ライフサイエンスコーパス: muscle-specific

1 relative abundances of sarcomeric Tmods are muscle specific.

2 Skeletal muscle-specific 4E-BP1 mediated metabolic protection dir

3 andial glucose disposal in mice, whereas its muscle-specific ablation impaired insulin action and led

4 loss-of-function animal models, we show that muscle-specific ablation of BDNF shifts the proportion o

5 Last, mice with muscle-specific ablation of IL-10 receptor (M-IL10R(-/-)

6 Muscle-specific ablation of Pik3c2b, but not Pik3c3, res

7 In the present study, smooth muscle-specific acid ceramidase (Ac) gene knockout mice

8 can provide feedback on the effectiveness of muscle-specific activation for standing promoted by the

9 Altogether, these results suggest that muscle-specific adaptations in contractile speed allow c

10 occur in the 68-residue insert unique to the muscle-specific, alternatively spliced isoform of vincul

11 in glucose tolerance by cIH was abolished in muscle-specific AMPKalpha1alpha2-deficient mice.

12 Muscle-specific anchoring protein (alphakap) encoded wit

13 In this study, we created skeletal muscle specific and inducible raptor knockout mice to el

14 Myomerger is skeletal muscle-specific and genetic deletion in mice results in

15 d Irs1 expression and insulin sensitivity in muscle-specific APC- and TAZ-double-knockout mice.

16 ppressed mTORC2 but not Nox4, induced smooth muscle-specific apoptosis in small pulmonary arteries, a

17 Skeletal muscle-specific ARNT deletion in young mice resulted in

18 ation experiments, binds to Cheerio, and the muscle-specific attenuation of cheerio leads to CryAB-li

19 issues; yet the role of skeletal and cardiac muscle-specific autophagy on the benefits of exercise tr

20 n of 1NMPP1, a PP1 derivative, and 2) smooth muscle-specific BDNF knockout (BDNF(fl/fl)/SMMHC11(Cre/0

21 lly, BDNF is secreted by skeletal muscle and muscle-specific BDNF knockout phenocopies the beta-cell

22 integrin activation, although levels of the muscle-specific beta1D-integrin isoform were reduced by

23 n in HSPB8-based PQC machinery may represent muscle-specific biomarkers useful to assess SBMA progres

24 al muscle of adult mice to generate skeletal muscle-specific Brca1 homozygote knockout (Brca1KO(smi)

25 Using a skeletal muscle-specific carnitine palmitoyltransferase-1 KO mode

26 ing single and dual AAV vector delivery of a muscle-specific Cas9 cassette together with single-guide

27 The muscle specific caveolin3 (Cav-3) and the caveolae have

28 live zebrafish embryos revealed that loss of muscle-specific Cavin-1 or expression of a dystrophy-ass

29 ty to membrane tension, which was rescued by muscle-specific Cavin-1 reexpression.

30 We have now developed a skeletal muscle-specific CB1R-knockout (Skm-CB1R(-/-)) mouse to s

31 Introduction of a muscle-specific Chkb transgene completely rescues motor

32 Heart- and muscle-specific circulating miRNAs (myomirs) increased u

33 regulate the expression and amplitude of the muscle specific clock-controlled gene, Titin-cap (Tcap).

34 We generated mice with muscle-specific conditional knockout of Trim33 by combin

35 In studying mice with muscle-specific constitutive ROCK1 activation (mCaROCK1)

36 avy chain-embryonic (MyHC-emb) is a skeletal muscle-specific contractile protein expressed during mus

37 , Met participants showed significantly less muscle-specific corticospinal sensitivity during action

38 isease states to which mechanisms induced by muscle-specific Cpt1b inhibition may mediate health bene

39 We used skeletal muscle-specific Cpt1b knockout mouse model where the inh

40 Using Myf5-Cre, a muscle-specific Cre driver, and the Cre-loxP recombinati

41 These novel muscle-specific CRMs result in a substantial increase in

42 To confirm that muscle-specific CTGF functions to mediate collagen organ

43 ediated by the release of myokines, skeletal muscle-specific cytokines, in response to exercise.

