ライフサイエンスコーパス: nM

1 lower limit of quantification (LLOQ) of 1.0 nM with a relative standard deviation (RSD, n = 3) of 0.

2 siologically relevant detection limit of 1.0 nM.

3 -binding inhibitor with a K(i) value of 12.0 nM.

4 anscriptase (HIV RT) with K(D)'s of ~0.4-4.0 nM.

5 3 ug/L concentration (corresponding to 0.03 nM of BZF).

6 iVEGF) at extremely low concentrations (0.04 nM), significantly reduced VEGF expression in hard-to-tr

7 mmonium had the highest affinity (K(50) 0.05 nM); this also showed the highest affinity for sigma-2 r

8 o detect PFOS with a detection limit of 0.05 nM, which is lower than the health advisory limit of 0.1

9 over a PFOS concentration range of 0 to 0.05 nM.

10 ch assay is 1.28 nM (0.74 fmole), while 4.05 nM (2.35 fmole) with the competitive format.

11 4 reference lesions ranged from 0.03 to 0.07 nM.

12 tics with a detection limit of 0.50 +/- 0.08 nM, a wide linear range of 0.01-500 muM, and a sensitivi

13 d the receptor with high affinity (K(D) 2.08 nM).

14 50 nM) and increasing the OT EC50 from 0.081 nM to 21 nM at a concentration of 600 nM.

15 inities with K(i) values from 0.069 to 0.084 nM, as well as high selectivity over the M(2) subtype (4

16 ear peptide aptamer, estimating K(D) as 10.1 nM, which is the lowest concentration reported by using

17 -2 with nanomolar potency (IC(50) = 17 +/- 1 nM).

18 MIF tautomerase active site (K(i) = 18 +/- 1 nM) that binds with concomitant quenching of its fluores

19 ing studies revealed that (68)Ga-FOL had 5.1 nM affinity for FR-beta.

20 n [IC(50)] range 19.2 +/- 5.8-175.3 +/- 61.1 nM) and in vivo characteristics (tumor-to-prostate and t

21 26-fold increase in brain accumulation (8.1 nM).

22 2 nM, under the optimal conditions, with a 1 nM detection limit.

23 which ultimately led to the discovery of a 1 nM inhibitor of thrombin.

24 rcoma cells with subcellular resolution at 1 nM, but also efficiently convert optical energy into hea

25 ded exposure to OPs, even at a level below 1 nM, may lead to liver and central nervous system damages

26 from 0.1 to 5 muM and a detection limit of 1 nM.

27 te good linearity in a broad linear range (1 nM to 100 muM) with an excellent limit of detection, i.e

28 ified antibody pair detects PA(83) down to 1 nM in phosphate-buffered saline and 5 nM in human serum,

29 etection (LOD) was 0.38 aM-20 muM, with 1-10 nM being the typical range.

30 sponding (S)-eutomers (K(i) = 6.30 and 11.10 nM, respectively).

31 of intracellular calcium release (IC(50) 10 nM) induced in human monocyte-derived macrophages by 100

32 leus) binds ssDNA containing N6mA, with a 10 nM dissociation constant.

33 phorbol 12-myristate 13-acetate (PMA) at 10 nM concentration reduced the intensity of alpha-smooth m

34 ared to the free haloperidol (~18-fold at 10 nM).

35 d SN-38 toxicity in a period of 7 days at 10 nM, and half-maximally accelerated cell death combined w

36 l inhibitors were highly potent (IC(50) < 10 nM) and selective against PI3Kgamma, delta and HDAC6 enz

37 d discovery of potent compounds (IC(50) < 10 nM) for every target.

38 ysteine proteases (inhibition constants < 10 nM).

39 t, and reversible covalent PROTACs, with <10 nM DC(50)'s and >85% degradation.

40 towards the detection of AA with a LOD of 10 nM.

41 ., VX-661) by ~2-fold (with an EC(50) of ~10 nM).

42 and quinone)] in concentration-response (10 nM - 100 muM) for effects in human induced pluripotent s

43 /mL) inhibits (P < 0.0001) NT-stimulated (10 nM) secretion of IL-1beta (at 1 ng/mL) and CXCL8 (at 100

44 The 10 nM sensitivity of Met-lead 1.44 M1 is five times below t

45 esicles at protein concentrations down to 10 nM (~100 proteins per vesicle).

46 centration in a dynamic range of 10 pM to 10 nM with a detection limit of 5.9 pM.

