ライフサイエンスコーパス: narrow down

1 quired for efficient inhibition of bsrE mRNA narrowed down.

2 s, summarize the current knowledge gaps, and narrow down a spectrum of 6 themes that serve as challen

3 We systematically narrowed down a role of serotonin in inhibiting endogeno

4 ially details of the indirect activation, we narrowed down allosteric inhibition sites of negative al

5 segregrant analysis and association mapping narrowed down an InDel marker regulating flowering time

6 weeps were applied as step-wise criteria for narrowing down an original pool of 30 candidates.

7 ideas (building castles in the sky) and then narrowing down and focusing on the most tractable and us

8 Taperin (TPRN) localizes to the narrowed-down base of stereocilia, where they pivot in r

9 s from this initial screen were then further narrowed down based on their ability to rescue cathepsin

10 between periplakin and BF/IF proteins and to narrow down binding domains.

11 datasets from leaves, fruits, and flowers to narrow down bound genes to a set of high confidence targ

12 , the three-recombinant consensus region was narrowed down by more than a megabase to 2.2 Mb at chrom

13 To narrow down candidates for further validation, quantitat

14 Here, using a G(0) marker (G(0)M), we narrow down CML LSCs as G(0)M- and CD27- double positive

15 dataset analysis, effectively allowed us to narrow down, compare and predict compound mode of action

16 s per the study's sequences, can effectively narrow down differential diagnoses and lead to accurate

17 Narrowing down even further, only a few tools allow comp

18 a list of candidate variants that cannot be narrowed down further or ranked.

19 hylated regions (DMRs) could help scientists narrow down genome regions and even find biologically im

20 m profiling data of 391 AML cases to further narrow down genomic regions of interest.

21 By fine-mapping, it was narrowed down into a 928 kb region.

22 obility to normal behavior, and the opposite narrowing down into immobility.

23 g a series of deletion mutations of TBX5, we narrowed down its functional domain to amino acids 339-3

24 exible tool that enables the user to rapidly narrow down large lists of DEEs to a small number of mos

25 It allows a user to narrow down many possible structures initially found by

26 Using linker scanning mutagenesis, we have narrowed down minimal Ter1 to 21 bp.

27 We finally narrow down on 10 informative features (including sequen

28 solving also requires convergent thinking to narrow down options and select the most effective soluti

29 sing docking and drug properties scoring, we narrowed down our selection to fourteen candidates.

30 he QTL, which, at the same time, are rapidly narrowed down over multiple generations of backcrossing.

31 tig into the susceptible rice cultivar TP309 narrowed down Pi9 to the candidate genes Nbs2-Pi9 and Nb

32 egy and high-density mapping populations, we narrowed down Pl(17) to a 15-kb region flanked by SNP ma

33 High-throughput experimental approaches narrow down possible binding partners but often include

34 se, symmetry, retention, and endurance which narrow down possible device material choices adequate fo

35 e proteomic data from large scale studies to narrow down potential phospho-tyrosine sites on the simp

36 d progeny testing for selected recombinants, narrowed down qSD12 to a genomic region of <75 kb, where

37 The criteria defined here will allow narrowing down reasonable receptor candidates and provid

38 we applied the model on the whole phenome to narrow down repositioning candidates and suggest alterna

39 As a narrowing-down strategy for selection of initial biomark

40 or the remaining 45%, our data allowed us to narrow down structural possibilities and eliminate incor

41 applied potential/current density allows for narrowing down suitable material choices as replacement

42 By reliably and rapidly narrowing down target interactions, (no more than 1.5 ho

43 To narrow down the amino acids dictating cell binding speci

44 Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to

45 mutants and 31 site-directed UBR1 mutations narrow down the degron-binding activity to a 72-residue

46 imaging, and nuclear medicine scans help to narrow down the differen-tials diagnosis.

47 This helps narrow down the differential diagnoses.

48 nd clinical presentation, we can effectively narrow down the differential diagnosis of corneal condit

49 often require several imaging modalities to narrow down the differential diagnosis.

50 it easier to detect and define injuries, and narrow down the differential diagnosis.

51 rom a number of filtering options to further narrow down the enzyme selection.

52 These results narrow down the function of parietal circuits, as well a

53 In this study, we attempted to narrow down the implicated regions by incorporating evid

54 If we would design FANCY in 2014, we would narrow down the inclusion criteria to include only the h

55 r Ciona betagamma-crystallin expression, and narrow down the likely factors that bind to these motifs

56 To narrow down the list of cellular pathways important for

57 ions of the cpe promoter region were made to narrow down the location of promoter elements.

58 of IL-10 induced by GAG binding were used to narrow down the location of the binding site and to asse

59 ssion of recombination and have been able to narrow down the location of the gene underlying this QTL

60 tilized trans-ancestral Bayesian analysis to narrow down the location of the probable causal variant

61 A bid to further narrow down the minimal region of 7SK led to a surprisin

62 tive change in transmission, we were able to narrow down the permanent wilting point of the seedlings

63 uggested that guides readers step-by-step to narrow down the plausible reasons for the unexpected pea

64 his process requires exquisite regulation to narrow down the pool of DSB intermediates that may form

65 can be interpreted, in order to empirically narrow down the possibilities for behavioral rules.