44 Female mice with a muscle-specific deficiency in BDNF (MBKO mice) were unab

45 Conversely, mice with global or muscle-specific deficiency in Nur77 exhibited reduced mu

46 mic glucose, we studied mice with a skeletal muscle-specific deficiency of long-chain acyl-CoA synthe

47 In contrast, smooth-muscle specific deletion of the L-type VGCC, Ca(v)1.2, c

48 r beta(2) -adrenoceptor activation, skeletal muscle-specific deletion of ATG7 blunts the beneficial e

49 Indeed, muscle-specific deletion of Bax, but not the apoptosis r

50 Smooth muscle-specific deletion of BDNF reduced AHR and blunted

51 g mice that allow for the inducible skeletal muscle-specific deletion of Bmal1 (iMSBmal1).

52 Herein, mice with skeletal muscle-specific deletion of carnitine palmitoyltransfera

53 ring aging, but the losses do not occur with muscle-specific deletion of CuZnSOD.

54 Here we report that muscle-specific deletion of FoxO members protects from m

55 Combined muscle-specific deletion of FoxO1, FoxO3, and FoxO4 in M

56 dels in mice with global or inducible smooth muscle-specific deletion of LMO7, and knockout, knockdow

57 Skeletal muscle-specific deletion of MED13 in mice conferred resi

58 generating mutant mice harboring a skeletal muscle-specific deletion of MRTF-B and a global deletion

59 smooth muscle in adult mice with (1) smooth muscle-specific deletion of MYPT1; (2) non-phosphorylata

60 However, combined muscle-specific deletion of Pak1 and Pak2 results in red

61 Likewise, in young mice, muscle-specific deletion of PKCdelta did not rescue high

62 scle increased, and by 6 to 7 months of age, muscle-specific deletion of PKCdelta improved whole-body

63 Using mice with muscle-specific deletion of the insulin receptor (M-IR-/

64 Through skeletal muscle-specific deletion of the Mediator subunit MED13 i

65 Moreover, muscle-specific deletion of X-box binding protein 1 (XBP

66 Muscle-specific depletion of klarsicht (nesprin) or klar

67 c mice harboring a ligand-activated skeletal muscle-specific derivative of the eIF2alpha protein kina

68 , and specifically for diseases, the related muscle-specific desmin IF networks.

69 We generated an inducible, skeletal muscle-specific Dicer knockout mouse to deplete microRNA

70 ohumeral muscular dystrophy mouse model with muscle-specific doxycycline-regulated DUX4 expression.

71 ring mass spectrometry, we demonstrated that muscle-specific dystrophin expression corrects mdx succi

72 proteasome and messenger RNA expressions of muscle-specific E3 ligases.

73 Up-regulation of specific genes, such as the muscle-specific E3 ubiquitin ligase MAFbx, by FoxO trans

74 d deprivation-induced expression of TRB3 and muscle-specific E3-ubiquitin ligases.

75 Here, we show that skeletal muscle-specific EcSOD transgenic mice are protected from

76 Smooth muscle-specific Efemp2 loss in mouse (termed SMKO) resul

77 em and present evidence supporting a cardiac muscle-specific effect of n-6 PUFAs.

78 ogenesis, but the functions of this striated muscle-specific enzyme in more differentiated skeletal m

79 human ERBB4 mRNA and by transposon-mediated muscle-specific ERBB4 overexpression.

80 showed that that PTBP1 represses many smooth muscle specific exons.