47 reated with either 1,25(OH)(2) D(3) (0 to 10 nM) or 25(OH)D(3) (0 to 100 nM) in the presence and abse

48 5.2 fM (a linear range of from 0.1 pM to 10 nM), as well as a high selectivity that discriminates si

49 In rats, GenX at 0.1 - 100 nM rapidly (in 1-2 h) inhibited P-gp and BCRP transport

50 tivity in the moderate range (EC(50) = 1-100 nM) were subjected to (18)F-fluorination, autoradiograph

51 arget concentration within the range 0.2-100 nM.

52 0 pM to 250 nM with the average being 50-100 nM.

53 the PEG-haloperidol conjugate (at 10 and 100 nM) was able to significantly inhibit dopamine-induced G

54 in human monocyte-derived macrophages by 100 nM C3a, (b) inhibition of beta-hexosaminidase secretion

55 om human LAD2 mast cells degranulated by 100 nM C3a, and (c) selectivity for human C3aR over C5aR.

56 tromethorphan and d(3)-dextrorphan (each 100 nM) for 1152 injections in 63 s at full width at half-ma

57 ted to bind very strongly (i.e., K (d) < 100 nM) from 40 to 52% (p = 0.027).

58 ontaneous uterine contractions and METx (100 nM) had no effect on OT induced uterine contractions.

59 both Mcl-1 and Bfl-1 with K(i) values of 100 nM and shows appreciable selectivity over Bcl-2/Bcl-xL.

60 ut FBS amplified the catalytic effect of 100 nM sCAR nearly 3-fold.

61 we assess whether acute (75 muM ouabain 100 nM blebbistatin) or chronic myocardial Na(i) load (PLM(3

62 derived F508del homozygous cells, PGD97 (100 nM) increased short-circuit currents by ~3-fold and furt

63 rget miRNA-21 in the range from 10 pM to 100 nM in phosphate-buffered saline (PBS); the limit of dete

64 2) D(3) (0 to 10 nM) or 25(OH)D(3) (0 to 100 nM) in the presence and absence of ultrapure or standard

65 ing device operates in the range of 0.1-1000 nM DA requiring only ~2.4 muL sample volume, which corre

66 ncentration was found for the range of 4-102 nM, under the optimal conditions, with a 1 nM detection

67 ith a nanomolar detection limit of 63 +/- 11 nM for 5-HT through a wide concentration range (63 nM-20

68 ated nanomolar detection limits of 63 +/- 11 nM for DA and 40 +/- 17 nM for 5-HT through a wide conce

69 eased SN-38-mediated cancer cell death at 11 nM (EC(50)), time-dependently doubled SN-38 toxicity in

70 ng in the most potent inhibition (K(i) >= 11 nM).

71 pentazocine had EC(50) values of 7.3 and 110 nM and maximal stimulation values of 79% and 35% when th

72 1) with lower detection limits of 52 and 110 nM, respectively.

73 he systems reached submicromolar ranges (110 nM).

74 affinity (dissociation constant (K(d)) = 114 nM) and disrupts the interaction between KEAP1 and the t

75 nt ($K_{\rm{D}}^{{\rm{app}}}$) of 150 +/- 12 nM.

76 ol-1-yl}methyl)benzonitrile (73, IC(50) = 12 nM) and 4-({5-[4-chloro-1-(2H-indazol-6-yl)-1H-1,2,3-ben

77 guished from other E3 ligases by having a 12 nM binding site at the proteasome contributed by substra

78 and H11-H4, that bind RBD (K(D) of 39 and 12 nM, respectively) and block its interaction with ACE2.

79 ) = 0.53 muM, K(i) = 0.36 muM, and K(D) = 12 nM.

80 , combined with ambient (4.5 nM) or high (12 nM) dissolved iron (dFe).

81 df1) attractant gradient ranges from 0 to 12 nM, values similar to the 3.4 nM K(d) of its receptor Cx

82 29 and 30 with EC(50) values of 110 and 120 nM, respectively, and without measurable host cell cytot

83 nM) compared to the full-length aptamer (124 nM), with a limit of detection (LOD) of 2 nM.

84 hest affinity for sigma-2 receptors (K(i) 13 nM).

85 lower than the health advisory limit of 0.14 nM reported by the U.S. EPA.

86 ation constants ranging between 6 muM and 14 nM.

