ライフサイエンスコーパス: naive T cell

1 ls of protein expression in Mettl3-deficient naive T cells.

2 ssion of CD45RA is generally associated with naive T cells.

3 cell counts, but was related to a decline in naive T cells.

4 of T cell activation (VISTA) is expressed on naive T cells.

5 degradation and thereby support survival of naive T cells.

6 SE = 0.59 +/- 0.21, p = .006), but not with naive T cells.

7 d increased memory T cells at the expense of naive T cells.

8 tile cell with a limited ability to activate naive T cells.

9 functional, and metabolic differentiation of naive T cells.

10 n the generation of Ca(2+) signals in murine naive T cells.

11 d in the final maturation of thymocytes into naive T cells.

12 rt survival and homeostatic proliferation of naive T cells.

13 mbrane domains, known as protein islands, on naive T cells.

14 onses by presenting HLA-epitope complexes to naive T cells.

15 become a cell superbly adapted to activating naive T cells.

16 a(2+) stores that were sensitive to NAADP in naive T cells.

17 nd increased memory T cells while decreasing naive T cells.

18 ant peptides and derived preferentially from naive T cells.

19 ase UBR5, which suppressed DUBA abundance in naive T cells.

20 y of mature DCs produced IL-12 and activated naive T cells.

21 allenge to maintain the functions unique for naive T cells.

22 icipate in the immune response as peripheral naive T cells.

23 s that were indistinguishable from wild-type naive T cells.

24 ted in cocultures with heterologous neonatal naive T cells.

25 e specialized APCs with the ability to prime naive T cells.

26 elta-like ligand 4 (DLL4) amplify priming of naive T cells.

27 g link between Wnt signaling and survival of naive T cells.

28 Cs) since they are also able to prime/induce naive T cells.

29 N TCM cells in similar numbers from the same naive T cells.

30 t unlike monocytes, DC3s drove activation of naive T cells.

31 idual MHC context during thymic selection of naive T cells.

32 optimizes their ability to efficiently prime naive T cells.

33 and were more susceptible to apoptosis than naive T cells.

34 pamycin, to induce Treg differentiation from naive T cells.

35 des where they present processed antigens to naive T-cells.

36 e phosphorylation (OXPHOS), in comparison to naive T-cells.

37 memory T cells detect low dose antigen, only naive T cells activate cell cycle effectors.

38 The expression of CCR8 during naive T cell activation is controlled by skin-specific f

39 alongside T cell receptor (TCR) ligation for naive T cell activation.

40 erienced grafts, but also through priming of naive T cells after BMT.

41 that enable them to be more protective than naive T cells against infectious threats.

42 One hallmark sets naive T cell aging apart from most other tissues except

43 nomic signature of aging including declining naive T cell and increasing monocyte and cytotoxic cell

44 Aging is associated with a gradual loss of naive T cells and a reciprocal increase in the proportio

45 can both preclude the study of unmanipulated naive T cells and alter subsequent differentiation.

46 s uncover a Fas-mediated interaction between naive T cells and antigen-experienced T cells that drive

47 ary lymphoid organs recruit large numbers of naive T cells and harbor lymphocyte subsets with opposin

48 on pathway predominantly controls priming of naive T cells and hence generation of adaptive memory ce

49 s can inhibit Th17 cell differentiation from naive T cells and IL-17 production in established Th17 c

50 n-educated" DCs stimulated the activation of naive T cells and polarized a subset of these cells into

51 phatic endothelial cells (LECs) chemoattract naive T cells and promote their survival in the lymph no

52 understanding on the identification of truly naive T cells and recent thymic emigrants.

53 in effector T cells as in their counterpart naive T cells and seemed to be equally important for the

54 e in response to lower doses of antigen than naive T cells and with reduced requirements for co-stimu

55 ith higher vs. lower CCR5 levels (memory vs. naive T cells) and in memory T cells with higher vs. low

56 high proportion of relatively HIV resistant naive T cells, and an unparalleled capacity to regenerat

57 , as well as differentiation and survival of naive T cells, and generation and maintenance of memory

58 alyzed the gene expression profile of Tregs, naive T cells, and memory T cells in aged mice.