81 Smooth muscle-specific expression of a Kir6.1 gain-of-function

82 mice for doxycycline-inducible and skeletal muscle-specific expression of active CELF1 mutants engin

83 Muscle-specific expression of alphaLNNd in dy2J mice res

84 Here, we developed transgenic dy2J mice with muscle-specific expression of alphaLNNd, a laminin/nidog

85 We used the sporadic, low-level, muscle-specific expression of DUX4 enabled by the iDUX4p

86 Smooth muscle-specific expression of Kir6.1 gain-of-function mu

87 and Kv1.5(-/-) and WT with inducible, smooth muscle-specific expression of Kv1.5 channels), we measur

88 We find that adult muscle-specific expression of pvf1 increases rapidly dur

89 EFIP), which exhibited a heart- and skeletal muscle-specific expression profile.

90 ity, which govern later heart vs. pharyngeal muscle-specific expression profiles, demonstrating exten

91 Mutations in the gene encoding the muscle-specific family member calpain 3 (CAPN3) underlie

92 roved voluntary exercise, increased skeletal muscle specific force and tetanic Ca(2+) transients, dec

93 in generator of NO in skeletal muscle is the muscle-specific form of neuronal nitric oxide synthase (

94 may interact with other partners to perform muscle-specific functions.

95 -specific protein isoforms needed to sustain muscle-specific functions.

96 Our results demonstrate that AAV-mediated muscle-specific gene editing has significant potential f

97 the enzymatic activity of UTX in activating muscle-specific gene expression during myofiber regenera

98 Resulting changes in muscle-specific gene expression that take place in dystr

99 TEAD1 is a novel general repressor of smooth muscle-specific gene expression through interfering with

100 ounts of TFIID-TBP being required to promote muscle-specific gene expression.

101 fic CRMs result in a substantial increase in muscle-specific gene transcription (up to 400-fold) when

102 ed high coverage and efficient enrichment of muscle specific genes, with low background noise.

103 e stem cells, leading to derepression of non-muscle-specific genes and p16INK4a, a senescence driver

104 these QTLs and their relationship to smooth muscle-specific genes and transcription factors.

105 pecific genes while repressing white fat and muscle-specific genes in adipocytes.

106 ned exon microarray containing probes for 57 muscle-specific genes to assay the transcriptional profi

107 tal muscle fibers, and reduced expression of muscle-specific genes, as well as reduced motoneuron len

108 otein synthesis and widespread activation of muscle-specific genes, many of which are targets of MEF2

109 directly control the expression of a set of muscle-specific genes.

110 s (TADs) that are significantly enriched for muscle-specific genes.

111 HDAC5 to myogenic gene promoters to repress muscle-specific genes.

112 repress cell-of-origin genes and to activate muscle-specific genes.

113 Muscle-specific genetic ablation of p21-activated kinase

114 Muscle-specific genetic interventions can induce systemi

115 and hypertrophic growth were not impaired in muscle-specific GLUT4 knockout mice, demonstrating that

116 In this study we generated a novel skeletal muscle-specific GRK2 knock-out (KO) mouse (MLC-Cre:GRK2(

117 e JCI, Bosnakovski et al. used an inducible, muscle-specific human DUX4 to reproduce the low-level, s

118 Finally, we show that skeletal muscle-specific human UCP3 expression is able to signifi

119 Here, we show that muscle-specific HuR knockout (muHuR-KO) mice have high e

120 We generated muscle-specific IGF-I-deficient (MID) mice that afford i

121 Wild-type (ILK(lox/lox)) and muscle-specific ILK-deficient (ILK(lox/lox)HSAcre) mice

122 Moreover, mice with muscle-specific inactivation of the SIRT1 deacetylase do

123 Moreover, a skeletal muscle-specific increase in timeless expression extends

124 of DEPDC5 in skeletal muscle, we generated a muscle-specific inducible Depdc5 knockout mouse, hypothe

125 ker muscle strength, reduced locomotion, and muscle-specific insulin resistance.

126 Desmin is an abundant muscle-specific intermediate filament, and disease mutat

127 Here we show that a major muscle specific isoform of the murine LINC complex prote

128 The muscle specific isoform of the supervillin protein (SV2)

129 ices associated with actin filaments and the muscle-specific isoform of alpha-actinin at the PM of di

130 nformatic analysis approach and identified a muscle-specific isoform of an RNA splicing regulator, RB

131 eased expression and alternative splicing of muscle-specific isoforms of ANK1.

