ライフサイエンスコーパス: mutagenicity

1 rase activity, which could underlie its high mutagenicity.

2 lead compounds were tested for toxicity and mutagenicity.

3 cranial Doppler ultrasonography, growth, and mutagenicity.

4 ied base pair size, consistent with its high mutagenicity.

5 reated plasmids confirmed a lack of acrolein mutagenicity.

6 P and a significant elevation in DDP-induced mutagenicity.

7 rs, such as DNA adduct levels, toxicity, and mutagenicity.

8 drial damage plays a crucial role in arsenic mutagenicity.

9 g properties of these lesions underlie their mutagenicity.

10 DNA intermediates in regulating AFB1-induced mutagenicity.

11 erocyclic amines (HCAs), benzo[a]pyrene, and mutagenicity.

12 ts and accounted for more than 90% of Cr(VI) mutagenicity.

13 three groups based on clinical phenotype and mutagenicity.

14 dvantage of the latter for the prediction of mutagenicity.

15 -induced oxidative stress, cytotoxicity, and mutagenicity.

16 tion of structure and context effects define mutagenicity.

17 cytotoxicity on human dermal fibroblasts nor mutagenicity.

18 biana, are potential candidates for in vitro mutagenicity.

19 ases do not contribute to the adduct-induced mutagenicity.

20 ith tetracycline TPs often showing increased mutagenicity.

21 s use and further research into V. cribbiana mutagenicity.

22 Overall, the air samples exhibited a weak mutagenicity.

23 ed to quantify directly its genotoxicity and mutagenicity.

24 ajor viral issues such as immunogenicity and mutagenicity.

25 ain (CTD) was found to be essential for high mutagenicity.

26 stability, GSH adduct formation, and aniline mutagenicity.

27 gested EDB extract inhibited oxidant-induced mutagenicity (26%) in the Salmonella typhimurium TA102 s

28 Derivatives 2g and 2d exhibited maximum anti-mutagenicity against Salmonella typhimurium TA 98 and TA

29 YP selectivity using a panel of CYP enzymes, mutagenicity (Ames screen), and hepatic stability.

30 marker expressions (CYP1A1, IL8, COX-2), and mutagenicity (Ames) show that RNG exhaust has toxicity t

31 Mutagenicity analysis showed that riboflavin treatment c

32 ) has received the most attention due to its mutagenicity and because of the possible correlation bet

33 ow that JB253 is well-tolerated with minimal mutagenicity and can be used to optically-control glucos

34 the historical and current evidence for the mutagenicity and carcinogenicity of AA, and the effect o

35 se two detrimental effects contribute to Acr mutagenicity and carcinogenicity.

36 toxicity but also provides a basis for their mutagenicity and carcinogenicity.

37 on the human body and eventually bring about mutagenicity and carcinogenicity.

38 tests excluded potential concerns regarding mutagenicity and cardiotoxicity, respectively.

39 Ames mutagenicity and CHO-K1 micronucleus assays were applied

40 seven sites, we report the first integrated mutagenicity and comprehensive analytical chemistry of s

41 ransferase (AGT) paradoxically increases the mutagenicity and cytotoxicity of 1,2-dibromoethane (DBE)

42 that Cr(VI) exposure can greatly enhance the mutagenicity and cytotoxicity of PAHs by inhibiting the

43 ity to induce apoptosis as well as for their mutagenicity and cytotoxicity.

44 on location, allowing accurate prediction of mutagenicity and enabling direct genotyping of mutant al

45 ted a modified piggyBac vector with improved mutagenicity and generated insertions in >2000 genes.

46 yet its presence is associated with elevated mutagenicity and genome instability.

47 hat Cr-DNA adducts were responsible for both mutagenicity and genotoxicity of Cr(VI).

48 groups have been extensively associated with mutagenicity and genotoxicity.

49 mprehensive toxicology assessment, including mutagenicity and maximum/repeated tolerated dose studies

50 perimental and clinical investigation of the mutagenicity and other hidden collateral costs of therap

51 recognized by GG-NER, explaining their high mutagenicity and persistence in target tissues.

52 consistent with observed activity as well as mutagenicity and photoaffinity cross-linking studies of

53 Both mutagenicity and pollutant emission factors may be infor

54 Mutagenicity and pollutant emission factors of solid-fue

55 te statistical approach we have examined the mutagenicity and potential consequences of adduct format

56 eference is likely to play a key role in the mutagenicity and repair of IQ-modified oligonucleotides.

