ライフサイエンスコーパス: mutationally

1 gh shear stress, and verified its importance mutationally.

2 We examined mutationally a two-hairpin structure (nucleotides 57 to

3 of prsA2 mutant strains in the presence of a mutationally activated allele of the virulence regulator

4 However, a mutationally activated alpha s (alpha sR201C) is diffuse

5 rmal growth factor receptor (EGFR), which is mutationally activated and/or overexpressed in a wide va

6 tion, confirming that the three FAD-APPs are mutationally activated APP695.

7 these malignancies, the PI3K pathway is not mutationally activated as in many other cancers, but it

8 -Ras, that promote oncogenesis when they are mutationally activated at codon 12, 13, or 61.

9 Mutationally activated BRAF is detected in approximately

10 Mutationally activated BRAF(V600E) (BRAF(VE)) is detecte

11 In contrast, mutationally activated BRAF(V600E), a KRAS effector, fai

12 th elevated tumoural PBF/PTTG expression and mutationally activated BRAF.

13 inhibitor, sodium vanadate, or expression of mutationally activated c-Src resulted in enhanced curren

14 ion by the same Galpha proteins; conversely, mutationally activated Cdc42 stimulates the JNK pathway

15 g activities that determine addiction to the mutationally activated EGFR in human lung cancer cells.

16 es in relation to aberrant overexpression of mutationally activated erbB-2/neu.

17 endogenous patterning: ectopic expression of mutationally activated FAST-1, ectopic expression of dom

18 Together, our results demonstrate that mutationally activated FGFR4 acts as an oncogene, and th

19 y proteins that specifically interact with a mutationally activated form of Galpha(z).

20 identify proteins that could interact with a mutationally activated form of Gzalpha.

21 The presence of a mutationally activated form of PrfA, known as PrfA*, inc

22 increased secretion by strains containing a mutationally activated form of prfA, the key regulator o

23 naling defects, even in strains expressing a mutationally activated G alpha-subunit, which activates

24 The introduction of mutationally activated G12 proteins into K562 cells expr

25 utations are biochemically distinct, and how mutationally activated Galpha are unique compared with G

26 tivation and unique mechanisms that regulate mutationally activated Galpha in cells.

27 t described activation of Akt in response to mutationally activated Galpha(q) and Galpha(i) transfect

28 Moreover, the mutationally activated Galpha12 and Galpha13 stimulated

29 lls stably expressing specific NHE isoforms, mutationally activated Galpha12 inhibited NHE1 activity

30 Transient expression of mutationally activated Galpha12 inhibited serum- and Gal

31 for beta-catenin degradation, expression of mutationally activated Galpha12 or Galpha13 causes an in

32 In contrast, mutationally activated Galpha13, another member of the G

33 assa, we examined properties of strains with mutationally activated gna-1 alleles (R178C or Q204L) as

34 that just such dysregulation resulting from mutationally activated GRK4 contributes to the heritable

35 e that is stimulated by Mg2+, forskolin, and mutationally activated Gsalpha.

36 ia coli extract that can efficiently convert mutationally activated GTP-bound Ras to the inactive GDP

37 d Akt activation resulting from betagamma or mutationally activated H-Ras co-transfection in these ce

38 Expression of mutationally activated H-Ras fails to activate Rin in no

39 Ras proteins are mutationally activated in a variety of human cancers.

40 a catalytic subunit of PI3 kinase (PI3K), is mutationally activated in cancer and in overgrowth disor

41 s are critical regulators of mitosis and are mutationally activated in many human tumors.

42 erexpressed in numerous human cancers and is mutationally activated in N-ethyl-N-nitrosourea (ENU)-in

43 hway is highlighted in the fact that EGFR is mutationally activated in over 50% of GBM tumors.

44 is a key regulator of the ERK pathway and is mutationally activated in two-thirds of human melanomas.

