human muscle development.

9 (G12D) expression at different stages during muscle development.

10 genous nhp2l1 in zebrafish disrupts skeletal muscle development.

11 scriptome are known to play central roles in muscle development.

12 scribed player during cardiac and pharyngeal muscle development.

13 wn about the regulatory mechanisms of tongue muscle development.

14 l JAM family paralogues may also function in muscle development.

15 nes in the muscle precursors during forelimb muscle development.

16 s required for homeostasis during Drosophila muscle development.

17 s in decreased Wnt signaling and lung smooth-muscle development.

18 ulatory factor Myf5 plays important roles in muscle development.

19 s play an instructive role in guiding tongue muscle development.

20 llite cell activation and therefore skeletal muscle development.

21 transcriptional responses and impaired early muscle development.

22 /4 proteins, and prevents adipose tissue and muscle development.

23 targets of EBF activity with known roles in muscle development.

24 known function of EBF proteins in vertebrate muscle development.

25 f the earliest aspects of lung airway smooth muscle development.

26 e the earliest aspects of lung airway smooth muscle development.

27 tors that is important in heart and skeletal muscle development.

28 ue-tissue interaction during tongue skeletal muscle development.

29 factor availability during craniofacial and muscle development.

30 ell-cell interactions in regulating skeletal muscle development.

31 tributing factor in early postnatal skeletal muscle development.

32 plasticity of titin splicing during skeletal muscle development.

33 nuclear co-repressor that regulates bone and muscle development.

34 ntial role in zebrafish skeletal and cardiac muscle development.

35 strong deficits in notochord but not somitic muscle development.

36 rimarily in regulation of cardiac and smooth muscle development.

37 me, without abnormalities of vascular smooth muscle development.

38 for muscle stem cell commitment and skeletal muscle development.

39 pel and Even-skipped expression required for muscle development.

40 nd bomb2 (mib2) gene is a novel regulator of muscle development.

41 tically important for fast and slow skeletal muscle development.

42 l pathways that control cardiac and skeletal muscle development.

43 s MyoD and myogenin are crucial for skeletal muscle development.

44 n factors are well-established regulators of muscle development.

45 tional regulation combine to direct skeletal muscle development.

46 urther suggesting that Maml1 is required for muscle development.

47 ylation proteins were upregulated throughout muscle development.

48 se to delete Myog before and after embryonic muscle development.

49 ulmonary septal defects, and abnormal smooth muscle development.

50 embryogenesis in the developing mesoderm for muscle development.

51 nscripts and proteins consistent with smooth muscle development.

52 o be a major target of Pcs regulation during muscle development.

53 inent roles in regulating smooth and cardiac muscle development.

54 d-gestation period is important for skeletal muscle development.

55 4 methylation and impairs adipose tissue and muscle development.

56 cally in the developing mesoderm, throughout muscle development.

57 2C transcription and is essential for proper muscle development.

58 regulatory network involved in Drosophila's muscle development.

59 promoter during the late stages of embryonic muscle development.

60 ly growing rats may be requisite for optimal muscle development.

61 tion of the abdomen and defects in embryonic muscle development.

62 ssential roles in transcriptional control of muscle development.

63 ll behavior is likely specified during early muscle development.

64 pecific contractile protein expressed during muscle development.

65 s critical in smooth muscle (SM) and cardiac muscle development.

66 erases MLL3/4 and impairs adipose tissue and muscle development.

67 Lipin1 is critical for skeletal muscle development.

68 des RNA binding proteins (FXR1P) involved in muscle development.

69 is transiently expressed in vascular smooth muscle development.

70 m centrosomes to the nuclear envelope during muscle development.

71 ing pathway and miRNAs regulate the skeletal muscle development.

72 ethylase and promote adipogenesis and smooth muscle development.

73 e critical step in myofiber formation during muscle development.

74 ursor cells impairs brown adipose tissue and muscle development.

75 II activity resulted in inefficient skeletal muscle development.

76 ranscriptional processes during normal fetal muscle development.

77 into mice caused repression of gastrocnemius muscle development.

78 ecluding analysis of its effects on skeletal muscle development.

79 r insights into the merits and mechanisms of muscle development.

80 enrichment of upregulated genes involved in muscle development.

81 these proteins, as well as genes involved in muscle development.

82 rchestrates the early phases of adult flight muscle development.

83 r Myod to regulate fast-muscle, but not slow-muscle, development.

