ライフサイエンスコーパス: myocardial ischemia

1 nt, repetitive coronary artery occlusion and myocardial ischemia).

2 closure on coronary collateral function and myocardial ischemia.

3 outcome depends on the extent of reversible myocardial ischemia.

4 ery disease but often correlates poorly with myocardial ischemia.

5 role in treating heart failure, angina, and myocardial ischemia.

6 be the coronary perfusion territories during myocardial ischemia.

7 t 90% sensitivity for exclusion of inducible myocardial ischemia.

8 proves the understanding of the mechanics of myocardial ischemia.

9 relevant outcomes, such as the detection of myocardial ischemia.

10 ccurring alternans (n=7), in the presence of myocardial ischemia.

11 stem cell therapy in large animal models of myocardial ischemia.

12 ng ectopies to be arrhythmia triggers during myocardial ischemia.

13 s the reference standard for the presence of myocardial ischemia.

14 ias, in the presence of pathologies, such as myocardial ischemia.

15 in vivo in a porcine model of stress-induced myocardial ischemia.

16 ction in patients with residual or recurrent myocardial ischemia.

17 al ischemia, and (3) no ECG signs indicating myocardial ischemia.

18 MI, or urgent coronary revascularization for myocardial ischemia.

19 tle is known about lncRNAs in the setting of myocardial ischemia.

20 ed cardiac functional recovery after chronic myocardial ischemia.

21 the presence or absence of stress-inducible myocardial ischemia.

22 stress, thereby providing information about myocardial ischemia.

23 d arrhythmia vulnerability in the setting of myocardial ischemia.

24 in myocyte death and cardiac function after myocardial ischemia.

25 oxygen consumption leading to arrhythmia and myocardial ischemia.

26 uced wall motion abnormalities suggestive of myocardial ischemia.

27 s in which angiogenesis is impaired, such as myocardial ischemia.

28 nce of cardiac function and remodeling after myocardial ischemia.

29 Overall, 865 patients (46%) had inducible myocardial ischemia.

30 d arrhythmia vulnerability in the setting of myocardial ischemia.

31 ise treadmill tests were performed to detect myocardial ischemia.

32 ainly studied patients with exercise-induced myocardial ischemia.

33 cal characteristics of mental stress-induced myocardial ischemia.

34 the left circumflex artery to induce chronic myocardial ischemia.

35 ruction, but is limited for the detection of myocardial ischemia.

36 ging (CTP) to detect atherosclerosis causing myocardial ischemia.

37 thermia may decrease arrhythmogenesis during myocardial ischemia.

38 of young adults evaluated by angiography for myocardial ischemia.

39 e ischemic heart disease and moderate/severe myocardial ischemia.

40 ion as a potential new strategy for treating myocardial ischemia.

41 onary angiography for evaluation of possible myocardial ischemia.

42 etecting obstructive atherosclerosis causing myocardial ischemia.

43 DA-approved biomarker for early diagnosis of myocardial ischemia.

44 option for the treatment of acute or chronic myocardial ischemia.

45 , BOLD magnetic resonance imaging can detect myocardial ischemia.

46 ng LV preloads, increased contractility, and myocardial ischemia.

47 udden death, especially when associated with myocardial ischemia.

48 (CI, 88% to 92%) for exclusion of inducible myocardial ischemia.

49 aluation of anti-arrhythmic therapy in acute myocardial ischemia.

50 th abnormal exercise physiology or inducible myocardial ischemia.

51 rtery disease, but without evidence of acute myocardial ischemia.

52 ally allow users to safely exclude inducible myocardial ischemia.

53 h left main disease and extensive underlying myocardial ischemia.

54 NV)) is the standard technique for assessing myocardial ischemia.

55 asma was administered over 10 minutes before myocardial ischemia.

56 hold an unparalleled potential for treating myocardial ischemia.

57 ve (FFR-CT) is a novel, noninvasive test for myocardial ischemia.

58 d to profile transcriptome remodeling during myocardial ischemia.

59 eads to heart failure and death during acute myocardial ischemia.

60 l new targets for diagnosis and treatment of myocardial ischemia.

61 xhibit the highest accuracy for diagnosis of myocardial ischemia.

62 ll-cell coupling in instances of anticipated myocardial ischemia.

63 leading cause of death in patients suffering myocardial ischemia.

