ライフサイエンスコーパス: nanomolar

1 (IC(50)) values between 24 picomolar and 35 nanomolar.

2 n A2-targeted taxane liposomes exhibited sub-nanomolar (0.69 nM) apparent equilibrium dissociation co

3 -expressing neuronal cells were treated with nanomolar Abeta(1-42) to gain insights into the molecula

4 inhibitor of activated FXII (FXIIa) with sub-nanomolar activity (K(i) = 370 +/- 40 pM) and a high sta

5 describe RCB-185, a lipophilic prodrug with nanomolar activity against asexual parasites.

6 and a powerful negative chronotrope with low nanomolar activity in a neonatal rat cardiomyocyte (NRCM

7 duction, and many of these complexes exhibit nanomolar activity in vitro as well as powerful tumor in

8 Remarkably, all analogues retained the low nanomolar activity of native CIA toward muscle-type nACh

9 zoles were the most potent scaffold with mid-nanomolar activity on P. falciparum blood stage and game

10 rally related to an antiprotozoal agent with nanomolar activity which we identified recently.

11 not cause leakage and excel as carriers with nanomolar activity, with P((Cl/Na)) = 10.4 for anion/cat

12 dent TCRs (A11 and B12A) that bind with high nanomolar affinities to mouse adhesion receptor CD155.

13 Results: All tracers exhibited nanomolar affinities, were labeled in good radiochemical

14 lead inhibitors (iKeap1) engages KEAP1 with nanomolar affinity (dissociation constant (K(d)) = 114 n

15 With a sub-nanomolar affinity (K(i) for CB2) of 0.8 nM and a remark

16 he inhibitors are allosteric, they bind with nanomolar affinity and are highly specific for the 1A3 i

17 We show that ERFE binds to BMP6 with nanomolar affinity and binds BMP2 and BMP4 with somewhat

18 nding site to MIF, selectively bind MIF with nanomolar affinity and block MIF/CXCR4 without affecting

19 compound that specifically binds to Hb with nanomolar affinity and displays strong partitioning into

20 ive C3 and its degradation products with low nanomolar affinity and does not interfere with the endog

21 inds to 12 diverse synthetic cathinones with nanomolar affinity and does not respond to 11 structural

22 ide human cathelicidin LL-37 binds IAPP with nanomolar affinity and effectively suppresses its amyloi

23 All rhPSMAs showed low nanomolar affinity and high internalization by PSMA-expr

24 l-DNA aptamers bind pre-miR-155 with low nanomolar affinity and high selectivity despite the inab

25 monovalent decoy, CTC-445.2, bound with low nanomolar affinity and high specificity to the receptor-

26 L-11 and IL-11Ralpha form a 1:1 complex with nanomolar affinity and present a model of the complex.

27 VHH) that bind the LRP6 P3E3P4E4 region with nanomolar affinity and strongly inhibit Wnt3/3a-induced

28 we show that cGAS binds to nucleosomes with nanomolar affinity and that nucleosome binding potently

29 with hen-egg white lysozyme demonstrate how nanomolar affinity binding of asymmetrical antigen is en

30 n of monovalent and bivalent antibodies with nanomolar affinity for Abeta fibrils.

31 inoline-3-carboxamide, a pan antagonist with nanomolar affinity for all four subtypes.

32 that this new variant exhibits single-digit nanomolar affinity for KRasGTP, confirming the computati

33 modified cell-SELEX procedure to display low-nanomolar affinity for the T-cell marker CD8) enable the

34 peptide from green mamba venom that exhibits nanomolar affinity for the V2R without any activity on 1

35 The hC3Nb3 nanobody binds C3 with low nanomolar affinity in an SDS-resistant complex, and the

36 elective MMP-12 inhibitors with single-digit nanomolar affinity in vitro and in vivo efficacy.

37 ation of PG fragments to NOD2 and NLRP1 with nanomolar affinity is shown.

