ライフサイエンスコーパス: mutated form

1 s showed a complete lack of secretion of the mutated form.

2 therapeutic targeting of p53, especially the mutated forms.

3 th expression constructs for both normal and mutated forms.

4 g its over-expression in either wild-type or mutated forms.

5 nvestigate the molecular properties of these mutated forms and their relationship with the resulting

6 then to the midzone during mitosis, but the mutated forms are detected at greater intensities.

7 and 94 formed stable complexes only with the mutated forms, causing their retention in the ER.

8 ndard Escherichia coli L-ASP to predict what mutated forms could be engineered to retain activity aga

9 Its mutated form, D290V, is implicated in multisystem protei

10 sensor kinases such as ataxia telangiectasia-mutated, forming gamma-H2AX.

11 and their N-terminal lobes, in wild-type and mutated forms, has been successfully accomplished by sev

12 COL7A1 promoter GT-rich element but not its mutated form in gel mobility shift assays.

13 ms fibrils both under cellular stress and in mutated form in neurodegenerative conditions.

14 abeled consensus sequence STAT6, but not its mutated form, inhibits NF-kappaB binding.

15 alpha-syn degradation, suggesting that this mutated form is a bona fide substrate of this degradatio

16 Such a mutated form is predominantly targeted to plastids at th

17 at GOLD36 is a vacuolar protein and that its mutated form is retained in the ER.

18 of decorin proteoglycan or protein core as a mutated form lacking any glycosaminoglycan side chains i

19 In contrast, a mutated form, lacking two cysteine palmitoylation sites,

20 tutively activated in AML and thus, like its mutated form, might contribute to the altered signaling

21 es indicated that immunization with a single mutated form of 3D7 AMA1 was sufficient to increase the

22 d Ctk1), a histone demethylase (Jhd2), and a mutated form of a nucleosome-remodeling factor (Spt6) th

23 induce MCF, a recombinant virus expressing a mutated form of A10 unable to phosphorylate its tyrosine

24 A mutated form of AF endonuclease with its first 60 residu

25 A(.) We have also solved the structures of a mutated form of ALDH2 where Arg-475 is replaced by Gln (

26 etected in the early secretory pathway and a mutated form of BACE1 that retains its prodomain cleaves

27 dent assays document that cells expressing a mutated form of Bves are severely impaired in the recycl

28 -ray scattering (SAXS) analysis shows that a mutated form of c-Abl, in which the N-terminal cap and t

29 v-Rel is a truncated and mutated form of c-Rel and transforms cells by inducing t

30 of the misfolded protein mimics zeolin or a mutated form of carboxypeptidase Y (CPY*) also induced a

31 nchial epithelial cells with a functional or mutated form of CF transmembrane conductance regulator.

32 By contrast, a mutated form of Cosmc observed in patients with Tn syndr

33 This mutated form of Cot also acts as a dominant negative for

34 Unexpectedly, a cell line expressing a mutated form of CR3 deficient in the cytoplasmic domains

35 logy showed that cortical expression of this mutated form of CREB during monocular deprivation preven

36 Membrane targeting of a tyrosine-mutated form of Crk could overcome inhibition of NK cell

37 ased on specificity studies conducted with a mutated form of cSN50, a functional nuclear localization

38 animals treated with anti-CD80 mAb or with a mutated form of CTLA4Ig (which does not bind to CD86) re

39 A destruction box-mutated form of cyclin B (cyclin B triple-point mutant [

40 Herein, a crystallizable mutated form of CYP3A7 was saturated with its primary en

41 dGal-1 binding, we examined the binding of a mutated form of dGal-1 that weakly dimerizes (monomeric

42 tedly, overexpression of a dominant negative mutated form of Fas-associated death domain protein (FAD

43 ogenase (D-LDH) activity was identified as a mutated form of glycerol dehydrogenase (GlyDH; D121N and

44 -induced cell proliferation, whereas a point-mutated form of Grb14 incapable of binding to FGFR1 enha

45 roteasomal activity, expression of the R120G mutated form of HspB5 (associated with myofibrillar myop

46 (90-94 hours after egg laying) expressing a mutated form of human alpha-Syn (A53T) in dopaminergic (

47 This led to the identification of a mutated form of human CDC27, which gave rise to an HLA-D

48 We created a novel mutated form of human interleukin-13 (IL-13) in which a

49 e groups of mice engineered to overexpress a mutated form of human SOD1 (SOD1(G93A)) resulted in an e

50 w PRG-PRP system that employs, as the PRG, a mutated form of human thymidine kinase 2 (TK2) and 2'-de

51 ial epithelial cells overexpressing a kinase-mutated form of IkappaB kinase beta (IKKbeta-KM), the ac

52 terrupted by stable transfection of a kinase-mutated form of IkappaB kinase beta (IKKbeta-KM).

