ライフサイエンスコーパス: myosin-binding protein C

1 in a computational model of loss of cMyBP-C (myosin binding protein-C).

2 with cardiac troponins and cMyBP-C (cardiac myosin-binding protein C).

3 7 (beta-myosin heavy chain) and MYBPC3 (beta-myosin-binding protein C).

4 ost probably related to reduced abundance of myosin binding protein C.

5 cardiac sarcomere or from the truncation of myosin binding protein C.

6 response to Ca(2+) with glutathionylation of myosin binding protein C.

7 ms of the thick-filament-associated protein, myosin binding protein-C.

8 orylation of the myofilament protein cardiac myosin binding protein-C.

9 thers, filamin C and the slow isoform of the myosin-binding protein C.

10 ed PKA phosphorylation of the PKA substrate, myosin-binding protein C.

11 utations) were predicted to truncate cardiac myosin-binding protein C.

12 drugs and in cells expressing low levels of myosin-binding protein C.

13 t the stability of that motif is affected by myosin-binding protein C.

14 hin filaments in resting muscle, potentially myosin-binding protein C.

15 roteins, the commonest being MYBPC3 encoding myosin-binding protein C.

16 osphorylation of its targets, troponin I and myosin-binding protein C.

17 pendent of AMPK increased phosphorylation of myosin-binding protein C.

18 hs-cTn I, 0.71 [95% CI, 0.67-0.74]; cardiac myosin-binding protein C, 0.67 [95% CI, 0.61-0.73]; C-te

19 yses revealed 8 sequence variants in cardiac myosin binding protein-C (1 nonsense, 1 splice acceptor

20 orm identification, endogenous human cardiac myosin binding protein C (140 kDa) was identified for th

21 eased phosphorylation of Ser(273) of cardiac myosin binding protein-C, a cGMP-dependent protein kinas

22 Cardiac myosin-binding protein C, a cardiac-specific myofilament

23 he thin filament: phosphorylation of cardiac myosin binding protein-C accelerates cross bridge bindin

24 Mutations in the gene for cardiac myosin-binding protein C account for approximately 15 pe

25 ies, PKA increased phosphorylation levels of myosin binding protein C and troponin I, and reduced Ca(

26 pectroscopy revealed hyperphosphorylation of myosin-binding protein C and phosphorylation of atypical

27 ments contain additional nonmyosin proteins, myosin-binding protein C and titin, the latter being the

28 ple myofibrillar substrates including titin, myosin-binding protein-C and cardiac troponin I (cTnI),

29 enes, most commonly beta myosin heavy chain, myosin binding protein C, and cardiac troponin T.

30 iac myocyte proteins (alpha-actinin, cardiac myosin-binding protein C, and cardiac troponin I).

31 phosphorylation of cTnI, cTnT, tropomyosin, myosin-binding protein C, and desmin.

32 een the myosin heads, the cardiac isoform of myosin-binding protein-C, and titin will aid in understa

33 We confirm that the nine stripes ascribed to myosin binding protein-C are not related to the titin se

34 variants in MYBPC3, encoding cardiac MyBP-C (myosin binding protein C), are the most common cause of

35 r 170 normal chromosomes; 1 variant (cardiac myosin binding protein-C Arg326Gln) also occurred in a h

36 ryanodine receptor, troponin I, and cardiac myosin-binding protein C at PKA sites was increased in p

37 at Ser16, phospholemman at Ser68 and cardiac myosin-binding protein C at Ser282, was unaltered.

38 vs 115 [28-576] ng/L; P < .001), and cardiac myosin-binding protein C (at presentation: median [IQR],

39 ol myocytes with phosphorylation of cTnI and myosin binding protein C (C-protein) in myocytes with in

40 Several other proteins such as synemin, myosin binding protein C (C-protein), glycogen debranchi

41 n of troponin T (TnT), troponin I (TnI), and myosin-binding protein C (C-protein).