59 s the most effective at improving memory and naive T cell anti-H60 responses and GVL.

60 Naive T cells are actively maintained in a quiescent sta

61 +) T cells and includes only memory T cells; naive T cells are excluded to limit the potential for al

62 and subtracted from the naive pool if truly naive T cells are needed to respond to antigens.

63 Immature and naive T cells are present in both healthy and atheroscle

64 e periphery, the majority of HDAC3-deficient naive T cells are recent thymic emigrants, indicating a

65 We also show that naive T cells are recruited into the mouse brain by anti

66 e knockdown with RNAi is challenging because naive T cells are refractory to transduction with viral

67 oduction is a signatory effector function of naive T cells, at least in newborns.

68 During immune responses, naive T cells become functional, as they are primed with

69 Thymic involution and proliferation of naive T cells both contribute to shaping the naive T-cel

70 x (MHC) ligands is essential for survival of naive T cells but not memory cells.

71 is essential not only for the circulation of naive T cells, but also for their survival.

72 ogether with Egr2 and 3, T-bet is induced in naive T cells by Ag stimulation, but Egr2 and 3 expressi

73 urred during the initial activation phase of naive T cells by an antigenic stimulus.

74 Activation of naive T cells by antigen-presenting cells (APCs) is an e

75 t transendothelial migration (diapedesis) of naive T cells by modulating molecular assembly the at T

76 SOCE directs the metabolic reprogramming of naive T cells by regulating the expression of glucose tr

77 -) fraction of the allograft was depleted of naive T cells by using magnetic CD45RA beads.

78 cid pH does not hinder initial activation of naive T-cells by dendritic cells.

79 he biology of CD4 T cells is complex because naive T cells can differentiate into various subpopulati

80 exhaustion of the proliferative capacity of naive T cells causes a sharp decline of their effective

81 sleep greater than 8 hours), epigenetic age, naive T cell (CD8+CD45RA+CCR7+), and late differentiated

82 In contrast, permanence of naive T cell clones would be determined by their affinit

83 ricts proliferation of peripherally expanded naive T-cell clones that accumulate with age.

84 d thus is decreased in peripherally expanded naive T-cell clones.

85 after the age of approximately 60 y because naive T cells collectively approach replicative senescen

86 with a concomitant decrease in frequency of naive T cells compared to non-ATG induction.

87 ght on functional differentiation within the naive T cell compartment and the importance of the thymu

88 eport an unexpected heterogeneity within the naive T cell compartment in mice, where loss of VISTA di

89 fe resulted in functional restoration of the naive T cell compartment, implicating the thymus as havi

90 Naive T cell conditioning occurs in lymph nodes (LNs), b

91 High frequencies of CD8+CCR9+ naive T cells correlated with prolonged OS, while neutra

92 ly distinct from their more mature but still naive T cell counterparts, because they exhibit dampened

93 The naive T-cell counts were particularly low for age, and m

94 , we argue that the developmental history of naive T cells creates a 'hidden layer' of diversity that

95 To find and activate naive T cells, DCs must migrate to lymph nodes, yet the

96 The number of naive T cells decreases and susceptibility to new microb

97 t of potential new therapeutics, centered on naive T-cell depletion, interleukin-17/21 inhibition, ki

98 ne phosphatases induced by the activation of naive T cells determine the way activated or memory CD4(

99 Following antigen stimulation, naive T cells differentiate into memory cells that media

100 cGVHD is mediated by naive T cells differentiating within IL-17-secreting T c

101 We now understand that cGVHD is initiated by naive T cells, differentiating predominantly within high

102 RORgammat, GATA3 and others is essential for naive T cell differentiation into effector T cells.

103 uite of in vitro functional assays measuring naive T-cell differentiation, B-cell/T-cell cocultures,

104 ells, while retaining the ability to enhance naive T-cell differentiation.

105 can be understood as mechanisms to maximize naive T cell diversity.

106 e T-cell turnover as a putative regulator of naive T-cell diversity and identify a molecular pathway

107 ne the changes in chromatin accessibility in naive T cells during T(H)1 and T(H)2 cell differentiatio

108 How this functional signature relates to naive T cell dynamics and aging is unknown.

109 neral and that are instructive to understand naive T cell dysfunction.