84 s, which, due to its unique mode of hypaxial muscle development, allows us to examine myoblast develo

85 h Smyd1a and Smyd1b partake in slow and fast muscle development although Smyd1b plays a dominant role

86 al muscle would be valuable in understanding muscle development and a variety of muscle diseases that

87 nin plays a dual role as both a regulator of muscle development and an inducer of neurogenic atrophy.

88 ELF) family contribute to heart and skeletal muscle development and are implicated in myotonic dystro

89 netic evidence that Fndc5 is dispensable for muscle development and basal metabolism but essential fo

90 genes that fall into heart, vasculature and muscle development and body growth categories, which pro

91 at regulates cell-specific functions such as muscle development and breast cancer metastasis.

92 o alter transcription of genes that regulate muscle development and cell cycle progression.

93 le precursor cells is a key step during limb muscle development and depends on the activity of PAX3 a

94 OB mothers, which may play a role in altered muscle development and development of insulin resistance

95 Mef2 is the key transcription factor for muscle development and differentiation in Drosophila.

96 ogenic microRNAs are important regulators of muscle development and differentiation.

97 platform enables novel studies into skeletal muscle development and disease and chronic drug testing

98 function of MTMR14 and its specific role in muscle development and disease is much less well underst

99 r signaling axis that is critical for smooth muscle development and disease progression in the lung.

100 Given the role of Zasp proteins in mammalian muscle development and disease, our results have relevan

101 pecific genes and to play important roles in muscle development and diseases.

102 tubes such as is necessary for both skeletal muscle development and during regeneration, by remodelin

103 -24 clusters have subtle effects on skeletal muscle development and endurance-exercise-induced muscle

104 down-regulates a key splicing factor during muscle development and establishes a role for microRNAs

105 netic motif underlies cardiac and pharyngeal muscle development and evolution in chordates.

106 din die during the earliest stages of smooth muscle development and fail to express multiple smooth m

107 out of smyd1a alone had no visible effect on muscle development and fish survival.

108 ynein-interacting proteins during Drosophila muscle development and found that several factors, inclu

109 The role of cofilin-2 in muscle development and function is unclear.

110 Muscle activity contributes to muscle development and function largely by means of regu

111 ibution of the NAM-NAD(+) salvage pathway to muscle development and function using Caenorhabditis ele

112 ological roles for SOCE and ECCE in skeletal muscle development and function, as well as other curren

113 on as a novel mechanism for regulating heart muscle development and function, in particular the assem

114 he role of alpha7 integrin and dystrophin in muscle development and function, we generated integrin a

115 determinant of cardiac and skeletal striated muscle development and function, with misexpression freq

116 s, consistent with essential roles of JPs in muscle development and function.

117 rganized sarcomere structure is critical for muscle development and function.

118 is a muscle-enriched microRNA that regulates muscle development and function.

119 to disturbed proprioception causing aberrant muscle development and function.

120 to connective tissue organization as well as muscle development and functionality.

121 d is a potent negative regulator of skeletal muscle development and growth in mammals.

122 Follistatin is essential for skeletal muscle development and growth, but the intracellular sig

123 onic myoblasts resulted in apparently normal muscle development and growth.

124 n (MSTN) is a dominant inhibitor of skeletal muscle development and growth.

125 osphatidylinositol 3-phosphate metabolism in muscle development and homeostasis remain poorly underst

126 s of WNT/beta-catenin signaling molecules in muscle development and homeostasis, we used in vitro cul

127 c splicing can influence FXR1 condensates in muscle development and how mis-splicing promotes disease

128 We have applied this technique to skeletal muscle development and identified new genes with interes

129 r methylation and are critical regulators of muscle development and implicated in neoplastic transfor

130 own to regulate the formation of extraocular muscle development and in this report we show that its e

131 x3 plays an essential role in early skeletal muscle development and is a key component in alveolar rh

132 However, its role in skeletal muscle development and its mechanism of actions remains

133 h that MYMK activity is necessary for normal muscle development and maintenance in humans, and expand

134 rst evidence that FLNc has a crucial role in muscle development and maintenance of muscle structural

135 Cardiac and skeletal muscle development and maintenance require complex inter

136 on and lactation exhibited impaired skeletal muscle development and metabolic disorders normally asso

137 athways through which GHR regulates skeletal muscle development and modulates nutrient metabolism.

138 rtance of RNA binding/processing proteins in muscle development and muscle disease.