42 degradation of myosin heavy chain 6, cardiac myosin binding protein C, calcineurin (PPP3CB), and p-MT

43 st four N-terminal domains (NTDs) of cardiac myosin binding protein C (cMyBP-C) (e.g. C0, C1, M and C

44 A-mediated (PKA) phosphorylation of cardiac myosin binding protein C (cMyBP-C) accelerates the kinet

45 rylation of the cardiac myofilament proteins myosin binding protein C (cMyBP-C) and troponin I (cTnI)

46 In the cardiac sarcomere, both cardiac myosin binding protein C (cMyBP-C) and troponin-I (cTnI)

47 Cardiac myosin binding protein C (cMyBP-C) appears to modulate t

48 Mutations in cardiac myosin binding protein C (cMyBP-C) are a leading cause o

49 Cardiac myosin binding protein C (cMyBP-C) has a key regulatory

50 Cardiac myosin binding protein C (cMyBP-C) has three phosphoryla

51 Cardiac myosin binding protein C (cMyBP-C) modulates cardiac con

52 Protein expression of myosin binding protein C (cMyBP-C) was significantly low

53 traction, and its accessory protein, cardiac myosin binding protein C (cMyBP-C), are the two most com

54 Cardiac myosin binding protein C (cMyBP-C), bound to the sarcome

55 The cardiac isoform [cardiac myosin binding protein C (cMyBP-C)] is essential for nor

56 Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) accelerates cardiac c

57 We investigated the influence of cardiac myosin binding protein-C (cMyBP-C) and its constitutivel

58 myofilaments PKA targets troponin I (cTnI), myosin binding protein-C (cMyBP-C) and titin.

59 RLC) by myosin light chain kinase (MLCK) and myosin binding protein-C (cMyBP-C) by protein kinase A (

60 Although mutations in cardiac myosin binding protein-C (cMyBP-C) cause heart disease,

61 Although phosphorylation of cardiac myosin binding protein-C (cMyBP-C) has been recognized a

62 Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) is a determinant of c

63 Cardiac myosin binding protein-C (cMyBP-C) is a member of the im

64 Myosin binding protein-C (cMyBP-C) is a thick filament a

65 Cardiac myosin binding protein-C (cMyBP-C) is a thick filament a

66 Cardiac myosin binding protein-C (cMyBP-C) is a thick filament-a

67 Cardiac myosin binding protein-C (cMyBP-C) is a thick-filament p

68 Cardiac myosin binding protein-C (cMyBP-C) is an important regul

69 We examined the effect of cardiac myosin binding protein-C (cMyBP-C) on contractile effici

70 The role of cardiac myosin binding protein-C (cMyBP-C) phosphorylation in ca

71 Cardiac myosin binding protein-C (cMyBP-C) phosphorylation modul

72 opy, we examined the contribution of cardiac myosin binding protein-C (cMyBP-C) to thick-filament len

73 advances in the molecular biology of cardiac myosin binding protein-C (cMyBP-C), little is understood

74 ns, most often MYBPC3, which encodes cardiac myosin binding protein-C (cMyBP-C).

75 the gene encoding cardiac C-protein [cardiac myosin binding protein-C (cMyBP-C)] are one of the princ

76 23/24) of cardiac troponin I (cTnI), cardiac myosin-binding protein C (cMyBP-C) and titin.

77 Mutations in cardiac myosin-binding protein C (cMyBP-C) are a leading cause o

78 Cardiac myosin-binding protein C (cMyBP-C) interacts with actin

79 Cardiac myosin-binding protein C (cMyBP-C) is a component of the

80 The cardiac isoform of myosin-binding protein C (cMyBP-C) is a key regulatory p

81 Cardiac myosin-binding protein C (cMyBP-C) is a regulatory prote

82 Cardiac myosin-binding protein C (cMyBP-C) is a sarcomeric prote

83 Cardiac myosin-binding protein C (cMyBP-C) is a thick filament-a

84 Cardiac myosin-binding protein C (cMyBP-C) is a thick-filament-a

85 The N-terminal modules of cardiac myosin-binding protein C (cMyBP-C) play a regulatory rol

86 Cardiac myosin-binding protein C (cMyBP-C) plays a modulatory ro

87 Cardiac myosin-binding protein C (cMyBP-C) regulates actin-myosi

88 bait, identified cardiac troponin I (cTnI), myosin-binding protein C (cMyBP-C), and telethonin as PK

89 ariants in MYBPC3, the gene encoding cardiac myosin-binding protein C (cMyBP-C), are the leading caus

90 potential regulator of these motors, cardiac myosin-binding protein C (cMyBP-C), cause hypertrophic c

91 esolve the structure and dynamics of cardiac myosin-binding protein C (cMyBP-C), focusing on the N-te

92 arcomeric PKA targets, troponin I (cTnI) and myosin-binding protein C (cMyBP-C), lead to these effect

93 ion to myosin, the filaments contain cardiac myosin-binding protein C (cMyBP-C), which modulates cont

94 ardiac cells derived from both wild-type and myosin-binding protein C (cMyBP-C)-null mouse hearts.