38 I-2852 (1), a KRAS inhibitor that binds with nanomolar affinity to a pocket, thus far perceived to be

39 the N-terminal region of Evasin-4 possessed nanomolar affinity to CCL5 and inhibited CCL5 activity i

40 for is a radiotracer for PET that binds with nanomolar affinity to CXCR4.

41 Several compounds bound with one-digit nanomolar affinity to hCD80 and displaced CTLA-4 and CD2

42 The developed probe retained a nanomolar affinity to HER2-overexpressing cancer cells,

43 4-specific scFv-Fc construct that binds with nanomolar affinity to human CD44.

44 AR T cells possessing micromolar rather than nanomolar affinity to ICAM-1 to avoid cytotoxicity in no

45 to identify molecules with low micromolar to nanomolar affinity to influenza A group 1 HAs.

46 We determined that Lpg2505 binds with nanomolar affinity to SidI and suppresses SidI-mediated

47 are highly selective for STAT3 and bind with nanomolar affinity to the N-terminal and coiled-coil dom

48 tide minimal aptamer, SiRA, which binds with nanomolar affinity to the target SiR.

49 and biologically derived, with apparent mid-nanomolar affinity while discriminating against uniform

50 not inhibit coagulation, binds Tau with low nanomolar affinity, and inhibits cellular Tau aggregate

51 ctly interacted with the GPR56 ECR with high-nanomolar affinity, and used site-directed mutagenesis t

52 of CLEC14A binds one-to-one to heparin with nanomolar affinity, and using molecular modeling and mut

53 that, because native IL-37 forms dimers with nanomolar affinity, higher IL-37 only weakly suppresses

54 in both l- and d-configurations, to produce nanomolar affinity, selective GlyT2 inhibitors.

55 r findings indicate that SWG binds OSBP with nanomolar affinity, that this binding is sensitive to th

56 lded a variant with considerably higher, low-nanomolar affinity, which subsequently was shortened to

57 hboring first brace helix of human MLKL with nanomolar affinity.

58 jor structural protein VP1 with single-digit nanomolar affinity.

59 that alphaT-catenin binds vinculin with low nanomolar affinity.

60 ha and beta, which bind to decernotinib with nanomolar affinity.

61 tions between stem I and tRNA, achieving low-nanomolar affinity.

62 man integrin alphavbeta(6) with single-digit nanomolar affinity.

63 inds bFGF, HGF, neuregulin, and PDGF AB with nanomolar affinity.

64 tified a number of Bicycle families with low nanomolar affinity.

65 hin disease-causing RNAs, with micromolar to nanomolar affinity.

66 -mer cyclic peptide that binds to Cdc42 with nanomolar affinity.

67 bind the LRR domain of LRX proteins with low nanomolar affinity.

68 nositide 3-kinase gamma (PI3Kgamma), forming nanomolar-affinity, intracellular TRPV4-PI3Kgamma comple

69 and 10-100-fold increased potency (up to low nanomolar) against clinically relevant K103N, Y181C, Y18

70 Most of the nanomolar agonists were found to be highly selective for

71 Remarkably, this compound displays low nanomolar alphavbeta8 binding affinity and a strong disc

72 Gelsolin, at both nanomolar and micromolar Ca(2+) concentration, appreciab

73 conformational shifts occurring between low nanomolar and physiologically high intracellular [Ca(2+)

74 del compounds were successfully conducted at nanomolar and picomolar analyte concentrations.

75 fication of cysteine-rich binding sites with nanomolar and picomolar metal affinity utilizing iodoace

76 rochromatin at a concentration as low as one nanomolar, and at this concentration there were no detec

77 affinities ranging from 100 picomolar to 10 nanomolar, and blocked SARS-CoV-2 infection of Vero E6 c

78 ically well-behaved, first-in-class hit with nanomolar anti-RABV potency that blocks RABV G protein-m

79 s (12d,e and 13c) showing similar (picomolar/nanomolar) anti-HIV-1 potency as the corresponding alpha

80 nes, leading to the discovery of potent, low nanomolar antiplasmodial compounds against a Plasmodium

81 bitors of HIV-1 integrase that exhibited low nanomolar antiviral potency in cell culture and encourag

82 The Slp-4 C2A domain binds with low nanomolar apparent affinity to PIP(2) in lipid vesicles

83 with coactivator yes-associated protein with nanomolar apparent IC(50) values, and reduce TEAD target

84 cells demonstrate that NDD-713 and -825 have nanomolar beta1-AR affinity >500-fold beta1-AR vs beta2-

85 ntification of key interactions critical for nanomolar binding affinity and high selectivity of A9g f

86 he obtained compounds described here exhibit nanomolar binding affinity and mechanism-based cellular

87 ized therapeutic candidate (GC132a) with sub-nanomolar binding affinity.

