ライフサイエンスコーパス: naked

1 Moreover, administration of naked and AAV-packaged AONs to the retina of a humanized

2 We here explore the therapeutic potential of naked and adeno-associated virus (AAV)-packaged AONs in

3 d regulated budding yeast DNA replication on naked and chromatinized templates in vitro, providing ke

4 Naked and Damaraland mole rats also showed reduced later

5 Most conspicuously, in both naked and Damaraland mole rats, inner hair cell (IHC) af

6 however, not always shared similarly between naked and Damaraland mole rats.

7 heir patterns of developmental refinement in naked and Damaraland mole rats.

8 carriers for multiple cargos, including both naked and nanoparticle-encapsulated chemotherapeutics, g

9 nt human cohesin-NIPBL complex compacts both naked and nucleosome-bound DNA by extruding DNA loops.

10 inity but are impaired for diffusion on both naked and nucleosome-coated DNA.

11 Naked and protein-blocked DNA ends occur naturally durin

12 Thus naked and quasi-enveloped virions enter via similar endo

13 tors that are required for infection by both naked and quasi-enveloped virions.

14 e factors contributing to altered hearing in naked and the related Damaraland mole-rats and to examin

15 utant with reduced binding affinity to both "naked" and phospholipid-coated oil-water interfaces.

16 trategies that involve encapsulation of the "naked" anion.

17 in a 1:1 molar ratio) gives the first stable naked anionic dithiolene radical 3(*), which, when coupl

18 ed analysis of structural parameters of the "naked" anions of [3]TrTol without interference from meta

19 Treatment with naked anti-CD26 mAb KU44.13A did not have any effect on

20 Although naked antibodies have proven valuable as pharmaceutical

21 evidenced by efforts to target CLDN18.2 via naked antibody and CAR-T modalities.

22 , and p = 0.001 for sacituzumab govitecan vs naked antibody, and sacituzumab govitecan vs control-ADC

23 sed ADC samples when compared to that of the naked antibody.

24 Previously, we showed that naked antisense oligonucleotides (AONs) effectively rest

25 platforms were carried out and compared with naked AuE, BPDT/AuE, AuNPs/AuE, and AgNPs/AuE.

26 ween Watson-Crick and HG base pairs for both naked B-DNA and A-RNA duplexes.

27 Electrical Resistivity (ER) surveys showed a naked burial produced large, low-resistivity anomalies f

28 225 MHz GPR data was optimal, but the naked burial was poorly imaged after six years.

29 infectious HSV particles in their lumens and naked capsids docked to their cytoplasmic surfaces.

30 pai interactions from 12-15 kcal mol(-1) in "naked" cations to 5-9 kcal mol(-1) in the salts.

31 s of radiation induced early DNA damage on a naked cell nucleus model.

32 adsorption coefficients than non-calcified (naked) cells.

33 Our results challenge the old vision of "naked" chromium species (i.e., low coordinated) as the a

34 Naked collagen microfibrils and weaker banded structure

35 ration of heme-peroxo-Cu compounds, using a "naked" complex synthon, [(F8)Fe(III)-(O2(2-))-Cu(II)(MeT

36 One of these immediate early genes encodes naked cuticle homolog 1 (NKD1), which is a repressor of

37 Naked cuticle results from Wg repression of shavenbaby (

38 n of denticle belts separated by smooth, or 'naked', cuticle.

39 }(1 a(2-) )(2) ], revealed the presence of a naked dianion.

40 e first time, the formation of O(4)-POBdT in naked DNA and in genomic DNA of cultured mammalian cells

41 sing a chromatin donor template instead of a naked DNA donor template.

42 tive, Hoogsteen (HG) base pairing pattern in naked DNA duplexes, and estimated its relative stability

43 MV-qPCR) was developed to differentiate free naked DNA from virion DNA.

44 similar to those occurring in vivo, whereas naked DNA gave many aberrant transcripts.

45 Here, we visualized the binding of PRC2 to naked DNA in liquid at the single-molecule level using a

46 Although the elasticity of naked DNA in vitro is well characterized, the elasticity

47 th high processivity and at rates similar to naked DNA in vitro.

