ライフサイエンスコーパス: mutagenic

1 mplating cytosine (nonmutagenic) or adenine (mutagenic).

2 ydroxylamines, 10-aza-9-oxakalkitoxin is not mutagenic.

3 had low mutagenic activity and 75% were not mutagenic.

4 investigated whether NB disruption might be mutagenic.

5 data suggest that iPSC reprogramming is not mutagenic.

6 between the repeats, and hence is relatively mutagenic.

7 t block to DNA replication and are extremely mutagenic.

8 te blockage effects, with none of them being mutagenic.

9 nsgenes, random integrations are potentially mutagenic.

10 iscriminates against DNA junctions harboring mutagenic 3'-DNA mismatches or oxidative DNA damage, but

11 ER) is the primary pathway to remove the pre-mutagenic 8-oxo-7,8-dihydroguanine (8-oxoG) from DNA.

12 The highly mutagenic A:8-oxoguanine (oxoG) base pair is generated m

13 have broad effects on development, but their mutagenic actions that can lead to cancer have been less

14 Measured E2eq and mutagenic activities correlated well with predicted path

15 Endocrine and mutagenic activities of the water samples were well corr

16 CRISPR target sequences with their relative mutagenic activities.

17 onella bioassay (reported here), 25% had low mutagenic activity and 75% were not mutagenic.

18 The generation of AID off-target mutagenic activity in precursor B-cells does not promote

19 Our findings therefore identify the highly mutagenic activity of benznidazole metabolites in T. cru

20 kers than never-smokers, pointing toward the mutagenic activity of the SN2-type alkylating carcinogen

21 One possible explanation is the mutagenic activity of these foods, perhaps due to genera

22 grades A3F and, in some cases, overcomes A3G mutagenic activity to replicate.

23 For increased mutagenic activity, formation of a dimer was more import

24 contributes to tumor development through its mutagenic activity.

25 ndicated that the selected compounds have no mutagenic activity.

26 tions and in patients' samples where AraC is mutagenic, addition of CHK1i appears to eliminate the ge

27 -115 ug L(-1)), which is considered a potent mutagenic agent, above the potability limit in 75% of th

28 trand breaks (DSBs) that arise from external mutagenic agents and routine cellular processes is essen

29 Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed descenda

30 by stimulating the endogenous production of mutagenic aldehydes and N-nitroso compounds.

31 y ligand, and independent of any chemical or mutagenic alteration.

32 e zeta (Polzeta) is responsible for a highly mutagenic alternative mechanism.

33 However, a mutagenic alternative NHEJ pathway, microhomology-mediat

34 ote inappropriate chromosome fusions via the mutagenic alternative non-homologous end joining (A-NHEJ

35 human whole blood, navigation away from Ames mutagenic amine fragments while balancing metabolic stab

36 ocyclic aromatic amines (HAAs) classified as mutagenic amines by the International Agency for Researc

37 ensitive determination of six representative mutagenic amines was developed.

38 ular modeling, substrate-capture assays, and mutagenic analyses, we identified a single conserved sur

39 erminal of both sequences, by an approach of mutagenic analysis and saturation mutagenesis of mutable

40 Mutagenic analysis and the atomic structure of MPH-220-b

41 amics simulations and based on a comparative mutagenic analysis of AQPs 1, 3, and 4, suggest that loo

42 Mutagenic analysis of K6a confirmed that the site-specif

43 This study represents the first mutagenic analysis of nairoviral NTRs in the context of

44 Mutagenic analysis shows H3 tail residues 11-27 to be th

45 rogen-deuterium exchange studies followed by mutagenic analysis to test the activation mechanism.

46 A comprehensive mutagenic analysis, guided by homology mapping in atomic

47 eilled by Aprataxin (APTX), which suppresses mutagenic and abortive ligation at sites of oxidative DN

48 ge], within which 5-methylchrysene (5-MC), a mutagenic and carcinogenic PAH, had the highest individu

49 ffects, such as the formation of potentially mutagenic and carcinogenic substances.

50 ng of meats and are known or suspected to be mutagenic and carcinogenic.

51 bundant form of oxidative DNA damage that is mutagenic and contributes to the pathogenesis of human d

52 BER counters the mutagenic and cytotoxic effects of damage that occurs co

53 DNA is detrimental to cells due to its high mutagenic and cytotoxic potential and is repaired by the

54 products in genomic DNA that are potentially mutagenic and detrimental to epidermal cell function.