88 All conjugates demonstrated similar (nanomolar) binding affinity towards HER2-positive ovaria

89 d inhibit [(3)H]ryanodine binding to RyR1 at nanomolar Ca(2+).

90 SD-36 achieves nanomolar cell growth inhibitory activity in leukemia an

91 construct that inhibits fibril elongation at nanomolar concentration (IC(50) ~ 20 nM).

92 96 disturbed the microtubule dynamics at the nanomolar concentration in A375 and B16F10 melanoma cell

93 abels the catalytic cysteine of UCHL1 at low nanomolar concentration in cells.

94 CH-3-8 disrupted microtubule dynamics at the nanomolar concentration in MIA PaCa-2 and PANC-1 pancrea

95 diastereomers was possible down to the lower nanomolar concentration range, and enantiomeric ratios c

96 specific protein targets present in the low-nanomolar concentration range.

97 mpounds exert neuroprotective effects in the nanomolar concentration range.

98 One of the developed dyes could be used at a nanomolar concentration to selectively stain lipid dropl

99 At nanomolar concentration, disulfiram covalently modifies

100 ds and proteins bearing aromatic residues at nanomolar concentration, i.e., a full order of magnitude

101 id detection of trypsin activity even at sub-nanomolar concentration.

102 s in a few minutes with both partners at low nanomolar concentration.

103 The dyes inhibited parasite proliferation at nanomolar concentrations (0.019-1.83 muM) and a synergis

104 showed potent antiplasmodial activity at low nanomolar concentrations (EC50 <500 nM) and low cytotoxi

105 ]JW199, labels active NCEH1 in live cells at nanomolar concentrations and greater than 1000-fold sele

106 preferential cytotoxicity towards PEL at low nanomolar concentrations and is approximately 10 and 100

107 ctively inhibits leukemia cell growth at low nanomolar concentrations and is capable of achieving par

108 oxic compounds known to kill cancer cells at nanomolar concentrations by targeting the microtubule ne

109 imetric detection of synthetic cathinones at nanomolar concentrations in biological samples is achiev

110 SD-36 induces rapid STAT3 degradation at low nanomolar concentrations in cells and fails to degrade o

111 Remarkably, low nanomolar concentrations of 12(S)-HETE-lysophospholipids

112 rolimus in the treatment of HGG cells at low nanomolar concentrations of both agents, with a reductio

113 milar to many other FPR2 agonistic peptides, nanomolar concentrations of both PSMalpha2 and PSMalpha3

114 range (1.6 nM to 1 muM) and was sensitive to nanomolar concentrations of glucose with a very low limi

115 E2) biomaterial scaffolds that release E2 at nanomolar concentrations over the course of 1-10 years v

116 In Panc-1 cells, alkyl CPs at nanomolar concentrations promote a dramatic downregulati

117 endent manner, from cell-cycle arrest at low nanomolar concentrations to cell death at concentrations

118 to achieve protein-protein cross-coupling at nanomolar concentrations within hours.

119 affinity and inhibition of HIV infection at nanomolar concentrations without mitogenicity.

120 eficial effects in globin gene expression at nanomolar concentrations without perturbing erythroid ex

121 oceans despite ammonium being present at low nanomolar concentrations(2,3).