132 We next characterized muscle-specific isoforms of BIN1 and DNM2.

133 hermore, mutations that cause frameshifts in muscle-specific isoforms result in congenital multi-mini

134 ese abnormalities were observed in liver- or muscle-specific Kbtbd2 knockout mice.

135 We have previously isolated a muscle-specific Kelch gene, Kelch repeat and BTB domain

136 vector was used to elevate the expression of muscle specific kinase (MuSK) and rapsyn (a cytoplasmic

137 Muscle specific kinase (MuSK) has a well-defined role in

138 ting the acetylcholine receptor (AChR-MG) or muscle specific kinase (MuSK-MG).

139 nsity lipoprotein receptor-related protein 4-muscle-specific kinase (LRP4-MuSK) pathway.

140 s against the acetylcholine receptor (AChR), muscle-specific kinase (MuSK) or other AChR-related prot

141 scular synapses which function downstream of muscle-specific kinase (MuSK), a receptor tyrosine kinas

142 k-7) is essential for the full activation of muscle-specific kinase and consequently for dense cluste

143 The muscle-specific kinase MuSK is one of the key molecules

144 oglycan and LRP4 coreceptors involved in the muscle-specific kinase signaling pathway.

145 in, aquaporin 4, acetylcholine receptor, and muscle-specific kinase) was performed with live cell-bas

146 ly the acetylcholine receptor (AChR) and the muscle-specific kinase.

147 is regulation, we generated mice with smooth muscle-specific knock in of the hepcidin-resistant isofo

148 ibility, we generated inducible and skeletal muscle-specific knock-out mice for Rheb (iRhebKO) and TS

149 in muscles from both inducible and skeletal muscle-specific knock-out mice for Rheb and iTSC2KO mice

150 didates that we classify using fat body- and muscle-specific knockdown and biochemical assays.

151 Skeletal muscle specific knockout of Brca1 in mice caused a loss

152 tal muscle-specific loss of Nrf2 [i.e., Nrf2 muscle-specific knockout (mKO) mice] abolished the expre

153 gical inhibition or genetic deletion of Rac1.Muscle-specific knockout (mKO) of Rac1, a kinase-dead al

154 e effects were not found in AMPKalpha1alpha2 muscle-specific knockout mice.

155 nl1; Mbnl2) and triple (Mbnl1; Mbnl2; Mbnl3) muscle-specific knockout models that recapitulate the co

156 In high-fat diet-fed mice with skeletal muscle-specific knockout of CEPT1, systemic and muscle-b

157 P methodology to generate mice with skeletal muscle-specific knockout of E1a-binding protein (mKO).

158 We find that mice with muscle-specific knockout of p110alpha, but not p110beta,

159 en these abnormalities, we created mice with muscle-specific knockout of the p110alpha or p110beta ca

160 the authors generated and compared striated muscle specific knockouts (KOs) with progressive postnat

161 We discovered a putative muscle-specific long noncoding RNA that encodes a peptid

162 In summary, skeletal muscle-specific loss of Brca1 leads to a myopathy and mi

163 Muscle-specific loss of E2F results in a significant red

164 ow that small arteries from mice with smooth muscle-specific loss of G(12)/G(13) or the Rho guanine n

165 Skeletal muscle-specific loss of Nrf2 [i.e., Nrf2 muscle-specific

166 scle force production were lost in mice with muscle-specific loss of Orai1 function.

167 Interestingly, skeletal muscle-specific loss of p62 (i.e., p62 mKO mice) also ab

168 The Kelch protein Klhl31 is expressed in a muscle-specific manner under control of the transcriptio

169 myogenic activity and that MEF2Calpha2, the muscle-specific MEF2C isoform, was required for efficien

170 Myostatin is a muscle-specific member of the TGF-beta superfamily and a

171 t ablation in mice, we show that myomaker, a muscle specific membrane protein essential for myoblast

172 us studies identified myomaker (Tmem8c) as a muscle-specific membrane protein essential for fusion.

173 usion and requires fusogenic activity of the muscle-specific membrane protein myomaker.