87 Of these, 57, with EC(50) = 145 nM and a solubility of 33 muM, showed high clearance in

88 addition, strawberry fruits treated with 150 nM PSKalpha exhibited a sufficient availability of ATP r

89 that the strawberry fruits treated with 150 nM PSKalpha exhibited lower expression of poly-ADP-ribos

90 NADPH in strawberry fruits treated with 150 nM PSKalpha.

91 In contrast, 63, with EC(50) = 162 nM and a solubility of 9 muM, showed lower clearance and

92 the glycoconjugate, FGlc-FAPI (IC(50) = 167 nM), showed slightly lower affinity for FAP in vitro, wh

93 limits of 63 +/- 11 nM for DA and 40 +/- 17 nM for 5-HT through a wide concentration range (40 nM-20

94 y in drug-resistant NSCLC cells (IC(50) = 17 nM) and in mice with H1975 xenograft tumor.

95 lerated cell death combined with SN-38 at 17 nM.

96 IC(50) 280 nM, corresponding to K (i) of 173 nM.

97 -SWCNT-Pc 3D/GCE were found to be 53 and 177 nM in the range of 0.1-4.8 muM, respectively.

98 ty against SARS-CoV-2 (4-6 nM for H11-H4, 18 nM for H11-D4) and additive neutralization with the SARS

99 -specific DNA binding in vitro (IC(50) = 180 nM) and in vivo.

100 InsP(8) to the XPR1 N-terminus (K (d) = 180 nM) was demonstrated by isothermal titration calorimetry

101 hown to exhibit a limit of detection of 0.19 nM and a linear detection ranging from 1 to 50 nM, the A

102 ike binders to MDM2, and to a family of 3-19 nM-affinity, alpha/beta-peptide-based binders to 14-3-3.

103 ol-1-yl}methyl)benzonitrile (74, IC(50) = 19 nM).

104 with B cells (apparent K(D) between 5 and 19 nM), was obtained for an average inter-antigen spacing o

105 lar, compound 10b had an EC(50) value of 190 nM in L6 myoblast cells.

106 y TDP1 in a FRET assay with an IC(50) of 190 nM.

107 ced binding affinity by 19 times (K(d) = 1.2 nM).

108 r formaldehyde with detection limits of 48.2 nM and 31.6 muM, respectively.

109 mal inhibitory concentration, 8 nM [human]/2 nM [murine]) and can be obtained from the parent chelato

110 viral spike glycoprotein tightly (K(D) of 2 nM), and a 2.6- angstrom-resolution crystal structure of

111 24 nM), with a limit of detection (LOD) of 2 nM.

112 ependence was within the 3 x 10(-4) to 10(2) nM BZF range.

113 and damaged duplex substrates are 100 +/- 20 nM and 80 +/- 30 nM, respectively.

114 bit the function of P-gp (log IC(50) of 4.20 nM for quinidine and 4.61 nM for the mPEG-glycine-quinid

115 e.g., quinuclidine 17 (MRS4608, IC(50) ~ 20 nM at hP2Y(14)R/mP2Y(14)R), or of triazole 2, preserved

116 nce derives from p44/p62's high affinity (20 nM) for damaged ssDNA.

117 is difficult to reconcile with the high, 20 nM K(d) binding of TnT onto tropomyosin.

118 not release the MNPs, however addition of 20 nM of papain to the urine samples resulted in a time-dep

119 that use low concentrations of SiR-PyPDS (20 nM) to provide informative measurements representative o

120 inhibitors with IC(50) values lower than 20 nM for mPTPB.

121 s show an analytical range between 5 and 200 nM of histamine, corresponding to physiologically normal

122 ts DPAGT1 enzyme with an IC(50) value of 200 nM.

123 lial cell adhesion molecule (EpCAM; K(D), 21 nM), and with [(89)Zr]Zr-DFO-N-suc-hyS110, targeting onl

124 d increasing the OT EC50 from 0.081 nM to 21 nM at a concentration of 600 nM.

125 ciation constant K (d) values of 320 and 210 nM, respectively.

126 tubulin dissociation constant (8.48 +/- 1.22 nM) and its tightening in the presence of GTP (3.69 +/-

127 high sensitivity (the detection limit of 22 nM) and high specificity.