122 ed as selective live cell imaging probes (at nanomolar concentrations) and stained lipid-based struct

123 This was achieved at biologically relevant, nanomolar concentrations, allowing determination of pona

124 tro, paclitaxel was found to be effective at nanomolar concentrations, complement therapy with temozo

125 at is endowed with an inhibitory activity at nanomolar concentrations, suitable pharmacokinetic prope

126 nt ligation of peptide fragments down to low nanomolar concentrations, without resorting to solubilit

127 DI, APT-6K, exerted bactericidal activity at nanomolar concentrations.

128 dependent Pseudomonas aeruginosa biofilms at nanomolar concentrations.

129 ell growth of many different cancer types at nanomolar concentrations.

130 milar to that of intracellular CO release at nanomolar concentrations.

131 so showed significant anticancer activity at nanomolar concentrations.

132 unprecedented sensitivity for Zn(2+) at sub-nanomolar concentrations.

133 tively engages cellular menin protein at low nanomolar concentrations.

134 ty to hCD80 and displaced CTLA-4 and CD28 at nanomolar concentrations.

135 depress the cortical network activity at low nanomolar concentrations.

136 cts of exposure to a drug valinomycin at sub-nanomolar concentrations.

137 These novel ADCs displayed sub-nanomolar cytotoxicity against HER2-expressing cancer ce

138 s, we discovered potent HDAC6 degraders with nanomolar DC(50) and promising antiproliferation activit

139 HTP(2) MOFs for the detection of 5-HT with a nanomolar detection limit of 63 +/- 11 nM for 5-HT throu

140 n particular, Ni(3)HHTP(2) MOFs demonstrated nanomolar detection limits of 63 +/- 11 nM for DA and 40

141 ng in a titratable manner, up to 20 nm, with nanomolar detection limits.

142 We produced more than 20 synbodies with low nanomolar dissociation constants (KD < 10 nM) for GII.4

143 nserved P-H...pai interaction, which confers nanomolar dissociation constants for their respective li

144 aintained less length-promoting responses to nanomolar DM.

145 utes, and this regulation was gated by tonic nanomolar dopamine.

146 hat, upon treatment with clinically-relevant nanomolar doses of the Topoisomerase I inhibitor camptot

147 VoltageSpy enables voltage imaging with low nanomolar dye concentration and offers a promising metho

148 killed cultured P. falciparum parasites with nanomolar efficacy and did not give rise to new resistan

149 Among them, compound 9u possessed nanomolar FLT3 inhibitory activities and subnanomolar in

150 GLUT3 and GLUT4, with an IC(50) value of low nanomolar for GLUT1.

151 itors with picomolar enzymatic Ki values and nanomolar functional activity in human Raji cells.

152 om 5 fM to 73 nM), which translated into sub-nanomolar gammadelta T-cell-mediated eradication of blad

153 llent antiproliferative properties, with low nanomolar GI50 values (16o, mean GI50 of 3.3 nM) against

154 ), yielding short-, medium-, and long-acting nanomolar hBChE inhibitors (with a half-life of the carb

155 Two nanomolar hCA IX and XII inhibitors were also screened f

156 Given the nanomolar high affinity between ACE2 and SARS-CoV-2 spik

157 and to the development of BAY-298, the first nanomolar hLH-R antagonist reducing sex hormone levels i

158 replication of wild-type R5-HIV-1 with a sub-nanomolar IC(50) value.

159 ition of growth of RS4;11 cells and also low nanomolar IC(50) values in a panel of leukemia cell line

160 a panel of primary AML blast cells, with low nanomolar IC(50)s and, based on colony-forming unit assa

161 rt a SPIN1 chemical probe inhibitor with low nanomolar in vitro activity, exquisite selectivity on a

162 ofuran-3(2H)-one scaffold that possessed low nanomolar in vitro potency in cell proliferation assays

163 Cell-based assays demonstrate nanomolar inhibition (EC(50)) of BKV infection and sugge

164 ly inhibit at least one hCA isozyme with low nanomolar inhibition constants.

165 Sub-nanomolar inhibition of Kgp is achieved by tight binding

166 revealed several combinations that produced nanomolar inhibition, and seven unique pairs produced gr

167 d modules (ProMs) to succeed in developing a nanomolar inhibitor ([Formula: see text] Da).

