ライフサイエンスコーパス: mushroom body

1 e neural circuits, in this case the honeybee mushroom body.

2 t synaptic resolution, the Drosophila larval mushroom body.

3 r brain areas including the lateral horn and mushroom body.

4 rain, partly in response to signals from the mushroom body.

5 lobe connect randomly to Kenyon cells of the mushroom body.

6 oordinate synaptic plasticity throughout the mushroom body.

7 sticity at the output site of the Drosophila mushroom body.

8 decorrelation of odor representations in the mushroom body.

9 nd innervate a single anatomical target, the mushroom body.

10 heterogeneously distributed over the entire mushroom body.

11 of the antennal lobe and Kenyon cells of the mushroom body.

12 of a domed hemiellipsoid body and a columnar mushroom body.

13 pils of the secondary eyes are linked to the mushroom body.

14 version depends on the immune system and the mushroom body.

15 Kenyon cells of the Drosophila melanogaster mushroom body.

16 ergic neurons with axonal projections in the mushroom body.

17 in structuring olfactory codes in the locust mushroom body.

18 he complex neuronal system of the Drosophila mushroom body.

19 eam transformations in the antennal lobe and mushroom body.

20 even after lesions in m-ALT or blocking the mushroom bodies.

21 een viewed as evolutionarily convergent with mushroom bodies.

22 an cerebellum and hippocampus and the insect mushroom bodies.

23 a subpopulation of intrinsic neurons of the mushroom bodies.

24 e neural sites for taste associations in the mushroom bodies.

25 nding brain areas, but not directly from the mushroom bodies.

26 hat gustatory conditioning also requires the mushroom bodies.

27 lfactory pathway, the antennal lobes and the mushroom bodies.

28 n patterns within the antennal lobes and the mushroom bodies.

29 ae formed from optical glomeruli, and robust mushroom bodies.

30 underdeveloped laminae, no medullae, and no mushroom bodies.

31 tocerebra, situated in the eyestalks, paired mushroom bodies.

32 bsters, and shrimps are homologous to insect mushroom bodies.

33 ers had large laminae, no medullae and large mushroom bodies.

34 ae and some evidence of reduced medullae and mushroom bodies.

35 ns between olfactory sensory input and bees' mushroom bodies [6], incorporating empirically determine

36 These signatures occur in the mushroom bodies, a high-level integration center of the

37 ment in insect olfactory learning target the mushroom bodies, a higher-order "cortical" brain region

38 ting neural network and demonstrate that the mushroom bodies, a sleep-regulatory center, are a module

39 growth and guidance in the adult Drosophila mushroom body, a brain center for learning and memory.

40 injury in adults and the development of the mushroom body, a brain structure required for learning a

41 Instead, Slit is enriched in the mushroom body, a neuronal structure covering large areas

42 s of the supraesophageal brain including the mushroom body, a part of the posterior head capsule cuti

43 adult nervous system, or specifically in the mushroom body alpha/beta-lobes show reduced ethanol sens

44 nal expression of either OAMB isoform in the mushroom body alphabeta and gamma neurons.

45 tory learning and its functional site is the mushroom body alphabeta and gamma neurons.

46 ve and appetitive learning: Octbeta1R in the mushroom body alphabeta neurons processes aversive learn

47 Although the mushroom body also receives projections from the lobula,

48 rebellum-like circuits, including the insect mushroom body, also exhibit large divergences in connect

49 lations, we find that the gamma lobes of the mushroom bodies and a subset of dopaminergic input neuro

50 and that their expression is required in the mushroom bodies and also in a single pair of closely con

51 This is localized to the mushroom bodies and antennal lobes and organized by a ne

52 s concomitant memory phases that localize to mushroom bodies and propose a decentralized organization

53 diated by distinct neurons of the Drosophila mushroom bodies and require the function of the dBtk non

54 over, activity in alpha'beta' neurons of the mushroom body and a subset of ellipsoid body ring neuron

55 e antennal lobe, and then transferred to the mushroom body and lateral horn through dual pathways ter

56 ation to higher brain centers, including the mushroom body and lateral horn, seats of learned and inn

57 from projection neurons in the calyx of the mushroom body and project axons to the central brain.

