ライフサイエンスコーパス: myb gene

1 is estimated to contain more than a hundred MYB genes).

2 phila melanogaster, which possesses a single myb gene.

3 lymphoma by insertional activation of the c-myb gene.

4 in the chromosomal region that includes the myb gene.

5 ng 2 cases with gain of an apparently intact MYB gene.

6 e rhomboid protease gene and a SHAQKY family Myb gene.

7 isruptions are now in clinical trial, is the myb gene.

8 nscription in the 3' ends of the pim-1 and c-myb genes.

9 mong the anthocyanin biosynthesis regulatory MYB genes.

10 s positively correlated with that of the two MYB genes.

11 ted a comprehensive phylogenetic analysis of Myb genes.

12 recently expanded P-to-A group of maize R2R3 Myb genes.

13 Vertebrates have three related Myb genes.

14 es examined thus far contain three different Myb genes (A-Myb, B-Myb, and c-Myb).

15 p107 has a significant role in regulating B-myb gene activity.

16 The protein products of the myb genes all bind the Myb-binding site (MBS) [YG(A/G)C(

17 lencing efficacy assays on seven Arabidopsis MYB genes, all of which contain conserved miR159-binding

18 i1, which maps 30 to 40 kb downstream of the Myb gene and appears to be the most common site of somat

19 ise of mice with targeted deletions of the c-myb gene and incomplete of knowledge about c-myb's expre

20 The avian retroviral v-myb gene and its cellular homologues throughout the anim

21 ution of MIR828 from an ancestral gymnosperm MYB gene and subsequent formation of TAS4 by duplication

22 e predict a connection between the RUNX1 and MYB genes and a suppressive role for the NOTCH pathway i

23 ntrast, the Chlamydomonas genome has only 38 MYB genes and eight bHLH genes.

24 s in the 5'-flanking sequence of the human c-myb gene, and we found that the positive regulators diff

25 ined that maize expresses >80 different R2R3 Myb genes, and evolutionary distances among maize Myb(BR

26 although inherited noncoding variants of the MYB gene are a susceptibility factor for many hematologi

27 The A-myb and B-myb genes are both expressed in a cell- and stage-specif

28 ressed, and, consequently, the corresponding MYB genes are highly expressed, shaping multiple distinc

29 iological phenotypes produced by A-myb and c-myb genes are mediated by their COOH-terminal domains.

30 However, while the functions of some plant MYB genes are relatively well understood they are, at pr

31 R2R3 Myb genes are widely distributed in the higher plants an

32 1380, which encodes a small R3 single repeat MYB gene, as a negative regulator of trichome initiation

33 is thaliana line that is mutant for the R2R3 MYB gene, AtMYB4, shows enhanced levels of sinapate este

34 deficient mutant (dn-CDK9) also represses B-myb gene autoregulation.

35 e frequently up-regulate expression of the c-myb gene, but it is unclear whether this is a cause or a

36 The Arabidopsis genome harbors >100 R2R3 Myb genes, but few have been found in monocots, animals,

37 that R1R2R3 Myb genes were derived from R2R3 Myb genes by gain of the R1 repeat through an ancient in

38 on recently duplicated maize (Zea mays) R2R3 Myb genes (C1/Pl1 and P1/P2) by cloning and characterizi

39 ide evidence that the product of the human B-myb gene can be activated in vivo by coexpression with c

40 bstitution in an anthocyanin-activating R2R3-MYB gene causing flower color variation between a pair o

41 transcription and splicing to the downstream myb gene, causing overexpression of a slightly truncated

42 Additionally, we found that two R2R3-MYB genes (CgsMYB6 and CgsMYB11) are also involved in pe

43 evidence also suggests that R2R3 and R1R2R3 Myb genes co-existed in eukaryotes before the divergence

44 ient overexpression of two nuclear localized MYB genes (CstMYB1 and CstMYB1R2) in Crocus confirmed th

45 utant embryos that carry a deletion of the c-myb gene demonstrates that c-myb is not required for pri

46 To date, v-myb is the only myb gene directly implicated in tumorigenesis, a propert

47 The phylogenetic analysis of Crocus MYB genes divided them into 27 clusters.

48 ypic analysis of mutations in the Drosophila myb gene, Dm myb, has revealed a previously undiscovered

49 adult transgenic mice expressing the human B-myb gene, driven by the basal cytomegalovirus promoter,

50 routes of sequence divergence that followed Myb gene duplication, we supplemented the information av

51 eful for determining the precise role of the MYB genes during stress responses with crop improvement.