64 vel therapeutic avenue for the prevention of myocardial ischemia.

65 arget for secondary disease prevention after myocardial ischemia.

66 T-segment depression (P=0.003) and therefore myocardial ischemia.

67 show that H2S levels increase in vivo during myocardial ischemia.

68 f transient ischemic attack (TIA)/stroke and myocardial ischemia.

69 4 groups with different durations of induced myocardial ischemia (0, 30, 60, 90 s).

70 f patients at highest risk for perioperative myocardial ischemia, 2) evaluation and development of ca

71 ofiled the plasma miRNAs 4 h after transient myocardial ischemia (45 min) or sham procedure.

72 Myocardial ischemia (50 minutes followed by reperfusion)

73 arrhythmias during the early phase of acute myocardial ischemia after ligation of the left anterior

74 ven in the absence of ECG changes indicating myocardial ischemia, an acute culprit lesion may be pres

75 92%, and a specificity of 72% for detecting myocardial ischemia and 86%, 92%, and 72%, respectively,

76 lic, low diastolic [HSLD]) may contribute to myocardial ischemia and also be a predictor of adverse c

77 Mental stress can induce myocardial ischemia and also has been implicated in trig

78 Coronary spasm can cause myocardial ischemia and angina in patients with and thos

79 t it did not show a significant reduction of myocardial ischemia and angina versus placebo.

80 cvrPhone can be used to detect myocardial ischemia and arrhythmia susceptibility using

81 Myocardial ischemia and cardioprotection by ischemic pre

82 he-art noninvasive modality for detection of myocardial ischemia and coronary artery disease.

83 d locations, deviations from which can cause myocardial ischemia and death.

84 del of chronic ischemic heart disease (IHD), myocardial ischemia and exertional angina are caused by

85 important in making an accurate diagnosis of myocardial ischemia and for choosing the best interventi

86 e potential of a coronary stenosis to induce myocardial ischemia and guide decisions for percutaneous

87 that can lead to adverse remodeling such as myocardial ischemia and heart failure.

88 Glucose deprivation mimics myocardial ischemia and induces apoptosis in cardiomyocy

89 Myocardial ischemia and infarction, both in the acute an

90 ion, impairs vascular function, and promotes myocardial ischemia and injury in healthy firefighters.

91 ficult to distinguish between that caused by myocardial ischemia and may impact both the treatment st

92 ular dysfunction, can cause chronic or acute myocardial ischemia and may lead to development of heart

93 condition; however, the association between myocardial ischemia and MBs has increased their clinical

94 zed inflammatory response is triggered after myocardial ischemia and necrosis and involves all compon

95 nclusion, the cvrPhone can be used to detect myocardial ischemia and periods of respiratory apnea usi

96 lnerability to fatal arrhythmia during acute myocardial ischemia and provides a plausible mechanistic

97 Myocardial ischemia and reperfusion in cytomegalovirus-s

98 Losartan protects against myocardial ischemia and reperfusion injury via vascular

99 alpha-mediated activation of monocytes after myocardial ischemia and reperfusion using a mouse model

100 sized that mild hypothermia induced prior to myocardial ischemia and reperfusion will have a benefici

101 ith oxidative or nitrosative stress, such as myocardial ischemia and reperfusion, increase mitochondr

102 g 4 common forms of myocardial inflammation: myocardial ischemia and reperfusion, sepsis, viral myoca

103 sonance imaging in an in vivo mouse model of myocardial ischemia and reperfusion.

104 achycardia exacerbates injurious episodes of myocardial ischemia and significantly increases the prod

105 aboratory protocol provides a model to study myocardial ischemia and the actions of novel and establi

106 ardium as well as the presence and degree of myocardial ischemia and the extent of the scar.

107 ular territories exhibiting stress-inducible myocardial ischemia and those with normal perfusion.

108 cardioprotective actions in animal models of myocardial ischemia and ventricular dysfunction through

109 m, so-called Prinzmetal's angina, leading to myocardial ischemia and ventricular tachycardia, which w

110 derwent diagnostic angiography for suspected myocardial ischemia and were found to have unobstructed

111 nitrite in 2 clinical models: stress-induced myocardial ischemia and whole-arm ischemia-reperfusion.

