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1 to B. cinerea negative effects in grapes and musts.
2 of this difference, inhibitors of metastasis must account for each migration mode.
3                             We argue that we must account for these frames of reference to meaningful
4                        Aedes aegypti females must accurately discriminate blood and nectar because ea
5               Streptococcus pneumoniae (Spn) must acquire iron from the host to establish infection.
6  For instance, paralogous signaling proteins must acquire mutations that endow them with different in
7               During infection, A. baumannii must acquire nutrients for replication and survival.
8 computational problem-this is what the brain must actually accomplish to support perception and actio
9                                 Cancer cells must adapt metabolism to thrive despite nutrient limitat
10 dapts to a new environment, its taste system must adapt to detect new death threats.
11                               Because a cell must adapt to different stresses and growth rates, its p
12 ause invasive disease in the vertebrate host must adapt to host efforts to cripple their viability.
13 w challenges for public-health agencies that must adapt to support a new set of expertise, which mean
14 novel selective pressures to which organisms must adapt.
15           To do so, academic medical centers must address 2 key research issues: (1) how to effective
16                   Successful islet isolation must address the challenges of severe pancreatic fibrosi
17  by technology improvements alone-the demand must also be stabilized.
18 at besides interaction, the role of disorder must also be taken into account in understanding the dif
19                                         They must also be used in pre-clinical research if the excess
20                                           We must also learn more about how the microbiome varies amo
21 perate the Calvin cycle independent of light must also recycle phosphoglycolate.
22                                  Tumor cells must alter their antioxidant capacity for maximal metast
23 ifferent UV-C doses were applied to Riesling must and compared with thermal pasteurization.
24  covering all the concentrations expected in must and wine samples, a detection limit of 75 +/- 12 mg
25 n the profile of volatile compounds of grape must and wine.
26 thway, latent 26S proteasomes in the cytosol must assume an active form.
27             In these analyses, investigators must assume that the instrument is as-if randomly assign
28         Safe and effective COVID-19 vaccines must avoid VAH.
29 nt cells and their immediate environment and must balance multiple functionalities, including the reg
30                                        Cells must be able to cope with the challenge of folding newly
31                To answer these questions, we must be able to detect and quantitate cGAMP with an assa
32 st be eliminated, and chest imaging findings must be abnormal.
33 es are crosscut by thousands of dykes, which must be accommodated through a combination of flank slip
34  the transmembrane cavity and cytosol, which must be accommodated.
35 s with primary sclerosing cholangitis (PSC), must be accompanied by functional changes.
36 teroatoms is one of the essential goals that must be achieved in order to control the electronic prop
37 Another key finding is that prazole prodrugs must be activated inside the cell, while their rate of a
38               Transcriptionally silent genes must be activated throughout development.
39 uring acute liver failure; however, TGFbeta1 must be activated to bind its receptor and generate down
40 ignificant impediment to DNA replication and must be actively managed in order to preserve genetic an
41                           Metabolic pathways must be adapted to support cell processes required for t
42     Corrosive properties of MgCl(2) hydrates must be addressed at the operating temperatures of 500-7
43 but are rooted in structural inequities that must be addressed to adequately care for communities of
44 heless, there are still many challenges that must be addressed to enable a complete understanding of
45 leads to long-term profound alterations that must be addressed to optimize quality of life.
46 sed learning, as well as open questions that must be addressed to unify our understanding cerebellar
47 g efficiency, specificity and immunogenicity must be addressed.
48 rdiovascular health, certain core challenges must be addressed.
49  that early healing after orthopaedic trauma must be allowed prior to the initiation of exercise to a
50 nes could be improved, vaccine effectiveness must be analyzed by vaccine and virus type.
51 are well placed for analysing these data but must be applied with an understanding of the relevant bi
52 d post-contrast T(1) values, but its utility must be assessed.
