ライフサイエンスコーパス: myogenic tone

1 Ca2+ free) to 116 +/- 7 micron or by 45 % ('myogenic tone').

2 intraluminal pressure, critically determines myogenic tone.

3 dently and the signals integrated to trigger myogenic tone.

4 ncreased mtROS, inhibited STOCs and elevated myogenic tone.

5 effect on blood glucose or resistance artery myogenic tone.

6 numerous physiological processes, including myogenic tone.

7 ations of XE991 enhance mesenteric and renal myogenic tone.

8 ls, other ion channel proteins that modulate myogenic tone.

9 ansgenic mice exhibited a robust increase in myogenic tone.

10 ks and waves but increased global Ca(2+) and myogenic tone.

11 diabetic pigs developed comparable levels of myogenic tone.

12 (2)S production, depolarize VSM, and enhance myogenic tone.

13 ne expression of each subunit, which reduced myogenic tone.

14 ity, synaptic transmission and regulation of myogenic tone.

15 anism in the regulation of resistance artery myogenic tone.

16 elevated arterial [Ca(2+)](i), and enhanced myogenic tone.

17 ntracellular calcium ([Ca2+]i) and decreased myogenic tone.

18 a2(+/-), but not alpha1(+/-), have increased myogenic tone.

19 ood pressure reflect the in vitro changes in myogenic tone.

20 Regulation of the microcirculation includes myogenic tone.

21 nels play an essential role in regulation of myogenic tone.

22 o 80 mmHg and allowed to develop spontaneous myogenic tone.

23 l volume, electrical activity and, possibly, myogenic tone.

24 l arterioles resulting in the development of myogenic tone (28% from maximum dilatation).

25 Arteries and arterioles exhibit myogenic tone, a partially constricted state that allows

26 ng MR in SMCs (SMC-MR) have reduced vascular myogenic tone, agonist-dependent contraction and express

27 Hypoxic arteries exhibit weak myogenic tone and a limited response to nifedipine, indi

28 ation to pregnancy, promoting a reduction in myogenic tone and an increase in blood flow.

29 he AT1 R blocker losartan (1 mum) diminished myogenic tone and blocked stretch-induced cation current

30 in arteriolar myocytes dynamically regulates myogenic tone and blood flow in the heart and skeletal m

31 role, for TRPV1 in the dynamic regulation of myogenic tone and blood flow in the heart and skeletal m

32 tion, and in vivo changes in cerebral artery myogenic tone and blood flow were ameliorated by spirono

33 lation of SMC membrane potential and loss of myogenic tone and contribute to age-related cSVD in Col4

34 and latrunculin) inhibit the development of myogenic tone and decrease the effectiveness of myogenic

35 Inhibiting CSE also enhanced myogenic tone and depolarized VSM in sham but not IH art

36 man and porcine retinal arterioles developed myogenic tone and dilated dose dependently to bradykinin

37 bligatory role in force development, both in myogenic tone and during alpha1-adrenoceptor activation.

38 kinase (ROCK) inhibitor H-1152 blocked both myogenic tone and endothelin-1-induced constriction.

39 Conversely, ROCK activation mediates myogenic tone and endothelin-1-induced vasoconstriction.

40 hese data suggest that streptomycin inhibits myogenic tone and K+-induced isometric force largely by

41 /-) or chronic ouabain) apparently regulates myogenic tone and long-term blood pressure whereas reduc

42 ocin on cerebral artery (250 to 300 microns) myogenic tone and on vasodilations to the synthetic KATP

43 knockdown in vivo in pregnant sheep enhances myogenic tone and phenylephrine-induced vasoconstriction

44 age-matched control rats were evaluated for myogenic tone and reactivity.

45 Baseline myogenic tone and resting membrane potential were not af

46 ebellar arteries (SCA) developed spontaneous myogenic tone and showed a marked and sustained constric

47 nished this sexual dimorphism and found that myogenic tone and SK channel activity differences persis

48 Both myogenic tone and the pressure- and temperature-dependen

49 e several physiological processes, including myogenic tone and thus, artery diameter.