58 Consistently, the mushroom body and projection neurons in the octbeta1r br

59 hat innervates the beta'2 compartment of the mushroom body and responds to sweet taste.

60 relaying gain-controlled ORN activity to the mushroom body and the lateral horn.

61 c plasticity between the Kenyon cells of the mushroom body and their output neurons.

62 dent ethanol reward is also localized to the mushroom bodies, and Sir2 mutants prefer ethanol even wi

63 ons, including the cerebellar cortex, insect mushroom body, and dentate gyrus.

64 rt of a striking volumetric expansion of the mushroom body, and explore patterns of differential post

65 nd beta' lobes of a higher brain centre, the mushroom body, and function in dopaminergic re-inforceme

66 s neuronal signaling functions, a functional mushroom body, and neurally driven apoptosis of oocytes

67 and perhaps sole source of inhibition in the mushroom body, and that inhibition from this cell is med

68 Transcriptome analysis of mushroom body, antennal lobe and type II neuroblasts com

69 hers to promote the very opposite view: that mushroom bodies are a derived trait of hexapods and that

70 are a derived trait of crustaceans, whereas mushroom bodies are a derived trait of hexapods.

71 The Drosophila mushroom bodies are critical association areas whose rol

72 Mushroom bodies are essential for visual learning and me

73 Mushroom bodies are the iconic learning and memory cente

74 tory organ in spiders and its effects on the mushroom body are also discussed.

75 the vertebrate hippocampus and the arthropod mushroom bodies, are both structurally and functionally

76 Our findings establish the fly mushroom body as a model for homeostatic plasticity in v

77 These results establish the mushroom body as an important site of integration in the

78 previously described crustacean possesses a mushroom body as defined by strict morphological criteri

79 iates adhesion between functionally distinct mushroom body axon populations to enforce and control ap

80 ion is dispensable for the initial growth of Mushroom Body axons, but is required for the stabilizati

81 of dDAAM essential for correct targeting of mushroom body axons.

82 ponsive dopaminergic neurons that target the mushroom body beta' lobe.

83 displaying similarly increased frequency of mushroom-body beta-lobe midline crossing, a metric of ax

84 of metabolic learning requires not only the mushroom body but also the hypothalamus-like pars interc

85 to localize precisely a segmentation of the mushroom body by differential contacts with aminergic ne

86 nd an axon from the AL to the calyces of the mushroom body (CA) as well as the lateral horn (LH) of t

87 ard inhibitory GABAergic interneurons of the mushroom body, called MVP2, or mushroom body output neur

88 ons ascend to the brain and terminate in the mushroom body calyx on a set of secondary olfactory glom

89 nitoring responses to taste compounds in the mushroom body calyx with calcium imaging reveals sparse,

90 These features are less prominent in the mushroom body calyx, the insect analog of the mammalian

91 However, unless other examples of mushroom bodies can be identified in Eumalacostraca, the

92 ng to assess how the Kenyon cells in the fly mushroom bodies change their activity and reactivity to

93 orating empirically determined properties of mushroom body circuitry (random connectivity [7], sparse

94 fly feeding circuits and suggest a role for mushroom body circuits in processing naive taste respons

95 loss and, in others, by the incorporation of mushroom body circuits into lobeless centers.

96 e patterning requires further processing and mushroom body circuits.

97 lso report a novel canonical circuit in each mushroom body compartment with previously unidentified c

98 wing APL to differentially inhibit different mushroom body compartments.

99 l inhibition is removed, suggesting that the mushroom body compensates for excess inhibition.

100 een shown that the 2,000 Kenyon cells of the mushroom body converge onto a population of only 34 mush

101 rganization of glomerular connections to the mushroom body could allow the fly to contextualize novel

102 Here we show that mutation of mushroom body defect (mud) dramatically enhances the phe

103 d following loss of the Pins-binding protein Mushroom body defect (Mud).