48 sviruses infecting animals and humans, where naked DNA is packed under very high pressure due to the

49 ndamental question of whether nucleosomal or naked DNA is the preferred substrate of plant and animal

50 dingly, we demonstrate confluent staining of naked DNA molecules presented within microfluidic device

51 ted more potent B- and T-cell responses than naked DNA or DCs pulsed with inactivated HIV.

52 s [(6-4)PPs] from UV-irradiated cellular and naked DNA revealed that the effect of transcription fact

53 Although nicks in naked DNA stimulate PARP3 autoribosylation, nicks in mon

54 termediates that occurs during the repair of naked DNA substrates differs significantly from that in

55 During BER of naked DNA substrates, APE1 completely bypasses the ineff

56 relatively little effect on Cas9 cleavage of naked DNA substrates, but strongly inhibit cleavage of n

57 bunit Rpa12.2 showed a lower processivity on naked DNA templates, which was even more reduced in the

58 tion of the DNA template, as it evolved from naked DNA to chromatin, in the biochemical analysis of t

59 was at least sevenfold greater than that of naked DNA, and chromatin gave patterns of transcription

60 Moreover, in nucleosomes but not in naked DNA, APE1 was able to process NTHL1 lyase-generate

61 e binding orientation of the metallohelix to naked DNA, but does not substantially alter the overall

62 the nucleosomal sites relative to those for naked DNA, demonstrating that the high affinities are ac

63 While BER is well studied on naked DNA, it remains unclear how BER efficiently operat

64 During BER of oxidized bases in naked DNA, products generated by the DNA glycosylase NTH

65 osomes with similar binding affinities as to naked DNA, trapping a partially unwrapped nucleosome wit

66 As herpesvirus genomes enter the nucleus as naked DNA, we asked whether the HIRA chaperone complex a

67 hexasome H2A-H2B distal side is identical to naked DNA, while the accessibility on the H2A-H2B proxim

68 solated nucleoprotein complexes on otherwise naked DNA.

69 ing tumor DNA (ctDNA) is a component of the "naked" DNA found in blood.

70 by using a candidate preventive/therapeutic naked-DNA vaccine that expresses human calreticulin (hCR

71 (ATM) kinase is activated synergistically by naked dsDNA and the Mre11-Rad50-Xrs2(NBS1) complex (MRX)

72 packing fractions than viruses encapsidating naked dsDNA.

73 However, the instability of naked dsRNA sprayed on plants has been a major challenge

74 ve to the level seen in larvae injected with naked dsRNA(alphatub) alone.

75 nfectious as a purified entity but also as a naked dsRNA.

76 own on a whole body concentration basis than naked dsRNA.

77 DNA, which is potentially infectious, versus naked EBV DNA, which is not infectious.

78 (Zea mays [Zm]) has a single aleurone layer, naked endosperm (nkd) mutants produce multiple outer cel

79 NAKED ENDOSPERM1 (NKD1) and NKD2 are duplicate INDETERMI

80 etic parameters are improved compared to the naked enzyme suggesting longer blood circulation after i

81 The assay was evaluated by the naked eye (on/off) and quantitatively with use of a smar

82 ny forming unit per 1 mL (CFU mL(-1)) by the naked eye and 10(1) CFU mL(-1) using ImageJ software.

83 ssembled monolayer (SAM) was detected by the naked eye and analysed using an image analysis software

84 netic nanobeads moieties was detected by the naked eye and analysed using ImageJ analysis software fo

85 e liquid mineral phase visible even with the naked eye and its transformation into amorphous nanopart

86 entify significant traces not visible to the naked eye and not detectable by XRF spot measurements or

87 es the detection of a few molecules with the naked eye and quantified by an auto-analysis software.

88 ation, which can be easily observed with the naked eye at the nanomolar level.

89 show any obvious signs of iridescence to the naked eye but where a highly ordered chloroplast structu

90 The synthesized CNDs showed dual mode naked eye colorimetric ultrasensitive sensing capability

91 punching machine crafted paper biosensor for naked eye detection of ALP in milk samples.

92 f target analyte, which provides a means for naked eye determination.

93 r sensors give a yes or no response with the naked eye down to 10 muM when a preconcentration step wa

94 Counting the plaques by the naked eye enables the quantification of miRNAs with dete

95 Negative read-out was observed by the naked eye for all tested isolates except for MRSA.

96 ion of adenosine as a model analyte with the naked eye in buffer samples and undiluted human serum.