57 In the present study, we assessed the mutagenicity and the genotoxicity of complete diesel exh

58 gnificant negative correlation between TALEN mutagenicity and the number of CpG repeats in TALEN targ

59 This coupling between mutagenicity and tolerance for expression variability of

60 ) provides a mechanism for the genotoxicity, mutagenicity, and carcinogenicity of PAHs.

61 ve metabolite of PAHs) induced cytotoxicity, mutagenicity, and DNA adduct formation in Chinese hamste

62 d PA, is highly toxic, causing liver damage, mutagenicity, and DNA cross-linking through metabolic ac

63 nds were subjected to in vitro cytotoxicity, mutagenicity, and estrogenicity studies.

64 Hepatic DNA adduct formation, in vivo mutagenicity, and hepatocarcinogenicity of MeIQx were ex

65 ng correlation between somatic and germ-line mutagenicity, and identified germ line mutations using Z

66 The mutagenicity/antimutagenicity of proteins and protein hy

67 thods for detecting exhaust genotoxicity and mutagenicity are needed to avoid the widespread applicat

68 mechanisms of nitrous acid cross-linking and mutagenicity, as well as the mechanisms responsible for

69 nd urinary mutagenicity using the Salmonella mutagenicity assay (Ames test).

70 y of the PM (determined using the Salmonella mutagenicity assay with TA98 strain), were measured prio

71 ombinant cytochrome P-450 2E1 Ames bacterial mutagenicity assay, the R597M/W677A protein increased th

72 ed-PAHs (NPAHs) and tested in the Salmonella mutagenicity assay, using Salmonella typhimurium strain

73 Mutagenicity was assessed by the Salmonella mutagenicity assay.

74 Comparative mutagenicity assays (Ames test) were performed on 1 vers

75 The Microscreen mutagenicity assays indicated that certain water column

76 ats but generally tests negative in standard mutagenicity assays.

77 rk showcases the utility of DS for effective mutagenicity assessment of environmental pollutants.

78 an complete exhaust is used for genotoxicity/mutagenicity assessment, which may reduce the reliabilit

79 Follow-up in vivo mutagenicity assessments will be required to validate th

80 such as in vitro phototoxicity and in vitro mutagenicity associated with compounds 1 and 2 or the in

81 tion and accounts for the surprising lack of mutagenicity associated with this DNA adduct.

82 All HCAs with S9 induced mutagenicity at 10(-10) mol/plate.

83 Without S9, IQ and MeIQ showed mutagenicity at 10(-8) mol/plate, MeIQx and Glu-P-1 at 1

84 The mutagenicity at such sites in many human genes is associ

85 f AZT (as measured by a competitive RIA) and mutagenicity at the HPRT and TK loci (as assessed by cel

86 carcinogen due to its high genotoxicity and mutagenicity attributed to its ability to form DNA-DNA c

87 enic heterocyclic amines (HCA), reducing HCA mutagenicity, but is itself also an antimicrobial agent

88 ity that the enhancement of cytotoxicity and mutagenicity by Cr(VI) is caused by the inhibition of NE

89 a and suggest that some efflux pumps prevent mutagenicity by exporting mutagenic products of metaboli

90 ential biological effects, such as toxicity, mutagenicity, carcinogenicity, and endocrine disrupter a

91 ion in a number of high-quality databases on mutagenicity, carcinogenicity, and skin sensitisation.

92 , and safety (EHS) reasons such as toxicity, mutagenicity, carcinogenicity, or for practical handling

93 kely to exhibit a similar or higher level of mutagenicity/carcinogenicity, respectively, than their p

94 n time prediction and finally toxic effects (mutagenicity caused by aromatic amines).

95 protective effects against the toxicity and mutagenicity caused by quinones.

96 protective effects against the toxicity and mutagenicity caused by quinones.