45 Mutationally activated kinases define a clinically valid

46 Mutationally activated kinases play an important role in

47 Similarly to Ha-Ras, expression of mutationally activated M-Ras in NIH 3T3 mouse fibroblast

48 We describe a knockin mouse with mutationally activated Met (Met(mut)) that develops a hi

49 ity of Met and that NIH 3T3 cells expressing mutationally activated Met are transformed in vitro and

50 e also report that transgenic mice harboring mutationally activated Met develop metastatic mammary ca

51 suggest that signaling via wild type Met and mutationally activated Met may proceed through distinct

52 portance of these residues for signaling via mutationally activated Met.

53 trifolii, a fungal pathogen of alfalfa, the mutationally activated oncogenic fungal Ras (DARas) elev

54 rt here the first example of an alternative, mutationally activated pathway for meiotic recombination

55 the wild-type catalytic subunit of PIK3CA to mutationally activated PIK3CA(H1047R).

56 These experiments revealed that mutationally activated PIK3CAH1047R cooperates with BRAF

57 ty measured in vitro, as it is enhanced by a mutationally activated Plk, T210D, but is not observed w

58 The use of mutationally activated prfA alleles therefore provides a

59 s(12V, 37G), cooperates synergistically with mutationally activated Raf to induce foci of growth and

60 Introduction of a mutationally activated Raf-1 kinase domain reversed tumo

61 The well-validated role of mutationally activated RAS genes in driving cancer devel

62 Expression of mutationally activated RAS is a feature common to the va

63 Although only two of the lines harbor mutationally activated ras, we found that five of nine b

64 ly transfected to constitutively overexpress mutationally activated rat neu oncogene.

65 wild-type H-Ras but failed to interact with mutationally activated soluble H-Ras (G12V).

66 Src) but does not form a stable complex with mutationally activated Src (v-Src).

67 an cells, TRAP-1 was co-precipitated only by mutationally activated TbetaR-I and ligand-activated Tbe

68 ), that interacts in yeast specifically with mutationally activated TbetaR-I, but not wild-type Tbeta

69 constitutively dimerized form of Met, and a mutationally activated version of Met corresponding to t

70 nd/autocrine stimulation, Met which has been mutationally activated, and Tpr-Met (a constitutively ac

71 that Ras may only affect PI3K signaling when mutationally activated, such as in Ras(V12)-transformed

72 n induce tumorigenesis when overexpressed or mutationally activated.

73 s independent of MEKK, and microinjection of mutationally active Galpha 13 results in a Rho phenotype

74 In contrast, expression of mutationally active MAP kinase kinase causes activation

75 Furthermore, mutationally active p160ROCK phosphorylated an NHE1 C-te

76 HE1 activity was stimulated by expression of mutationally active p160ROCK, but not by mutationally ac

77 of mutationally active p160ROCK, but not by mutationally active protein kinase N, another RhoA targe

78 ormation driven by a strong oncogenic insult-mutationally active Ras.

79 Our results uncover a mutationally adjustable, caliper-like mechanism that gen

80 evidence for the same genomic position being mutationally affected multiple times in individual tumor

81 Here, we mutationally alter a hydrophobic patch on the third comp

82 Here we describe a method for directing a mutationally altered activator to either one or the othe

83 We propose that the side chains of these mutationally altered amino acids are in direct contact w

84 re involved in transcription activation by a mutationally altered CRP derivative, FNR and AraC.

85 Several mutationally altered forms of TyrR were deficient in the

86 specifically targeting the kinases that are mutationally altered in individual melanomas.

87 The V(max) of the mutationally altered protein was only 4% that of the unm

88 TRAP-1 protein that specifically binds these mutationally and ligand-activated forms of TbetaR-I can

89 re the fitness effects of genotypes that are mutationally available to the two populations.

90 arnesyl transferase inhibitor rac-R115777 or mutationally by alteration of the CaaX motif dramaticall

91 complex provides general insights into how a mutationally challenged enzyme, i.e., an enzyme whose ev

92 niversally conserved aspartic acid that were mutationally characterized.