139 myoblasts differentiate into myotubes during muscle development and muscle regeneration after injury.

140 studies showing the contribution of NFIX to muscle development and muscular dystrophies, hematopoies

141 tently resulted in grossly abnormal skeletal muscle development and myofibrillar disorganization at t

142 ific phenotypes, such as vascular and smooth muscle development and neonatal epithelial and mast cell

143 alogs of FMRP that are involved in promoting muscle development and neural development, respectively.

144 muscle hypoplasia was due to abnormal early muscle development and not disuse atrophy.

145 Regulation of skeletal muscle development and organization is a complex process

146 results indicate that BIN1 and DNM2 regulate muscle development and organization, function through a

147 MRTFs in sarcomere formation during skeletal muscle development and point to the potential involvemen

148 Hmga2 knockout mice exhibit impaired muscle development and reduced myoblast proliferation, w

149 any protein regulatory factors essential for muscle development and regeneration are degraded via the

150 ing checkpoint mRNAs regulates each stage of muscle development and regeneration by reprogramming eac

151 Muscle development and regeneration require delicate cel

152 Skeletal muscle development and regeneration requires the fusion

153 otein abundance of MyoD, a master switch for muscle development and regeneration, but not that of its

154 eated myotubes is a crucial step in skeletal muscle development and regeneration.

155 is and angiogenesis: 2 crucial processes for muscle development and regeneration.

156 a membrane-associated protein important for muscle development and regeneration.

157 study aimed to define the role of Trim33 in muscle development and regeneration.

158 functions of Pax7(Lo) satellite cells during muscle development and regeneration.

159 erogeneity by fine-tuning Pax7 levels during muscle development and regeneration.

160 the role of HIF1alpha during murine skeletal muscle development and regeneration.

161 PTRH2 is critical in muscle development and regulates myogenic differentiatio

162 s sperm motility (Fer-1), mammalian skeletal muscle development and repair (MYOF and dysferlin), and

163 ated myocytes is a critical step in skeletal muscle development and repair.

164 y myoblasts, with important implications for muscle development and repair.

165 le precise control of transcripts throughout muscle development and repair.

166 However, a role for cilia in normal muscle development and rhabdomyosarcoma (RMS) has not be

167 ched BAR protein with an established role in muscle development and skeletal myopathies.

168 play a synergistic effect on zebrafish early muscle development and some effects of GRK2 knockdown ca

169 myogenin is absolutely required for skeletal muscle development and survival until birth, but it is d

170 transcriptional network during ductal smooth muscle development and that disruption of this pathway m

171 omplexity in even this well-studied model of muscle development and that it can improve transcriptome

172 d that the receptors were present throughout muscle development and that, in adult muscle fibres, the

173 lude that Ci-MRF is required for larval tail muscle development and thus that an MRF-dependent myogen

174 s distinct from those occurring in embryonic muscle development and uncover an unsuspected non-cell a

175 essential for cardiac, skeletal, and smooth muscle development and uses its N-terminal TEA domain (T

176 strongly suggesting its importance in smooth muscle development and/or function, which could explain

177 a severe neonatal disorder in which skeletal muscle development and/or regeneration is impaired.

178 Minion as a novel microprotein required for muscle development, and define a two-component programme

179 to categories related to the nervous system, muscle development, and especially to metabolic diseases

180 Hedgehog transcriptional responses, impaired muscle development, and neural patterning.

181 linking Fat1 to cancer, abnormal kidney and muscle development, and neuropsychiatric disease, this F

182 orm a regulatory loop with Notch1 to repress muscle development, and this result expands our understa

183 ragm's muscle connective tissue and regulate muscle development, and we show that the striking migrat

184 In Ihh(-/-) embryos, skeletal muscle development appears abnormal at embryonic day 14.

185 beta1 integrins, suggesting that defects in muscle development are not primarily caused by defects i

186 uscle-specific gene expression during smooth muscle development are poorly understood.

187 s, which have crucial functions in embryonic muscle development, are assumed to have similar roles in

188 cise control of Mef2 levels is essential for muscle development as different Mef2 protein levels acti

189 the 6664 CNVs are enriched for immunity and muscle development, as well as head and limb morphology.