50 nhibited pressure-induced vasoconstriction ("myogenic tone"), and attenuated pregabalin-induced vasod

51 on, leading to an increase in both pressure (myogenic tone)- and depolarization-induced vasoconstrict

52 a(V)1.2 cooperativity, alpha1(C) clustering, myogenic tone, and blood flow in human and mouse arteria

53 nd TRPM4 channel activity, prevented loss of myogenic tone, and reduced ICHs.

54 nsient outward currents (STOCs) and elevates myogenic tone, and these effects are blocked by MitoQ.

55 ees C, arteries developed pressure-dependent myogenic tone, and this was associated with a pressure-d

56 lop enhanced aortic stiffness, microvascular myogenic tone, AngII constriction, and AngII type 1 rece

57 tion in mediating the HF-induced increase in myogenic tone are two further findings: a blunting of pa

58 Myogenic tone, assessed as the difference between intern

59 TRPP2 knockdown did not alter myogenic tone at 20 mmHg but reduced tone between approx

60 HFD/STZ treatment induced a progressive myogenic tone augmentation in mesenteric and olfactory c

61 alcohol exposure did not affect spontaneous myogenic tone, but enhanced the dilator response of pene

62 icted pressurized (to 60 mmHg) arteries with myogenic tone by 44 micron (approximately 22 %).

63 permeability, responses to oxidative stress, myogenic tone, cellular proliferative activity, and ther

64 Arteries from diabetic rats showed decreased myogenic tone compared with control arteries, and this d

65 n-dependent inhibition of pressure-dependent myogenic tone consistent with previous reports of mechan

66 d from patients with diabetes have augmented myogenic tone, despite reasonable blood glucose control.

67 Myogenic tone developed at an intraluminal pressure of 3

68 rted effects of altered Ca(2+) signalling on myogenic tone, endothelium-dependent vasodilatation, and

69 mated pressure protocols enable standardized myogenic tone experiments, and both real-time and offlin

70 hypothesized that sex hormone regulation of myogenic tone extends to the microcirculation and charac

71 e, BK beta1 allows the BK channels to reduce myogenic tone, facilitating vasodilation.

72 tation of saphenous vein, with its intrinsic myogenic tone, from the low-pressure, minimally pulsatil

73 Only the NCX blockers normalize the elevated myogenic tone in alpha2(+/-) arteries because this tone

74 r Ca(2+) signaling during the development of myogenic tone in arterial blood vessels.

75 regulation of excitability, [Ca(2+)](i), and myogenic tone in arterial myocytes.

76 ) attenuated Ca(2+) waves, global Ca(2+) and myogenic tone in arteries and arterioles but had no effe

77 Iberiotoxin enhanced myogenic tone in both groups but more in sham than IH.

78 n the SR of arterial smooth muscle regulates myogenic tone in cerebral arteries solely through activa

79 cerebral arteries show that estrogen lowers myogenic tone in female mice by enhancing NO release; ho

80 a blunting of paxilline-induced increase in myogenic tone in HF mice compared to controls (0.9 vs. 1

81 irect addition of prostaglandin D(2) rescued myogenic tone in high-fat diet-fed control mice.

82 erfering RNA targeting RGS5 caused augmented myogenic tone in intact mesenteric arteries and increase

83 ilatory responses to an NO donor and loss of myogenic tone in KW animals were also rescued with Nox1

84 CX blockers (SEA0400 and KB-R7943) normalize myogenic tone in ouabain-treated arteries.

85 emale compared with male mice and found that myogenic tone in ovariectomized female mice matched that

86 f obesity-induced hypertension by preserving myogenic tone in resistance arteries.

87 inactivation or scavenging of H(2)S enhanced myogenic tone in sham arteries to the level of IH.

88 ses endothelial H(2)S production to increase myogenic tone in small mesenteric arteries.

89 iotensin II as a neurohumoral signal for the myogenic tone in the internal anal sphincter.

90 bserved a similar contribution of 20-HETE to myogenic tone in the mesenteric microvasculature.

91 el activity, thus providing tight control of myogenic tone in the microcirculation.