110 Because antigen-stimulated naive T cells either die as effectors or enter the activ

111 During infectious challenges, naive T cells encountering their cognate antigen become

112 s a growing body of evidence that the use of naive T cells enhances the efficacy of adoptive T cell t

113 CD8(+)CD62L(+)CD45RA(+) naive T cells enriched by streptamer-based serial-positi

114 secondary lymphoid environment that impaired naive T cell entry and access to key survival factors.

115 cking to inflamed tissues, without affecting naive T cell entry into secondary lymphoid organs.

116 8(+) T cells, reduction in the proportion of naive T cells, evidence of T cell exhaustion and senesce

117 irst, a small population of epitope-specific naive T cells expands by several orders of magnitude.

118 ext built a map of cell state changes during naive T-cell expansion.

119 go positive selection and differentiate into naive T cells expressing a highly diverse self-MHC-restr

120 ins mechanistically enforce and maintain the naive T-cell fate.

121 When dormant naive T cells first become activated by antigen-presenti

122 nse to IL-7 signalling in order to reprogram naive T cells for proliferation and differentiation.

123 ted loci and show the advantage of utilizing naive T cells for understanding autoimmune diseases.

124 issue, and elevated thymic T-cell export and naive T-cell frequencies in old mice.

125 KMO inhibition increased naive T cell frequency and lowered PD-1 expression in na

126 In studies of immune aging, naive T cells frequently take center stage.

127 an naive T cells, the selective depletion of naive T cells from allografts might constitute a way of

128 study shows that clinical-grade depletion of naive T cells from an allograft through the use of magne

129 the abundance of TCR sequences in samples of naive T cells from blood using an accurate quantitative

130 Priming of naive T cells from healthy donors with aberrant peptides

131 Piperacillin-primed naive T cells from healthy volunteers also secreted IFN-

132 Naive T cells from healthy volunteers were primed to pip

133 (sex determining region Y)-box 30 activated naive T cells from human leukocyte antigen A*02:01-posit

134 lymph nodes promptly increase the influx of naive T cells from the circulation in order to screen an

135 b(+)CD16(+) neutrophils, and CD4(+)CD45RA(+) naive T cells from the same 125 healthy individuals.

136 We demonstrate that naive T-cell generation decreases with age because of a

137 response to acute viral infection, activated naive T cells give rise to effector T cells that clear t

138 On activation, naive T cells grow in size and enter cell cycle to mount

139 predicting treatment-induced remission using naive T-cells had an odds ratio of 15.4 (p < 0.0001).

140 We show that naive T cells harness cytoskeletal coupling to transmit

141 owever, the role for Wnt signaling in mature naive T cells has not been investigated.

142 Naive T cells have long been regarded as relatively quie

143 Human naive T cells have low RNA content and their numbers can

144 Salsa6f during T cell receptor activation in naive T cells, helper Th17 T cells and regulatory T cell

145 t this molecule is an important regulator of naive T cell homeostasis and it has been linked to immun

146 f robust T cell activation to encompass both naive T cell homeostasis and models of weak activation,

147 nt and the importance of the thymus in human naive T cell homeostasis and premature aging.

148 mice deficient in coronin 1, a regulator of naive T cell homeostasis, fully retained allografts whil

149 Although a critical player in naive T cell homeostasis, the ability of VISTA to restra

150 age-dependent changes in factors supporting naive T cells homeostasis may also be involved.

151 reatment with IL-7/mAb complexes can restore naive T cell homeostatic proliferation in aged mice.

152 Similarly, naive T cell IL-10Ralpha expression also allows IL-10 to

153 Similarly, 2W:I-A(b)-specific naive T cells in different neonatal mice varied signific

154 ning protein coronin 1 in the maintenance of naive T cells in peripheral lymphoid organs.

155 st potent APCs that induce the activation of naive T cells in response to pathogens.