55 wever, it is banned due to its carcinogenic, mutagenic and genotoxic properties, which represent a se

56 e alleles together with the contamination of mutagenic and nonmutagenic chemical pollution offers new

57 position of endogenous retroelements through mutagenic and nonmutagenic mechanisms.

58 an important role in the evolution of these mutagenic and pathogenic agents.

59 (O (6)-alkyl-dG) lesions are among the most mutagenic and prevalent alkylated DNA lesions that are a

60 Such bursts are mutagenic and thus potentially deleterious.

61 allowing far greater precision than previous mutagenic and transgenic approaches.

62 d a likely basis for its dramatically higher mutagenic and tumorigenic effects.

63 The mutagenic APOBEC3B (A3B) cytosine deaminase is frequentl

64 Herein, we use a structure-based mutagenic approach to demonstrate that cobalamin riboswi

65 Several mutagenic approaches were undertaken to better define th

66 dentified 14 amines including the two potent mutagenic aromatic amines 2,3- and 2,8-phenazinediamine,

67 ironmental contaminants including two weakly mutagenic aromatic amines, and the known alkaloid comuta

68 dant adduct can be considered as potentially mutagenic as a highly miscoding but rare lesion.

69 g of dead Cas9 (dCas9) is presumed not to be mutagenic, as dCas9 lacks DNA endonuclease activity.

70 Notably, extension from the mutagenic base pair is favored over the non-mutagenic ba

71 mutagenic base pair is favored over the non-mutagenic base pair.

72 of active Cas9 to a genomic locus is highly mutagenic because Cas9 creates DNA double strand breaks,

73 NHEJ has the potential to be highly mutagenic because it uses DNA polymerases, nucleases, an

74 This report evaluates the pro-mutagenic behavior of 8-oxo-guanine (8-oxo-G) by quantif

75 tabase were compared with observed endocrine/mutagenic bioactivities.

76 a dynamic and complex system, we carried out mutagenic, biochemical, hydrodynamic and structural stud

77 DBAN is not mutagenic but causes DNA breaks and elevates sister chro

78 These DNA cross-links can be mutagenic by damaging the integrity of the DNA structure

79 e of pol mu in mediating ligation during the mutagenic bypass of 8-oxodG, while 3'-preinserted noncan

80 ore, Pol mu exhibits a strong preference for mutagenic bypass of 8OG by insertion of adenine.

81 Strikingly, POLRMT shows a high mutagenic bypass rate, which is exacerbated by TEFM (tra

82 es into a thymine dimer which is potentially mutagenic, carcinogenic, or lethal to the organism.

83 Here, we describe a battery of mutagenic cassettes that can be applied in conjunction w

84 th an efficiency of >40%, without unintended mutagenic changes at the targeted genetic loci.

85 from miPSCs, we assessed the risk of 110 non-mutagenic chemical compounds, most of which are known as

86 nosuppressants, and a mixture of potentially-mutagenic chemicals.

87 IP) is considered as a human carcinogenic or mutagenic compound that is produced from the co-condensa

88 Mutagenic compounds are a potent source of human disease

89 To identify the mutagenic compounds, we applied effect-directed analysis

90 eratures are thus likely to have significant mutagenic consequences for plants growing in the wild an

91 herapeutic applications, given the potential mutagenic consequences of off-target cleavage.

92 n insight into this process, we analyzed the mutagenic consequences of replication fork stalling at a

93 as a cause of cancer development through its mutagenic consequences.

94 o been shown to cut at off-target sites with mutagenic consequences.

95 on of checkpoint kinases ATM and CHK2 has no mutagenic consequences.

96 onal subtypes is primarily determined by the mutagenic context.

97 Here, we show that mutagenic damage accounts for the majority of the errone

98 DNA damage sites resulting in error-free or mutagenic damage bypass.

99 Because much mutagenic damage is expressed following cell division, m

100 has implications for the control of another mutagenic deaminase, human AID, and provides a rationale

101 sine (gamma-OHPdG) is an endogenously formed mutagenic DNA adduct derived from lipid peroxidation.