104 these mechanisms have been shown to underlie mushroom body development and spacing of mechanosensory

105 ith functions in long-term memory formation, mushroom body development, and visual processing, traits

106 the presence of taste ligands, and find that mushroom body dopaminergic input neurons and their respe

107 Strikingly, upregulation of mushroom body energy flux is both necessary and sufficie

108 ius display a remarkably large investment in mushroom bodies for a lepidopteran, and indeed rank high

109 se models, we examine reconstructions of the mushroom bodies from the first instar larva and adult Dr

110 ons of this are considered in the context of mushroom body function and early ecologies of ancestral

111 tomically defined compartments of the insect mushroom body function as parallel units of associative

112 ntisera against proteins required for normal mushroom body function in Drosophila are indicative of g

113 Here, we show that the Drosophila mushroom body functions like a switchboard in which neur

114 rons that innervate a restricted zone of the mushroom body gamma lobe.

115 We show that evolved variations of the mushroom body ground pattern are, in some lineages, defi

116 s age- and experience-dependent posteclosion mushroom body growth comparable to that in foraging Hyme

117 In insects, mushroom bodies have been an important model system for

118 ters in the forebrain of insects, called the mushroom bodies, have become the most investigated brain

119 dditionally, intense signals derive from the mushroom bodies, higher-order integration centers for ol

120 rs consider the identification of a possible mushroom body homolog in Brachyura as problematic.

121 detailed neural circuit model of the insect mushroom body implements sensory processing, learning, a

122 andicus further demonstrate the existence of mushroom bodies in Malacostraca.

123 ion of centers that are comparable to insect mushroom bodies in processing olfactory information.

124 ral arrangements, we demonstrate insect-like mushroom bodies in stomatopod crustaceans (mantis shrimp

125 neurons that carry information away from the mushroom bodies in the brains of fruit flies has improve

126 t evolution, describing in detail the paired mushroom bodies in the lateral protocerebrum of a decapo

127 nd for their exclusion from dendrites of the mushroom body in Drosophila, a brain structure involved

128 emory expression, whereas it activates other mushroom-body-innervating DANs to facilitate hunger-depe

129 Leucokinin inhibits two types of mushroom-body-innervating dopaminergic neurons (DANs) to

130 rosophila brain and was strongly enriched at mushroom body input synapses.

131 Kenyon cells, the intrinsic neurons of the mushroom body, integrate input from olfactory glomeruli

132 ositive and subdivide the medial lobe of the mushroom body into four distinct subunits.

133 localize this function to Kenyon cells, the mushroom body intrinsic neurons, as well as GABAergic AP

134 A few mushroom body-intrinsic neurons solely receive thermosen

135 by neuronal activity and Tob activity in the mushroom body is required for stable memory formation.

136 parse odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of p

137 re, for a comprehensive understanding of the mushroom body, it is of interest not only to determine w

138 ls, the neurochemistry of the memory-storing mushroom body Kenyon cell output synapses is unknown.

139 monomolecular odors, and of 174 PNs and 209 mushroom body Kenyon cells (KCs) to mixtures of up to ei

140 Next, in the mushroom body Kenyon cells (KCs), the representation is

141 ociative learning to the axons of Drosophila mushroom body Kenyon cells for normal olfactory learning

142 Here, using recordings from mushroom body Kenyon cells in acutely isolated honeybee

143 assign value to odor representations in the mushroom body Kenyon cells.

144 reasing Tip60 HAT levels specifically in the mushroom body learning and memory center in the Drosophi

145 rebrum (SLP) and convey taste information to mushroom body learning centers.

146 r of simple neuronal connectivity within the mushroom bodies (learning centres) show performances rem

147 ed hemiellipsoid bodies that are resolved as mushroom bodies-like structures.

148 d in Eumalacostraca, the possibility is that mushroom body-like centers may have undergone convergent

149 observations demonstrate that across phyla, mushroom body-like centers share a neuroanatomical groun

150 ns in the morphology of gamma neurons in the mushroom body lineage, as well as many neurons in the an

151 Imp and Syp control neuronal fates in the mushroom body lineages by regulating the temporal transc

152 opaminergic neurons innervating the vertical mushroom body lobes substantially reduced behavioral col

153 odifications of the columnar organization of mushroom body lobes that, as shown in Drosophila and oth

154 ject to the beta'2 and gamma4 regions of the mushroom body lobes.

155 oss different anatomical compartments of the mushroom body lobes.

156 nnal lobes and highly correlated activity in mushroom body lobes.