128 Potent TLR8 agonism (IL-12p40 EC(50) = 220 nM) and >100-fold TLR7 selectivity (IFN-alpha EC(50) > 5

129 Y as 0.0325 muM (32.5 nM) and 0.221 muM (221 nM), respectively.

130 te a high affinity pool (KD range: 0.399-233 nM) of CD160 targeting monoclonal antibodies.

131 2-76) than the leads (K(I)s-CA IX 103, 2400 nM; II/IX-SI 56, >4) against CA IX/XII over off-target i

132 n human serum with a detection limit of 1.25 nM and preserved its stability up to around 95% during a

133 ncentration of the investigation range (1.25 nM-2.56 muM).

134 platforms carrying higher siRNA doses (6.25 nM).

135 ha-synuclein in the range from 0.25 pM to 25 nM.

136 limits of detection ranged from 50 pM to 250 nM with the average being 50-100 nM.

137 InhA inhibitors with affinities of up to 250 nM.

138 on the initial hit, compound 4 (IC(50) = 257 nM), resulted in several highly potent inhibitors with I

139 h IC(50) values in the range of 0.18 to 0.26 nM (p = 0.02, and p = 0.04 for CVX-8, and ADX-3, respect

140 ally relevant levels of LE up to at least 26 nM (800 mug L(-1)) in the microliter-sized samples of bo

141 cm(-2), and the limit of detection (LOD) 26 nM.

142 teases and also finding compound 21m with 27 nM inhibitory activity toward thrombin.

143 be achieved with the sandwich assay is 1.28 nM (0.74 fmole), while 4.05 nM (2.35 fmole) with the com

144 mization, the most potent hit has IC(50) 280 nM, corresponding to K (i) of 173 nM.

145 owed identifying derivative 21i, a potent 29 nM inhibitor of FXIIa, with improved selectivity over ot

146 pha3beta2 neuronal nAChR subtype (IC(50) 1.3 nM).

147 half-maximal inhibitory concentration of 6.3 nM.

148 sing platform with a limit of detection of 3 nM and capable of the detection of human C-reactive prot

149 x substrates are 100 +/- 20 nM and 80 +/- 30 nM, respectively.

150 ind to TM with four-fold higher affinity (30 nM) compared to the full-length aptamer (124 nM), with a

151 that combine remarkable affinity (K(i) < 30 nM) and exquisite selectivity.

152 ICT12035 is a selective and potent (30 nM in calcium mobilisation assay) small molecule FPR1 an

153 muM and 10 muM, with a detection limit of 31 nM.

154 A linear response in the range of 1-32 nM with a detection limit of 0.34 nM and excellent recog

155 ximal inhibitory concentration [IC(50)] = 32 nM), the glycoconjugate, FGlc-FAPI (IC(50) = 167 nM), sh

156 equilibrium dissociation constant (K(D) = 32 nM) close to values previously reported from in vitro an

157 binds to Pfs47 with high affinity (17 to 32 nM).

158 r exhibited a very wide dynamic range (13.33 nM-66.67 muM), with an estimated detection limit in the

159 ge of 1-32 nM with a detection limit of 0.34 nM and excellent recognition specificity for PNG over it

160 oncentrations (>1 muM for demethylation; >35 nM for cleavage), characteristic of microscale hotspots

161 uency of OT induced contractions (EC50 = 350 nM) and increasing the OT EC50 from 0.081 nM to 21 nM at

162 rs, with compound 21 reaching EC(50) of 0.36 nM.

163 ffinity to E. faecalis cells (K(D)-value: 37 nM) and successfully discriminated E. faecalis from 20 d

164 owed PDE2A inhibition IC(50) of 1.3 +/- 0.39 nM, ~100-fold selectivity versus other PDE enzymes, clea

165 is a potent antagonist with an IC(50) of 396 nM.

166 igher binding affinity for HBeAg (K(d) = 0.4 nM) than the unmodified original aptamer.

167 ing VEGFR1 with a weaker affinity-K(D) = 1.4 nM.

168 thiazol-5-yl)thiourea 47 (hIDO IC(50) = 16.4 nM).

169 ndrial H2O2 will be in the low nM range (2-4 nM) and will be inversely dependent on the total pool of

170 DMX at respective affinities of 0.49 and 2.4 nM.

171 s from 0 to 12 nM, values similar to the 3.4 nM K(d) of its receptor Cxcr4.