92 increase in L-type Ca2+ channel activity and myogenic tone in two animal models of diabetes.

93 ersal of the effects of hypoxia on STOCs and myogenic tone in uterine arteries.

94 are likely to play a key role in regulating myogenic tone in vascular tissue.

95 SMTNL1 deletion was associated with enhanced myogenic tone in vessels isolated from male, but not fem

96 In conclusion, thermosensitive myogenic tone is a fundamental homeostatic mechanism reg

97 rteries at low intravascular pressure, where myogenic tone is absent.

98 Coronary myogenic tone is dependent on ERK1/2 and decreased after

99 We conclude that myogenic tone is not significantly different in pregnant

100 y role in myogenic vasoconstriction and that myogenic tone is required to maintain local and systemic

101 Although pressure-induced constriction ("myogenic tone") is a major contributor to the regulation

102 in two indirect assays of Na+ pump function: myogenic tone (MT) in isolated, pressurized rat mesenter

103 EGFR transactivation under pressure-induced myogenic tone (MT).

104 y), and that HF does not alter the increased myogenic tone of BK beta1-null mice.

105 Myogenic tone of coronary arterioles was measured by vid

106 ion- and endothelium-dependent effect on the myogenic tone of rat ophthalmic artery.

107 eveal a critical role for TRPV1 in the rapid myogenic tone of these tissues.

108 systolic HF post-myocardial infarction, the myogenic tone of third-order mesenteric resistance vesse

109 sure causes depolarization and constriction (myogenic tone) of small arteries and arterioles, and thi

110 LRRC26 knockdown also increased myogenic tone over a range (40-100 mm Hg) of intravascul

111 -kappaB inhibitors had significantly reduced myogenic tone potentiation and improved EDR.

112 f prostaglandin D(2) synthesis inhibited the myogenic tone protection in resistance arteries of endot

113 itivity is tuned to this temperature, making myogenic tone sensitive to small thermal fluctuations.

114 tal autoregulatory property, termed vascular myogenic tone, stabilizes downstream capillary pressure.

115 1.2 clusters, larger [Ca(2+)](i), and larger myogenic tone than male myocytes.

116 (Ca) channels and vasodilation, reducing the myogenic tone that underpins tissue blood-flow autoregul

117 pendent dilation of pressurized vessels with myogenic tone that was accompanied by a corresponding de

118 In the control condition of myogenic tone the arteries were constricted to 62 % (n =

119 channels in arterial myocytes and increased myogenic tone upon acute hyperglycemia.

120 ooth muscle cell TNF drives the elevation of myogenic tone via enhanced sphingosine-1-phosphate (S1P)

121 Myogenic tone was abolished by 2 microM nimodipine, but

122 Myogenic tone was absent in KO rings.

123 Myogenic tone was assessed over a range of intraluminal

124 Myogenic tone was decreased in coronary microvessels aft

125 Myogenic tone was enhanced by 25 mM, but decreased by 40

126 However, we found that development of myogenic tone was greater in arteries from AT1 Ra knocko

127 Myogenic tone was greater in mesenteric arteries from IH

128 Pressure-induced myogenic tone was increased in MRA and coronary artery f

129 Myogenic tone was increased in obese human arteries with

130 2+) event frequency was inhibited, and basal myogenic tone was increased, by either RN1734 or TRAM-34

131 Myogenic tone was reduced in coronary arterioles post-C/

132 Pressure-induced myogenic tone was significantly potentiated, while endot

133 Myogenic tone was unchanged, but over a range of transmu

134 .2 activity and enhanced ex vivo and in vivo myogenic tone were prevented in arterial myocytes and ar

135 ced suppression of STOCs and augmentation of myogenic tone were reversed by TET2 knockdown in uterine

136 Pressure-induced constrictions ("myogenic tone") were greater (approximately 2-fold) in i

137 depolarization and constriction to pressure (myogenic tone) were blunted in PAs from TgNotch3(R169C)

138 osterior cerebral arteries display augmented myogenic tone, which can be fully reversed in vitro by t