53 activation by stable expression of a kinase-mutated form of IkappaB kinase caused increased and prol

54 vity using an adenoviral vector expressing a mutated form of IkappaBalpha.

55 s encoded NKG2D binding protein (OMCP) and a mutated form of IL-2 with poor affinity for IL-2Ralpha.

56 l neuronopathy is caused by infection with a mutated form of JCV, leading to a shift in viral tropism

57 The P-loop mutated form of K13Q CooC was generated by site-specific

58 We found that a mutated form of KlenTaq DNA polymerase, i.e., KTqM747K,

59 estored U50,488-CPA, whereas expression of a mutated form of KOR that could not initiate p38alpha MAP

60 contrast, lentiviral expression in DRN of a mutated form of KOR that fails to activate p38 MAPK requ

61 However, cells expressing a mutated form of KSR1 unable to bind ERK did not recover

62 anced whole-cell K(+) currents produced by a mutated form of Kv2.1 mimicking apoptosis in a mammalian

63 Expression of a mutated form of Lck lacking SH3 domain function (LckW97A

64 Our results indicate that having a mutated form of LEC1 gene in K. daigremontiana is essent

65 tion-time of flight/mass spectrometry of the mutated form of lipomannan shows a family of phosphatidy

66 Surprisingly, a point-mutated form of LOXL2 (LOXL2(Y689F)) lacking enzymatic a

67 We studied mice that expressed a mutated form of Mecp2 that encodes the S80A substitution

68 Cells expressing a noncleavable mutated form of membrane-anchored HB-EGF demonstrated in

69 Larvae with only this mutated form of Msn show a marked disruption in photorec

70 -in mouse in which Munc18-1 is replaced by a mutated form of Munc18-1 that cannot be phosphorylated.

71 ull-length mVps24p are co-transfected with a mutated form of mVps4p (which is defective in ATP hydrol

72 ation by both MyoD and myogenin, including a mutated form of myogenin in which two potential inhibito

73 re transduced with lentiviruses expressing a mutated form of nucleophosmin (NPM1), referred to as NPM

74 otor neuron degeneration 2 mice that carry a mutated form of Omi that affects its proteolytic activit

75 ce either lacking SKP2 or expressing a T187A mutated form of p27(Kip1).

76 Although class II associated with the mutated form of p41 is initially retained in the endopla

77 Ectopic expression of p53R175H, a mutated form of p53 that does not bind DNA or regulate t

78 in cells in a p53-dependent manner and by a mutated form of p53 that is competent in inducing apopto

79 A point-mutated form of PC4 within the C-terminal domain beta-ri

80 the Fv fragment of an antibody is fused to a mutated form of PE, induces apoptosis of the MCF-7 breas

81 We used a mutated form of plasminogen activator inhibitor type 1 t

82 Sporozoites expressing a mutated form of Plasmodium berghei PKG or carrying a del

83 are, however, reversed by the presence of a mutated form of pRB which cannot be hyperphosphorylated.

84 However, a mutated form of prune that has replacement of four aspar

85 t immunotoxin comprised of human IL-13 and a mutated form of Pseudomonas exotoxin (IL-13-PE) might af

86 f a chimeric protein composed of IL-13 and a mutated form of Pseudomonas exotoxin (IL13-PE38QQR) to c

87 imeric fusion protein comprising IL-13 and a mutated form of Pseudomonas exotoxin (termed IL13-PE38QQ

88 prised of a circularly permutated IL-4 and a mutated form of Pseudomonas exotoxin [IL4(38-37)-PE38KDE

89 ric protein composed of interleukin-13 and a mutated form of Pseudomonas exotoxin A, IL13-PE38QQR.

90 composed of a targeting moiety (IL-4) and a mutated form of Pseudomonas exotoxin.