93 in several cell lines, especially those with mutationally compromised p53.

94 NA in which the UUUU loop of stem-loop I was mutationally configured into a single-stranded RNA by re

95 r the formation of large neutral networks of mutationally connected genotypes which enhance the capac

96 s of HLA class I peptide stability to define mutationally constrained CD8(+) T cell epitopes across t

97 Mutationally constrained epitopes of variable pathogens

98 cause loss of function of highly expressed, mutationally constrained genes, as well as noncoding SVs

99 These data thereby elucidate key mutationally constrained regions and immunogenic epitope

100 Mutationally converting this His to either Tyr or Trp re

101 length that may be intact and 167 apparently mutationally damaged and/or unexpressed genes (pseudogen

102 Aside from the mutationally defined CHE-1-binding site, cog-1 contains

103 al techniques, this is the first report of a mutationally defined prolyl-4-hydroxylase in any animal.

104 This function is dependent on the mutationally defined Rev activation domain, which also f

105 This action depends on the mutationally defined Rev activation domain, which both b

106 Of the mutationally defined rhythm genes in Drosophila melanoga

107 n the limited sequence identity observed for mutationally defined Tas or Bel-1 response elements and

108 he human and simian foamy viruses, have been mutationally defined, they show little evident sequence

109 rs are genetically heterogeneous, containing mutationally-defined subclonal cell populations that oft

110 Donors mutationally derepressed for blcC yielded transconjugant

111 he stability of the protein by comparing two mutationally destabilized variants of the protein.

112 Putative magnesium transporter genes were mutationally disrupted, singly and in combination, in or

113 Thus, we show that mutationally disrupting the hydrophobic network in vario

114 previous studies, this packaging domain was mutationally dissected into at least seven functional el

115 Sequential immunization with mutationally distant variants is shown to robustly induc

116 On mutationally engineering the ensemble to exhibit more or

117 One idea is that all excess DNA is mutationally hazardous, but weakly enough so that genome

118 molecular epigenetic signatures within this mutationally homogeneous group that point to ways to str

119 becomes promiscuous when these proteins are mutationally impaired, thus promoting templated mutation

120 We used mutationally imposed adaptational modification states an

121 perativities of Tsr receptors with different mutationally imposed modifications at sites 1 to 4 and/o

122 r of mutations best predicted the ability to mutationally inactivate HIV.

123 A T4 whose gene 43 has been mutationally inactivated can be replicated by a cognate

124 LKB1 (also called STK11) tumor suppressor is mutationally inactivated in approximately 20% of non-sma

125 The CDC73 gene is mutationally inactivated in hereditary and sporadic para

126 The CDC73 tumor suppressor gene is mutationally inactivated in hereditary and sporadic para

127 Although Pdcd4 is not mutationally inactivated in human cancer, the mechanisms

128 pha-1,3-galactosyltransferase (alpha3GT), is mutationally inactivated in humans, leading to the prese

129 TP53 is mutationally inactivated in most types of cancer and is

130 Liver kinase B1 (LKB1) is mutationally inactivated in Peutz-Jeghers syndrome and i

131 The Tsc2 gene, which is mutationally inactivated in the germ line of some famili

132 In contrast, transgenic mice bearing a mutationally inactivated NF-IL-6 site showed no increase

133 Comparison to a mutationally inactivated precursor structure revealed se

134 When the hMSH6 is mutationally inactivated, hMSH3 increases by both transc

135 or Rb and p16, suggesting that they were not mutationally inactivated.

136 reported KSHV miRNA, miR-K9, was found to be mutationally inactivated.

137 plex in which the low affinity site had been mutationally inactivated.

138 nd in enzyme forms where C2 and T3 have been mutationally inactivated.

139 d if either the cyclin D1 or Cdk2 domain was mutationally inactivated.

140 Mutationally-inactivated ARSs that co-reside with 3'-end

141 1 is not activated in fibroblasts expressing mutationally inactive Cdc42-N17.