97 orm in its identification and detection with naked eye in point-of-care.

98 determination of metabolites in sweat by the naked eye in the form of a 3 x 15 mm colour bar.

99 etection of small-molecule targets using the naked eye is demonstrated.

100 , real-time detection of metastases with the naked eye is possible.

101 les such as cancer-biomarker miRNAs with the naked eye is seemingly impossible in molecular diagnosti

102 Invisible to the naked eye lies a tremendous diversity of organic molecul

103 uared) lithography-free sensing films with a naked eye limit of detection of ~3 pg/mm(2), lower than

104 by taking advantage of excellent generality, naked eye observation, the 4-plex detection, simplicity,

105 source and a colored plastic gel filter, the naked eye or a camera can easily discriminate between po

106 Results can be visually observed by the naked eye or imaged by a smartphone camera under a porta

107 umor phenotypes that fail to be perceived by naked eye that semantic features do not describe and vic

108 connected to a visual readout, allowing the naked eye to evaluate and quantify direct bacterial elec

109 This quenching could be visualized by the naked eye under a UV (365 nm) lamp and performed almost

110 e sample vials were easily visualized by the naked eye under ultraviolet light illumination.

111 The SNF markers can be easily identified by naked eye using a novel micro Spin-Tube device "Spin-Tub

112 s enable the detection of hydrazine with the naked eye well below sub-ppm concentrations (ca. 30 ppb)

113 ntrations of rabbit IgG and human PSA by the naked eye were down to 0.1 and 4 ng/mL, respectively.

114 rations through UV-vis absorption and by the naked eye were estimated to be 0.3 and 60nM, respectivel

115 detection of 1ngmL(-1) and assessed with the naked eye within 10min.

116 Undetectable to the naked eye, analytical techniques are required to identif

117 line with probe P2 can be viewed through the naked eye, and the corresponding fluorescence turn-on de

118 ctrode, which is clearly measurable with the naked eye, correlates linearly with an analyte concentra

119 of megafauna and/microbial mats (DM) to the naked eye, covered with bacterial mats (BM), or colonize

120 h deposits or cryptotephra, invisible to the naked eye, discovered within Greenland ice-cores, and ra

121 examining the samples surfaces with both the naked eye, first, and microscopically (10x and 50x), imm

122 6 mM), SM sensing can be visualized with the naked eye, leading to the formation of a fluorescent gre

123 noparticles and enables visual detection, by naked eye, of meat species-specific DNA sequences.

124 micrometer-sized droplets, invisible to the naked eye, persists on leaves during daytime due to deli

125 he presence of the final DNA amplicon to the naked eye, providing a "sample-to-answer" diagnosis from

126 ary tumors before they become visible to the naked eye, supporting the added value of this technique

127 ride ions at micromolar concentration by the naked eye, UV-vis absorption, and fluorescence.

128 ss to dark yellow/brown, also visible to the naked eye, with a detection limit of 500 ppm.

129 blue ECL emission, easily observable even by naked eye, with quantum yield higher than the standard 9

130 es on agar before they became visible to the naked eye.

131 ingle nucleotide polymorphisms (SNPs) by the naked eye.

132 nge, which can be directly observed with the naked eye.

133 ith traditional RGB intensity sensors or the naked eye.

134 le by UV-vis spectroscopy and obvious to the naked eye.

135 or growth, before they became visible to the naked eye.

136 orescence changes are easily observed by the naked eye.

137 h UV-vis spectroscopy and estimated with the naked eye.

138 o isomeric states to be distinguished by the naked eye.

139 emoved that are difficult to detect with the naked eye.

140 s exosome surface proteins in minutes by the naked eye.

141 linical disease not readily visible with the naked eye.

142 he oscilloscope that wiggle similarly to the naked eye.

143 ing color changes that are detected with the naked eye.

144 ELISA can be observed within an hour by the naked eye.

145 ctive route for halocarbon analysis with the naked eye.

146 mm in diameter and was not visible with the naked eye.

147 absorbing at 537 nm, which is visible to the naked eye.

148 ic, i.e., smaller than the resolution of the naked eye.

149 of oxygenation under ambient light with the naked eye.