91 n which circular-permuted IL-4 is fused to a mutated form of Pseudomonas exotoxin.

92 Exogenous overexpression of a mutated form of PTEN with enhanced phosphatase activity

93 ded when infecting with a virus encoding the mutated form of pUL21 that lacks the ability to activate

94 red with Ad-GFP or PBS controls, whereas the mutated form of Rad GTPase, which can bind GDP but not G

95 The expression of a mutated form of Ras in A549 epithelial cells blocked the

96 specific alterations were not seen when the mutated form of Six3 cDNA was used in similar experiment

97 ormal levels by wild-type SOS2, but not by a mutated form of SOS2 lacking the T168 residue phosphoryl

98 Furthermore, overexpression of a mutated form of STRAD, underlying the disorder polyhydra

99 Expression of a mutated form of synapsin that prevents phosphorylation a

100 The coexpression of TAZ, but not a mutated form of TAZ that lacks TEAD binding, with platel

101 ly, the only selectable marker is gyrB(r), a mutated form of the chromosomal gyrB gene that encodes t

102 d-type form of Vigna aconitifolia P5CS and a mutated form of the enzyme (P5CSF129A) whose feedback in

103 ransgenic mouse model of AD overexpressing a mutated form of the human amyloid precursor protein (APP

104 olfactory system in mice that overexpress a mutated form of the human amyloid-beta precursor protein

105 d mitogenic defects of cells expressing this mutated form of the human CSF-1 receptor.

106 independent MKR transgenic mice expressing a mutated form of the human insulin-like growth factor 1 r

107 ssay system is demonstrated in an assay of a mutated form of the human pancreatic ribonuclease gene i

108 odel of ALS (G93A-SOD1) that overexpresses a mutated form of the human SOD1 gene that is a cause of f

109 described a fusion protein between Cre and a mutated form of the ligand binding domain of the estroge

110 uitination was also observed for an inactive mutated form of the molecule (M1WI), suggesting that MAR

111 inant negative inhibition of the HIV PR by a mutated form of the protease and found relative dimeriza

112 uence by combining the high sensitivity of a mutated form of the protein pore Mycobacterium smegmatis

113 ngtin gene, which drives the toxicity of the mutated form of the protein.

114 The mutated form of the receptor is constitutively activated

115 roduction in a receptor chimera expressing a mutated form of the rPAFR3i domain (rPACAPR2/rPAFR3imut)

116 ontrol of the scaffold protein STM, a triply mutated form of the stable intracellular protein inhibit

117 We report that a mutated form of the transcription factor Mafa (Mafa(4A))

118 d inhibition of the proteolytic process by a mutated form of the ubiquitin-conjugating enzyme Ubc4.

119 either wild type full-length Six3 cDNA or a mutated form of this gene in which the interaction with

120 products and to activate JNK, while a kinase-mutated form of this protein showed no activation.

121 By contrast, a mutated form of this receptor fails to activate the MAP

122 A mutated form of triosephosphate isomerase, isolated by a

123 A mutated form of truncated proplasmepsin 1 (proPfPM1) fro

124 Interestingly, expression of this mutated form of XPF in the XPF-deficient Chinese hamster

125 e membrane association of both wild type and mutated forms of 3AB.

126 Finally, while AlHV-1 mutants expressing mutated forms of A10 devoid of ITAM or SH3 motifs (or bo

127 an antibody to Vif; upregulation of A3G; and mutated forms of A3G.

128 ed weak inhibition of HDV RNA replication by mutated forms of ADARs defective for deaminase activity.

129 Certain mutated forms of Akt induce oncogenic transformation in

130 in cell lines harboring either wild type or mutated forms of ALK.

131 In addition, point-mutated forms of AP-2alpha within the activation domain

132 Analysis of mutated forms of apoA-I and oxidized apoA-I treated with

133 in the Wnt pathway, we generated a series of mutated forms of Axin.

134 Studies using the mutated forms of beta2-chimerin revealed that these effe

135 necessary for an ethylene response, because mutated forms of both LeETR4 and LeETR5 confer dominant

136 Three mutated forms of BRCA1 (A1708E, M1775R and Y1853X), that

137 Two mutated forms of BRCA1, a missense (A1708E) and a nonsen

138 ht function during B cell development, seven mutated forms of Bright were produced.