142 y, loss of endogenous RBBP9 or expression of mutationally inactive RBBP9 leads to elevated Smad2/3 ph

143 r68Ala can be understood in the context of a mutationally induced alteration in protein motions that

144 Mutationally induced changes at site II of cTnC alter ca

145 A clear correlation is observed between mutationally induced conformational differences in one o

146 may have greater evolutionary potential than mutationally induced ones.

147 ibility, changing 3' end complementarity, or mutationally inducing 3' end release impacts TDMD effici

148 However, natural, altered, and mutationally interconverted editing sites reveal that U-

149 A mutationally intolerant region was also observed on the

150 A mutationally intolerant region was found on CXCR4 that m

151 The highly conserved and mutationally intolerant retroviral zinc finger motif of

152 Thus, DIBAs chemically modified the mutationally intolerant retroviral zinc fingers in infec

153 terface increases ligand-binding affinity by mutationally introducing an N-glycosylation site into it

154 The alpha(L) I domain can be mutationally locked with disulfide bonds into two distin

155 Using purified rAAV containing a mutationally marked globin gene (A(gamma)*) and sites 2,

156 These findings suggest that mutationally modified PTEN can actively contribute to we

157 irm that GMS-B (copy-number gain) and GMS-D (mutationally noisy) are specific to African populations,

158 eir key roles in viral replication and their mutationally nonpermissive nature.

159 Many TKs are mutationally or autocrine activated and/or often overexp

160 Using modified substrates to either mutationally or chemically block the second step, we fou

161 this interaction is more pronounced with the mutationally or functionally activated form of Galpha(13

162 this interaction is more pronounced with the mutationally or functionally activated form of Galpha13

163 lomerase-specific T motif of human TERT were mutationally probed, leading to variant telomerases with

164 are specific to African populations, GMS-A (mutationally quiet) is universal (all ethnicities) and t

165 ts are in turn composed of subsets which are mutationally related, suggesting a high degree of flexib

166 s adaptive landscape is remarkably broad and mutationally resilient, maximizing its chances of succes

167 n though the prototype sequence that is most mutationally robust is preferred by evolution, the prefe

168 er group had earlier shown that pre-miRNA is mutationally robust, even controlling for compositional

169 assification, implying that accessibility is mutationally robust.

170 sive losses of gene regulations that are not mutationally robust.

171 ilable in their local neighborhoods are more mutationally robust.

172 lower fitness peak also exists that is more mutationally robust.

173 Mutationally, secondary AML appears at least as similar

174 , Finb, as the protein binding to one of the mutationally sensitive elements.

175 onnecting the strands were largely devoid of mutationally sensitive positions.

176 It is therefore worth noting that the mutationally sensitive residues lie along one face of a

177 Region 4 of Taf1p is mutationally sensitive, can assemble several Tafps into

178 is of aminoacylation, and editing, have been mutationally separated.

179 By mutationally separating early and late requirements for

180 s residues Trp-342, Trp-430, and Trp-472 are mutationally silent when analyzed individually.

181 In contrast, when the alphaL I domain was mutationally stabilized in the open conformation with a

182 e transformation, we transduced wild-type or mutationally stabilized murine N-myc(T58A) into neural s

183 Mutationally stabilized nanobody expression was found to

184 ecific chromatin accessibility signature for mutationally stable AML, suggesting that AML undergoes e

185 However, when the mutationally tagged telomere is considerably longer than

186 When a mutationally tagged telomere is of normal length, its se

187 leotide changes continues to favor MKK4 as a mutationally targeted tumor suppressor gene.

188 the results support the prior designation of mutationally tolerant spacer regions of LacI as well as

189 Expression of a mutationally truncated form of the protein (C-Sst2) coul

190 We identified nine mutationally verified interaction sites between sigma(70

191 We were able to separate the AroK activities mutationally with an aroK mutant allele lacking shikimat