112 on, or urgent coronary revascularization for myocardial ischemia) and total coronary events (death fr

113 branch block, (2) other ECG signs indicating myocardial ischemia, and (3) no ECG signs indicating myo

114 rise in fibrinolytic capacity, asymptomatic myocardial ischemia, and an increase in plasma cardiac t

115 schemia, and fasting-dependent hypoglycemia, myocardial ischemia, and AV block.

116 t pain with a low burden of obstructive CAD, myocardial ischemia, and events.

117 se aortic constriction, in pigs with chronic myocardial ischemia, and in end-stage human heart failur

118 b signaling led to Per2 stabilization during myocardial ischemia, and in this setting, Per2(-/-) mice

119 action, revascularization and stress-induced myocardial ischemia, and revascularization and TID (all

120 entricular systolic function, stress-induced myocardial ischemia, and TID.

121 in atherogenesis and its major complication, myocardial ischemia; and summarizes LOX-1 modulation by

122 ry bypasses and their quantitative effect on myocardial ischemia are unknown.

123 here have been case reports of patients with myocardial ischemia, arrhythmia, and sudden cardiac deat

124 treat Kawasaki disease patients who develop myocardial ischemia as a consequence of coronary artery

125 iagnosis of MI is reserved for patients with myocardial ischemia as the cause of myocardial injury, w

126 We hypothesized that myocardial ischemia assessed by CMR is associated with m

127 Myocardial ischemia assessments by 3 independent, blinde

128 nary angiography for evaluation of suspected myocardial ischemia at 4 San Diego hospitals from 2005 t

129 rdiovascular magnetic resonance in detecting myocardial ischemia at rest secondary to severe coronary

130 netic resonance could be useful in detecting myocardial ischemia at rest.

131 Report of myocardial ischemia before or after onset of ocular cond

132 vels of free fatty acids are elevated during myocardial ischemia but also in other conditions that ha

133 contributes to ventricular remodeling after myocardial ischemia, but its role in nonischemic heart f

134 Mental stress can trigger myocardial ischemia, but the prevalence of mental stress

135 Myocardial ischemia by CMR is associated with myocardial

136 has shown significant promise in addressing myocardial ischemia by promoting angiogenesis that helps

137 Primary end point was absolute change in myocardial ischemia by SPECT.

138 ecular imaging approach for detecting recent myocardial ischemia by using recombinant P-selectin glyc

139 Myocardial ischemia can occur without overt symptoms.

140 s may remain silent until later in life when myocardial ischemia can occur.

141 Although reperfusion following myocardial ischemia can prevent death by restoring nutri

142 The risks of myocardial ischemia, cardiovascular instability and cere

143 CTA alone was a limited predictor of myocardial ischemia compared with SPECT, with a sensitiv

144 g DSE are more likely to have stress-induced myocardial ischemia compared with those with normal or h

145 ejection fraction in large animal models of myocardial ischemia, compared with placebo.

146 The primary end point was a composite of myocardial ischemia detected by continuous ECG and/or tr

147 ques, cardiac embolic source, TIA/stroke and myocardial ischemia differ among various ocular arterial

148 r elevations but with supporting evidence of myocardial ischemia, different after PCI and CABG.

149 In CAD with severe LV dysfunction, inducible myocardial ischemia does not identify patients with wors

150 a protective role in the pathophysiology of myocardial ischemia due to coronary artery disease, limb

151 sently at low risk for manifesting inducible myocardial ischemia during cardiac imaging procedures.

152 emporal change in the frequency of inducible myocardial ischemia during cardiac stress testing.

153 to assess whether the frequency of inducible myocardial ischemia during stress-rest single-photon emi

154 Myocardial ischemia evokes powerful reflex responses thr

155 Interestingly, during the acute phase of myocardial ischemia, focal ectopies arising from this lo

156 CRC 1116 Masterswitches in Myocardial Ischemia, German Research Council DFG.

157 Following myocardial ischemia, Gna(i2)(fl/fl)/PF4-Cre mice showed

158 al fibrillation, cardiomyopathy, and chronic myocardial ischemia had consistent patterns but were not

159 The arrhythmogenesis of ventricular myocardial ischemia has been extensively studied, but mo

160 nti-arrhythmic effects in the acute phase of myocardial ischemia has not been investigated so far.