139 hreonine) residue but fails to phosphorylate mutated forms of C(4) PEPc in which this specific site h

140 hybridomas transfected to express native or mutated forms of CD4, it was determined that IL-16/CD4 i

141 hybridomas transfected to express native or mutated forms of CD4, it was determined that IL-16/CD4 i

142 Conversely, mutated forms of CLRN2, identified in patients with post

143 hesion properties of fractalkine, we created mutated forms of CX3CR1 that have little or no ability t

144 Truncated and mutated forms of Desmolaris determined that Arg32 in the

145 Studies looking at mutated forms of Dishevelled suggested that stable recru

146 monomers and homodimers of the wild-type and mutated forms of EGFR ELREA and L858R, as well as of two

147 and 430 of enolase in A. hydrophila SSU; the mutated forms of enolase were hyperexpressed in Escheric

148 ed for complementation and for expression of mutated forms of essential genes.

149 Although the mutated forms of F10 were stable and concentrated in vir

150 We found that both wild-type and mutated forms of Fhit bind to tubulin strongly and speci

151 ssion, binding, and G protein coupling of 28 mutated forms of FPR in stably transfected Chinese hamst

152 cells, wild-type and several amino-terminal mutated forms of gamma-catenin had similar transforming

153 protein, we restored the localization of the mutated forms of Gar1 and Nhp2.

154 Mutated forms of gB were expressed in U373 glioblastoma

155 mouse to determine whether the expression of mutated forms of GluR2 can rescue WT synaptic responses.

156 Using these gangliosides and mutated forms of HCR/T that lacked one or both carbohydr

157 uires the presence of active enzyme, because mutated forms of heparanase lacking heparan sulfate-degr

158 begin to address these mechanisms, different mutated forms of HSV-1 TK at residue Gln-125 that have d

159 We then investigated mutated forms of hTR and dyskerin that are associated wi

160 cells expressing full-length and selectively mutated forms of human, murine, and human/murine chimeri

161 40 and Asp1-Glu3 and Lys16-Glu22 of Abeta42) mutated forms of IDE and NMR structures of the full-leng

162 In this regard, we have shown that various mutated forms of IkappaBalpha are potent inhibitors of o

163 clear proteins and viral antigens we studied mutated forms of influenza virus nucleoprotein (NP) that

164 olite 2-hydroxyglutarate (2HG), generated by mutated forms of isocitrate dehydrogenase (IDH1 and IDH2

165 Mutated forms of KIR2DL4 were engineered that lacked eit

166 By examining the effects of mutated forms of LIN-12 and reduced wwp-1 or alx-1 activ

167 s that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10

168 Both scrambler and yotari mice express mutated forms of mdab1 messenger RNA and little or no mD

169 By using wild-type and mutated forms of merlin and phospho-directed antibodies,

170 antly impaired in neurons expressing disease-mutated forms of MFN2.

171 re heteroplasmic, meaning that wild type and mutated forms of mitochondrial DNA (mtDNA) coexist in th

172 binding properties of native, precursor, and mutated forms of mitochondrial ssDNA-binding protein (mt

173 Mutated forms of mtSSB bearing amino acid substitutions

174 s as a homotrimer, and expression of several mutated forms of NF7 in oocytes demonstrated that both t

175 Those mutated forms of NIT2 that are insensitive to nitrogen r

176 signal transduction and the activity of the mutated forms of NOTCH1 found commonly in human T cell a

177 ls of breast cancer induced by wild-type and mutated forms of oncogenic ErbB2 or the polyomavirus mid

178 tation was mediated by functionally inactive mutated forms of P-glycoprotein.

179 nts in vitro yielded both the native and the mutated forms of P90, indicating that the protease prese

180 Previously, some mutated forms of PA, designated dominant negative (DN),

181 sent in cases of familial PD associated with mutated forms of parkin.

182 vestigated in 3T3-L1 cells stably expressing mutated forms of perilipin using microscopy.

183 to lipid droplets coated with perilipin A or mutated forms of perilipin with an intact C-terminal seq

184 Here, we report studies of the affinities of mutated forms of Pex5p for a series of PTS1 peptides and

185 However, inhibitors of PKC and mutated forms of PKB, both of which are known downstream

186 ibits both wild-type and clinically relevant mutated forms of Plasmodium falciparum (Pf) DHFR.