53 ysical connections between sister chromatids must be broken before cells can divide, and eukaryotic c
54               We argue that these narratives must be captured and shared publicly as an integral part
55                          Acute kidney injury must be carefully monitored when ATM inhibitors become a
56 ated that rigorous toxicological evaluations must be carried out prior to clinical translation of nan
57 sults that the hydrolysis of NO(2) in clouds must be catalyzed by organic or inorganic species adsorb
58                   Metabolism and development must be closely coupled to meet the changing physiologic
59 imaging and biopsy data from diverse sources must be combined to define a patient's phenotype.
60 f raw signal contained in fast5 files, which must be compressed to enable efficient storage and trans
61 t sufficient by itself; gist representations must be connected to values.
62 portant part of COVID-19 response, their use must be considered alongside a careful understanding of
63 ces, the lateral homogeneity of such samples must be considered as an important prerequisite for effo
64   As a form of screening, secondary findings must be considered differently from sequencing results i
65 ely affect key study outcomes; these effects must be considered during data analysis and interpretati
66 te that the effects of ASOs on transcription must be considered for appropriate experimental and ther
67 C storage that includes soil organic C (SOC) must be considered to determine whether planting trees f
68 ht that multiple biotic and abiotic pathways must be considered to scale up globally from site- and s
69 This shows that both the ERK5 kinase and TAD must be considered when assessing the role of ERK5 and t
70  factor and strength of association with HIV must be considered.
71 d achieve desired outcomes, persons with HIV must be consistently engaged in care and able to access
72 lyzed, the space of computational mechanisms must be constrained based on what is plausible within ne
73  New-diagnosed exfoliation glaucoma patients must be controlled and treated more strictly than primar
74  report, we suggest that the auxin signaling must be controlled harmoniously by two counteracted team
75        To capture fusion events, the process must be curtailed by trapping Env-receptor binding at an
76                             Barriers to care must be decreased at the societal, health system, clinic
77 tate power density must be improved and cost must be decreased.
78 , the data used to consider clinical utility must be derived from level I evidence studies.
79                      We show that the cornea must be described by at least two shear moduli, contrary
80                                        These must be disentangled on the top- or middle-down level to
81 rge volumes of brine ("produced water") that must be disposed of, treated, or reused.
82                          Additional research must be done to validate the GWAS and genomic prediction
83 segregate chromosomes, the kinetochore-fiber must be dynamic and generate and respond to force.
84 vation efforts, but to fulfil this role they must be effective at conserving the ecosystems and speci
85 cent vaping within 90 days, other etiologies must be eliminated, and chest imaging findings must be a
86 s (PKSs), many aspects of their biochemistry must be elucidated.
87 ing and treatment of such wastewater streams must be employed to minimize the adverse impacts on huma
88 pression decreased, implying Aire expression must be established before TSA expression can occur.
89 h the generality of the successful diversion must be established by further investigation.
90 lly distinct contraction and relaxation that must be established in the neighboring epithelium for ap
91 are usually unknown to the investigators and must be estimated.
92                        Additional mechanisms must be explored to minimize the necessary period of pro
93 ology practice, musculoskeletal radiologists must be familiar with the imaging appearance of malignan
94 sue targeting capabilities of these vehicles must be further improved.
95 photoinitiation step in the reaction cascade must be identified.
96 ase, tools to facilitate vaccine development must be identified.
97                         Therefore, the vRNPs must be imported into the nucleus for viral transcriptio
98 nt of wastewater, steady-state power density must be improved and cost must be decreased.
99 lusion criteria are based on a variable that must be imputed.
100 l features of the world are often hidden and must be inferred by constructing internal models based o
101               From the outset, these studies must be informed by and integrated with ecosystem models
102 ite directions along the genome, translation must be inhibited at a defined point following infection
103 ls, it has been proposed that macroautophagy must be inhibited to maintain genome integrity.