190 n signaling are capable of restricting heart muscle development at these relatively late stages of de

191 a new maturation step in vertebrate skeletal muscle development at which thick filament gene expressi

192 S deficiency contributes to misregulation of muscle development, blood flow, fatigue, inflammation an

193 The SOCS3 MKO mice had normal muscle development, body mass, adiposity, appetite, and

194 e found that genes and gene sets involved in muscle development, bone synthesis, immunity, reproducti

195 s of positive selection at genes involved in muscle development, bone synthesis, reproduction, immune

196 data support a model in which Hhip regulates muscle development both by sequestering Hedgehog and by

197 ses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30

198 ) has emerged as a key regulator of skeletal muscle development by governing distinct stages of myoge

199 le-specific miRNAs that are regulated during muscle development by the SRF transcription factor.

200 Both exhibited impaired skeletal muscle development characterized by reductions in myofib

201 n suggested to regulate collagen biogenesis, muscle development, ciliogenesis, and various aspects of

202 le differentiation and suggest that abnormal muscle development contributes to the manifestation of S

203 how that myogenin, an essential regulator of muscle development, controls neurogenic atrophy.

204 nscription factor, an essential regulator of muscle development, directly activates transcription of

205 Dicer activity is essential for normal muscle development during embryogenesis and Dicer muscle

206 HLH) transcription factors to drive skeletal muscle development during embryogenesis, but little is k

207 Impaired muscle development during this stage of gestation affect

208 t ex-myomiR levels are elevated in perinatal muscle development, during the regenerative phase that f

209 During Drosophila muscle development EBF proteins are expressed in muscle

210 e into myotubes and is required for skeletal muscle development, expression of muscle contractile pro

211 ased expression and reduced induction of key muscle development factors, such as MyoD and myogenin, w

212 myogenin, orchestrates the steps of skeletal muscle development, from myoblast proliferation and cell

213 develop the gene network leading to skeletal muscle development, growth and regeneration.

214 date genes related to osteogenesis, skeletal muscle development, growth, energy metabolism and lipid

215 The Fndc5 mutant mice have normal skeletal muscle development, growth, regeneration, as well as glu

216 n which Myog was deleted following embryonic muscle development had normal skeletal muscle, except fo

217 Understanding the mechanism of muscle development has great implication for animal bree

218 elationship between Notch1 and miRNAs during muscle development has not been established.

219 e potential involvement of MRTFs in skeletal muscle development has not been examined.

220 (G12D) expression at different stages during muscle development has profound effects on the ability o

221 malian cells, yet its role in non-vertebrate muscle development has remained enigmatic.

222 er, its precise role and in vivo function in muscle development has yet to be clearly defined.

223 Developmental mechanisms underlying somatic muscle development have mostly been studied in vertebrat

224 upstream factors required during extraocular muscle development have not been identified.

225 scriptional regulatory pathways that mediate muscle development, how these pathways are disrupted in

226 nsive genetic and genomic analyses to follow muscle development in a mouse model of BWS to dissect th

227 Thus, APOBEC2 may play an important role in muscle development in chickens.

228 ant embryos were strikingly normal; however, muscle development in double morphants was severely disr

229 on factor Mef2 has well established roles in muscle development in Drosophila and in the differentiat

230 ption factor that is necessary for embryonic muscle development in Drosophila and vertebrates; howeve

231 We now characterized muscle development in EHD1-null mice.

232 s, signalling through this receptor promotes muscle development in growing embryos and angiogenesis i

233 skeletal muscle and supports normal skeletal muscle development in laminin-alpha2-deficient muscle bu

234 important role in regulating and maintaining muscle development in mammals.

235 s also upregulated during perinatal skeletal muscle development in mice in vivo and that both miR-1 a

236 ailed analysis of both late foetal and adult muscle development in the absence of Meox2.

237 mises activation of WNT signaling and proper muscle development in the soft palate through tissue-tis

238 tiotemporal profiling of the early stages of muscle development in the zebrafish embryo, we identifie

239 plicing may be of functional significance in muscle development in this species.

240 Striated muscle development in vertebrates requires the redundant

241 he involvement of Trpc1 channels in skeletal muscle development in vitro and in vivo, and identify a

242 We explored the role of MRTFs in muscle development in vivo by generating mutant mice har

243 ttle is known about the function of skNAC in muscle development in vivo.

244 2a nor Mef2d is required for normal skeletal muscle development in vivo.