97 I)-DNA adducts play the dominant role in the mutagenicity caused by the metabolism of Cr(VI) by a bio

98 Bacterial mutagenicity correlated with micronucleus-forming activi

99 Also, rings identified in public domain mutagenicity data sets are compared to rings in drugs da

100 gs in drugs data sets; unfortunately, public mutagenicity data sets do not reflect the types of scaff

101 The distribution of ring systems in public mutagenicity databases is analyzed.

102 A photoproducts linked to skin cancer, whose mutagenicity depends in part on their frequency of forma

103 ing activities; however, the indirect-acting mutagenicity did not decline sharply with distance from

104 eveloped direct measurement of environmental mutagenicity (DMEM), a tool for mapping genome-wide inte

105 s of compounds contributing to surface water mutagenicity due to their widespread occurrence as precu

106 Nevertheless, the mutagenicity emission factor based on fuel energy used (

107 However, mutagenicity emission factors may be especially useful f

108 utagenicity emission factors, correlated the mutagenicity emission factors, and compared them to thos

109 fuel cookstoves for eight pollutant and four mutagenicity emission factors, correlated the mutagenici

110 polyaromatic hydrocarbon (PAH) and indirect mutagenicity emissions were detected with the DISI car.

111 intercalation as a likely mechanism for the mutagenicity-enabled modification of the core scaffold.

112 Cytotoxicity and induced mutagenicity experiments were measured in parallel in UV

113 de of action, specifically DNA adduction and mutagenicity, for aromatic amines, which may account for

114 ands-on mechanism-based guidelines to design mutagenicity-free ArNH(2).

115 In an effort to identify compounds with mutagenicity greater than that of ribavirin, we synthesi

116 For decades, mutagenicity has been observed in many surface waters wi

117 indings provide the first evidence of PFOS's mutagenicity in an aquatic model system.

118 in bacteria and mammalian cells and that its mutagenicity in Escherichia coli is dependent on inducti

119 scribed in this report directly examined the mutagenicity in Escherichia coli of both a deoxyadenosin

120 ctive in cisplatin-resistant tumors, but its mutagenicity in humans has not been reported.

121 es for the prediction of carcinogenicity and mutagenicity in methods described in the literature.

122 gnificantly higher level of genotoxicity and mutagenicity in nucleotide excision repair (NER)-deficie

123 , 6-ring positions were tested for bacterial mutagenicity in reverse-mutation assays using Salmonella

124 as similar for genotoxicity in CHO cells and mutagenicity in S. typhimurium, the Salmonella assay was

125 employed quantitative in vitro bioassays for mutagenicity in Salmonella typhimurium, and chronic cyto

126 2.5, levoglucosan (a wood-smoke marker), and mutagenicity in Salmonella.

127 Conversely, mixture mutagenicity in site-of-contact tissues (e.g., small int

128 Mechanistic analyses support a key role for mutagenicity in TCE-induced kidney carcinogenicity.

129 sh TLS in an error-free manner manifest high mutagenicity in the absence of WRN's exonuclease functio

130 g of an advanced compound revealed bacterial mutagenicity in the Ames test using TA97a Salmonella str

131 he particles and characterized the bacterial mutagenicity in the gas phase and the particles of the e

132 Among the 36 samples assayed for mutagenicity in the Salmonella bioassay (reported here),

133 - and UVB-induced DNA lesions in relation to mutagenicity in transgenic mouse fibroblasts irradiated

134 the first comprehensive investigation of SHS mutagenicity in vivo, in which we have established the m

135 l ZFN and TALEN target sites did not predict mutagenicity in vivo.

136 Determination of Fapy*dG mutagenicity in wild type and Pol beta knockdown HEK 293

137 be a large-scale comparison of ZFN and TALEN mutagenicity in zebrafish.

138 The direct-acting mutagenicity increased the most after NO3/N2O5 exposure,

139 of estrogenic effects, whereas the in vitro mutagenicity increased.

140 ion, as the absence of acute cytotoxicity or mutagenicity indicated.

141 cardio-, hepato-, and nephrotoxicity and no mutagenicity, indicating its "drug-like" potential.

142 ariations and sequence context also affected mutagenicity, indicating that a combination of structure

143 ffectively prevents BG-enhanced toxicity and mutagenicity induced by these agents.

144 angerous than nuclear traversal, because the mutagenicity is accomplished by little or no killing of

145 The mutagenicity is attributed to the C8- and N2-G adducts,

146 results strongly suggest that surface water mutagenicity is highly complex and driven by synergistic

147 Mutagenicity is increased in intergenic relative to geni

148 co-expressed with the methyltransferase its mutagenicity is kept in check.

149 vivo, how such events impact genome-wide MG mutagenicity is poorly understood.