104 ible with superoxide (O(2) (*-)) production, must be insensitive to deuteration, and yields a predict
105 ndent process suggests that activity history must be integrated to determine the dynamics of global P
106 -response relation was apparent, this result must be interpreted with caution.
107 ic laboratories and the time and effort that must be invested for intralaboratory method validation.
108 ll space completely, thus ion-by-ion filling must be invoked to fill interstitial pores.
109 ristics is crucial and lifesaving treatments must be made widely available.
110  potential, several improvements to REDCRAFT must be made.
111 ells are sensitive to heat stress and testes must be maintained outside the body for optimal fertilit
112 9, lapses in medical care and medication use must be minimized, and public health resources should be
113 th the correct tumor-targeting specificities must be mobilized.
114                            Striatal circuits must be modulated for behavioral flexibility, the abilit
115 matin landscape and epigenetic barriers that must be overcome for cardiac regeneration to occur.
116       Classes of nucleic acids, hurdles that must be overcome for effective intracellular delivery, t
117 12 rhizobia) help identify the barriers that must be overcome to engineer a bacterium to deliver a hi
118  transboundary species, the global community must be prepared to invest in some regions facing greate
119                         Iron supplementation must be prescribed to avoid chronic iron deficiency.
120 ntribution to the triple-alpha reaction rate must be present at high densities, this effect needs to
121                                   Crossovers must be properly placed along meiotic chromosomes for th
122 emories become destabilized on retrieval and must be reconsolidated into long-term memory stores to p
123 etector is susceptible to over-detection and must be refined for robust, reproducible detection in a
124      Under these conditions, the cell volume must be regulated to maintain optimal neural function.
125  its internalization into endolysosomes, Tat must be released in order for it to activate the HIV-1 L
126 f immune responses in patients and therefore must be removed at the expense of purification yields.
127 omes are refractory to TF binding, and often must be removed from regulatory regions.
128  proton transfer reactions, the product ions must be removed from the reaction cell as they are forme
129             For the system to be adopted, it must be reproducible.
130 of the risk variants linked to brain disease must be resolved.
131 riptional programs that define cell identity must be restarted in each cell cycle(2-5) but how this i
132 mple, when multiple stimulus-action mappings must be retained and used.SIGNIFICANCE STATEMENT Everyda
133 rmed the alternative scheme, the adh-1 locus must be retired from the PubMLST scheme if it is to be r
134 es are swept along the secretory pathway and must be retrieved to maintain cell viability.
135 eceptor that dissociates Cactus from Dorsal, must be saturated.
136                        Health care providers must be sensitive to older adults' experience of arthrit
137               Metabolism of this PG meshwork must be spatially and temporally regulated in order to s
138 states occur-such as condensed-phase systems-must be studied.
139 ses, large amounts of specific sphingolipids must be synthesized for specialized physiological functi
140 ory and practice, these reported experiences must be synthesized.
141           Intrinsicality means that a symbol must be taken as such and cannot be decomposed into sign
142                                         Care must be taken in interpreting RT-PCR tests for SARS-CoV-
143                               These findings must be taken into account in models of the clock disrup
144                 Thus, individual differences must be taken into account when aiming to assess an indi
145 chine-learning models, but appropriate steps must be taken to avoid overfitting.
146 nt functions throughout infection and, thus, must be temporally and precisely regulated for successfu
147                              Brain glutamate must be tightly controlled during hyperglycemia because
148                  NLRP3 inflammasome activity must be tightly controlled, as its over-activation is in
149 ration, nitrogen acquisition and utilization must be tightly regulated.
150              Learning of anticipatory forces must be ultrafast to minimize tilting a visually symmetr
151 tential, the diverse errors that affect them must be understood and suppressed.