157 odal input and the exceptional size of their mushroom bodies may support the navigational capabilitie

158 stimulation of 0273-GAL4 neurons showed that mushroom bodies (MB) and central complex (CX) both play

159 In Drosophila, the mushroom bodies (MB) constitute the central brain struct

160 of large neurons that broadly innervate the mushroom bodies (MB), the center of olfactory memory.

161 s required for specific memory phases in the mushroom bodies (MB), the olfactory memory center.

162 d by a paired brain structure, the so-called mushroom bodies (MB).

163 leep via release of GABA onto wake-promoting mushroom body (MB) alpha'/beta' neurons.

164 a specific set of wake-promoting neurons-the mushroom body (MB) alpha'beta' cells that link sleep to

165 at transposon expression is more abundant in mushroom body (MB) alphabeta neurons than in neighboring

166 ons projects dendrites into the calyx of the mushroom body (MB) and axons into the inferior protocere

167 learning in Drosophila have established the mushroom body (MB) as a key brain structure involved in

168 neurons that innervate distinct zones of the mushroom body (MB) assign opposing valence to odors duri

169 n the relative contributions of two parallel mushroom body (MB) circuits-the beta'- and beta-systems.

170 th single-unit extracellular recordings from mushroom body (MB) extrinsic neurons elucidating the neu

171 ll autonomously required for axon pruning of mushroom body (MB) gamma neurons and for ectopic synapse

172 mental elimination of two neuron populations-mushroom body (MB) gamma neurons and vCrz(+) neurons (ex

173 nt center of memory consolidation within the mushroom body (MB) implicated in arousal, and a structur

174 The Drosophila mushroom body (MB) is a key associative memory center th

175 In Drosophila, the mushroom body (MB) is critically involved in olfactory c

176 Dopaminergic signaling in the Drosophila mushroom body (MB) is involved in olfactory learning and

177 In Drosophila, the mushroom body (MB) is the major site of associative lear

178 In Drosophila, the mushroom body (MB) is the major site of associative odor

179 est that the compartment architecture of the mushroom body (MB) is the relevant resolution for distin

180 The mushroom body (MB) is well positioned for developing and

181 urons outside the core clock circuit and the mushroom body (MB) Kenyon cells (KCs).

182 dritogenesis in two extrinsic neurons of the mushroom body (MB) learning and memory brain center: (1)

183 ral sensory information to the central brain mushroom body (MB) learning/memory center.

184 els to activate autophagy for elimination of mushroom body (MB) neuroblasts.

185 cute neurotransmission from adult alpha/beta mushroom body (MB) neurons prevents premature stimulus d

186 lular signaling and plasticity in Drosophila mushroom body (MB) neurons, combining presynaptic thermo

187 e electric shock (unconditioned stimulus) in mushroom body (MB) neurons.

188 In Drosophila, the mushroom body (MB) plays a key role in these processes.

189 ate that neither ablating nor inhibiting the mushroom body (MB), a known Drosophila learning and deci

190 Most NBs, with the exception of those of the mushroom body (MB), are decommissioned by the ecdysone r

191 d to odor learning and memory, including the mushroom body (MB), for immediate sensory integration an

192 y through points of synaptic contacts on the mushroom body (MB), is essential for training during olf

193 first time distinct roles for dTau in adult mushroom body (MB)-dependent neuroplasticity as its down

194 mory-forming neurons of the adult Drosophila mushroom body (MB).

195 te an odor with coincident punishment in the mushroom body (MB).

196 100 neurons simultaneously in the Drosophila mushroom body (MB).

197 de olfactory receptor neurons (ORNs) and the mushroom body (MB).

198 ns associated with the fly memory center-the mushroom bodies (MBs) [3].

199 ted Rac1 or dominant-negative cofilin in the mushroom bodies (MBs) abolishes experience-dependent alc

200 Indirect evidence suggests the mushroom bodies (MBs) may be the substrate for visual me

201 higher order neuropils of the forebrain [the mushroom bodies (MBs) of insects and the hemiellipsoid b

202 rcuits in the bee brain to determine whether mushroom bodies (MBs), brain structures that are essenti

203 ial (DPM) neurons that broadly innervate the mushroom bodies (MBs), the center of olfactory memory.

