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1 bited equally by either TNF(p60) or TNF(p80) mutein.
2 d by TNF and by p60 or p80 receptor-specific muteins.
3 major conformational changes in any of these muteins.
4       Treatment of these cells with TNF(p60) mutein activate NF-kappa B within 30 min, whereas TNF(p8
5                                         IL-2 mutein administration prior to infection suppressed Flu-
6 ities of chimeric interspecies and homologue muteins and epitope mapping of a monoclonal antibody (Mo
7         We have exploited receptor-selective muteins and evaluated phosphorylation of receptor-specif
8           Thus, the human IL-15 superagonist muteins and fusions may create opportunities to construc
9 text for the therapeutic application of IL-2 muteins and highlight the importance of treatment timing
10 l model, predict that the properties of IL-2 mutein are a consequence of the reduction, of at least t
11                In contrast, the D9N and K37A muteins are 7-12-fold less active that wild-type ApB, an
12       The secondary structures of both these muteins are identical to that of the wild-type toxin as
13 napse composed of membrane-tethered cytokine muteins bound to cell-surface cytokine receptors on tumo
14 ular variant of interleukin-6 (interleukin-6 mutein) but not with hepatocyte growth factor or lisofyl
15 to IL13Ralpha1 was sufficient to pacify IL13-mutein CAR T cells in the presence of IL13Ralpha1-overex
16 ppropriate selectivity while validating IL13-mutein CARs with improved selectivity for application to
17           In organ culture, a TNFR1-specific mutein changes phosphorylation of ASK1 to threonine 845,
18 increase in biological activity of the IL-15 mutein compared with the native molecule based on prolif
19  demonstrate that the cytokine mutant, IL-11 Mutein, competitively inhibits signalling in human cell
20                                 One of these muteins, containing the mutation Arg-121 to Glu (IL-4/R1
21                                    This HVEM mutein did not bind CD160 or TNF ligands but did bind BT
22 em cells (MSCs) to successfully deliver IL-2 mutein dimer (SIL2-EMSC) to TILs.
23                             A TNFR2-specific mutein down-regulates TNFR1 in glomerular EC, up-regulat
24  coli expressing murine decoy-resistant IL18 mutein (DR18) induced robust CD8(+) T and natural killer
25              In contrast, administering IL-2 mutein during infection exacerbated disease and drove CD
26                                       The TB muteins, E706A and Q683A, have less pronounced deviation
27 acillus sp. MN chitosanase consisting of 167 muteins, enzymes that significantly differed in their su
28 e NF-kappa B within 30 min, whereas TNF(p80) mutein, even at a 1000-fold excess, had no effect, sugge
29                                The IL-15N72D mutein exhibited superagonist activity through improved
30                                          All muteins exhibited reduced polymerase activity on both RN
31 e activity of a CD8 T cell-preferential IL-2 mutein/Fc fusion protein with IL2 receptor beta linked t
32 prototype zetakine incorporates an IL13 E13Y mutein for selective binding to IL13Ralpha2.
33 re also obtained for the charge neutralizing muteins for Lys-29 and Lys-33 in the loop region.
34 hat can isolate matched pairs of interacting muteins from complex libraries.
35 inding studies were conducted on human IL-15 muteins generated by site-directed mutagenesis.
36 sults in a product that fails to fold, while muteins H39A and H34A have activities very similar or id
37 A) to encode a half-life-extended human IL-2 mutein (HSA-IL2m) with mutations promoting reliance on I
38 ions, two survival-selective recombinant NGF muteins, i.e./7-84-103 and KKE/7-84-103, were generated.
39 ues engineered an Fc domain fused to a human mutein IL-2 (mIL-2-Fc) bearing mutations that confer pre
40                Here, we designed a humanized mutein IL-2 with high Treg selectivity and a prolonged h
41 ntly produced IL-4 and IL-13 antagonist IL-4 mutein (IL-4M) on allergic sensitization and AIT outcome
42 ve ligation of TNFR2 with the TNFR2-specific mutein increased (pSer65-)4EBP1 expression in organ cult
43 tic excimer emission bands of pyrene-labeled muteins indicated stacking of the two pyrene rings in th
44 sis whereas wild-type TNF and TNFR2-specific mutein induce tubular cells to express proliferating cel