152  solvation behavior of the solvent molecules must be understood because the electrochemical propertie
153                            Novel antibiotics must be used sparingly to hinder the spread of resistanc
154 d risk reduction for each of these therapies must be weighed against its cost and potential adverse e
155                                Although heme must bind in the sGC beta1 subunit (sGCbeta) for sGC to
156 ong constraints on their binding sites; they must block the diffusion of the excess of twist through
157  Computational tools for Strand-seq analyses must capture the strand-specific information embedded in
158 o be sped up by a quantum computer, thus one must carefully identify areas where quantum advantage ma
159 sufficient flexibility, biological organisms must cognize beyond immediate reaction to a physically p
160   We propose that the song system motor code must compensate for these changes to achieve its acousti
161 cause the risk of isolation is low, and they must compete with other males to find a partner.
162 spin labels, the structure of the nitroxides must confer reduction resistance to withstand the reduct
163 interpreting loss-of-function phenotypes and must consider both cellular and developmental context.
164 heoretical studies of terrestrial exoplanets must consider the effect of dust.
165                            Image collections must contain not only thousands of images to provide suf
166 er, ~96% of movement routes in North America must contend with human land uses to some degree.
167  not taking PrEP; and finally, an individual must continue to attend health-care visits or discontinu
168                              Plant pathology must contribute to improving food security in a safe ope
169 y of nsp10, indicating that the four domains must cooperate to contribute to helicase function.
170  block of the Hessian, although these values must correctly reflect the influence of the whole enviro
171                                  The spindle must counter these forces with extensive forces to preve
172                                        Cells must couple cell-cycle progress to their growth rate to
173 event COVID-19 and future such pandemics, we must create the conditions that can keep population-leve
174 y the malnutrition universal screening tool (MUST), CT derived body composition as measured by skelet
175 rry out this function, the blood vasculature must deliver oxygen and nutrients and recruit circulatin
176           To adjudicate between theories, we must design experiments for which the theories make dist
177                       To overwinter, animals must detect constant cold temperatures before adapting t
178  the structure and function of chromatin, we must determine the structures of nucleosomes containing
179  finding of a small renal mass, radiologists must determine whether it is benign or malignant, and if
180  excess of one substrate relative to another must determine which activity is favored.
181 lity," the US biomedical research enterprise must directly confront the reality of structural racism
182 the mimetic pheromone during mate search but must discriminate against the model cue to avoid orienti
183 ALI is a diagnosis of exclusion; the patient must elicit a history of recent vaping within 90 days, o
184 oach to address this conservation gap, which must enable megafaunal populations to recover to functio
185 nt and future, a successful vaccine platform must enable rapid discovery, scalable manufacturing and
186                     The academic environment must establish a culture of excellence and faculty engag
187      To prevent future zoonoses, governments must establish effective legislation addressing wildlife
188 cessfully complete its life cycle, Chlamydia must evade both intracellular innate immune responses an
189      A successful mutation leading to cancer must evolve to be adaptive, enabling a cancer cell to se
190 a result, we find that DNA-bridging proteins must exert rather strong constraints on their binding si
191  smaller pixel arrays, the emissive material must exhibit wider colour gamut so that each of the vast
192        For metastasis to occur, cancer cells must exocytose proteases, like matrix metalloproteinases
193                     Our non-Black colleagues must fight anti-Black racism and white supremacy within
194 ion with offspring disease risk, a framework must first be built with insight into the expected biolo
195  integrate the senses, the developing system must first be calibrated.
196 ous recombination, 5'-terminated DNA strands must first be resected to reveal 3'-overhangs.
197 asite to establish an infection in flies, it must first colonize the area between the peritrophic mat
198 odels of memory updating propose that people must first generate memory-based predictions to detect a
199                       Future clinical trials must focus on patients who really need adjunct cardiopro
200 cleoid-associated proteins known to wrap DNA must form higher protein-DNA complexes to efficiently wo
201                                    First, we must formalize theories of suicide, expressing them as m
202   Animals that move through complex habitats must frequently contend with obstacles in their path.
203                                   'Cesanese' must from pressed dehydrated grapes (solid and liquid) w
204 safe delivery to cancer cells, nucleic acids must generally be packaged into a vehicle, such as a nan
205  it highlights that different soil processes must govern P availability as pH shifts.