95 +) levels, active cross-bridges, and cardiac myosin-binding protein C (cMyBP-C).

96 ice with gene targeted deficiency of cardiac myosin-binding protein-C (cMyBP-C(-/-), n=6) or muscle L

97 Phosphorylation of cardiac myosin-binding protein-C (cMyBP-C) by protein kinase A a

98 Cardiac myosin-binding protein-C (cMyBP-C) is a thick filament p

99 Cardiac myosin-binding protein-C (cMyBP-C) is a thick filament-a

100 Cardiac myosin-binding protein-C (cMyBP-C) is a thick-filament-a

101 Cardiac myosin-binding protein-C (cMyBP-C) is highly phosphoryla

102 P sensitivity highly correlated with cardiac myosin-binding protein-C (cMyBP-C) protein level.

103 n is the major regulatory subunit of cardiac myosin-binding protein-C (cMyBP-C) that modulates actin

104 ardiac muscle-specific myofibrillar protein, myosin-binding protein-C (cMyBP-C), is down-regulated.

105 omology with the carboxy-terminus of cardiac myosin-binding protein-C (cMyBP-C).

106 tations in MYBPC3, the gene encoding cardiac myosin-binding protein C, (cMyBP-C) occur in ~20%-25% of

107 Decreased expression of cardiac myosin binding protein C (cMyBPC) as a result of genetic

108 Decreased expression of cardiac myosin binding protein C (cMyBPC) in the heart has been

109 Cardiac myosin binding protein C (cMyBPC) phosphorylation is ess

110 Cardiac myosin-binding protein C (cMyC) is a cardiac-restricted

111 Cardiac myosin-binding protein C (cMyC) is a cardiac-specific sa

112 Homozygous cardiac myosin binding protein C-deficient (Mybpc(t/t)) mice dev

113 e mutation leads to reduced cMyBP-C (cardiac myosin binding protein-C) expression, supporting haploin

114 This Ag is a novel member of the myosin binding protein-C family, which we call masticato

115 nd heterozygous variant in a candidate gene (myosin binding protein C, fast type [MYBPC2] and vacuola

116 Fast skeletal myosin-binding protein-C (fMyBP-C) is one of three MyBP-

117 MYBPC3 (Myosin-binding protein C) founder mutations account for

118 hese results suggest that the 40-kDa cardiac myosin-binding protein C fragment, which is produced at

119 ded] N'-terminal domains C0 to C7 of cardiac myosin binding protein-C) fragment and an insoluble C'-t

120 Extraction of myosin binding protein-C from skinned muscle normalized

121 Mutations in the cardiac myosin binding protein-C gene (cMyBP-C) are among the mo

122 f 50 years who had a mutation in the cardiac myosin-binding protein C gene (68 of 117 patients) had c

123 heritable nature of mutations in the cardiac myosin-binding protein C gene.

124 re events between the myosin heavy chain and myosin-binding protein C genotype-positive patients.

125 nt rates seen between myosin heavy chain and myosin-binding protein C genotype-positive patients.

126 osin light chain MLY2, myosin heavy chain 6, myosin-binding protein C), glucose metabolism proteins (

127 regulation of S-glutathionylation of cardiac myosin binding protein-C in FTY720-treated Tm-E180G mice

128 rs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.

129 Ser/Thr phosphorylation of myosin-binding protein C increased primarily by PKCzeta

130 Myosin binding protein C is a thick filament protein of

131 e suggesting that phosphorylation of cardiac myosin binding protein-C is a key regulator of the kinet

132 ression of mutations in the gene for cardiac myosin-binding protein C is often delayed until middle a

133 cMyBP-C (cardiac myosin-binding protein-C) is a critical regulator of hea

134 MYBPC3, encoding cMyBP-C (cardiac myosin-binding protein C), is the most frequently mutate

135 The myosin-binding protein C isoform 3 (MYBPC3) variant Arg5

136 Among these is the myosin-binding protein C (MBP-C).

137 protein-C family, which we call masticatory myosin binding protein-C (mMyBP-C).