168 resent a thorough description of the potent, nanomolar inhibitor [2-(2-methoxy-5H-1,4b,9-triaza(inden

169 The lead compound, AS15, is a covalent nanomolar inhibitor of PDI, and the combination of AS15

170 tructure-guided elaboration to design potent nanomolar inhibitors against Mab TrmD.

171 Most of these oxa-analogues are nanomolar inhibitors of both the human and murine sEH.

172 ese ligands are then modified to develop low nanomolar inhibitors of SIRT2.

173 l fragment screening hit led to double-digit nanomolar inhibitors of SPR with excellent ligand effici

174 n inhibitor of HDACs, AES-135, that exhibits nanomolar inhibitory activity against HDAC3, HDAC6, and

175 The compounds reach low micromolar to upper nanomolar inhibitory potency in cell-based assays, are s

176 lected aptamers bind with high affinity (low nanomolar K(d) values) and selectivity to exposed surfac

177 bind alternative G4DNA topologies with a low nanomolar Kd value of approximately 2 nm, similar to tha

178 ng aqueous Hg(II) concentrations down to the nanomolar level in freshwater environments.

179 h IDO1, to the inhibitory potency at the low nanomolar level in several tumoral settings, and to the

180 continuously monitoring fentanyl down to the nanomolar level through a nanomaterial-based multilayere

181 ent activity with GI(50) values reaching the nanomolar level, with mean graph midpoints of 0.08-0.41

182 hat is detectable in lymphoid tissues at the nanomolar level.

183 Nanomolar levels of GenX inhibited P-gp and BCRP but not

184 Melor is successfully evaluated by detecting nanomolar levels of various small molecules, including u

185 IspH inhibitors and refine their potency to nanomolar levels through structure-guided analogue desig

186 By consuming O(2) to nanomolar levels, aerobic nitrifying microbes cede their

187 t the same pathogens from 16 to 32 mug/mL to nanomolar levels.

188 At low (nanomolar) levels, it modulates synaptic transmission an

189 Six of the described compounds were nanomolar ligands, and the best compound possessed an af

190 rm" to codetect guanosine and adenosine with nanomolar limits of detection in real time with FSCV.

191 DE1 isoforms, with IC(50) values in the high nanomolar/low micromolar concentration range, and showed

192 This enabled the discovery of the first low nanomolar LRH-1 agonist, one hundred times more potent t

193 h the limit of detection (LOD) down to a few nanomolar (<3 nM), which is close to the World Health Or

194 eous detection of picomolar (pM) insulin and nanomolar (nM) cortisol concentrations in a single micro

195 respective chemokines with affinities in the nanomolar (nM) range, similar to the affinities of nativ

196 human polySia-specific mAb that retained low nanomolar (nmol/L) target affinity and exhibited exquisi

197 The key compound VUF16839 (14d) combines nanomolar on-target activity (pK(i) = 8.5, pEC(50) = 9.5

198 res of three macrocyclic inhibitors with low nanomolar or subnanomolar potency in complex with CatD a

199 e inhibitor exhibiting at least single-digit nanomolar (or lower) potency and a broad spectrum.

200 zymes provides a detection platform with low nanomolar peptide substrate consumption, and the assay i

201 simultaneously inhibited PI3K and HDAC with nanomolar potencies and demonstrated favorable antiproli

202 ation of a series of VHL inhibitors with low nanomolar potencies and improved cellular permeability.

203 esistant EGFR(L858R/T790M/C797S) mutant with nanomolar potencies in a reversible binding mechanism.

204 ionship of these two scaffolds, resulting in nanomolar potencies in an ATP synthesis inhibition assay

205 ioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (A

206 ty relationship and delivered analogues with nanomolar potencies.

207 cific small-molecule inhibitor of CLC-2 with nanomolar potency (IC(50) = 17 +/- 1 nM).

208 lines identified eight analogues displaying nanomolar potency (IC(50) ranging from 1 to 32 nM), high

209 te to high activities with low micromolar to nanomolar potency against all four serotypes.