206 irst, the shape of the substrate nanocrystal must guide the crystallographic orientation of the overg
207 can successfully create these two properties must have a rank that is nearly linear in the number of
208 rm DNA as the carrier of genetic information must have co-evolved with a means to manipulate its comp
209 ral standard-of-care and long-acting groups, must have completed the 52-week comparative phase with a
210                              Decision makers must have sufficient confidence in models if they are to
211 ranscription factor network of proteins that must heterodimerize with MYC-associated factor X, or MAX
212         Specifically, technology ease of use must improve and support multiparty videoconferencing.
213 hieve cardiovascular health for all, the AHA must include a broader vision of health and well-being a
214            Building a robust, stable network must include strategies to minimize perturbations caused
215 complete understanding of the nervous system must incorporate glial cells.
216                   To achieve this, the field must incorporate human neuroscience tools including mobi
217 rmal behavior when the established framework must incorporate new information.
218 aw of thermodynamics that states how entropy must increase.
219           Further 20 g/L of GSP added to the must induced less changes to wine composition than direc
220 Surveillance programs for invading pathogens must initially meet challenges that include low rates of
221                                        K-Ras must interact primarily with the plasma membrane (PM) fo
222                              Future research must investigate the pathogenesis of recurrent pregnancy
223 es sensory information to guide behavior, we must know how stimulus representations are transformed t
224               The American Heart Association must look internally to correct its own shortcomings and
225                                     Proteins must maintain proper folding conformations and express t
226 t of complex, chronic illness management and must make difficult decisions about their own health, pa
227            To produce consequential work, we must make social epidemiology more causal and causal inf
228                                       Plants must manage cell swelling during flooding, rehydration,
229 y, the demands of written health information must match the reading capacities of the target audience
230 ID-19 risk estimates, the research community must meet robust methodological and communication standa
231             To fully exploit this method, we must move towards new alloys and processes.
232                        During entry, viruses must navigate through the host endomembrane system, pene
233 tomic environment through which dislocations must navigate.
234 ic drugs, their bioaccessibility predictions must not be based only on the determination of their fre
235  outcome: first, a person who initiates PrEP must not seroconvert; second, there should be no more th
236 synthesize amino acids de novo and therefore must obtain oligopeptides from its host cell for growth.
237    HIV-1 capsid core disassembly (uncoating) must occur before integration of viral genomic DNA into
238 and breaks (DSBs), pairing and crossing over must occur for correct meiotic segregation(1,2).
239 es which and how many somatic mutations (sM) must occur for malignant transformation.
240  indicate that conformational rearrangements must occur in the N terminus of FepA during FeEnt transp
241 tigate the impact of UV-C treatment of grape must on the sensory characteristics of the resulting win
242 through unique biosynthetic pathways, plants must orchestrate their production simultaneously.
243  products encoded in foreign genes, bacteria must overcome the silencing effects of H-NS.
244 f MNW networks as a replacement to ITO, they must overcome their inherent stability issues while main
245 (p < 0.01), mGPS (p < 0.05), NLR (p < 0.01), MUST (p <= 0.001), Low SMD (p < 0.05), SUVmax (p <= 0.00
246 nveloped polyomavirus simian virus 40 (SV40) must penetrate the host endoplasmic reticulum (ER) membr
247              Social health insurance reforms must place emphasis on reducing out-of-pocket spending f
248 sent; and (c) mitochondrial oxidative stress must precede the insulin stimulus to cause insulin resis
249  many species enter a period of anorexia but must preserve sufficient reserves to fuel hunting and th
250                          To move forward, we must proceed by understanding that cats are not exclusiv
251   In this computerized task, the participant must rapidly decide to shoot or not shoot at White and B
252  is therefore an autoinhibitory element that must re-orient during catalysis, as supported by molecul
253  To accomplish these repair activities, APE1 must recognize and accommodate several diverse DNA subst
254 vered that influenza-generated CD4 effectors must recognize cognate Ag at a defined effector checkpoi
255 n that coastal flooding will only worsen, we must reframe this problem as one that will disproportion
256 hat SMO, and likely also other GPCR cargoes, must release their amphipathic helix 8 from the membrane
257 actile sensory information, prosthetic users must rely on incidental visual and auditory cues.