138 In this G+LVH- population, cardiac myosin-binding protein C mutation carriers had twice the

139 familial hypertrophic cardiomyopathy mutant myosin binding protein C (MyBP-C(MUT)) expression.

140 eta-adrenergic stimulation increases cardiac myosin binding protein C (MyBP-C) and troponin I phospho

141 quasi-helical order of the myosin heads and myosin binding protein C (MyBP-C) decreased in the sarco

142 (FHC), individuals bearing a mutant cardiac myosin binding protein C (MyBP-C) gene usually have a be

143 The large multidomain muscle protein myosin binding protein C (MyBP-C) has been implicated fo

144 s contractile proteins, troponin-I (TnI) and myosin binding protein C (MyBP-C) in the heart and induc

145 Myosin binding protein C (MyBP-C) is a component of the

146 Myosin binding protein C (MyBP-C) is a thick filament pr

147 Myosin binding protein C (MyBP-C) is an integral part of

148 Myosin binding protein C (MyBP-C) is expressed in striat

149 Myosin binding protein C (MyBP-C) is one of a group of m

150 f mice to reduce the level of troponin I and myosin binding protein C (MyBP-C) phosphorylation in the

151 c proteins, including the cardiac isoform of myosin binding protein C (MyBP-C), and multiple mutation

152 , titin, and the cardiac modulatory protein, myosin binding protein C (MyBP-C).

153 We have determined the effects of myosin binding protein-C (MyBP-C) and its domains on the

154 We hypothesize that phosphorylation of myosin binding protein-C (MyBP-C) and troponin I (TnI) a

155 Myosin binding protein-C (MyBP-C) exists in three major

156 Myosin binding protein-C (MyBP-C) is a key regulatory pr

157 Myosin binding protein-C (MyBP-C) is a multidomain prote

158 Myosin binding protein-C (MyBP-C) is a poorly understood

159 Myosin binding protein-C (MyBP-C) is a thick filament-as

160 Myosin binding protein-C (MyBP-C) is a thick-filament pr

161 Myosin binding protein-C (MyBP-C) is localized to the th

162 These structural changes also drive Myosin Binding Protein-C (MyBP-C) to promote first motor

163 Among these, mutations that affect myosin binding protein-C (MyBP-C), an abundant component

164 myofilaments proteins, troponin I (TnI) and myosin binding protein-C (MyBP-C), are phosphorylated fo

165 to phosphorylation of troponin I (TnI) or of myosin binding protein-C (MyBP-C).

166 s mutant mice expressing a truncated form of myosin-binding protein C (MyBP-C(t/t)) develop severe di

167 r fasting, atrophying muscles show a loss of myosin-binding protein C (MyBP-C) and myosin light chain

168 ally phosphorylate the myofibrillar proteins myosin-binding protein C (MyBP-C) and the regulatory lig

169 ther changes in the phosphorylation state of myosin-binding protein C (MyBP-C) are a potential cause

170 Myosin-binding protein C (MyBP-C) is a long and flexible

171 Myosin-binding protein C (MyBP-C) is a multidomain prote

172 Skeletal muscle myosin-binding protein C (MyBP-C) is a myosin thick fila

173 Myosin-binding protein C (MyBP-C) is a thick filament pr

174 Myosin-binding protein C (MyBP-C) is a thick filament pr

175 Myosin-binding protein C (MyBP-C) is an accessory protei

176 Myosin-binding protein C (MyBP-C) is an approximately 13

177 unclear, although it has been proposed that myosin-binding protein C (MyBP-C) may stabilize the SRX

178 After phosphorylation of myosin-binding protein C (MyBP-C) with protein kinase A

179 imensional organization of myosin, titin and myosin-binding protein C (MyBP-C).

180 ther with a depression in phosphorylation of myosin-binding protein-C (MyBP-C) and troponin I (TnI).