161 as many as one-half of women with suspected myocardial ischemia have no obstructive coronary artery

162 bearing recombinant human PSGL-1 can detect myocardial ischemia hours after resolution.

163 sitron-emission tomography imaging agent for myocardial ischemia, hypoxic tumors, and brain disorders

164 d measure of large- and small-vessel CAD and myocardial ischemia, identifies patients at risk for CVD

165 icular ejection fraction, and stress-induced myocardial ischemia, improved discrimination of cardiac

166 sevoflurane did not reduce the incidence of myocardial ischemia in high-risk patients undergoing maj

167 Myocardial ischemia in hypertrophic cardiomyopathy (HCM)

168 gated the relationship between DE on CMR and myocardial ischemia in hypertrophic cardiomyopathy.

169 pared with propofol reduces the incidence of myocardial ischemia in patients undergoing major noncard

170 ation between mood and anxiety disorders and myocardial ischemia in patients with and without a CAD h

171 thods for the prediction of underlying acute myocardial ischemia in patients with chest pain.

172 s correspond to exercise pathophysiology and myocardial ischemia in patients with coronary microvascu

173 dverse cardiac events such as arrhythmia and myocardial ischemia in rats undergoing a dobutamine chal

174 enzyme inhibitors have been shown to relieve myocardial ischemia in stable patients and to improve ep

175 ic changes found during an episode of severe myocardial ischemia in the canine heart is presented.

176 Myocardial ischemia in this context occurs as a result o

177 deprivation (GD) in vitro, and during acute myocardial ischemia in vivo.

178 Myocardial ischemia induces the ER stress response; howe

179 ecommended when initial CMR or CTA suggested myocardial ischemia, infarction, or obstructive coronary

180 the potential application of such systems in myocardial ischemia injury or for suppressing tumor grow

181 and MR contrast agents for the diagnosis of myocardial ischemia is a case in point, as the utility o

182 Acute myocardial ischemia is a precursor of sudden arrhythmic

183 Myocardial ischemia is characterized by reduced blood fl

184 sses mitochondrial function, protection from myocardial ischemia is enhanced as a result of a coordin

185 Thus, myocardial ischemia is lack of coronary blood flow with

186 Mental stress-induced myocardial ischemia is prevalent and a risk factor for p

187 mpaired in S100A9(-/)(-) mice with permanent myocardial ischemia, leading to depressed cardiac functi

188 Tissue ischemia, such as transient myocardial ischemia, leads to release of cellular RNA in

189 tients who already harbor silent cTOD (i.e., myocardial ischemia, left ventricular hypertrophy, systo

190 investigate the metabolomic profile of acute myocardial ischemia (MIS) using nuclear magnetic resonan

191 nally, we transplanted hESC-ECs into a mouse myocardial ischemia model.

192 -modulated hearts, and pressure overload and myocardial ischemia models were applied.

193 ions aimed at reducing mental stress-induced myocardial ischemia (MSIMI) have not been well studied.

194 Mental stress-induced myocardial ischemia (MSIMI) was defined as the developme

195 METHODS AND In different murine models of myocardial ischemia, myeloperoxidase deficiency profound

196 Associations of cardiac arrhythmia, myocardial ischemia, myocardial infarction, stroke, and

197 ients in 2003 and 2007 were derived from the Myocardial Ischemia National Audit Project (n=51 755).

198 Myocardial ischemia occurred in 75 patients (40.8%) in t

199 enal replacement therapy, occurrence rate of myocardial ischemia, occurrence rate of arrhythmias, and

200 eptum-ratio and LAVi >/=32 ml/m(2); however, myocardial ischemia on MPS was not a predictor.

201 The discriminative value for myocardial ischemia on myocardial perfusion scintigraphy

202 P<0.001), and was an excellent predictor of myocardial ischemia on SPECT-MPI in the presence of sten

203 ardiovascular disease except a suggestion of myocardial ischemia on treadmill testing and mild athero

204 severely ill as a result of pulmonary edema, myocardial ischemia, or cardiogenic shock.