150 re, our data indicate that the nature of the mutagenicity may not be identical for complete exhaust a

151 While such mutagenicity might undermine functionality of these elem

152 ibute to the much higher carcinogenicity and mutagenicity of (+)-BPDE-2 compared with its (-)-enantio

153 Our data indicate that DD suppresses the mutagenicity of (+/-)-anti-BPDE by producing BPQ, but in

154 at the C9 position led to elimination of the mutagenicity of 1, while a crucial hydrogen bond interac

155 ylguanine-DNA alkyltransferase increases the mutagenicity of 1,2-dibromoethane by reacting with it at

156 The results show that WLT inhibited the mutagenicity of 2-aminoanthracene (2-AA), an indirect mu

157 ML in the range of 1-5mg/plate inhibited the mutagenicity of 2-aminoanthracene (2-AA), an indirect mu

158 The results showed that WFI inhibited the mutagenicity of 2-aminoanthracene (2-AA), an indirect mu

159 Modulation of the cytotoxicity and mutagenicity of 4-hydroxyestradiol (4-OHE(2)), an oxidat

160 00 mumol/l, the five compounds inhibited the mutagenicity of 4-nitroquinoline-N-oxide, a direct mutag

161 respectively, by poleta indicating that the mutagenicity of 5-FU incorporation is higher in the pres

162 etic damage, as illustrated by the increased mutagenicity of 5-methylcytosine and the silencing of th

163 c studies provided a molecular basis for the mutagenicity of 5ClC; a snapshot of human polymerase bet

164 The mutagenicity of a prominent tobacco carcinogen, benzo[a]

165 ith chemoprotective properties to reduce the mutagenicity of AFB1, also proliferation of a cancer cel

166 ecific sites in DNA and the cytotoxicity and mutagenicity of alkylating agents.

167 Mutagenicity of ArNH(2) can be removed by structural alt

168 The mutagenicity of aromatic amines (AAs) and HCAs, measured

169 r current knowledge on the DNA adduction and mutagenicity of aromatic amines in relation to smoking-a

170 he radical scavenger DMSO, which reduced the mutagenicity of arsenic in these cells, and provide conv

171 dimethyl sulfoxide significantly reduces the mutagenicity of arsenite.

172 Lower toxicity and high mutagenicity of ascorbate-Cr(III)-DNA adducts in human c

173 We investigated the clastogenicity and mutagenicity of benzo[b]fluoranthene (BbF), one of 16 pr

174 ium-modified plasmids demonstrated increased mutagenicity of binary Cr(III)-DNA and ternary cysteine-

175 It is known that the cytotoxicity and mutagenicity of BPDE are mainly caused by the formation

176 ome resistance to DNA damage and much of the mutagenicity of bulky DNA adducts in dividing cells.

177 nockout cell lines reveal that the increased mutagenicity of clustered DSBs is primarily mediated by

178 r differences in the efficacy, toxicity, and mutagenicity of CP and OX.

179 The observed mutagenicity of Cr(III)-induced phosphotriesters demonst

180 rent forms of DNA damage in genotoxicity and mutagenicity of Cr(VI) activated by physiological concen

181 vestigated the effect of nitric oxide on the mutagenicity of crocidolite in G12 cells.

182 intracellular glutathione indicated that the mutagenicity of cytoplasmic irradiation depends on gener

183 an REV1 (hREV1) affects the cytotoxicity and mutagenicity of DDP.

184 ession and BER activity results in increased mutagenicity of dimethyl sulfate as evidenced by a 2-fol

185 However, there are no previous studies on mutagenicity of disinfected spa (hot tub) waters or comp

186 Neither toxicity nor mutagenicity of DSMZ16671 was detected.

187 This work explores lesion bypass and mutagenicity of EA replicated in vivo and demonstrates t

188 We determine the mutagenicity of EcN and three CRC-derived pks(+)E. coli

189 Assessment of the mutagenicity of emitted VOCs should consider VOC photoox

190 To take advantage of the mutagenicity of ENU and its ability to create allelic se

191 Standard tests of toxicity and mutagenicity of heat-killed DSMZ16671 were performed.

192 Furthermore, the mutagenicity of KP1212 was found to increase dramaticall

193 lly, a model is proposed that correlates the mutagenicity of KP1212 with its tautomeric distribution

194 ed the molecular mechanism(s) underlying the mutagenicity of KP1212, and specifically whether tautome

195 We investigated the in vivo mutagenicity of long-term thiopurine treatment by determ

196 The mutagenicity of M(1)dG in Escherichia coli is dependent

197 The results are consistent with the reported mutagenicity of M1dG and illustrate how the lesion may a

198 In contrast, the mutagenicity of m1G and m3T in AlkB(-) cells dropped sli

199 indicated that the SOS response enhances the mutagenicity of M1G and that M1G is a substrate for repa