181 To elucidate the role of cardiac myosin-binding protein-C (MyBP-C) in myocardial structur

182 Myosin-binding protein-C (MyBP-C) is a thick filament-as

183 Myosin binding protein C (MyBPC) is a multidomain protei

184 rotein was identified as the 140-kDa cardiac myosin binding protein C (MyBPC).

185 Mutations in cardiac myosin-binding protein C (MyBPC) gene have been associat

186 ing a heterozygous truncation variant in the myosin-binding protein C ( MYBPC3) gene, which causes hy

187 thm missed a pathogenic 18 bp duplication in myosin binding protein C (MYBPC3) because of low coverag

188 eral sarcomeric genes, including the cardiac myosin binding protein C (MYBPC3) gene.

189 d in several sarcomeric genes, including the myosin binding protein C (MYBPC3) gene.

190 the frequency and phenotype of mutations in myosin binding protein C (MYBPC3) in a large outpatient

191 D cardiomyopathy genes, lamin A/C (LMNA) and myosin binding protein C (MYBPC3).

192 tudies suggest that mutations in the cardiac myosin binding protein-C (MYBPC3) gene cause late-onset,

193 k filament components myosin heavy chain and myosin binding protein C (MYH7 and MYBPC3) together expl

194 -dependent phosphorylation of troponin I and myosin binding protein C on isoproterenol stimulation wa

195 domains of titin and the cardiac isoform of myosin-binding protein-C on the surface of the myosin fi

196 s in thick filament proteins such as cardiac myosin binding protein-C or titin, cause familial hypert

197 The myosin binding protein C, or C protein, has 4 sites that

198 Cardiac myosin binding protein-C phosphorylation plays an import

199 K gene ablation did not affect troponin-I or myosin-binding protein-C phosphorylation in vivo.

200 rmed reduced abundance of sarcomeric protein myosin binding protein C, potentially playing a role in

201 e myosin-binding motif (m-domain) of cardiac myosin-binding protein-C remains unclear.

202 analysed, myosin heavy and light chains and myosin-binding protein C require Mef2 for normal express

203 nd MYBPC3, encoding B-myosin heavy chain and myosin binding protein C, respectively, are the two most

204 MYBPC3, encoding beta-myosin heavy chain and myosin-binding protein C, respectively, are the 2 most c

205 treatment, which coincided with the level of myosin binding protein-C-S glutathionylation.

206 ant] N'-terminal domains C0 to C7 of cardiac myosin binding protein-C)-sc returned pCa(50) and k(tr)

207 2 domain of obscurin with a novel isoform of myosin binding protein-C slow (MyBP-C slow), correspondi

208 Myosin Binding Protein-C slow (sMyBP-C) is expressed in

209 Myosin Binding Protein-C slow (sMyBP-C), encoded by MYBP

210 MYBPC1 encodes slow myosin binding protein-C (sMyBP-C), a modular sarcomeric

211 lament signaling pathways based on titin and myosin-binding protein-C that couple thin and thick fila

212 e confined to the filament domain containing myosin binding protein-C, the "C-zone." Myosin motors in

213 osin, binds with the C0-C2 region of cardiac myosin-binding protein-C to regulate cardiac muscle cont

214 Rather, mutations in cardiac myosin binding protein-C, troponin I, and alpha-cardiac

215 Myosin-binding protein C, troponin T, tropomyosin and my

216 phic cardiomyopathy is the recurrent MYBPC3 (myosin-binding protein-C) variant c.1504C>T, p.Arg502Trp

217 oponin, tropomyosin, and the C0C2 domains of myosin-binding protein C was also observed, influencing

218 mbers with mutations in the gene for cardiac myosin-binding protein C was assessed.

219 of cardiac troponin inhibitor (cTnI) and the myosin-binding protein C was reduced by 26 and 35%, resp

220 DNA sequences encoding cardiac myosin-binding protein C were determined in unrelated pa

221 ble 40-kDa fragment is produced from cardiac myosin-binding protein C when the heart is stressed usin

222 ansgenic (TG) mouse model expressing cardiac myosin binding protein-C with a non-phosphorylatable Ser

223 nd disrupt the interaction of native cardiac myosin-binding protein C with the thin filament.

224 e suggested that the interactions of cardiac myosin-binding protein-C with its binding partners vary