174 The muscle-specific membrane proteins myomaker and myomixer

175 s (TAO and STK25) that cooperate to maintain muscle-specific messenger RNA transcription.

176 tructure and function of vinculin and of its muscle-specific metavinculin splice variant.

177 ion), a smORF encoding an essential skeletal muscle specific microprotein.

178 how that microRNA-1 (miR-1), a member of the muscle-specific microRNA (myomiR) family, is responsible

179 ostnatal regeneration of skeletal muscle and muscle-specific microRNAs (miR-1 and -206) to further ac

180 MyomiRs are muscle-specific microRNAs (miRNAs) that regulate myoblas

181 ative regulation of BAF60a and BAF60b by the muscle-specific microRNAs (myomiRs) miR-133 and miR-1/20

182 n of the ryanodine receptor 1, a decrease in muscle-specific microRNAs and a considerable up-regulati

183 R1 mutations exhibit decreased expression of muscle-specific microRNAs, increased DNA methylation and

184 Skeletal muscle-specific miR-486 overexpression in Dmdmdx-5Cv ani

185 terestingly, the levels of the four exosomal muscle-specific miRNAs are associated with the progressi

186 Here we show that the four muscle-specific miRNAs are encapsulated within exosomes

187 s to characterise the ontology of these four muscle-specific miRNAs in the blood circulation of DM1 p

188 We propose that exosomal muscle-specific miRNAs may be useful molecular biomarker

189 The levels of the four muscle-specific miRNAs were elevated in the serum of DM1

190 In one of these, our group identified four muscle-specific miRNAs, miR-1, miR-133a, miR-133b and mi

191 together, our results show that circulating muscle-specific miRNAs, miR-378a-3p and miR-434-3p, are

192 xhibited decreased expression of RYR1 and of muscle-specific miRNAs, whereas acute knock-down of RYR1

193 Here, skeletal muscle-specific Mitochondrial Pyruvate Carrier (MPC) del

194 Herein, 2 muscle-specific mouse models were studied: 1) Lpin1 exon

195 Its muscle-specific mutation led to progressive NMJ degenera

196 -miRs (c-miRs-21-5p, -126-3p, and -146a-5p), muscle specific (myo)-miR-206, c-proteasome, and IL-6/le

197 expression of 3 myogenic regulatory factors-muscle-specific myogenic factor 5, myoblast determinatio

198 n vivo although nuclear reprogramming of the muscle-specific myosin light chain promoter did occur.

199 envelope-genome contacts, we show that three muscle-specific NETs, NET39, Tmem38A, and WFS1, direct s

200 Muscle-specific neural drive was at low frequencies (<5

201 ncy causes a decrease and mislocalization of muscle-specific neuronal nitric oxide synthase (nNOSmu),

202 ssing NO66(flox/flox) with MCK-Cre mice bred muscle-specific NO66 (MCK-NO66) knockout mice.

203 Muscle-specific NO66 knockout in mice blocks CKD-induced

204 but injection of Pgk1 rescued denervation in muscle-specific NogoA-overexpression of zebrafish and an

205 A muscle-specific nonkinase anchoring protein (alphakap),

206 It has been shown that muscle specific O2 binding protein, Myoglobin (Mb), is l

207 Skeletal muscles from constitutive, muscle-specific Orai-KO mice exhibited normal postnatal

208 Using tamoxifen-inducible, muscle-specific Orai-KO mice, these functional deficits

209 s revealed reduced endurance in constitutive muscle-specific Orai-KO mice.

210 Here, we used constitutive and inducible muscle-specific Orai1-knockout (KO) mice to determine th

211 Muscle-specific over-expression of AMPKalpha and down-st

212 anization, we generated mice with transgenic muscle-specific overexpression of CTGF.