102 O(6)-Methylguanine (O(6)-MeG) is a highly mutagenic DNA adduct that forms in human genomic DNA upo

103 strategy to identify, locate, and quantify a mutagenic DNA adduct, advancing tools for linking DNA al

104 roposed mechanism allows cells to respond to mutagenic DNA damage removed by NEIL3 associated with ox

105 S with 8-oxo-guanine (8-oxo-G), a highly pro-mutagenic DNA lesion formed by reactive oxygen species.

106 Here we reveal that most mutagenic DNA lesions are not resolved into a mutated DN

107 Potentially mutagenic DNA lesions induced by UVB (wavelengths 280-32

108 bstrate that tunes the enzyme to release pro-mutagenic DNA nicks.

109 some structural aberrations, and error-prone mutagenic DNA repair following exposure to ICL-inducing

110 tic domains result in greater involvement of mutagenic DNA synthesis by Pol zeta as well as diminishe

111 ma(S)) general-stress response, which allows mutagenic DNA-break repair.

112 dictate preferential use of the potentially mutagenic double-strand break repair pathway.

113 denine during DNA replication leading to non-mutagenic dU/A base pairs ('uracilation').

114 r incorporated by DNA polymerases, is highly mutagenic due to mispairing with adenine.

115 Moreover, these lesions were highly mutagenic during cellular replication and exclusively di

116 Taken together, this suggests that the mutagenic effect depends on a complex mechanism, where d

117 xygenase 2 (COX-2) expression as well as the mutagenic effect in bystander cells.

118 mans, but few studies have ever examined its mutagenic effect in vivo.

119 ing of multiple DT40 clones to determine the mutagenic effect of eight common cytotoxics used for the

120 an important contribution to determining the mutagenic effect of environmental agents or genetic defe

121 ding a general mechanistic framework for the mutagenic effect of ethanol, our findings may also provi

122 ecific error-prone polymerases abolishes the mutagenic effect of ethanol.

123 use a standard NGS pipeline to show that the mutagenic effect of favipiravir can be measured by whole

124 hat replication delay greatly attenuates the mutagenic effect of ultraviolet irradiation, confirming

125 oxorubicin and paclitaxel have no measurable mutagenic effect.

126 vated carbon (GAC) significantly reduced the mutagenic effects as well as the concentrations of remai

127 important implications for understanding the mutagenic effects of chemotherapeutic drugs that stabili

128 Compared to the relatively moderate mutagenic effects of UVR, acute UV exposure induced subs

129 air is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which

130 A polymerase II (pol II) have inhibitory and mutagenic effects on transcription.

131 cardiovascular diseases and carcinogenic and mutagenic effects.

132 Given the exceptional mutagenic efficiency and specificity of the Cas9 strains

133 sequence to the gene confirmed to have high mutagenic efficiency.

134 Our results suggest that the input of a mutagenic effluent from a WWTP resulted in a strong incr

135 long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic

136 berrant coexpression of FOXP1 and the B-cell mutagenic enzyme activation-induced deaminase, and immun

137 ADAT2/3 is a highly mutagenic enzyme, but we also show that when co-expresse

138 ver of mammalian genome evolution, but these mutagenic events can also cause genetic disorders.

139 implications of this model toward increasing mutagenic events in lung cancer are discussed.

140 sis, suggesting a requirement for additional mutagenic events or microenvironmental stimuli, includin

141 grammable manner and determined the order of mutagenic events that leads to development of glioblasto

142 Duplex sequencing detects rare mutagenic events, independent of selection and in multip

143 represent an important source of these hyper-mutagenic events.

144 ranslational fidelity of coding RNAs and the mutagenic evolution of viral RNA genomes.

145 viding new insights into the contribution of mutagenic exposures to cancer incidence.

146 eading mechanism to protect primer-ends from mutagenic extensions.

147 , and various other endogenous and exogenous mutagenic factors.

148 on bias, a parental age effect, and a highly mutagenic first cell division contributing to the embryo

149 TDG removes thymine from mutagenic G.T mispairs arising from deamination of 5-met

150 roducts (DBPs), some of which are cytotoxic, mutagenic, genotoxic, teratogenic, and potential carcino

151 agonistic/antagonistic endocrine activities, mutagenic/genotoxic activities, cytotoxic activities, fu

152 ference between faithful repair and wreaking mutagenic havoc on the genome lies in the accurate discr

153 of photoproducts in DNA that are potentially mutagenic if not properly removed by the nucleotide exci

154 fficiently recognizes and excises the highly mutagenic imidazole ring-opened AFB1-deoxyguanosine addu

155 with predictions derived from analyzing the mutagenic impact at the genome level for each entity.