172 permeable analogue DC432 (IC(50) of 54 +/- 4 nM) decreases the N-terminal methylation level of the re

173 PC3, with HN3-T20 having a K(D) value of 7.4 nM.

174 aginal epithelium were treated with either 4 nM 17beta-estradiol (E) for seven days, 50 ng/ml E.coli

175 re-treating VK2 E6/E7 cells with estrogen (4 nM) and challenging with 1L-17A & F (12 h) significantly

176 (i) = 3 pM) and good NTS1 affinity (K(i) = 4 nM), providing a >1300-fold NTS2 selectivity.

177 Ps after 3.5 minutes incubation using just 4 nM of the cysteine protease, papain.

178 50 ng/ml E.coli flagellin (F) for 12 h, or 4 nM 17beta-estradiol plus 50 ng/ml flagellin (E + F(12 h)

179 nding) and reported K(d) values of 56 and 40 nM (R and S, respectively), the rates of binding to P450

180 5-HT through a wide concentration range (40 nM-200 muM).

181 METx (41 nM) had no effect on spontaneous uterine contractions an

182 oliferation, with the IC(50) of 402 and 4220 nM, respectively.

183 combines strong anti-HIV activity (IC(90)<45 nM), photostability and improved cell safety.

184 over two orders of magnitude from 3.5 to 455 nM, 0.4-52 mg/L), without the hook effect.

185 D) (equilibrium dissociation constant) of 46 nM.

186 IC(50) was determined to be 460 nM.

187 of detections (LOD) for cytochrome c was 0.5 nM.

188 aG with a dissociation constant (K(d)) = 0.5 nM.

189 iotensin converting enzyme 2 (ACE2) with 1-5 nM affinity.

190 ta2 receptor ligand with a K(i) value of 1.5 nM.

191 an healthy participants (mean 172.8 vs 115.5 nM; p = 0.14).

192 detection for Tz and SY as 0.0325 muM (32.5 nM) and 0.221 muM (221 nM), respectively.

193 2100 (900 muatm), combined with ambient (4.5 nM) or high (12 nM) dissolved iron (dFe).

194 ined to be ca. 0.5 to 6.2 ng/mL (3.9 to 40.5 nM) by high-performance liquid chromatography (HPLC) (th

195 owed greater potency (K(I)s-CA IX 19.1-408.5 nM) and selectivity (II/IX SI 2-76) than the leads (K(I)

196 est cytotoxic activity on BT474 (IC50 = 55.5 nM, BRCA2 and TP53 co-mutant) compared to MCF7 (IC50 = 7

197 n to 1 nM in phosphate-buffered saline and 5 nM in human serum, which are physiologically relevant co

198 ding to several PKC isoforms with K(i)'s < 5 nM, while the latter exhibited PKC affinities that were

199 ess human PNMT (hPNMT) inhibitory potency <5 nM versus AdoMet.

200 centration range and limit of detection of 5 nM.

201 even wider linear response range of 0.005-50 nM, and a lower limit of detection of 1.9 pM (S/N = 3),

202 ited a wide linear response range of 0.01-50 nM, with a high sensitivity of 3.33 mF cm-2 Logc-1 (unit

203 hotoactivity for cationic Pcs (EC(50) ~ 3-50 nM) than for anionic Pcs (EC(50) ~ 0.3-10 muM), the latt

204 DO-Im (in contrast to CDDO-Me), as low as 50 nM, can covalently transacylate arginine and serine resi

205 even concentrations of ML336, starting at 50 nM.

206 ce even when the concentration of DmFc is 50 nM.

207 compounds that reach cellular potencies <50 nM and exhibit >2,700-fold selectivity for PPARalpha ove

208 ns with a breakthrough detection limit of 50 nM.

209 and a linear detection ranging from 1 to 50 nM, the AuNPs modified Au chip was proven to clearly be

210 molecule reaction detection limits below 500 nM, the detection limits are within the physiologically

211 e with atorvastatin, the ability of CDC (500 nM) to elevate [Ca(2+)](c) was diminished and the potent

212 y at low nanomolar concentrations (EC50 <500 nM) and low cytotoxicity in mammalian cells.

213 h nociceptin/orphanin FQ peptide (N/OFQ; 500 nM), an endogenous opioid-like peptide, normalized GABA

214 inding affinities in the range of 500 pM-500 nM.

215 ry effects with IC(50) values lower than 500 nM.

216 T with a detection limit of 4.7, 3.5 and 55 nM, respectively.

217 (max) = 118%, EC(50) = 0.24 muM, K(D) = 19.6 nM; inactive at autotaxin and LPA(2-6) receptors).