213 In agreement, muscle-specific overexpression of Drosophila Tsp or mous

214 Muscle-specific overexpression of EcSOD by somatic gene

215 We show that muscle-specific overexpression of human mitochondrial tr

216 metabolism in 18-mo-old transgenic mice with muscle-specific overexpression of IL-10 (M(IL10)) and in

217 Muscle-specific overexpression of IL-10 in ob/ob mice (M

218 the effects of chronic obesity in mice with muscle-specific overexpression of interleukin-10 (M(IL10

219 This study used mice with muscle-specific overexpression of PGC-1alpha, a transcri

220 Furthermore, mice with muscle-specific p300 knockout were resistant to LLC tumo

221 unaffected in whole-body PAK1 knockout (KO), muscle-specific PAK2 KO and in mice with combined whole-

222 in mice with combined whole-body PAK1 KO and muscle-specific PAK2 KO.

223 d myogenesis, we discovered an 84-amino acid muscle-specific peptide that we call Myomixer.

224 er, we find that voluntary wheel running and muscle-specific peroxisome proliferator-activated recept

225 Using muscle-specific PGC-1alpha knock-out mice, we show that

226 In response to kidney injury, mice with muscle-specific PGC-1alpha overexpression (mPGC-1alpha)

227 Because XLMTM patients have a predominantly muscle-specific phenotype a number of pathogenic mechani

228 the LGMD1D mutant, F93L, in DNAJB6b under a muscle-specific promoter became weak, had early lethalit

229 yeast two-hybrid screens and identified the muscle-specific protein archvillin as a gamma-SG and dys

230 Recently, we showed that the muscle-specific protein myoglobin (Mb) interacts with co

231 Myomaker (Tmem8c) is a muscle-specific protein required for myoblast fusion.

232 ker [Transmembrane protein 8c (TMEM8c)] is a muscle-specific protein that is essential for myoblast f

233 onin (also known as titin-cap or t-cap) is a muscle-specific protein whose mutation is associated wit

234 Here, we demonstrated that loss of a muscle-specific protein, kelch-like family member 40 (KL

235 enes (proteins) to the human vascular smooth muscle-specific protein-protein interactome (218 nodes a

236 Ms) develop autoimmunity to FHL1, which is a muscle-specific protein.

237 esults provide new insights into the role of muscle-specific proteins on the structural arrangement o

238 elegans strains expressing blue-fluorescent muscle-specific proteins, which enabled identification o

239 dromes that have been mapped to mutations in muscle-specific proteins.

240 ant DNA replication; defective expression of muscle-specific proteins; progressive heart abnormalitie

241 To date no known intrinsic determinants of muscle-specific pSN fates have been described in vertebr

242 rate experiment, skeletal muscle tissue from muscle-specific Rac1 knockout (Rac1 mKO) was harvested t

243 horylates the receptor tyrosine kinase MuSK (muscle specific receptor tyrosine kinase) at the neuromu

244 ncers, and identify glycolytic and oxidative muscle-specific regulators.

245 eveal a putative causal variant in a cardiac muscle specific regulatory region activated during cardi

246 Finally, we identify a muscle-specific regulatory element of p57(kip2) directly

247 As are thought to move between cells because muscle-specific rescue of rde-4 using repetitive transge

248 has lost its ancestral function and became a muscle-specific resident of the inner nuclear membrane.

249 Inducible smooth muscle-specific restoration of RhoBTB1 fully corrected t

250 g inflammation in germline and airway smooth muscle-specific Rgs4(-/-) mice and in mice treated with

251 d hypertension which was prevented by smooth muscle specific RhoBTB1 restoration.

252 that the AMPKalpha2 isoform is necessary for muscle-specific ring finger protein 1 (MuRF1) up-regulat

253 In a proof-of-concept study in a muscle-specific ring finger protein-1 (MuRF-1) knockout

254 amed myoregulin (MLN), encoded by a skeletal muscle-specific RNA annotated as a putative long noncodi

255 Uncovering the muscle-specific role of TRIM32 in LGMD2H pathogenesis ha

256 (<5 Hz) drive comprised shared (primary) and muscle-specific (secondary) components.