150 emporal inspection by digital cameras or the naked eye.

151 or change of the EC sensor is visible to the naked eye.

152 olor of the sensor surface observable by the naked eye.

153 quantification of disease biomarkers by the naked eye.

154 hange in turbidity that could be seen by the naked eye.

155 ustained luminescence that is visible to the naked eye.

156 ots that are too small to be resolved by the naked eye.

157 e strip test was determined at 2 ug/L by the naked eye.

158 signal, which could be directly observed by naked eye.

159 ve, reversible, and easily detectable by the naked eye.

160 ally related cells that are invisible to the naked eye.

161 the results can be visually inspected by the naked eye.

162 2 h, producing a signal detectable with the naked eye.

163 production of a color that is visible to the naked eye.

164 he developed mini-column at visible light by naked eye; where MG was seen as compact green band at th

165 generation, enabling unprecedented one-pot, naked-eye detection of a catalytic reporter from 1 mum d

166 tional ELISA counterparts for ultrasensitive naked-eye detection of biomolecules and small contaminan

167 er the cellulosic strips and applied for the naked-eye detection of PA down to 1muM.

168 and avidin-conjugated GOx for the selective naked-eye detection of rabbit immunoglobulin G (IgG) and

169 a surfactant-induced aggregation, results in naked-eye detection of these common anionic surfactants

170 amplification (LAMP) and provides real-time, naked-eye detection with Hydroxynaphthol blue reagent in

171 Naked-eye fluorescent visualization of amplicons reveale

172 most cases, the detection is made by simple naked-eye observation of agglutinates without any access

173 assay has some advantages such as useful for naked-eye observation, disposable, not time-consuming, i

174 on of the body TAC through saliva via simple naked-eye or smartphone-based inspection.

175 e proposed plasmonic immunoassay allowed the naked-eye quantification of 0-10 ng/mL PSA at an interva

176 initially describes the design of low-cost, naked-eye quantitative aptamer-based assays by using mic

177 sulfonamides using spectrophotometry and for naked-eye semi-quantitative estimation.

178 yes with high molar absorptivities to permit naked-eye sensing.

179 e observed enhanced "turn-on" emission and a naked-eye sensitive blue-green color in the medium is at

180 nt, the proposed method was further used for naked-eye tracking glycolytic inhibition in living cells

181 s are fused in the form of fluorene, allows "naked-eye" detection of fluoride in subppm levels (<1.0

182 can be simply interpreted through the human naked-eye, it provides a simple method for fast-screenin

183 ir multicolor emission from green to red and naked-eye-sensitive green emission with tunable lifetime

184 spray kit to directly spot the explosives by naked eyes, implying great potential for quick, low-cost

185 to red, which could be directly observed by naked eyes.

186 ich can be used to detect Hg(2+) in water by naked eyes.

187 de extrusion step through protonation of the naked fluoride.

188 rdination motifs, in addition to an unusual "naked" [Ga](+) ion, are found.

189 lar ones involving stereoselective attack on naked glycosyl oxocarbenium ions.

190 he immunologic effectors stimulated by these naked HER2 antibodies provide only modest activity as mo

191 RNAs vectors targeting the IL-8 gene and the naked homologous repair DNA carrying different haplotype

192 tergent, we have been able to interrogate a "naked" HTL complex, with the scattering contribution of

193 arrangements, resulting in the expression of naked IgL on a surface of precursor B cells.

194 mputations support the catalytic activity of naked In(I)(+) ions, with an outer sphere mechanism for

195 t syngeneic CC islets was lower than that of naked islets, we showed that CC (PEG MG) islets from ful

196 , and cancer cell killing effect compared to naked KOX or KOX/PEGbPHF at pH7.4, demonstrating that KO

197 model was significantly higher than that of naked KOX.

198 In addition, due to the fact that naked linker regions of DNA in the interphase and metaph

199 a simple [Cr(III) L3 ] metalloligand and a "naked" M(II) salt.

200 story nicely demonstrates that the future of naked mAbs is to design agents with optimized and tailor

201 A single weekly administration of the naked mAbs reduced splenomegaly, liver tumor spots, and

202 The naked mole rat (Heterocephalus glaber) is a long-lived a

203 Recent studies in naked mole rat and long-lived sea urchins showed that th

204 hippocampal and olfactory structures of the naked mole rat brain.