156 resent processed antigen from these sites to naive T cells in secondary lymphoid organs while also pr

157 The naive T cells in structured lymphoid tissues, once being

158 ll motility suggested that the activation of naive T cells in the lymph node occurs in distinct phase

159 and resulted in a linked contraction of all naive T cells, including CD31(+)/CD4(+) putative thymic

160 central memory T cells were reduced, whereas naive T cells increased in treated patients.

161 c reticular cells support the maintenance of naive T cells, induce Ag-specific tolerance, and restric

162 Ag-dependent activation of naive T cells induces dramatic changes in cellular metab

163 into non-lysosomal compartments and polarize naive T cells into an interferon-gamma(low), interleukin

164 or blockade prevented differentiation of the naive T cells into antigen-specific IL-22-secreting cell

165 Furthermore, differentiation of naive T cells into antigen-specific TH22 cells is depend

166 Selective differentiation of naive T cells into multipotent T cells is of great inter

167 el where colitis is induced upon transfer of naive T cells into Rag1(-/-) mice.

168 Differentiation of naive T cells into T helper 17 cells or regulatory T cel

169 fferent stages during the differentiation of naive T cells into T helper 2 cells.

170 e found that MR regulates differentiation of naive T cells into T-helper type 17 (Th17) effector cell

171 nscription factor induces differentiation of naive T cells into Th17 cells and loss of STAT3 in T cel

172 The generation of naive T cells is dependent on thymic output, but in adul

173 Apc-deficient T cells, we found that loss of naive T cells is due to T cell intrinsic dysregulation o

174 2+) stores targeted by NAADP in conventional naive T cells is less clear.

175 duced NF-kappaB phosphorylation in CD4+CD31- naive T cells is linked to reduced homeostatic prolifera

176 Although memory cells are the progeny of naive T cells, it is unclear that all naive cells from a

177 unction of the memory differentiation state (naive T cells < central memory T cells < effector memory

178 To determine the contribution of naive T cell, memory stem T cell, central memory T cell,

179 Compared with naive T cells, memory CD8(+) T cells have a transcriptio

180 the production of T cells declines with age, naive T cells must be long-lived.

181 EBV-related T-cell expansions do not impair naive T-cell numbers or maintenance of protective respon

182 ized by increased thymopoiesis and increased naive T cell output.

183 ut not long sleep, was associated with fewer naive T cells (p < .005) and neither was related to late

184 ion, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informat

185 Enforced expression of IL-10Ralpha on naive T cells permits an IL-10-generated STAT3 signal eq

186 tenance of immunotherapy-specific memory and naive T-cell phenotypes as early as 3 mo into immunother

187 rmed that the Treg-DC-mediated skewed CD4(+) naive T cell polarization resulted from decreased IL-12

188 nt novel evidence that Treg-DC skewed CD4(+) naive T cell polarization toward a regulatory phenotype

189 factor; (ii) increases T(reg) cells, driving naive T cells polarization, through a lactate-based NF-k

190 mory T cell populations showed that even the naive T cell pool contained self-reactive T cell precurs

191 that homeostatic mechanisms that support the naive T cell pool deteriorate with age.

192 n of LIP ensures the generation of a diverse naive T cell pool in lymphopenic neonates that is mandat

193 pendent on thymic output, but in adults, the naive T cell pool is primarily maintained by peripheral

194 nctional competency and enter the long-lived naive T cell pool.

195 strongest support for a model in which both naive T-cell pools contain kinetically distinct subpopul

196 Stochastic numerical simulations of naive T cell population dynamics, based on experimental

197 n, a marker of thymic proximity for the CD4+ naive T-cell population.

198 cells, little is known about the effects on naive T cell populations.

199 termined the turnover rates of CD4+ and CD8+ naive T-cell populations and defined their dynamics in h

200 N TCM cell clones were derived from a common naive T cell precursor after skin immunization, generati

201 n treatment-induced remission, a score using naive T-cells predicted disease flare (p < 0.0001).

202 ic stimulation, suggesting key roles in both naive T cell priming and memory T cell responses.

203 LR-2 costimulation also dramatically reduced naive T cell production of the immunosuppressive cytokin

204 nes and inhibitory for genes associated with naive T cell programs.