156 of dasabuvir that significantly reduced the mutagenic impurity burden of the process.

157 ortantly, these dNTP imbalances are strongly mutagenic in genetic backgrounds where DNA polymerase fu

158 er-associated POLD1-R689W allele is strongly mutagenic in human cells.

159 Here, we discover that Z-DNA is mutagenic in yeast as well as human cells, and that the

160 ndings indicate that DNA binding by dCas9 is mutagenic in yeast, likely because dCas9 induces the for

161 Transcription is mutagenic, in part because the R-loop formed by the bind

162 the product of C-nitrosation of tyramine is mutagenic, in the present article tyramine nitrosation m

163 igh temperature (HT; 29 degrees C) is highly mutagenic, increasing the mutation rate to 12 x 10(-9) S

164 d expression of Polkappa was not excessively mutagenic, indicating that noncatalytic or other functio

165 at lower concentrations of the mixtures (not mutagenic individually), and decreased MF at higher conc

166 the consideration for obviating the risk of mutagenic insertion and enables more accurate controllin

167 media and by cryogenic storage, (2) identify mutagenic insertion sites and physical coordinates in th

168 genes, rendering these genes susceptible to mutagenic insults, with carcinogenesis accelerated by ge

169 slesion synthesis was seen to be potentially mutagenic leading to errors that are reminiscent of dA:8

170 the major DNA modifications and a potent pre-mutagenic lesion prone to mispair with 2'-deoxyadenosine

171 s in DNA transactions and failures to remove mutagenic lesions cause heritable genome changes.

172 n species generate potentially cytotoxic and mutagenic lesions in DNA, both between and within the nu

173 Etheno (epsilon) DNA base adducts are highly mutagenic lesions produced endogenously via reactions wi

174 However, mutagenic library construction methods often yield vastl

175 ropose that saturation mutagenesis under low mutagenic loads, followed by whole-genome sequencing, sh

176 Surprisingly, the mutagenic LTR retrotransposons differed in the active li

177 Unlike the mutagenic LTR retrotransposons identified previously, dR

178 lysis of concatemeric channels, which permit mutagenic manipulation of individual pores, show that ea

179 anocytes are primed for transformation via a mutagenic mechanism involving an excess of T>G substitut

180 Together, these data support a mutagenic mechanism of inhibition by NHC and further sup

181 These results point to a virus-mutagenic mechanism of NHC inhibition in CoVs and indica

182 e findings indicate that HR factors suppress mutagenic MMEJ following DSB resection.

183 athways to protect themselves from these pro-mutagenic modifications.

184 rmed during chlorination, such as the highly mutagenic MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H

185 has a chronic toxic effect and proved to be mutagenic, nephrotoxic, teratogenic, immunosuppressive,

186 e damaged chromatin and shifts DSB repair to mutagenic NHEJ, revealing a backup function of 53BP1 whe

187 error-free homologous recombination (HR) or mutagenic non-homologous end-joining(1).

188 iggers competition between error-free HR and mutagenic nonhomologous EJ.

189 nucleotide insertions/deletions (indels) via mutagenic nonhomologous end joining.

190 gation reveals that Msd specifically acts on mutagenic nucleobases such as 5-azacytosine and isoguani

191 (HF)) mutant virus was more resistant to the mutagenic nucleoside analogs ribavirin and 5-fluorouraci

192 l therapeutics for several viral infections, mutagenic nucleoside analogues, such as ribavirin and 5-

193 l mechanism is unveiled to explain why a pro-mutagenic nucleotide lesion (oxidized guanine, 8-oxoG) c

194 n strains obtained by selective pressure via mutagenic nucleotides or adaptation approaches.

195 ylguanine-DNA alkyltransferase (AGT) repairs mutagenic O6-alkylguanine and O4-alkylthymine adducts in

196 ted during successive steps in BER may prove mutagenic or lethal, making it critical that they be 'ha

197 as low toxicity in Daphnia magna, and is not mutagenic or phytotoxic.

198 We further show that mutagenic or posttranslational modifications of transmem

199 DNA structures, and therefore the subsequent mutagenic outcome, represent valuable tools to study DNA

200 elf-propagation in the genome with potential mutagenic outcomes.