210 with nanomolar potency against CA IX and sub-nanomolar potency against CA II and CA IV, and with pote

211 Very potent pan-inhibitors with nanomolar potency against CA IX and sub-nanomolar potenc

212 ly-selective inhibitor, CCG258747, which has nanomolar potency against GRK2 and excellent selectivity

213 GHP-88309 showed nanomolar potency against HPIV3 isolates in well-differe

214 ucei rhodesiense and Leishmania donovani and nanomolar potency against Plasmodium falciparum.

215 collection of natural products that display nanomolar potency against select isoforms of eukaryotic

216 tic marine natural product with reported sub-nanomolar potency against several cancer cell lines.

217 les (AB) protein kinase inhibitors that show nanomolar potency against T. brucei bloodstream forms, L

218 eries of thienopyrimidinone derivatives with nanomolar potency against TrmD in vitro and discovered a

219 Optimized derivatives with nanomolar potency allowed us to investigate the mechanis

220 RAC was the most active TH on PPARgamma with nanomolar potency and binding affinity.

221 ysteine protease and a serine hydrolase with nanomolar potency and exceptional specificity.

222 igand efficiency (LLE = 8.5), which displays nanomolar potency in cells (peripheral blood mononuclear

223 Compounds with nanomolar potency versus Plasmodium DHODH and Plasmodium

224 Isolated mAb inhibitors exhibited nanomolar potency, exclusive selectivity, excellent prot

225 100-fold SK2 selectivity, with retention of nanomolar potency.

226 h of many tumor cell lines with single-digit nanomolar potency.

227 le to degrade its target protein by 98% with nanomolar potency.

228 erative peptide modifications conferring low nanomolar potency.

229 mproved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chlorid

230 Here, we describe the design of a nanomolar potent 17beta-hydroxysteroid dehydrogenase typ

231 This led to the identification of LEI-301, a nanomolar potent inhibitor for the PLAAT family members.

232 Compound 24 is a nanomolar potent inhibitor of human 17beta-HSD2 (IC(50)

233 activity by 10-fold, affording LEI-401 as a nanomolar potent inhibitor with drug-like properties.

234 The study identified several low nanomolar potent inhibitors against CA IX, with lipophil

235 imultaneous readout of glutamate release and nanomolar presynaptic Ca(2+) in situ.

236 escence, enabling PPI monitoring even at low nanomolar protein concentrations.

237 and RAS/RAF interaction inhibitors using low nanomolar protein concentrations.

238 BA(A) receptor binding affinities in the mid-nanomolar range ( K(i), 90-450 nM).

239 wth of Plasmodium falciparum in vitro in the nanomolar range (IC(50) = 74 nM) with high selectivity i

240 rs for cocaine/quinine (MN4), chosen for its nanomolar range affinity, and l-argininamide (1OLD) to s

241 ometallics showed inhibitory activity in the nanomolar range against histone deacetylases (HDACs) as

242 he analogues displayed IC(50) within the low nanomolar range against Trypanosoma cruzi, with very hig

243 hese, three compounds showed activity in the nanomolar range and one, 2-((4-fluoro-3-(trifluoromethyl

244 phototoxicity in the very low micromolar to nanomolar range at clinically relevant 595 nm, in monola

245 ree aptamers with a reported affinity in the nanomolar range for ampicillin, a beta-lactam antibiotic

246 PR) with dissociation constants (Kd ) in the nanomolar range for choline and glycine betaine, micromo

247 23d, 23e, 23f, and 23h) were identified with nanomolar range potency based on a systematic structure-

248 r agonist activities of cell adhesion in the nanomolar range were obtained.

249 their low circulating concentrations (in the nanomolar range) and poor fragmentation characteristics

250 rapid and highly sensitive target detection (nanomolar range) in complex media such as human serum.