245 analysis showed that hnrpdl is important for muscle development in zebrafish, causing a myopathic phe

246 Defective skeletal muscle development, in both GHR and IGF-1R mutants, was

247 examined the roles of Brg1 and Brm in smooth muscle development, in vivo, through generation and anal

248 Using a robust model of MyoD-mediated muscle development, in which dominant-negative Akt block

249 signals are essential for several aspects of muscle development, including myofibrillogenesis-the ter

250 is necessary for aspects of Xenopus skeletal muscle development, including somite organization, migra

251 Radiation exposure during muscle development induces long-term decrements to skele

252 Skeletal muscle development is controlled by regulation of myobla

253 Skeletal muscle development is controlled by the myocyte enhancer

254 That C. elegans bodywall muscle development is dependent on transcription factors

255 the defects in lung development, esophageal muscle development is disrupted in Foxp2(-/-);Foxp1(+/-)

256 ate muscle development, whereas invertebrate muscle development is largely independent of MRF functio

257 s and muscle progenitors during craniofacial muscle development is largely unknown.

258 Wnt regulation of muscle development is thought to be mediated by the beta

259 te decisions over the course of mesoderm and muscle development is unclear.

260 verall, cofilin-2, although not critical for muscle development, is essential for muscle maintenance.

261 d that pomk function is necessary for normal muscle development, leading to locomotor dysfuction in t

262 that Hsp90alpha1 plays an important role in muscle development, likely through facilitating myosin f

263 like growth factors (IGFs) play key roles in muscle development, maintenance, and repair, but their m

264 and this result expands our understanding of muscle development mechanism.

265 ved in local adaptations such as coat color, muscle development, metabolic processes, osteopetrosis,

266 osed to regulate various aspects of skeletal muscle development, metabolism, and mitochondrial functi

267 During Drosophila embryonic muscle development, multiple nuclei transition from bein

268 the alpha2/delta1 subunit may be crucial for muscle development, muscle repair and at times in which

269 During skeletal muscle development, myoblasts fuse to form multinucleate

270 dinated changes in H3K27ac and RNA implicate muscle development, neuronal regulation, and sensory res

271 During skeletal muscle development, nuclei move dynamically through myot

272 Skeletal muscle development, nutrient uptake, and nutrient utiliz

273 e indicates the total dependence of skeletal muscle development on the presence of RLC-f during embry

274 deletion supports a role for dystroglycan in muscle development or differentiation.

275 does not play a critical role in regulating muscle development or energy expenditure, but it is an i

276 Pak2 in mice has no overt effect on skeletal muscle development or regeneration.

277 Myoblast fusion is essential for muscle development, postnatal growth and muscle repair a

278 fusion is an indispensable step for skeletal muscle development, postnatal growth, and regeneration.

279 Although muscle development proceeded normally, Actg1-msKO mice p

280 nd a positive relationship in expression for muscle development related genes, and a negative relatio

281 whether this factor is required during later muscle development remains largely unknown.

282 beta signaling in regulating tongue skeletal muscle development remains unclear.

283 Skeletal muscle development requires fusion of mononuclear progen

284 Striated muscle development requires the coordinated expression o

285 Removing myogenin before embryonic muscle development resulted in myofiber deficiencies ide

286 During skeletal muscle development, sensory (Ia-afferent) innervation in

287 alpha7B is tightly regulated during skeletal muscle development suggests different and distinct roles

288 or knockout of myostatin, a key repressor of muscle development that can regulate Smad3 and mTOR sign

289 , possess a primary defect in bladder smooth muscle development that is apparent by embryonic day 15.

290 In skeletal muscle development, the myogenic regulatory factors myf5

291 clude that although BAG3 is not required for muscle development, this co-chaperone appears to be crit

292 extend the role of Fn14 in wound repair and muscle development to involvement in the etiology of cac

293 Here we investigated the role of SMN in muscle development using muscle cell lines and primary m

294 initiate gene transcription during heart and muscle development, was reported to bind histones H3 and

295 To identify new players in muscle development we screened Drosophila and zebrafish

296 es of Dicer and miRNAs in mammalian skeletal muscle development, we eliminated Dicer activity specifi

297 tter assess the role of kindlin-2 in cardiac muscle development, we used morpholinos to knockdown the

298 that talin 1 and 2 are crucial for skeletal muscle development, where they regulate myoblast fusion,

299 ctor (MRF) genes is essential for vertebrate muscle development, whereas invertebrate muscle developm

300 as neurogenesis, neuron differentiation and muscle development, which are increasingly disturbed in