ライフサイエンスコーパス: muscle mitochondria

1 ly and reduced complex IV levels in skeletal muscle mitochondria.

2 y level, as well as at the level of skeletal muscle mitochondria.

3 ng and myriad other disease states impacting muscle mitochondria.

4 in L6 and RC13 rodent myocytes and isolated muscle mitochondria.

5 (2) transport pathway from lungs to skeletal muscle mitochondria.

6 nvestigated in isolated cardiac and skeletal muscle mitochondria.

7 his adaptation is mediated by an increase in muscle mitochondria.

8 this increase in endurance is an increase in muscle mitochondria.

9 c muscle fibers and increased the numbers of muscle mitochondria.

10 for hydrogen peroxide) compared with control muscle mitochondria.

11 , complex V was less abundant in extraocular muscle mitochondria.

12 ochondria were 40% to 60% lower than in limb muscle mitochondria.

13 of ATP by F1F0-ATPase in heart and skeletal muscle mitochondria.

14 aged 21-87 years on insulin sensitivity and muscle mitochondria.

15 cluding a dramatic proliferation of skeletal muscle mitochondria.

16 he increase in PDK4 protein in gastrocnemius muscle mitochondria.

17 much more abundant in the liver rather than muscle mitochondria.

18 tly on SDS gels, as did CPT I from liver and muscle mitochondria.

19 sport at all points between inspired air and muscle mitochondria.

20 ctron transport chain compared with neonatal muscle mitochondria.

21 ets occurs despite a concomitant increase in muscle mitochondria; 2) mitochondrial deficiency severe

22 2, also known as MnSod) in muscle tissue and muscle mitochondria, a modest increase in Sod2 in heart

23 g reverse electron transport in rat skeletal muscle mitochondria: a protonmotive force generated by A

24 voluntary wheel running can improve skeletal muscle mitochondria activity and function in a rat model

25 mechanisms by which IL-6 influences skeletal muscle mitochondria acutely and chronically are unclear.

26 ic proteins, which enabled identification of muscle mitochondria among mitochondria from other tissue

27 lation reaction network in isolated skeletal muscle mitochondria and attempted to extrapolate these r

28 Thus, fusion dynamically connects skeletal muscle mitochondria and its prolonged loss jeopardizes b

29 ase inhibitor subunit, IF1, in their cardiac muscle mitochondria and show marked IF1-mediated mitocho

30 1) that is enriched in skeletal and cardiac-muscle mitochondria and transcriptionally regulated by P

31 contraceptives (OCs) on hepatic and skeletal muscle mitochondria and whole-body energy metabolism, we

32 , subsarcolemmal and interfibrillar skeletal muscle mitochondria) and to determine the pIs of other b

33 lyzed ADP-stimulated respiration of isolated muscle mitochondria, and ADP-stimulated mitochondrial re

34 such as short-chain fatty acids to skeletal muscle mitochondria, and the composition and activity of

35 s of working muscles, fatty acid delivery to muscle mitochondria, and the oxidation of other substrat

36 cellular energetics and metabolism, skeletal muscle mitochondria appear to play a key role in the dev

37 complexes I and IV was lower in extraocular muscle mitochondria (approximately 50% the activity in t

38 These findings demonstrate that skeletal muscle mitochondria are a critical pathological link bet

39 Respiration, distribution and quantity of muscle mitochondria are unaffected by NR.

40 ing, with respiratory uncoupling in skeletal muscle mitochondria, associated with increased uncouplin

41 and manifest limited respiration, similar to muscle mitochondria at high [ADP].

42 alcium stimulates NADH synthesis in skeletal muscle mitochondria but not in cardiac mitochondria.

43 itration protocol to examine the function of muscle mitochondria by high-resolution respirometry.

44 entration is low, complex II in rat skeletal muscle mitochondria can generate superoxide or H(2)O(2)

45 Mammalian liver and striated muscle mitochondria can oxidize exogenous lactate becaus

46 fore, both plasticity and evolved changes in muscle mitochondria contribute to thermogenesis at high

47 fore, both plasticity and evolved changes in muscle mitochondria contribute to thermogenesis at high

48 -CoA substrates by liver, heart and skeletal muscle mitochondria differed among the three genotypes.

49 Bioenergetic phenotyping of skeletal muscle mitochondria displayed metabolic inflexibility in

50 In past work, we found that in skeletal muscle mitochondria energized by succinate alone, oxaloa

51 iratory systems to supply oxygen to skeletal muscle mitochondria for energy production needed during

52 Striated muscle mitochondria form connected networks capable of r

53 ce mitochondrial dysfunction was assessed in muscle mitochondria from 5 healthy individuals incubated

54 rial oxidative enzyme activity was normal in muscle mitochondria from a CMT2 patient with an MFN2 mut

55 Cardiac and skeletal muscle mitochondria from ant1(-)/ant1(-) mice had increa

56 Respirometry of skeletal muscle mitochondria from iPLA(2)gamma(-/-) mice demonstr

57 Skeletal muscle mitochondria from penguins that had been either e

58 In contrast, isolated muscle mitochondria from the type 2 subjects exhibited a

59 a expressing UCP1 and was absent in skeletal muscle mitochondria from UCP3 knockout mice.