205 is may contribute to worsen the prognosis of myocardial ischemia, peripheral arterial disease, ischem

206 fect of immediate treatment of perioperative myocardial ischemia (PMI) because of early graft failure

207 ole in atherogenesis and thrombosis-mediated myocardial ischemia, processes that are accelerated in d

208 These differences in response to myocardial ischemia provide insight into the sexual dimo

209 ES trial and atorvastatin arm of the MIRACL (Myocardial Ischemia Reduction with Acute Cholesterol Low

210 tivity were measured in 2587 patients in the Myocardial Ischemia Reduction With Acute Cholesterol Low

211 observed that blood selenium decreases after myocardial ischemia reperfusion and displays an inverse

212 ide, would target to injured heart tissue in myocardial ischemia reperfusion and injured leg muscle i

213 Anesthetized mice were subjected to myocardial ischemia reperfusion injury (coronary artery

214 Recent efforts to identify treatments for myocardial ischemia reperfusion injury have resulted in

215 aded neutrophils in a human-disease-relevant myocardial ischemia reperfusion injury mouse model after

216 We also measured damage after myocardial ischemia reperfusion injury using morphometry

217 a model of coronary artery ligation-induced myocardial ischemia reperfusion injury where inhibition

218 on injury, whereas neon was only explored in myocardial ischemia reperfusion injury.

219 ly implicating MerTK in cardiac repair after myocardial ischemia reperfusion.

220 e by resident and recruited phagocytes after myocardial ischemia reperfusion.

221 tabolic alteration in a rat model with acute myocardial ischemia-reperfusion (AMI/R) injury and myoca

222 -specific GRK2 ablation-each initiated after myocardial ischemia-reperfusion (I/R) injury-was investi

223 or in skeletal muscles protects mice against myocardial ischemia-reperfusion (I/R) injury.

224 ardioprotective effects in a murine model of myocardial ischemia-reperfusion (MI/R) injury with a bel

225 Myocardial ischemia-reperfusion injury (MIRI) is a serio

226 targeted microbubble destruction attenuates myocardial ischemia-reperfusion injury and could avoid u

227 asound targeted hs-MB destruction attenuates myocardial ischemia-reperfusion injury and may avoid unw

228 Myocardial ischemia-reperfusion injury was induced via l

229 gen sulfide (H2S) is an attractive agent for myocardial ischemia-reperfusion injury, however, systemi

230 ole, and crosstalk with innate leukocytes in myocardial ischemia-reperfusion injury, wound healing, a

231 uction was investigated in a rodent model of myocardial ischemia-reperfusion injury.

232 s a valid therapeutic strategy in mitigating myocardial ischemia-reperfusion injury.

233 ith reduced myocardial fibrosis 28 days post-myocardial ischemia-reperfusion injury.

234 importance was tested in an ex vivo model of myocardial ischemia-reperfusion injury.

235 Furthermore, myocardial ischemia/reperfusion (I/R) in CMiPLA2gammaKO

236 In the present study, myocardial ischemia/reperfusion (I/R) induced autosis in

237 sis that ADAMTS13 reduces VWF-mediated acute myocardial ischemia/reperfusion (I/R) injury in mice.

238 evelop new dedicated therapies, experimental myocardial ischemia/reperfusion (I/R) injury would requi

239 important pathophysiological process during myocardial ischemia/reperfusion (I/R) injury, and the tr

240 Endothelial damage is a critical mediator of myocardial ischemia/reperfusion (I/R) injury.

241 were used to determine the role of SIRT1 in myocardial ischemia/reperfusion (I/R) tolerance.

242 s play a major role in the early response to myocardial ischemia/reperfusion (MI/R) injury.

243 abetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury.

244 uman cells in a clinically relevant model of myocardial ischemia/reperfusion in immunocompetent anima

245 Myocardial ischemia/reperfusion in MBL2 KI mice revealed

246 Dual molecular imaging of myocardial ischemia/reperfusion injury allows characteri

247 cles of limb ischemia/reperfusion may reduce myocardial ischemia/reperfusion injury and improve patie

248 ated a more robust functional recovery after myocardial ischemia/reperfusion injury and significantly

249 Our data show that ADAMTS13 reduces myocardial ischemia/reperfusion injury in mice and indic

250 In response to myocardial ischemia/reperfusion injury in the mouse, FGF

251 lterations in endothelial BH4 content impact myocardial ischemia/reperfusion injury remains elusive.