204 y, we reveal that dopaminergic inputs to the mushroom body modulate synaptic transmission with exquis

205 These attributes indicate that a mushroom body morphology is the ancestral ground pattern

206 phic variants affecting natural variation in mushroom body morphology.

207 For example, mushroom body neuroblast cycling can continue under star

208 n Eyeless is ectopically expressed, some non-mushroom body neuroblasts divide independent of dietary

209 When Eyeless is knocked down, mushroom body neuroblasts exit cell cycle when nutrients

210 However, a small subset, the mushroom body neuroblasts, which generate neurons import

211 by Eyeless, a Pax-6 orthologue, expressed in mushroom body neuroblasts.

212 om glia regulates the temporal factor Imp in mushroom body neuroblasts.

213 We find that in the intrinsic mushroom body neuron lineage, the numbers for each class

214 ein, Rac1, as a key player in the Drosophila mushroom bodies neurons (MBn) for active forgetting.

215 The mushroom body neurons (MBn) in Drosophila melanogaster s

216 RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory

217 We show that all three classes of mushroom body neurons (MBNs) are involved in the retriev

218 y defined, terminal identity of alpha'/beta' mushroom body neurons and identity maintenance.

219 We find that aggregated Orb2 in a subset of mushroom body neurons can serve as a "molecular signatur

220 effects of G(o) signaling in the gamma lobe mushroom body neurons during memory formation.

221 Mushroom body neurons form a sparse olfactory population

222 Caffeine potentiated responses of mushroom body neurons involved in olfactory learning and

223 Here, we report that OAMB in the mushroom body neurons mediates the octopamine's signal f

224 ever, sleep and memory are coupled such that mushroom body neurons required for sleep-dependent memor

225 ing sensory input from both eyes onto single mushroom body neurons returned correct discriminations e

226 n forms part of a transcriptional program in mushroom body neurons to alter presynaptic properties an

227 Like that of mushroom body neurons, M4/6 output is required for expre

228 rformance in flies expressing Abeta42 in the mushroom body neurons, which are intimately involved in

229 ression of axonal and dendritic branching of mushroom body neurons, which mediate a variety of cognit

230 tein Grb2, is essential for ARM within adult mushroom body neurons.

231 or negative value to odor representations in mushroom body neurons.

232 distinct odor tuning converge on individual mushroom body neurons.

233 nation for the characteristic selectivity of mushroom body neurons: these cells receive different typ

234 The mushroom body neuropils have been identified as a crucia

235 ist in Reptantia thereby indicating that the mushroom body, not the hemiellipsoid body, provides the

236 d loss, paired lobed centers referred to as "mushroom bodies" occur across invertebrate phyla.

237 te of neuroanatomical characters that define mushroom bodies of dicondylic insects have been identifi

238 Synapsin and by locally restoring it in the mushroom bodies of mutant flies.

239 We find that Sir2 in the mushroom bodies of the fruit fly Drosophila promotes sho

240 stream of all DANs in a learning center, the mushroom body of Drosophila larva.

241 cortex of vertebrates or Kenyon cells in the mushroom body of insects), which in the model correspond

242 The mushroom body of the insect brain represents a neuronal

243 s recruits activity in specific parts of the mushroom body output network and distinct subsets of rei

244 t different combinations of junctions in the mushroom body output network; combining two outputs appe

245 eurons of the mushroom body, called MVP2, or mushroom body output neuron (MBON)-gamma1pedc>alpha/beta

246 s two main targets, the Kenyon cells and the mushroom body output neuron MBON-i1, further suggest tha

247 associated depression of odor responses in a mushroom body output neuron.

248 interconnected glutamatergic and cholinergic mushroom body output neurons (MBON).

249 direct recurrent feedback from gamma5beta'2a mushroom body output neurons (MBONs) and behavioral expe

250 identify a class of downstream glutamatergic mushroom body output neurons (MBONs) called M4/6, or MBO

251 show that odor tracking is regulated by two mushroom body output neurons (MBONs) connecting the MB t

252 Finally, in mushroom body output neurons (MBONs), the representation

253 m body converge onto a population of only 34 mushroom body output neurons (MBONs), which fall into 21

254 t Kenyon cell activation, evokes activity in mushroom body output neurons (MBONs).