257 We show that muscle-specific sensory axons project to motor neurons a

258 lation state of two Z-disc kinases (striated muscle-specific serine/threonine protein kinase and obsc

259 Specifically, we recreated skeletal muscle specific signaling networks in healthy and chroni

260 Our findings show that klotho undergoes muscle-specific silencing at the acute onset of mdx path

261 ed both SLN knockout (Sln(-/-)) and skeletal muscle-specific SLN overexpression (Sln(OE)) mice to exp

262 The well-known, muscle-specific smooth muscle myosin light chain kinase

263 ith CNM, and it has been shown that striated muscle-specific Speg-knockout (KO) mice have defective t

264 ion of myogenic cells obtained from striated muscle-specific Speg-KO mice and compared them with wild

265 of metavinculin (MVt) upon actin binding, a muscle-specific splice isoform that suppresses actin bun

266 inter-chromosomally, and are targets of the muscle-specific splicing factor RBM20.

267 norhabditis elegans Rbfox1 homolog regulates muscle-specific splicing.

268 Skeletal muscles harbor quiescent muscle-specific stem cells (MuSCs) capable of tissue reg

269 Myofibers from muscle-specific STIM1 transgenic mice showed a significa

270 Muscle-specific TAZ-knockout mice shows significantly de

271 se findings reveal mechanistic roles for the muscle specific transcription factor MYOD1 in the regula

272 , including Myf5, MyoD (Myod1) and Myog, are muscle-specific transcription factors that orchestrate m

273 were mediated by up-regulation of the smooth muscle-specific transcriptional activator myocardin at m

274 In the current study, we identify potent muscle-specific transcriptional cis-regulatory modules (

275 lling through common effectors that regulate muscle-specific transcriptional programs.

276 ynamics, we have isolated and sequenced body muscle-specific transcriptomes from C. elegans lacking f

277 Likewise, muscle-specific transgenic animals expressing a SNARK do

278 We also show that both exercise training and muscle-specific transgenic expression of EcSOD result in

279 ed cardiac dysfunction in WT mice but not in muscle-specific transgenic mice expressing dominant-nega

280 By using skeletal muscle-specific transgenic mice for PGC-1alpha1 and -alp

281 Consistent with these results, skeletal muscle-specific transgenic mice overexpressing Ctss show

282 We also generated MAPK kinase 6 (MKK6) muscle-specific transgenic mice to model heightened p38a

283 Serpina3n muscle-specific transgenic mice were generated to model

284 Employing skeletal muscle-specific transgenic mouse models with unbiased-om

285 ously demonstrated that myomaker, a skeletal muscle-specific transmembrane protein necessary for myob

286 In further in vivo experiments, muscle-specific TRB3 transgenic mice increase food depri

287 In the current study, we used muscle-specific TRIB3 overexpressing (MOE) and knockout

288 cell membrane repair and is believed to be a muscle-specific TRIM protein.

289 MG53 is a muscle-specific TRIM-family protein that presides over t

290 iabetic muscle wasting, we created mice with muscle-specific triple knockout of FoxO1/3/4 and induced

291 d a defect in the splicing regulation of the muscle-specific Troponin T3 (TNNT3) mutually exclusive e

292 mine this possibility, we developed a smooth muscle-specific TRPC3 knockout (TRPC3smcKO) mouse.

293 onstrate that with progressive age, skeletal muscle-specific TWEAK-transgenic (TWEAK-Tg) mice gain in

294 Pathogenic muscle-specific tyrosine kinase (MuSK)-specific IgG4 aut

295 icotinic acetylcholine receptor (AChR) or to muscle-specific tyrosine kinase (MuSK).

296 Muscle RING finger protein 1 (MuRF1), a muscle-specific ubiquitin ligase, is implicated in many

297 Male wild-type (WT) and muscle-specific UCP3-overexpressing transgenic (UCP3 Tg)

298 Changes in arteriolar function that are muscle specific underlie age-induced changes in blood fl

299 le is known about muscle zinc homeostasis or muscle-specific zinc functions.

300 ere abolished in skeletal muscle lacking the muscle-specific, ZMP-sensitive AMPK-gamma3 subunit and i