201 ested, DAMP requires proteins scavenging the mutagenic oxidised nucleotide 8-oxo-dGTP.

202 Regulation of the BER pathway for mutagenic oxidized bases, initiated by NEIL1 and other D

203 homologous end joining and potentially other mutagenic pathways of DSB repair.

204 open reading frames and a large quantity of mutagenic peptides highly distinct from self, might cont

205 is(232) and His(237) We found that different mutagenic perturbations of His(232), just below the meta

206 gents for the purpose of correlating genomic mutagenic phenotypes with drug sensitivity.

207 in the same transcript, reducing the size of mutagenic plasmids and simultaneously simplifying their

208 s mutagenic TLS by preventing recruitment of mutagenic POL zeta.

209 sed significantly the DBP concentrations and mutagenic potencies for most pools and spas.

210 evidence that human precursors can increase mutagenic potencies of pools and spas and that this incr

211 The mutagenic potencies of samples from a brominated site co

212 Mutagenic potencies of samples from a chlorinated site c

213 onically exposed to PAH mixtures (p.o.), and mutagenic potency (MP) values were determined for five t

214 es that dose-additive predictions of mixture mutagenic potency based on the concentrations and potenc

215 sed from finished to tap to pool to spa; and mutagenic potency increased from finished/tap to pools t

216 d ribonucleotide 1,N (6)-erA in DNA exhibits mutagenic potential and can also alter the reading frame

217 rall, these results provide insight into the mutagenic potential and dual-coding nature of the major

218 ydroxy-2'-deoxyguanosine (8-oxo-dG) has high mutagenic potential as it is prone to mispair with deoxy

219 onse, may be important for understanding the mutagenic potential of food and the etiology of diet-ass

220 hESCs limit the mutagenic potential of Lig3-mediated EJ by DNA break end

221 However, the structural basis for the mutagenic potential of oxoA, which induces A to C mutati

222 Consistent with the low mutagenic potential of the beta-anomer in vitro, the mut

223 g a superior pharmacological profile with no mutagenic potential.

224 inference, N (7)-CH(3) dG have miscoding and mutagenic potential.

225 cular environments and furthermore that this mutagenic process can be regulated through histone acety

226 at maintains telomeres, acts upon a DSB in a mutagenic process termed telomere healing.

227 romosomal circular DNAs represent a multihit mutagenic process, with important functional and clinica

228 -derived rearrangements represent an ongoing mutagenic process.

229 process is much more specific than previous mutagenic processes and allows for targeting of nearly a

230 As a result, the combination of mutagenic processes can be identified in any query sampl

231 rs and can, for example, elucidate different mutagenic processes in different cancer groups.

232 tal exposures, DNA repair abnormalities, and mutagenic processes in individual tumors with implicatio

233 ion classes supporting a role for additional mutagenic processes in melanoma development in individua

234 s, identifies the combinations of underlying mutagenic processes including those related to infidelit

235 These mutagenic processes often produce characteristic mutatio

236 to identify the mutagens, and to reveal the mutagenic processes responsible for human cancer.

237 , and tissues carried signatures of distinct mutagenic processes such as oxidative DNA damage and tra

238 ield of molecular epidemiology are to assign mutagenic processes to orphan and newly discovered tumou

239 respect to their vulnerability to different mutagenic processes, and helped us to uncover pairs of g

240 pes, we reveal widespread asymmetries across mutagenic processes, with transcriptional ("T-class") as

241 dy of spontaneous or environmentally induced mutagenic processes.

242 se postcatalytic changes prevent potentially mutagenic processive synthesis by Rev1 and facilitate di

243 n tyramine is C-nitrosation, which generates mutagenic products.

244 ver, was essential for the generation of the mutagenic products.

245 R in RNase HII-deficient cells and the known mutagenic profile of DnaE, we propose that misincorporat

246 Non-mutagenic promoting agents, either endogenous or environ

247 The toxicological and mutagenic properties as well as the fate of these newly

248 Due to the inherent mutagenic properties of radiation exposure, however, thi

249 The mutagenic properties of ultraviolet radiation drive the

250 l use of NMs is limited because of their own mutagenic properties.

251 itizes the skin and causes the production of mutagenic reactive oxygen species.

252 anism to minimize the release of potentially mutagenic repair intermediates.