252 N would protect the heart against subsequent myocardial ischemia/reperfusion injury via direct effect

253 n (Epac1(-/-)) protects against experimental myocardial ischemia/reperfusion injury with reduced infa

254 nd chronic inflammatory processes, including myocardial ischemia/reperfusion injury, sepsis, and adul

255 is not only the culprit but also a victim of myocardial ischemia/reperfusion injury.

256 ed as an important pathological mechanism in myocardial ischemia/reperfusion injury.

257 ected to experimental models of cerebral and myocardial ischemia/reperfusion injury.

258 myocytes and immune cells and contributes to myocardial ischemia/reperfusion injury.

259 y reduces the infarct size in a rat model of myocardial ischemia/reperfusion injury.

260 MTS13 could be of therapeutic value to limit myocardial ischemia/reperfusion injury.

261 cycles of limb ischemia/reperfusion reduces myocardial ischemia/reperfusion injury.

262 lack of gamma2-AMPK sensitizes the heart to myocardial ischemia/reperfusion injury.

263 eoxygenation and in the heart after regional myocardial ischemia/reperfusion, in the presence or abse

264 Here we show, using a mouse model of myocardial ischemia/reperfusion, that selective pharmaco

265 organ remote from the heart before sustained myocardial ischemia/reperfusion, was confirmed in all sp

266 ving von Willebrand factor multimers, during myocardial ischemia/reperfusion, we used a mouse model o

267 ed left ventricular function at 7 days after myocardial ischemia/reperfusion.

268 sts in stable form for at least 1 week after myocardial ischemia/reperfusion.

269 of the edematous reaction after experimental myocardial ischemia/reperfusion.

270 In 10 patients with inducible myocardial ischemia, saline and low-dose sodium nitrite

271 Diagnosis at the early myocardial ischemia stage is not possible.

272 Patients referred for myocardial ischemia testing at 34 centers underwent rest

273 ads, and after a more stressful condition of myocardial ischemia that is known to robustly activate A

274 a dynamic interaction with the mechanics of myocardial ischemia that may be amenable to treatment.

275 use heart can also regenerate in response to myocardial ischemia, the most common antecedent of heart

276 e medications that have been shown to reduce myocardial ischemia through diverse mechanisms and have

277 The primary endpoint was Thrombolysis In Myocardial Ischemia (TIMI) scale 2 or 3 flow in all trea

278 (Responses of Myocardial Ischemia to Escitalopram Treatment [REMIT]; N

279 he REMIT (Responses of Mental Stress-Induced Myocardial Ischemia to Escitalopram) study underwent psy

280 subtype, there must be clinical evidence of myocardial ischemia to make the diagnosis.

281 at Sestrin2 plays an influential role during myocardial ischemia to promote AMPK activation.

282 ," coronary arterial stenosis, and inducible myocardial ischemia to understanding coronary heart dise

283 examined the effect of insulin resistance on myocardial ischemia tolerance.

284 During both permanent and transient myocardial ischemia, Trem-1 blockade also ameliorates ca

285 n addition, betaCys93Ala mutation results in myocardial ischemia under basal normoxic conditions and

286 61.7+/-11.9 years; 37% women) with suspected myocardial ischemia underwent stress perfusion cardiac m

287 Presence of inducible myocardial ischemia was adjudicated using myocardial per

288 Myocardial ischemia was induced during stress testing in

289 Prevalence of obstructive CAD and myocardial ischemia was low (11.9% versus 12.7%, respect

290 The presence and extent of myocardial ischemia was quantified using the conventiona

291 secutive patients referred for evaluation of myocardial ischemia, we determined the net reclassificat

292 abnormal ostium-and symptoms or evidence of myocardial ischemia) were offered surgery or exercise re

293 Myocardial ischemia, while causing cardiomyocyte injury,

294 (CVD) between primates; humans are prone to myocardial ischemia, while chimpanzees are prone to myoc

295 ns on physical activity owing to angina) and myocardial ischemia, who were not candidates for revascu

296 rstanding the emerging overlap of MS-induced myocardial ischemia with microvascular dysfunction and s

297 up to develop a consensus on the syndrome of myocardial ischemia with no obstructive coronary arterie

298 lowing (ischemic postconditioning) sustained myocardial ischemia with reperfusion reduce infarct size

299 CTP was a better predictor of myocardial ischemia, with a sensitivity, specificity, PP

300 enables non-invasive objective assessment of myocardial ischemia without ionizing radiation.