45         The p80 mutein, like TNF and the p60 mutein, induced apoptosis and activation of NF-kappa B a
46                            However, the R25K mutein is almost as active as natural toxin.
47                                      The p80 mutein, like TNF and the p60 mutein, induced apoptosis a
48 al for biotin binding, creating streptavidin muteins (M88 and M112) with novel disulfide-switchable b
49 get of rapamycin reduced both TNFR2-specific mutein-mediated phosphorylation of 4EBP1 and cell cycle
50          Here, we assessed one such improved mutein, named superbeta 834 (SB834Fc), and performed a c
51 liary neurotrophic factor (CNTF), Axokine (a mutein of CNTF), leukemia inhibitory factor, basic fibro
52 opagate CAR(+) T cells, we developed a novel mutein of IL-21 bound to the cell surface of aAPC that r
53                        For comparison, D732A mutein of pol I was also included.
54 The E13Y amino acid substitution of the IL13 mutein of the zetakine endows CTL transfectants with the
55                                  Recombinant muteins of IL13 were produced in Escherichia coli, and t
56 at neither the wild type nor any of the K152 muteins of MuLV RT are capable of forming stable ternary
57 i-LILRB4 blockade, using a CD8-directed IL-2 mutein, or targeted loss of cDC2/monocytes.
58                            Furthermore, this mutein prolonged survival in a model of graft-versus-hos
59          Detailed analyses of a few selected muteins proved that the screening method is efficient an
60 e effects of shIL-4Ralpha and an IL-4 double mutein (R121D/Y124D, IL-4R antagonist) on IL-4- and IL-1
61                                         Both muteins reduced neuritogenesis in PC12 (TrkA(+)/p75(NTR+
62                                          The muteins representing conserved aspartate (Asp-707 of TB
63 issue treated with wild-type TNF or specific muteins selective for TNFR1 (R1-TNF) or TNFR2 (R2-TNF).
64                              Engineered IL-2 muteins selectively expand functional Tregs with minimal
65  virus (Flu) infection to determine how IL-2 mutein shapes T cell responses to respiratory virus infe
66                                         This mutein showed a stronger antitumor effect than IL-2Fc in
67                                 By using TNF muteins specific to the p60 and p80 receptors, we have p
68                                    The C197S-mutein still forms a tetrameric structure but shows impa
69                      Our data show that IL-2 mutein subcutaneous delivery as lipid-encapsulated mRNA
70 P resistance patterns were unchanged for all muteins, suggesting no participation of K152 in ddNTP re
71 e NSC, we generated 'agonist-only' Activin A muteins that activate ACVR1B but cannot form the NSC wit
72        This study aimed to identify ADAMTS13 muteins that are resistant to autoantibodies and maintai
73 tudy was aimed at developing recombinant NGF muteins that did not support neuritogenesis while mainta
74 est a new option for HIV gene therapy; bcl-2 muteins that have noncleavable alterations surrounding t
75 ration of survival-selective recombinant NGF muteins that may represent novel pharmacologic lead agen
76                However, two SLPI mutants (or muteins) that contain single amino acid substitutions an
77 inding scFv and an IL13Ralpha2-binding IL-13 mutein to make a tandem CAR exodomain (TanCAR) and a CD2
78                The binding kinetics of these muteins to 11 monoclonal, inhibitory anti-FVIII-C2 antib
79                    The ability of individual muteins to add dNTP on the covalently cross-linked enzym
80 th distinct response dynamics following IL-2 mutein treatment.
81             Wild-type TNF and TNFR1-specific mutein trigger tubular cell apoptosis whereas wild-type
82                   Structural shifts in IL-11 Mutein underlie inhibition by altering cytokine binding
83 itumor effect, we generated a group of these muteins using phage display technology, in a previous wo
84 F-mediated activation of NF-kappa B TNF(p60) mutein was also effective in cell killing, but the TNF(p
85                                         This mutein was found to retain substantial IL-5 receptor alp
86  effective in cell killing, but the TNF(p80) mutein was totally ineffective.
87                                   A panel of muteins was generated using rational and random mutagene
88                           Using one of these muteins, we demonstrate that failure to form the NSC in
89                                 The selected muteins were assessed for pharmacodynamic biomarkers and
90                                        These muteins were evaluated in T cell and endothelial cell as
91                             A series of IL-4 muteins were generated that were substituted in the regi
92 eted mutagenesis of human IL-2 to generate a mutein with approximately 3,000-fold in vitro selectivit
93     The generation of IL-2 mutated variants (muteins) with changes in the affinity for different chai
94 nt of its antiprotease activity because SLPI muteins, with significantly lower antiprotease activity,