205 is predicts that, without an increase in the naive T cell proliferation rate, this decline will occur

206 Furthermore, cDCs, but not moDCs, stimulated naive T cell proliferation.

207 well as strengthen DC capacity to stimulate naive T cell proliferation.

208 d that NF-kappaB signaling was essential for naive T-cell proliferation to the homeostatic growth fac

209 lling maintains the mitochondrial content of naive T cells, providing cells with the energy to contin

210 ally and the frequency of 2W:I-A(b)-specific naive T cells reached that of adult mice.

211 The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important d

212 lial R-Ras impairs the rapid acceleration of naive T cell recruitment to the lymph nodes upon inflamm

213 on of high endothelial venules to accelerate naive T cell recruitment to the lymph nodes.

214 About half of the patients had less than 10% naive T cells, reduced/absent T-cell proliferation, and

215 Thus, naive T cells regulate B cell survival in a SLAMF6- and

216 responses to infection is a function of the naive T cell repertoire combined with the context and du

217 The diversity of the naive T cell repertoire drives the replenishment potenti

218 Describing the complexity of the human naive T cell repertoire remains a daunting task; however

219 diverse, in line with the expected idea of a naive T cell repertoire, samples of HEU infants showed a

220 anti-viral T cell response is drawn from the naive T cell repertoire.

221 naive T cells both contribute to shaping the naive T-cell repertoire as humans age, but a clear under

222 (EF4.1) expressing a limited, yet polyclonal naive T-cell repertoire was used.

223 Despite having low resting metabolic rates, naive T-cells respond to TCR stimulation with robust and

224 ble the study of endogenous antigen-specific naive T cell responses in disease and infection, but has

225 omeostasis, the ability of VISTA to restrain naive T cell responses was lost under inflammatory condi

226 ymic degeneration is associated with loss of naive T cells, restriction of peripheral T-cell diversit

227 ow that, compared with more mature but still naive T cells, RTEs are impaired in their ability to per

228 This demonstrates that naive T cells signal during phase I and support the hypo

229 phylaxis showed increased T-cell activation, naive T-cell skewing, and elevated serum CXCL9 and CXCL1

230 reveal the presence of a broad repertoire of naive T cells specific for cryptic H1-HA peptides and de

231 Moreover, donor naive T cells specific for exogenous and self/tumor anti

232 At the naive T cell stage, two intrinsic checkpoints that activ

233 ges in chromatin accessibility away from the naive T cell state.

234 In summary, we found the naive T cell subpopulation of young adult Malawians was

235 loss of VISTA disrupted the major quiescent naive T cell subset and enhanced self-reactivity.

236 n preclinical models, the use of a purified, naive T cell subset enhances persistence and antitumor i

237 in vivo differentiation landscapes of human naive T cells, supporting the notion that progenies of s

238 ring life that is responsible for peripheral naive T cell survival and homeostasis.

239 However, it remains unclear how naive T cells survive for years while constantly travell

240 ed with two antigens suppressed conventional naive T cells (T(naive) cells) specific for both cognate

241 ergo an additional maturation step to mature naive T cells that circulate through secondary lymphoid

242 Cs, but instead, directly regulates genes in naive T cells that control the differentiation process.

243 ue to a small population of Helios-deficient naive T cells that had differentiated into Ag-specific p

244 rants [RTEs]) are functionally distinct from naive T cells that have completed postthymic maturation.

245 VISTA is therefore a distinctive NCR of naive T cells that is critical for steady-state maintena

246 mune responses require a large repertoire of naive T cells that migrate throughout the body, rapidly

247 T cells possess functional differences from naive T cells that powerfully contribute to the efficien

248 It enables infiltration by naive T cells that significantly delay tumour outgrowth

249 alloreactivity is mainly derived from human naive T cells, the selective depletion of naive T cells

250 ections are due to diminished recruitment of naive T cells through infection-induced decreases in che

251 CCR7, CD27, CD28, and CD40L-suggestive of a naive T cell (TN).

252 a hallmark of which is the profound loss of naive T cells (TN) associated with decline in thymic out

253 In mice, naive T cells (TN) cause more severe GVHD than memory T

254 aft-versus-host disease (GVHD) compared with naive T cells (TN).