258 en hosted by public repositories, scientists must rely on inconsistent annotation to identify and int
259 ur findings emphasize that suspicion for MMP must remain high for patients who have Foster stage 3 co
260                                  Centrosomes must resist microtubule-mediated forces for mitotic chro
261                        Mammalian sperm cells must respond to cues originating from along the female r
262 icant limitation for artificial systems that must robustly operate in the natural world.
263  outpatient parenteral antimicrobial therapy must seek treatment in high-risk settings.
264               We argue that conservationists must seize the agenda to put biodiversity at the heart o
265  is a key difference: to choose friends, one must select few from many.
266                    Characteristically, cells must sense and respond to environmental cues.
267 tween sessile and motile forms in which they must sense and respond to internal and external signals
268 wn as Borreliella burgdorferi), the bacteria must sense conditions within the vertebrate and arthropo
269 gents used to treat type 2 diabetes mellitus must show cardiovascular safety.
270 er space that are unimportant for prediction must significantly exceed the sample size.
271 ending to currently-relevant information, we must simultaneously maintain future-relevant information
272 bsence of thermal damage in the UHPH-treated musts, since 5-hydroxymethylfurfural was not detected.
273 th this type of resection, and many problems must still be solved.
274                                    Countries must strengthen immunization programs to achieve high va
275     This suggests that forest carbon finance must strike a balance between controlling conservation i
276    Policy responses to the COVID-19 outbreak must strike a balance between maintaining essential supp
277              To constrain global warming, we must strongly curtail greenhouse gas emissions and captu
278 oals, funding agencies and training programs must support a new generation of scientists and clinicia
279 ithin this enveloping membrane, the organism must take in nutrients, secrete wastes, export proteins
280 dionuclide transport from disposal boreholes must take into account processes that may accelerate deg
281           Successful intervention strategies must target both the potency of SARS-CoV-2 and its evasi
282 age to art and to perceiving, as we argue we must, the sacred in science.
283          The clinical meaning of the results must then be determined to allow clinical and statistica
284                Animals navigating in a plume must therefore rely upon intermittent, and time-varying
285                             Other trade-offs must therefore shape ecological processes, and investiga
286              Under photomixotrophy, the cell must therefore tightly regulate electron fluxes from pho
287                           The colonic mucosa must therefore tightly regulate fluid influx to control
288 indings from present work in all probability must, therefore, provide a reference and background cont
289 es and growth rates, its proteostasis system must too.
290                                  All animals must transform ambiguous sensory data into successful be
291                     The contents of IBs also must transition prior to further viral maturation, assem
292 ation, when the lateral root primordia (LRP) must traverse three overlying cell layers within the par
293                             In addition, the must treated by UHPH keeps terpene concentrations simila
294                    Icosahedral viral capsids must undergo conformational rearrangements to coordinate
295  and genetic risk factors for celiac disease must undergo endoscopic evaluation after 1-3 years on a
296 s to achieve high vaccination coverage; some must undertake strategies to reach persons >=15 years of
297  high efficiencies, thermophotovoltaic cells must utilize the broad spectrum of a radiative thermal s
298    The antioxidant value of the UHPH-treated must was 156% higher than the control.
299    The initial microbial load of the settled must was 4-log CFU/mL for both yeast and moulds, and sli
300                                  However, we must work quickly to capture that enthusiasm and channel

 
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