253 We propose that 53BP1 has evolved to avoid mutagenic repair outcomes and does so by controlling the

254 induced SCVs emerge via the SOS response DNA mutagenic repair system.

255 s DSB repair, enhancing efficiency of likely mutagenic repair, and enabling radiation and cisplatin t

256 termediates could generate both faithful and mutagenic repair.

257 A model is proposed for enhanced pro-mutagenic replication catalyzed by pol eta that couples

258 nent role of TLS in promoting proficient and mutagenic replication through AraC suggests that TLS inh

259 Pool and spa samples were 2.4 and 4.1x more mutagenic, respectively, than corresponding tap waters.

260 We determined the mutagenic response to mixtures of BaP and PhIP at concen

261 Hypervariation occurs via a mutagenic retrotransposition process from a template rep

262 ese results raise concerns about a potential mutagenic risk in patients receiving long-term therapy.

263 ombined properties are consistent with a pro-mutagenic role for pol eta when replicating this DNA les

264 efine conditions that may produce cnLOH as a mutagenic signature in cancer and may, conversely, promo

265 In particular, we identify C > G as a mutagenic signature of male meiotic double-strand breaks

266 ed subjects can be differentiated from other mutagenic signatures, we included data from an ultraviol

267 rm of STAT5 (Stat5b-CA) with mice in which a mutagenic Sleeping Beauty transposon (T2/Onc) was mobili

268 Using yeast as a model, we demonstrate that mutagenic ssDNA is formed at multiple positions along th

269 x with both agonists, combined with in vitro mutagenic studies revealed important residues for bindin

270 Mutagenic studies supported by molecular dynamic simulat

271 Based upon these and mutagenic studies, we propose an allosteric mechanism wh

272 sults suggest that r8-oxo-GTP is a potential mutagenic substrate for DNA polymerases and provide stru

273 been widely studied and demonstrated to be a mutagenic substrate for DNA polymerases.

274 ess conditions, Fapy*dGTP could become a pro-mutagenic substrate for insertion into the genome by DNA

275 we show that discrimination against the pro-mutagenic syn-conformation occurs at the extension step

276 odel to generate tumors upon activation of a mutagenic T2Onc2 transposon via expression of a transpos

277 pse or transcription arrest, or can serve as mutagenic templates during nucleic acid synthesis reacti

278 egative health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms.

279 Rubisco biogenesis in tobacco hindered their mutagenic testing by chloroplast transformation.

280 of brominated pool/spa waters were 1.8x more mutagenic than chlorinated ones; spa waters were 1.7x mo

281 r, yet Pole-P301R is at least ten times more mutagenic than Pole-exo- at each location analyzed.

282 chlorinated ones; spa waters were 1.7x more mutagenic than pools.

283 R is conservative, less processive, and more mutagenic than replicative DNA synthesis.

284 isms induced by oncogenic stress, the highly mutagenic theta-mediated end-joining (TMEJ) pathway, whi

285 vation of aberrant expression of RE posing a mutagenic threat.

286 JH-RE-06 inhibits mutagenic TLS and enhances cisplatin-induced toxicity in

287 -molecule inhibitor, JH-RE-06, that disrupts mutagenic TLS by preventing recruitment of mutagenic POL

288 th high specificity and in vivo efficacy for mutagenic TLS has been challenging.

289 n dNTP elevation is needed to facilitate non-mutagenic tolerance pathways, while Polzeta synthesis re

290 Because mutagenic translesion synthesis (TLS) contributes to che

291 REV1/POLzeta-dependent mutagenic translesion synthesis (TLS) promotes cell surv

292 While monoubiquitination activates mutagenic translesion synthesis, polyubiquitination acti

293 his hybrid RNA-cDNA molecule is required for mutagenic transposition, revealing a unique mechanism of

294 ecades-old data from mouse tumor models, non-mutagenic tumor-promoting agents have been posited to ac

295 The mutagenic uncoupling of femtosecond motions between cata

296 ficantly inhibits the removal of potentially mutagenic UVB-induced DNA photolesions by nucleotide exc

297 the most potent compound 26 was found to be mutagenic via the Ames test.

298 ds aiming to identify aromatic amines in six mutagenic wastewater effluents from a chemical-industria

299 Insertion of 8-oxoG is mutagenic when opposite adenine but not when opposite cy

300 show that the replicative polymerase DnaE is mutagenic within the sequence context identified in RER-