187 arly to cells expressing either wild type or mutated forms of PSGL-1 in both flow cytometric and roll

188 Importantly, mutated forms of Rap also affect cytokinesis in other or

189 Mutated forms of Ras are involved in approximately 30% o

190 Although mutated forms of ras are not associated with the majorit

191 s of cell lines expressing wild type (WT) or mutated forms of ras or rac were generated and analysed

192 ed a library of plasmids expressing randomly mutated forms of recombinant VacA and identified 10 muta

193 Two mutated forms of RFX5 act as dominant negative proteins

194 of hematopoietic CD34(+) cells coexpressing mutated forms of RUNX1 and CSF3R.

195 These highly mutated forms of SARS-CoV-2 had enhanced rates of transm

196 riments in chicken embryos with the selected mutated forms of Sema6b expressed in commissural neurons

197 he pathogenicity of these variants, selected mutated forms of Sema6b were overexpressed in Human Embr

198 opathy), or expression of the G985R and G93A mutated forms of superoxide dismutase 1 (linked to famil

199 Using various mutated forms of synapsin Ia that prevent phosphorylatio

200 Here, studies with mutated forms of TBP demonstrate that dTAF(II)230-(2-81)

201 y 55% amino acid identity with Ras proteins, mutated forms of TC21 exhibit the same potent transformi

202 d in the brain of transgenic mice expressing mutated forms of the amyloid precursor protein (Tg2576 m

203 i1-5 and bri1-9 mutant plants, which harbour mutated forms of the brassinosteroid receptor BRI1.

204 Crosses involving lines with mutated forms of the CENH3 histone variant that organize

205 Wild-type and mutated forms of the CTP were overexpressed in Escherich

206 hen cells were transfected with wild-type or mutated forms of the decoy ODNs.

207 cific activities of native StxA1, as well as mutated forms of the enzyme with substitutions in cataly

208 pha, beta1, gamma2, pi, and sigma) and three mutated forms of the horse enzyme.

209 disorder associated with the aggregation of mutated forms of the huntingtin protein containing polyg

210 Murine thymoma cell lines expressing mutated forms of the mdr1b P-glycoprotein were isolated

211 The mutated forms of the PDH had a 10-fold-higher K(i) for N

212 Most mutated forms of the protein, however, display markedly

213 We demonstrate here, through analysis of mutated forms of the protein, that the non-canonical nin

214 Here we examine three mutated forms of the prrB gene that have the potential t

215 activity and fibrinogen binding of different mutated forms of the receptor.

216 e and characterized yeast strains expressing mutated forms of the RNA using a gene shuffle technique.

217 e expressed constructs coding for native and mutated forms of the two major splice variants of the pe

218 research and high vaccination rates, highly mutated forms of the virus continue to circulate.

219 are needed to combat the rapid emergence of mutated forms of the virus that are resistant to existin

220 s and OTRs with GRKs and PKC, wild types and mutated forms of these receptor subtypes were stably exp

221 omote biliary excretion of sterols, and that mutated forms of these transporters predispose to sterol

222 Functional studies with mutated forms of TopBP1 and Nbs1 suggested that the BRCT

223 Extracts containing mutated forms of toxin failed to cause host cell death,

224 ere are two periods of selection against the mutated form, one early on possibly during satellite cel

225 wild-type yeast profilin gene (PFY1) with a mutated form (pfy1-111) that has codon 72 changed to enc

226 ransferase*amphiphysin-SH3 domain, but not a mutated form that cannot bind to dynamin, inhibited both

227 ts expressing cDNA encoding wild type MPO or mutated forms that do not acquire heme.

228 igand binding truncated form, LBD (T), and a mutated form (Thr-->Ala substitution) identified in the

229 beta-catenin, for which only amino-terminal mutated forms transform RK3E epithelial cells, wild-type

230 mice that expressed either the wild-type or mutated forms, using cDNA clones encompassing only the c

231 nel of monoclonal antibodies showed that the mutated forms were indistinguishable from wild-type gB i

232 NOC and a mutated form, which lacks deadenylase activity, bind to

233 of the wild-type enzyme and its specifically mutated forms Y149F, S124A, S124V, and S124T.