52 Thus, the v-myb gene encoded by the Avian Myeloblastosis Virus, is t

53 The results suggest that the human c-myb gene encodes a family of related proteins with diffe

54 The c-myb gene encodes a sequence specific transactivator that

55 The c-Myb gene encodes a transcription factor required for pro

56 The c-myb gene encodes a transcription factor required for pro

57 The human B-myb gene encodes a transcriptional regulator that plays

58 Each of these three R2R3-MYB genes exhibits a different spatiotemporal expression

59 AP2, Myb113 and Myb114) showed downregulated Myb gene expression and obvious anthocyanin deficiencies

60 revealed an increase in endogenous NmU and c-myb gene expression at day 8 and a 16% expansion of earl

61 Microarray analysis showed that KLF13 and MYB gene expression changes were significantly greater i

62 E and phosphorothioate (PS) ODNs to target c-myb gene expression.

63 This review focuses on the evolution of the myb gene family and the role of these genes in developme

64 The myb gene family consists of three members, named A, B an

65 The myb gene family consists of three members, named A-, B-,

66 The myb gene family consists of three members, named A-, B-,

67 The Myb gene family currently consists of three members, nam

68 Members of the myb gene family exhibit different temporal and spatial e

69 ovide new insights into the evolution of the MYB gene family in Arabidopsis, and, more generally, the

70 f evidence for the amplification of the R2R3 Myb gene family in the early history of land plants and

71 The molecular evolution of the R2R3-MYB gene family is of great interest because it is one o

72 e that most of the amplification of the R2R3 Myb gene family occurred after the origin of land plants

73 Transactivation by myb gene family varies considerably depending on cell ty

74 is of the five members of a single-repeat R3 MYB gene family, including CAPRICE (CPC), TRIPTYCHON (TR

75 MYB98 is a member of the R2R3-MYB gene family, the members of which likely encode tran

76 ort a new model for the ordered evolution of Myb gene family.

77 The MYB-gene family encodes sequence-specific DNA-binding tr

78 a neomorphic origin of an ancestral A-Myb/c-Myb gene from a duplicated B-Myb-like gene.

79 were classified into 13 groups with the R2R3-MYB genes from Arabidopsis and rice.

80 this, we started with identification of 150 MYB genes from Crocus transcriptome databases.

81 hese two tomato myb clones are compared with myb genes from other plant species and organisms.

82 xplain the origin of the plant-specific R2R3 Myb genes from widely distributed R1R2R3 Myb genes, thro

83 to resolve previous discrepancies regarding myb gene function in Drosophila and vertebrates.

84 ts, originating from coding sequences of the MYB genes, function in wild soybeans by generating clust

85 l activation domain in the ancestral A-Myb/c-Myb gene generated from the initial duplication of an an

86 The myb gene has been shown to be an important regulator of

87 Two MYB genes have been identified which regulate apocaroten

88 The vertebrate Myb genes have been specifically implicated in regulatin

89 parative and bioinformatics analyses on R2R3-MYB genes identified from the rice (Oryza sativa subsp.

90 , primarily, to the ever-expanding number of MYB genes identified in higher plants (Arabidopsis thali

91 have previously established that the single myb gene in Drosophila melanogaster, Dm myb, which is re

92 e transcriptional regulation of the WEREWOLF MYB gene in epidermal cells at the H position.

93 Looking for mutations of the B-MYB gene in human cell lines and primary cancer samples,

94 hus, these findings strongly implicate the A-myb gene in the regulation of B-cell survival and confir

95 MADS-box genes in 9 clades and 42 Iris R2R3 MYB genes in 19 clades were identified.

96 The results revealed that the MYB genes in cotton were differentially expressed under

97 ere is great diversity in the number of R2R3-MYB genes in different plants.

98 nt duplication of particular classes of R2R3 Myb genes in the grasses.