255 lity to mount a more effective response than naive T cells (TN).

256 ntiation in vitro, preferentially committing naive T cells to a regulatory phenotype.

257 ell subsets and the plasticity of individual naive T cells to adopt different fates.

258 We found that low-affinity TCRs biased mouse naive T cells to become T follicular helper (Tfh) cells,

259 uding dendritic cells and monocytes instruct naive T cells to differentiate into various effector cel

260 ditioned medium of treated keratinocytes and naive T cells to disclose the molecular details that reg

261 ell receptors (TCRs) can be used to redirect naive T cells to eliminate virally infected or cancerous

262 PD-1H in mice blocks the differentiation of naive T cells to Foxp3(+) inducible Treg cells (iTreg) w

263 ipients had diminished ability compared with naive T cells to increase donor chimerism when transferr

264 Recruitment of naive T cells to lymph nodes is essential for the develo

265 e of T cell-intrinsic CD18 in trafficking of naive T cells to secondary lymphoid organs and in Ag-dep

266 n an increase in the intrinsic reactivity of naive T cells to self-antigens, it did not cause spontan

267 For effective induction, exposure of naive T cells to these epidermal factors needed to occur

268 rocess, allowing differentiation of neonatal naive T cells toward IFN-gamma-producing TH1 cells.

269 rophages and to favor the differentiation of naive T cells toward regulatory T cells.

270 Enhancer deletion skewed polarization of naive T cells towards a pro-inflammatory T helper (TH17)

271 tion of high endothelial venules to increase naive T cell trafficking to the lymph nodes.

272 equired for normal T-cell development or for naive T-cell trafficking to lymph nodes and spleen.

273 by a progressive harmonization of memory and naive T cell traits, is broadly amenable to experimental

274 During immune responses, naive T cells transition from small quiescent cells to r

275 Our results reveal an age-related decline in naive T-cell turnover as a putative regulator of naive T

276 ed changes in homeostatic regulation of CD4+ naive T-cell turnover, using mass cytometry to profile c

277 been shown that in a lymphopenic environment naive T cells undergo expansion due, at least in part, t

278 Naive T cells undergo metabolic reprogramming to support

279 a), and may be driven by a reduced number of naive T cells unmasking underlying memory clonality.

280 rred with myelin-specific 2D2 TCR-transgenic naive T cells, unrelated OT-II TCR-transgenic memory-lik

281 Scarcity of naive T cells was also associated with aging and poor di

282 The T memory-induced conversion of naive T cells was mediated by a nonapoptotic Fas signal,

283 tantly, expression of beta-catenin in mature naive T cells was sufficient to drive integrin alpha4bet

284 Naive T cells were cocultured with pDCs in specific stra

285 Naive T cells were isolated from wild-type mice or cord

286 proliferative response and reduced counts of naive T cells were observed in addition to a restricted

287 Tonsil naive T cells were readily chemoattracted by S1P in an F

288 Importantly, numbers of naive T cells were reduced in spleens and lymph nodes of

289 TL1A overexpressing naive T cells were transferred into Rag(-/-) , Rag(-/-)

290 Memory, but not naive, T cells were competent and monocytes were require

291 response to LPS but were unable to activate naive T cells, whereas the majority of mature DCs produc

292 persistent autoimmune-mediated depletion of naive T cells, which is induced by changes in erythrocyt

293 train-dependent, MHC class II disparity with naive T cells, which may explain organ- and strain-speci

294 Millions of naive T cells with different TCRs may interact with a pe

295 phenotype and promoted a Th2 polarization of naive T cells with increased IL-4 production.

296 nsive memory T cell response: stimulation of naive T cells with robust and persistent antigen signals

297 as in vitro during differentiation assays of naive T cells with specific inhibitor of Foxo1 or inhibi

298 We found that naive T cells with TCRs specific for the 2W:I-A(b) epito

299 showed quick opening of closed chromatin in naive T cells within 5 h of activation.

300 exclusively regulates homeostasis of mature naive T cells without affecting thymocytes and/or recent