200 ne technology, preliminary toxicology tests, mutagenicity of medicinal compounds, and other chemical

201 esculins were more efficient in reducing the mutagenicity of methyl methanesulphonate, by, respective

202 ly resistant to the cytotoxicity but not the mutagenicity of MNNG, presumably as a result of inactiva

203 tionary adaptation, which allows reconciling mutagenicity of non-B DNA structures with their location

204 ansgenic rodent mutation assay to assess the mutagenicity of nonpolar neutral and semipolar aromatic

205 lowered both the direct and indirect acting mutagenicity of NPAHs and may result in an underestimati

206 dTTP opposite O6mG and may contribute to the mutagenicity of O6mG.

207 ed model, yOgg2 activity should increase the mutagenicity of OG lesions.

208 This work reports the mutagenicity of oxanine as well as oxanine DNA glycosyla

209 The mutagenicity of oxoG is attributed to the lesion's abili

210 The structural basis for the mutagenicity of oxoG, which induces G to T mutations, is

211 The results suggest that much of the mutagenicity of oxopurines arises from their shapes in t

212 Mutagenicity of particle extracts was less efficiently d

213 transgenic medaka, to evaluate the potential mutagenicity of PFOS in vivo following a subchronic expo

214 nerating stable thioureas, may also decrease mutagenicity of processed meat.

215 To study the mechanism of mutagenicity of psoralens in humans, we examined the eff

216 The mutagenicity of ribavirin results from the incorporation

217 rong protection against sodium azide induced mutagenicity of Salmonella typhimurium strains TA 98 and

218 To determine sequence preferences and mutagenicity of SB-mediated transposition, we cloned and

219 The organ-specific mutagenicity of SHS is most pronounced in the lung and r

220 target site methylation may explain the poor mutagenicity of some TALENs in vivo.

221 To determine the mutagenicity of TA* in Escherichia coli, we constructed

222 ene expression are discussed in light of the mutagenicity of TA*.

223 We investigated DNA adduct-targeted mutagenicity of tamoxifen as a function of its genotoxic

224 Non-targeted mutations may enhance overall mutagenicity of the 10S-BPDE-dG lesion and contribute to

225 isomers accounted between 4.2 and 86% of the mutagenicity of the blue rayon extracts and may be bypro

226 Mutagenicity of the exhaust was low compared to previous

227 s well as nonregulated emissions such as the mutagenicity of the exhaust.

228 PAH emissions and mutagenicity of the exhausts were generally low, with HV

229 aromatic hydrocarbons (PAHs), and bacterial mutagenicity of the exhausts.

230 s may play a role in the carcinogenicity and mutagenicity of the parent hydrocarbons.

231 The bioavailability, pharmacokinetics and mutagenicity of the pigments were predicted using bioinf

232 adducts can affect both the cytotoxicity and mutagenicity of the platinum adducts.

233 s, as well as the direct and indirect-acting mutagenicity of the PM (determined using the Salmonella

234 The potential mutagenicity of the primary guanine oxidation product 8-

235 rain designed to bioactivate MeIQ and detect mutagenicity of the products.

236 We studied the mutagenicity of the proximate bladder carcinogen, N-hydr

237 suggests that this could greatly affect the mutagenicity of these lesions in vivo.

238 ng differences in the efficacy, toxicity and mutagenicity of these platinum anticancer agents.

239 he differences in tumor range, toxicity, and mutagenicity of these two important chemotherapeutic age

240 ion(s) that gives rise to this mutation, the mutagenicity of three oxidized cytosines, 5-hydroxycytos

241 s further suggest that asbestos enhances the mutagenicity of tobacco carcinogens and that it acts, at

242 Site-specific mutagenicity of trans-opened adducts at the exocyclic N(

243 In this study, we have investigated the mutagenicity of two model reactive intermediates of tamo

244 ere, we present data on general toxicity and mutagenicity of upper water column waters and, to a less

245 We investigated the mutagenicity of UVA alone and in combination with delta-

246 Here, we investigated the mutagenicity of UVA in relation to its DNA damaging effe

247 Notably, the 8-oxo-dG-mediated mutagenicity of UVA plus delta-ALA is similar to that es

248 y change the toxicity (oxidative capacity or mutagenicity) of biogas combustion exhaust.