218 P2-D26 achieves DC(50) values of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukem

219 (+/-)-47, and (+/-)-38 K(i) = 10.20 and 23.6 nM, respectively] into their two enantiomers, isolating

220 rs with K(i) values toward human CD73 of 3-6 nM.

221 rm of MMP-1 was found to have a K(D) of 34.6 nM for LRP-1, while the MMP-1/TIMP-3 complex had a seven

222 eutralizing activity against SARS-CoV-2 (4-6 nM for H11-H4, 18 nM for H11-D4) and additive neutraliza

223 ch possesses high affinity for APJ (K(i) 4.6 nM) and produces cardiorenal effects in vivo similar to

224 lded PGD97, which exhibits a K(D) value of 6 nM for the CAL PDZ domain, >= 130-fold selectivity over

225 and 5-30 muM with a limit of detection of 6 nM.

226 % for five replicate detections at 21 and 60 nM IXC, respectively.

227 0.081 nM to 21 nM at a concentration of 600 nM.

228 log IC(50) of 4.20 nM for quinidine and 4.61 nM for the mPEG-glycine-quinidine conjugate).

229 P HAT with their IC(50) values as low as 620 nM were discovered.

230 5-HT through a wide concentration range (63 nM-200 muM) in the presence of a constant background of

231 tening in the presence of GTP (3.69 +/- 0.65 nM), at a dissociation rate >10(-2) s(-1).

232 10(-3) M) with a low limit of detection (65 nM).

233 n affinity VEGF-A(121):VEGFR2 as K(D) = 0.66 nM.

234 active novel antagonist (S)-18g (K(i) = 3.66 nM) was validated.

235 itro HDAC8 activity (IC(50) = 66, 23, and 66 nM, respectively) and up to 410-fold selectivity for HDA

236 c bead (MB) platforms at levels as low as 66 nM.

237 ch showed an IC(50) of 5 uM and a K(d) of 66 nM.

238 2 to >357.14) or cotreatment (EC(50) = 34.69 nM to 7.52 muM; SI-MTT = 5.24 to > 1,441.33) settings.

239 human class I HDACs (e.g., JT86, IC(50) 0.7 nM, HDAC1), 25-fold increased cytotoxicity against five

240 lso exhibited high NTS2 affinity (K(i) = 1.7 nM), with low NTS1 affinity (K(i) = 4.7 muM), resulting

241 ection limits of 10.2, 158.2, 10.3 and 122.7 nM, respectively.

242 Among them, compound 4t showed a K(i) of 2.7 nM for mPTPB with over 4500-fold preference over 25 mamm

243 lso binds VEGFR1 with an affinity K(D) = 3.7 nM.

244 r fluid), with limits of detection down to 7 nM (35 amol).

245 ibited inhibition constants of 410 and 2,700 nM, respectively.

246 estibule of the channel with an IC(50) of 72 nM and greater than 200-fold selectivity over off-target

247 lta2 T-cells (EC(50) ranging from 5 fM to 73 nM), which translated into sub-nanomolar gammadelta T-ce

248 in vitro in the nanomolar range (IC(50) = 74 nM) with high selectivity index (SI > 1350).

249 e and TKI-resistant NSCLC cells (IC(50) = 77 nM) and in xenograft mice.

250 ipped with a low limit of detection of 79.77 nM and a high sensitivity of 45.77 Acm(-2) muM(-1) with

251 sub-nanomolar affinity (K(i) for CB2) of 0.8 nM and a remarkable selectivity factor of >12,000 over C

252 cond loop including one sequence (K(d) = 1.8 nM) containing an i, i+4 disulfide bond.

253 hynyl analogue 15 (MRS7591, K(i) = 10.9/17.8 nM, at human/mouse A(3)AR).

254 n of beta-hexosaminidase secretion (IC(50) 8 nM) from human LAD2 mast cells degranulated by 100 nM C3

255 to MDM2 and MDMX, with K(d) of 19.3 and 66.8 nM, respectively.

256 or (half-maximal inhibitory concentration, 8 nM [human]/2 nM [murine]) and can be obtained from the p

257 ibitor of CK1alpha kinase activity (K(i) = 8 nM).