205 HMW-HA triggers hypersensitivity of naked mole rat cells to contact inhibition, which is ass

206 K4a/b) is present in both cultured cells and naked mole rat tissues but is absent in human and mouse

207 V12 overriding anti-cancer mechanisms of the naked mole rat.

208 Compared to many other rodent species, naked mole rats (Heterocephalus glaber) have elevated au

209 Naked mole rats (NMRs) are currently one of the most pop

210 Naked mole rats (NMRs) live in sizable colonies where br

211 e mitochondria of various tissues from mice, naked mole rats (NMRs), and bats possess two mechanistic

212 usion is consistent with the hypothesis that naked mole rats are neotenous, with retention of juvenil

213 Naked mole rats are the longest-living rodents, whose ne

214 ochlear innervation in mature and developing naked mole rats compared to mice (Mus musculus), gerbils

215 Developmentally, naked mole rats showed reduced and prolonged postnatal r

216 some studies of social mole rats (including naked mole rats, Heterocephalus glaber, and Damaraland m

217 ar, a brain atlas was available only for the naked mole-rat (Heterocephalus glaber).

218 The subterranean-dwelling naked mole-rat (NM-R; Heterocephalus glaber) exhibits pr

219 tly demonstrated by us and Liang et al. that naked mole-rat (NMR) cells are more resistant to SV40LT

220 Naked mole-rat (NMR), the longest-living rodent, produce

221 l role of HA in the cancer resistance of the naked mole-rat (NMR), we undertook to explore the struct

222 adds to a growing list of adaptations in the naked mole-rat and provides a plausible proximate mechan

223 e of Gompertz's law 'uniquely identifies the naked mole-rat as a non-aging mammal'.

224 rences from the brain of the closely related naked mole-rat as well as from epigeic mammals (rat), wi

225 Here we cloned naked mole-rat ASIC3 (nmrASIC3) and used a cell-surface

226 x2 reversibly inhibits ASIC-like currents in naked mole-rat dorsal root ganglia neurons.

227 We found that the p53 protein in naked mole-rat embryonic fibroblasts (NEFs) exhibits a h

228 Analysis of the naked mole-rat genome revealed, uniquely among mammals,

229 as fish and amphibians, suggesting that the naked mole-rat is a powerful model for exploring the mec

230 The naked mole-rat is a subterranean rodent, approximately t

231 mouse and human p53, a larger proportion of naked mole-rat p53 protein is constitutively localized i

232 We determined that the long half-life of the naked mole-rat p53 protein reflects protein-extrinsic re

233 d basal nuclear localization of p53 in NEFs, naked mole-rat p53 retains its canonical tumor suppressi

234 During anoxia, the naked mole-rat switches to anaerobic metabolism fueled b

235 Fructose-driven glycolytic respiration in naked mole-rat tissues avoids feedback inhibition of gly

236 mers may reflect a further adaptation of the naked mole-rat to living in an environment with high-car

237 eight African rodent species related to the naked mole-rat with the painful substances capsaicin, ac

238 The African naked mole-rat's (Heterocephalus glaber) social and subt

239 ion of the p53 protein may contribute to the naked mole-rat's remarkable resistance to cancer.

240 observed in long-lived species including the naked mole-rat, bats, and the bowhead whale, but these a

241 The preternaturally long-lived naked mole-rat, like other long-lived species and experi

242 isms underlying the cancer resistance of the naked mole-rat, we investigated the regulation and funct

243 monly mutated tumor suppressor, TP53, in the naked mole-rat.

244 erformed a Kaplan-Meier survival analysis of naked mole-rats (Heterocephalus glaber) and concluded th

245 Naked mole-rats (Heterocephalus glaber) live in groups t

246 Naked mole-rats are adapted to living in a low-oxygen an

247 Naked mole-rats are highly vocal, eusocial, subterranean

248 with the diminished function of KCC2, adult naked mole-rats demonstrate a reduced efficacy of inhibi

249 sites at which the level of CRF1 binding in naked mole-rats exceeds that in Cape mole-rats include t

250 thout pharmacological intervention, in adult naked mole-rats exposed to a simulated hyperthermic surf

251 2 binding, the sites with a greater level in naked mole-rats include the basolateral amygdaloid nucle

252 Naked mole-rats live in large eusocial colonies that are

253 ppress neuronal activity, we studied whether naked mole-rats might demonstrate energy savings in GABA

254 Under experimental conditions, naked mole-rats tolerate hours of extreme hypoxia and su

255 eceptor binding densities in female and male naked mole-rats varying in breeding status.