255 urrent and hierarchical connectivity between mushroom body output neurons and dopaminergic neurons en

256 lation of neurons that provide feedback from mushroom body output neurons and link distinct memory sy

257 Surprisingly, downstream of Kenyon cells, mushroom body output neurons show stereotypy in their re

258 y reconsolidation requires the gamma2alpha'1 mushroom body output neurons.

259 tinct dopaminergic neurons and corresponding mushroom body output neurons.

260 al state of the fly guide behavior by tuning mushroom body output synapses.

261 Mushroom bodies possessing all the morphological attribu

262 sic temporal programs, we studied Drosophila mushroom body progenitors (neuroblasts) that sequentiall

263 ntrasts with the probabilistic wiring of the mushroom body, reflecting the distinct roles of these re

264 ond order projection neurons target both the mushroom body, required for learning, and the lateral ho

265 eurons innervating the vertical lobes of the mushroom body responded to decreases in temperature, but

266 ld using intracellular recordings to examine mushroom body responses to optogenetically controlled in

267 nsight into gustatory representations in the mushroom bodies, revealing the essential role of gustato

268 The complete circuit map of the mushroom body should guide future functional studies of

269 H projections converge with outputs from the mushroom body, site of olfactory learning and memory.

270 Mushroom-body-specific transcriptome analysis revealed t

271 A mushroom body subdomain whose development or function re

272 taceans possess structures equivalent to the mushroom bodies that play a role in associative memories

273 signalling mediates an energy switch in the mushroom body that controls long-term memory encoding.

274 ns (MBONs) of the alpha'3 compartment of the mushroom body that is rapidly suppressed upon repeated e

275 For the supraesophageal ganglion excluding mushroom body (the part of the brain investigated in the

276 c mutant with reduced OAMB expression in the mushroom bodies, the brain structure crucial for olfacto

277 at expression of a secreted-APPL form in the mushroom bodies, the center for olfactory memory, is abl

278 calcium imaging suggests that, as in insect mushroom bodies, the output regions exhibit stimulus-spe

279 on of this isoform is most pronounced in the mushroom bodies, the subesophageal ganglion, and the cor

280 with bidirectional neural plasticity in the mushroom body, the associative olfactory center of the f

281 tion of energy consumption in neurons of the mushroom body, the fly's major memory centre.

282 gely converge onto three target regions: the mushroom body, the lateral horn (both of which are well

283 ls but also to pinpoint where exactly in the mushroom body they do so.

284 expressed in the adult brain, mainly in the mushroom bodies, though sema1a.2 was expressed most robu

285 ual dimorphism of the relative investment in mushroom body tissue is observed only in Apis.

286 the theoretical storage capacity of the ant mushroom body to be estimated at hundreds of independent

287 mantis that he claimed correspond to insect mushroom bodies, today recognized as cardinal centers th

288 We demonstrate that mushroom bodies typify lineages that arose before Reptan

289 al anesthetic procaine [15, 17, 18] into the mushroom body vertical lobes (VLs) to selectively inhibi

290 ta provide neurobiological evidence that the mushroom body vertical lobes are necessary for retrievin

291 pair of dopaminergic neurons afferent to the mushroom bodies, via the D5-like DAMB dopamine receptor.

292 In addition to input to the mushroom body, we describe other general anatomical feat

293 udy homeostatic plasticity in the Drosophila mushroom body, where Kenyon cells receive feedforward ex

294 ndrites in the alpha and alpha' lobes of the mushroom body, which drive negatively reinforcing dopami

295 ned, behavior because the latter engages the mushroom body, which enables differentiated responses to

296 ique morphology of neurons in the Drosophila mushroom body, which receive input on large dendritic cl

297 terior-posterior alpha'/beta' neurons of the mushroom body, while memory under starvation is mediated

298 We addressed this problem in the Drosophila mushroom body, whose principal neurons, Kenyon cells, re

299 that sparse odor responses are preserved in mushroom bodies with reduced cellular repertoires, sugge

300 minergic circuits innervating the Drosophila mushroom body with in vivo calcium imaging and condition