258 50% effective concentration (EC(50)) = 3.80 nM to 1.73 muM; selective index SI for 3-(4,5-dimethyl-2

259 the N-CNT electrode detected LE down to 0.81 nM (25 mug L(-1)) and showed the fastest kinetics (2.1 x

260 igh binding affinity (IC(50) values of 67-84 nM) and good selectivity over other BRD family proteins

261 respective IC(50) values of 0.30 muM and 84 nM.

262 ection limit in the subnanomolar range (0.85 nM azithromycin).

263 xycodone with the Nafion/SWCNT sensor was 85 nM, and the linear range was 0.5-10 muM in buffer soluti

264 -affinity binding to STAT3, with K(D) of 880 nM (7g) and 960 nM (9k).

265 ve molecules with IC(50)'s from 2340 to 0.89 nM.

266 potent SphK2-selective inhibitor (K(i) = 89 nM, 73-fold SphK2-selective) with validated in vivo acti

267 half maximal inhibitory concentration of 89 nM.

268 PARP-2 inhibition with IC(50) of 1.3 and 0.9 nM, respectively.

269 2.5-130 muM and a low detection limit of 0.9 nM.

270 ydrogen peroxide levels (mean 172.8 vs 115.9 nM; p = 0.25), and these patients also trended toward hi

271 mouse CD3 (dissociation constant [K(D)], 2.9 nM) and mouse epithelial cell adhesion molecule (EpCAM;

272 -hyS110, targeting only mouse CD3 (K(D), 2.9 nM), showed uptake in the tumor, spleen, and other lymph

273 ated in glaucoma (K(i) in the range 0.36-6.9 nM).

274 ated by a calculated KD of approximately 6.9 nM.

275 mple, our dissolved Fe concentration (20,900 nM) and associated flux values (1.4 Gmol y(-1)) from AIS

276 inity (human/guinea pig/mouse K(d): 24/28/94 nM).

277 In addition, 84 had an EC(50) of 942 nM in the [(35)S]GTPgammaS binding assay using mouse str

278 alf-maximal inhibitory concentration of 3.96 nM.

279 had a sevenfold higher affinity (K(D) = 4.96 nM) for the receptor.

280 g to STAT3, with K(D) of 880 nM (7g) and 960 nM (9k).

281 nsitivity of 3.33 mF cm-2 Logc-1 (unit of c, nM) and a low limit of detection of 7 pM (S/N = 3).

282 ity of 1.65 x 103 Omega Logc(-1) (unit of c, nM).

283 aptasensor had a wide linear range of (fM ~ nM), and the detection limit reached (0.24-1.67) fM for

284 DroMiCo, can quantify unlabeled proteins in nM concentrations and analyze multicomponent mixtures wh

285 assays demonstrated target engagement at low nM concentrations, and molecular assays revealed that an

286 -state mitochondrial H2O2 will be in the low nM range (2-4 nM) and will be inversely dependent on the

287 otransmitters in the human body is very low (nM or pM level) and it is extremely difficult to detect

288 pM) and high sensitivity (39.56 +/- 0.41 muA nM(-1)) values is attributed to the fast and unhindered

289 ion of picomolar (pM) insulin and nanomolar (nM) cortisol concentrations in a single microliter sampl

290 nsitivities (44.54 pA/nM.mum(2) and 71.08 pA/nM.mum(2), respectively) and low detection limits (0.045

291 M respectively, high sensitivities (44.54 pA/nM.mum(2) and 71.08 pA/nM.mum(2), respectively) and low

292 ts of detection and quantification in the pM-nM range.

293 n of ribose over a wide concentration range (nM to mM).

294 These resistant lines retain nM sensitivity to CM03.

295 A, which irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome.

296 he prefolded conformation with a K(d) in the nM range.

297 calculated as 0.7 uA/nM (Cd(II)) and 3.5 uA/nM (Pb(II)) for A-MWCNT/Hyalu/l-Cys/GCE and 0.6 uA/nM (C

298 (II)) for A-MWCNT/Hyalu/l-Cys/GCE and 0.6 uA/nM (Cd(II)) and 2.6 uA/nM (Pb(II)) for A-MWCNT/Hyalu/l-S

299 /l-Cys/GCE and 0.6 uA/nM (Cd(II)) and 2.6 uA/nM (Pb(II)) for A-MWCNT/Hyalu/l-Ser/GCE.

300 The sensitivities were calculated as 0.7 uA/nM (Cd(II)) and 3.5 uA/nM (Pb(II)) for A-MWCNT/Hyalu/l-C