256 African naked mole-rats were likely the first mammals to evolve

257 into the neurobiology of social hierarchy in naked mole-rats, and add to a growing body of work that

258 d historical lifespan data on more than 3200 naked mole-rats, collected over a total observation peri

259 Naked mole-rats, despite having functional ASICs, are in

260 dy, we performed optic nerve injury in adult naked mole-rats, the longest living rodent, with a maxim

261 hole-colony behavioral monitoring of captive naked mole-rats, we found a durable nest, characterized

262 n function in outer hair cells isolated from naked mole-rats.

263 d of Micro encapsulated (MRT, 8 days) versus naked (MRT, 36 days; P < 0.01) baboon islets transplante

264 Naked/NKD destabilizes Dishevelled, which assembles Wnt

265 y Dishevelled and depends on accumulation of Naked/NKD during prolonged Wnt stimulation.

266 over that the molecular mechanism underlying Naked/NKD function relies on its assembly into ultra-sta

267 Naked/NKD HisC cores co-aggregate with a conserved histi

268 eered flies and human epithelial cells whose Naked/NKD HisC has been deleted.

269 Naked/NKD is a widely conserved feedback regulator of Wn

270 Thus, HisC aggregation by Naked/NKD provides context-dependent feedback control of

271 tumor growth suppression when compared with naked oAd and 9.5 x 10(6)-fold increased tumor-to-liver

272 ted more potent antitumor effect compared to naked oAd/RLX or oAd/RLX-treated hMSC in pancreatic tumo

273 y clinical trials have been done with either naked oncolytic Ad or combination with chemotherapies.

274 nd reproducible gene expression of exogenous naked pDNA in human skin using volumes that are consider

275 Anti-HER2 IgG was induced by Ad/E2TM or naked pE2TM, both encoding HER2 extracellular and transm

276 overwriting the original precursor with the naked peptide m/z and removing all of the glycan-related

277 to produce cotyledons and leaves and grow a naked pin while maintaining an active SAM.

278 h HSV or CMV, or transient transfection with naked plasmid DNA, HIRA re-localizes to PML bodies, site

279 plexation with LL-37 restored the uptake of "naked" (protein-free) NETs.

280 enfold with respect to the administration of naked rituximab.

281 onstrate that L alone initiates synthesis on naked RNA and that P serves to enhance the initiation an

282 se of VSV P stimulated RABV RdRP activity on naked RNA but was insufficient to permit initiation on t

283 ve that these assemblies can be connected by naked RNA regions of the transcript.

284 Naked RNAs are difficult to crystallize and NMR spectros

285 e to the issues regarding to the delivery of naked siRNA predominantly to target cells.

286 ilencing of 28% (rHSA/siRNA) compared to 4% (naked siRNA) 6days post-injection.

287 We observed that the naked skin has little UV protection showing an 18.2% dec

288 of-magnitude lower than required by standard naked SSOs.

289 Naked surgeons shed fewer bacteria into the operating ro

290 ively affecting species such as capybara and naked-tailed armadillo.

291 ernalized, consistent with slow recycling of naked TAS2R14 in the absence of the heterodimeric milieu

292 life extension in NMRI mice from t1/2 12min (naked) to t1/2 45min (single cholesteryl) and t1/2 71min

293 he HIRA chaperone complex represses incoming naked viral DNAs through chromatinization as part of int

294 udes populations of both viral particles and naked viral genomes.

295 By contrast, non-enveloped naked virions are shed in faeces and stripped of membran

296 Uncoating of naked virions occurs in late endosomes, whereas eHAV und

297 cell spread within the liver, whereas stable naked virions shed in feces are optimized for environmen

298 as quasi-enveloped particles and apically as naked virions, recapitulating essential steps of the nat

299 7 degrees C identified numerous examples of naked virus capsids located immediately beneath the plas

300 er, we and others have observed that various naked viruses, such as CVB, can trigger the release of i