60 t expressing UCP1, and is absent in skeletal muscle mitochondria from UCP3 knockout mice.

61 mentation has significant impact on skeletal muscle mitochondria in obese and insulin-resistant men.

62 ressor p53 has been implicated in regulating muscle mitochondria in response to cellular stress; howe

63 n impaired bioenergetic capacity of skeletal muscle mitochondria in type 2 diabetes, with some impair

64 ing of oxidative phosphorylation in skeletal muscle mitochondria: increased proton transport activity

65 sites produce superoxide/H2O2 using isolated muscle mitochondria incubated in media mimicking the cyt

66 of RYGB with or without exercise on skeletal muscle mitochondria, intramyocellular lipids, and insuli

67 The role of hypoxia on skeletal muscle mitochondria is controversial.

68 Skeletal muscle mitochondria isolated from penguins that had neve

69 Here, we provide evidence that skeletal muscle mitochondria lacking UCP3 are more coupled (i.e.

70 pared the structure and function of skeletal muscle mitochondria located either lateral to embedded c

71 of fatty acid hydroperoxides from denervated muscle mitochondria may be an important determinant of m

72 varying flux rate through beta-oxidation in muscle mitochondria minus/plus pharmacological or geneti

73 Neither respiratory capacity of skeletal muscle mitochondria nor abundance of mitochondrial assoc

74 t calcium has a stimulatory role in skeletal muscle mitochondria not apparent in cardiac mitochondria

75 Skeletal and heart muscle mitochondria of the CAP(R) mice were enlarged and

76 affinity form of IF1 present in the cardiac muscle mitochondria of the pigeon is partially functiona

77 f higher affinity IF1 present in the cardiac muscle mitochondria of the rat is, under these condition

78 we tested the relative capacities of cardiac muscle mitochondria of the three species to avert a pote

79 To examine whether skeletal muscle mitochondria oxidize lactate, mitochondrial respi

80 d methods to disrupt tissue using kidney and muscle mitochondria preparations as exemplars.

81 The ANT1-deficient muscle mitochondria produce excess reactive oxygen speci

82 dence of the elevated bioenergetic status of muscle mitochondria relative to their counterparts in th

83 The results demonstrate that extraocular muscle mitochondria respire at slower rates than mitocho

84 thors tested the hypothesis that extraocular muscle mitochondria respire faster than do mitochondria

85 Analysis of bioenergetics in skeletal muscle mitochondria revealed that knock-out of Grx2 (Grx

86 ntact cardiac myocytes and purified skeletal muscle mitochondria, robust mt-cpYFP flashes were accomp

87 Liver (but not muscle) mitochondria showed a positive relationship betw

88 tCU "hot spots" can be formed at the cardiac muscle mitochondria-SR associations via localization and

89 uscle insulin resistance despite an increase muscle mitochondria that enhances the capacity for fat o

90 te dehydrogenase kinase activity in skeletal muscle mitochondria that promotes phosphorylation and in

91 I-supported respiration by isolated skeletal muscle mitochondria to ADP concentrations.

92 We proposed that PGC1alpha enables muscle mitochondria to better cope with a high lipid loa

93 The capacity of muscle mitochondria to fully oxidize a heavy influx of f

94 ase intramuscular ATP and the ability of mdx muscle mitochondria to meet ATP demand.

95 Repeated bouts of exercise condition muscle mitochondria to meet increased energy demand-an a

96 However, the ability of skeletal muscle mitochondria to sequester Ca2+ released from the

97 AD(P)H reduction levels in isolated skeletal muscle mitochondria under conditions that favored supero

98 uperoxide in respiring isolated rat skeletal muscle mitochondria using hydroethidine.

99 ase activities were measured in rat skeletal muscle mitochondria using, as substrates, the synthesize

100 states were obtained in cardiac and skeletal muscle mitochondria utilizing physiologically relevant c

101 beetles results from the breakdown of flight muscle mitochondria via mitophagy.

102 Complementation among muscle mitochondria was suppressed by both in vivo genet

103 3, 4, and 5 respiration rates in extraocular muscle mitochondria were 40% to 60% lower than in limb m

104 In addition, skeletal muscle mitochondria were abnormally shaped, and activiti

105 o, isolated rat liver, cardiac, and skeletal muscle mitochondria were incubated with lactate, pyruvat

106 As measured by electron microscopy, skeletal muscle mitochondria were smaller in type 2 diabetic and

107 Isolated skeletal muscle mitochondria were used for real-time respirometry

108 Qo) has a very high capacity in rat skeletal muscle mitochondria, whereas the flavin site in complex

109 of the exercise-induced adaptive increase in muscle mitochondria, whereas the subsequent increase in

110 tae vesicles isolated from Drosophila flight-muscle mitochondria, which are very rich in ATP synthase

111 on is unaffected by loss of SDH subunit C in muscle mitochondria, which is consistent with the pulmon

112 Hsp60) is a chaperone localizing in skeletal muscle mitochondria, whose role is poorly understood.