249 idely used to study the biological activity (mutagenicity) of C(8)-arylamine-dG adducts with adduct c

250 ndent pathways for 1,2-dibromoethane-induced mutagenicity, one involving Gua N7-alkylation by alkyltr

251 he identification of signatures that predict mutagenicity or carcinogenicity.

252 n this context, efforts toward the structure-mutagenicity or structure-genotoxicity relationships hav

253 herefore, the previously reported increasing mutagenicity per dimer with increasing wavelengths canno

254 (4-HNE-dG) adducts, but its genotoxicity and mutagenicity remain elusive.

255 icant inhibitory effect of 2-aminoanthracene mutagenicity (respectively 82.4% and 79.3% in the presen

256 and models in DNA allowed resolution of the mutagenicity risk, affording molecules with favorable po

257 plore the application of in vitro assays for mutagenicity (Salmonella mutation assays) and cytotoxici

258 However, due to its weak mutagenicity, short chemical half-life, and the absence

259 Average post-event levels of urinary mutagenicity showed a significant, event-related 4.3-fol

260 rmining their selectivity and also performed mutagenicity studies.

261 s, such a nitro groups, for the outcome of a mutagenicity study.

262 Its relatively low contribution to mutagenicity suggests that other newly discovered DNA po

263 m TA100 and Chinese hamster V79) of standard mutagenicity tests treated with 1-MIM glucosinolate/myro

264 eatment leads to a positive response in Ames mutagenicity tests, which is then removed after granulat

265 ties with poor detectability by the standard mutagenicity tests.

266 uration mostly being associated with greater mutagenicity than the R configuration.

267 ously developed linear regression models for mutagenicity that include log(k(az)/k(s)) as an independ

268 mechanisms for combating DNA damage, and the mutagenicity that ultimately may lead to liver cancer.

269 their relative contribution to the acrolein mutagenicity, the genotoxic properties of alpha-OH-PdG a

270 Assuming little-biased mutagenicity, the results allow for an estimation of the

271 entified were not responsible for the sample mutagenicity, the structure-generation-based identificat

272 d be refined to reduce the potential risk of mutagenicity to consumers.

273 known DNA-damaging effects of acrolein, its mutagenicity to mammalian cells remains uncertain.

274 problems of classification and prediction of mutagenicity, toxicity and anti-cancer activity on three

275 Last, AVS100 showed no mutagenicity, toxicity, or adverse effects in preclinica

276 wipes and personal air samples, and urinary mutagenicity using the Salmonella mutagenicity assay (Am

277 Mutagenicity was abrogated for m1A, m3C, and e3C in wild

278 Moreover, their potential mutagenicity was also assessed.

279 Remarkably, m1G mutagenicity was also eliminated in AlkB(+) cells, estab

280 Mutagenicity was assessed at the thymidine kinase (TK) l

281 Mutagenicity was assessed by the Salmonella mutagenicity

282 No mutagenicity was confirmed according to the OECD guideli

283 Mutagenicity was determined by the standard plate incorp

284 In general, mutagenicity was higher with S9 hepatic microsomal activ

285 ning techniques based on these results, Mos1 mutagenicity was increased to within an order of magnitu

286 In bone marrow, mixture mutagenicity was less than dose-additive and the PEF-met

287 Moreover, MeIQx mutagenicity was lowered in the presence of ITCs, as wel

288 Cisplatin mutagenicity was most pronounced in xpf-1 mutants, sugge

289 The rank order of mutagenicity was N-nitrosodimethylamine (NDMA)>N-nitroso

290 The highest indirect-acting mutagenicity was observed for sites closest to mining ac

291 Mutagenicity was observed in Salmonella typhimurium TA98

292 3C in wild-type (AlkB(+)) cells, whereas m3T mutagenicity was only partially reduced.

293 The reduction of mutagenicity was particularly observed in the condensate

294 and subsequent study demonstrated that this mutagenicity was pervasive throughout the series.

295 No mutagenicity was seen in S. typhimurium TA100 or Escheri

296 Indirect-acting mutagenicity was strongly correlated with levels of tota

297 Radiation-induced toxicity and mutagenicity was then compared among p53-null cells, TK6

298 olic stability, cytotoxicity, and absence of mutagenicity were determined for selected analogues.

299 containing compounds also contributed to the mutagenicity when aromatic amines were present.

300 e of attached side chains appeared to induce mutagenicity with these agents, although other studies h