251 indicator Cal-590 is Ca(2+)-sensitive in the nanomolar range, and employ it in combination with green

252 CAs IX and XII, with K(I) values in the low nanomolar range, and strong antitelomerase activity in P

253 ibitory concentration (IC(50)) values in the nanomolar range, and the broadest bNAbs neutralize up to

254 results, showing limits of detection in the nanomolar range, confirm the validity of the proposed ap

255 arPEG-(KA7)(4) binds microtubules in the low nanomolar range, diffuses along their lattice with the a

256 affinities toward alpha(V)beta(3) in the low nanomolar range, good selectivity, and high plasma stabi

257 At the low physiological levels in the nanomolar range, H(2)O(2) is the major agent signalling

258 ains with affinities in the picomolar to low nanomolar range, orders of magnitude higher than unoptim

259 c anhydrase (hCA) IX and XII isoforms in the nanomolar range, while no affinity was encountered for o

260 tivity over GluN2A with potencies in the low nanomolar range.

261 0S proteasomes with IC(50) values in the low nanomolar range.

262 ortant binding does indeed take place in the nanomolar range.

263 etection limits for the D enantiomers in the nanomolar range.

264 ich reacting to their target HIPs in the low nanomolar range.

265 emotaxis of blood eosinophils are in the low nanomolar range.

266 pecificity groups with activities at the low nanomolar range.

267 cancer cell lines with an IC(50) in the low nanomolar range.

268 C(50)) values in the single- or double-digit nanomolar range.

269 en 75 and 93% and levels of detection in the nanomolar range.

270 iomarkers to be in the high picomolar to low nanomolar range.

271 ansferase enzymes to show an affinity in the nanomolar range.

272 h of Mcl-1-dependent tumor cell lines in the nanomolar range.

273 sceptible to the 5 INSTIs, with IC50s in the nanomolar range.

274 r the model system HER2-DIVMP was found in a nanomolar range.

275 equilibrium inhibition constants in the low nanomolar range.

276 l-1 occupancy-based inhibitor A-1210477 with nanomolar-range affinity.

277 the catalytic activity of USP2 in vitro with nanomolar-range potencies, and they bound and inhibited

278 n deep tissue, providing a basis for mapping nanomolar-scale analytes without the radiation or heavy

279 he mobile translocation is the major form at nanomolar ScPif1 concentrations although patrolling beco

280 toring of analytes in vivo have only reached nanomolar sensitivity and can measure only a handful of

281 ffects of PZQ on schistosomes, including (i) nanomolar sensitivity to PZQ; (ii) stereoselectivity tow

282 ives of the antibiotic tetracycline exhibits nanomolar sensitivity with visual detection of bead fluo

283 karyotic CDN levels in single cells with low nanomolar sensitivity.

284 for protein unfolding and PLI detection with nanomolar sensitivity.

285 we report the development of a series of low nanomolar, small-molecule inhibitors of human ACLY.

286 ized by micromolar solubilities give rise to nanomolar soluble concentrations in healthy animal arter

287 lant-derived lipid, responds to alpha-syn at nanomolar solution concentrations.

288 combined submicromolar cellular potency and nanomolar target affinity with balanced physicochemical

289 ed 25 excipient activities, ranging from low-nanomolar to high-micromolar concentration.

290 ng, binding affinities to the chromophore in nanomolar to low micromolar range, and high photostabili

291 TCRs exhibited high affinities, ranging from nanomolar to low micromolar.

292 ge over three orders of magnitude in the low nanomolar to micromolar concentration range and limit of

293 with very different binding affinities (low nanomolar to millimolar) for an integral membrane transp

294 ntative examples of the series also showed a nanomolar to picomolar efficacy against patient-derived

295 ificantly improved anti-HAdV activities with nanomolar to submicromolar IC(50) values and high select

296 aF/F(0) response to NE, good photostability, nanomolar-to-micromolar sensitivities, sub-second kineti

297 bcellular resolution, subsecond kinetics and nanomolar-to-submicromolar affinity.

298 ivity score metric capable of discriminating nanomolar versus micromolar sensitivity to a cell-permea

299 s aqueous solubility is ~200 fold lower (~60 nanomolar), whereas the potency of its stimulatory effec

300 ighly sensitive probes for investigating sub-nanomolar Zn(2+) dynamics, but also reveals new pools of