99 Activation of the myb gene into an oncogenic form has involved structural

100 The A-myb gene is a transcription factor that shares structura

101 Transcription of the B-Myb gene is cell cycle regulated by an E2F-dependent mec

102 The ubiquitously expressed B-Myb gene is essential for early embryonic development in

103 The c-myb gene is implicated in the differentiation and prolif

104 evidence indicates that the product of the B-myb gene is necessary for the growth and survival of sev

105 The c-myb gene is primarily expressed in hematopoietic cells,

106 Transcription of the B-Myb gene is regulated by retinoblastoma proteins acting

107 The A-Myb gene is required for spermatogenesis and mammary gla

108 The Myb gene is upregulated during oxidative stress and deve

109 examine the hypothesis that the expansion of Myb genes is associated with the regulation of novel pla

110 ralogs prior to the amplification of current Myb genes is identified.

111 sitional cues bias the expression of the WER MYB gene, leading to the induction of CPC and GL2 in cel

112 l assays demonstrated that deletion of the c-myb gene leads to a slightly reduced proliferative capac

113 oid pathway; therefore, we hypothesized that MYB genes might be involved in the regulation of the bio

114 Drosophila has a single Myb gene most closely related to B-Myb.

115 A R2R3-MYB gene MYB112 was also identified as being directly si

116 Similar experiments with a distantly related MYB gene (MYB2) showed that its product cannot functiona

117 The expression of the MIXTA-like MYB gene NOK was elevated.

118 Poplar has 192 annotated R2R3 MYB genes, of which only three have been shown to play a

119 lyses indicate that some recently duplicated Myb gene pairs display substantial differences in the nu

120 he entire corolla of M. lewisii and two R2R3-MYB genes, PELAN and NEGAN, controlling anthocyanin prod

121 and miR858 can collectively target up to 81 MYB genes potentially involved in diverse aspects of pla

122 the molecular evolutionary properties of six MYB genes previously shown to be expressed in cotton fib

123 lead to increased production of a truncated myb gene product from an ALV-myb readthrough RNA.

124 with retroviral vectors expressing different myb gene products.

125 lasias, we sought to determine whether the A-myb gene promoted proliferation and survival of B lympho

126 all four full-size members activate a common MYB gene (PtrMYB021).

127 re merely analogous structures, and that the myb genes regulating their differentiation are specific

128 species that inhibit the expression of their MYB gene relatives through post-transcriptional regulati

129 GLABROUS 1, a myb gene required for trichome development in Arabidopsi

130 Targeted disruption of the c-myb gene resulted in a critical depletion of the HSC poo

131 Loss of the c-myb gene results in embryonic lethality because mature b

132 analysis of the 5' flanking region of the c-myb gene revealed a consensus PU box at position +16 to

133 will be pigmented or white, corresponds to a myb gene segregating in southeastern U.S. populations fo

134 we identified an anthocyanin-activating R2R3-MYB gene, STRIPY, as the causal gene triggering the emer

135 protein-coding regions of each single-repeat MYB gene suggest that all five proteins are functionally

136 A total of 105 potential Myb gene targets were identified.

137 c experiments and identify a MIXTA-like R2R3 MYB gene that controls nectar guide formation in M. lewi

138 2R3 Myb genes from widely distributed R1R2R3 Myb genes, through a series of well-established steps.

139 conserved and divergent sequence features of MYB genes to initiate distinct regulatory networks targe

140 Changes in the rate of B-myb gene transcription could account for part of the obs

141 growth-suppressive activity by regulating B-myb gene transcription.

142 The functionality of these R2R3-MYB genes was confirmed through stable transformation of

143 To explore the evolutionary origin of Myb genes, we cloned and sequenced Myb domains from maiz

144 monious than the previous proposal that R2R3 Myb genes were derived from R1R2R3 Mybs by loss of the R

145 Based on our results, we propose that R1R2R3 Myb genes were derived from R2R3 Myb genes by gain of th

146 Expression patterns for the MYB genes were examined in several organs to determine i

147 present study, a total of 205 putative R2R3-MYB genes were identified in cotton D genome (Gossypium

148 amily because invertebrates possess a single Myb gene, whereas all vertebrate genomes examined thus f

149 CotMYBA, a myb gene which is expressed in Gossypium hirsutum ovules

150 H3T3 fibroblasts that transcription of the B-myb gene, which encodes a transcription factor required

151 le amebic genes, including an E. histolytica Myb gene, which is upregulated during oxidative stress r

152 closely related to the vertebrate family of Myb genes, which encode transcription factors that are i

153 he yellow pod phenotype of gp mutants; (2) a MYB gene with an upstream Ogre element insertion and a C

154 divergence for some recently duplicated R2R3 Myb genes, yielding important information on general pat