66 To narrow down the possibilities, 7-deaza adenine base subs

67 and (13)C (2-(13)C) labeling is employed to narrow down the possible dissociation mechanisms leading

68 So in silico predictions could help to narrow down the possible palmitoylation sites, which can

69 IDDI (knowledge-guided inference of DDIs) to narrow down the PPI sites to smaller regions/domains.

70 dditional chimeras within this region helped narrow down the PPPA-sensitive site to a region containi

71 wapping experiments between YmcB and YqeV to narrow down the protein domain(s) responsible for distin

72 S results on HSCR to fine-map these loci and narrow down the putatively causal variants to 99% credib

73 mongst climate model mean states may help to narrow down the range of global warming projections.

74 Nevertheless, the findings in this study narrow down the range of possibilities and present a nov

75 ents where genes are manipulated can help to narrow down the range of possible networks.

76 confirm these associations with IGF2 and to narrow down the region harboring the causal SNP.

77 g/binding processes is exquisitely poised to narrow down the regions of the sequence that drive prote

78 Machine learning algorithms helps to narrow down the search and provides information about es

79 ing the correlation matrix and pre-filter to narrow down the search space for epistasis analysis.

80 ining problem, we designed two techniques to narrow down the search space: (1) partition the input gr

81 lecular dynamics simulations are employed to narrow down the selection of peptides for experimental a

82 Furthermore, we were able to narrow down the sequences important for this function to

83 In our earlier work, we were able to narrow down the specificity of the N-terminal domain of

84 was digested with LysN to confirm or further narrow down the structure of the found catabolites.

85 We narrowed down the best binding site to a 20 nt long sequ

86 Using recombinant protein H fragments, we narrowed down the binding site to the N-terminal domain

87 In silico analysis narrowed down the candidates to 47 proteins, including C

88 ctor (COF1) and by deletion analysis we have narrowed down the COF1-binding motif to a 17-bp sequence

89 e-specific reversals of the temperature step narrowed down the critical period for compensation to be

90 same functional tests and DNA binding assays narrowed down the critical portion of FP9 to a 20-base p

91 Using homozygosity mapping, we narrowed down the critical region of the LCA3 locus to 3

92 We further narrowed down the element mediating the hypoxia response

93 In alpha, we narrowed down the functional domain to a 48-nt-long, hig

94 We then narrowed down the FXPs' binding site(s) within the mRNA,

95 We further narrowed down the interacting binding epitopes on both d

96 ilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate caus

97 The netWAS analysis narrowed down the list to 21 genes in adipose tissue.

98 ithin the chromosome 2 region, which further narrowed down the locus to <2 cM.

99 tial peptides derived from betac 450-517, we narrowed down the Lyn binding site to nine amino acid re

100 detailed 3' deletion mapping of the 5'-DPRS narrowed down the negative cis-acting element to a 34-ba

101 In our strategy we narrowed down the optimization to two accelerating poten

102 letion mutant/luciferase reporter constructs narrowed down the PACAP response element to a proximal r

103 Using WGS information, we narrowed down the positions of the two QTL detected on O

104 s) targeted remain to be identified, we have narrowed down the region of attack to within a 17 amino

105 a series of truncated Drosha constructs, we narrowed down the segment responsible for nuclear transl

106 In addition, we narrowed down the structural determinants to the N termi

107 We narrowed down the Treg-stimulating domain to a 15-residu

108 By narrowing down the 2.0-kb IL-2 promoter region, we found

109 We are in the process of narrowing down the critical region for positional clonin

110 It offers a methodology for narrowing down the decision-making field based on a stri

111 losses of H(2)O, CO(2), and CH(2)-H(2)O) by narrowing down the isomeric candidate structures using t

112 est available FPs provides a useful guide in narrowing down the options.

113 formation could help a criminal investigator narrowing down the owner of an object found at a crime s

114 s for maximum cellular uptake was helpful in narrowing down the particle characteristics.

115 e oligodendrocyte enhancers in the Myrf TAD, narrowing down the search space for Myrf enhancers from

116 ool to explore new uses of existing drugs by narrowing down the search space.

117 t in refining the starting dose of FSH while narrowing down the timing of the trigger injection durin

118 The diagnostic path presented narrows down the cause of acute vision loss to the cone

119 aceted theme of climate change, our approach narrows down the focus to 10 critical underlying themes

120 Our analysis narrows down the number of helix arrangements from about

121 sease-relevant cell type further refines and narrows down the potential gene targets.

122 This study narrows down the RNA foldase domain to amino acids 749-8

123 Our framework narrows down the search space based on strongly connecte

124 This pre-screening process narrows down the search to a much smaller set of candida

125 yze six traits in the UK Biobank, where GIFT narrows down the set size of putatively causal genes by

126 3, a tumor suppressor gene, and successfully narrows down the statistically finemapped variants compa

127 absorption of perovskite single crystals can narrow down their effective optical bandgap without chan

128 as well as immunologic hypotheses, can help narrow down this genome-wide search.

129 To narrow down this region further, we have examined the cl

130 predicting drug synergy are much needed for narrowing down this space, especially when examining new

131 quently expand into helices and spirals that narrow down to the incipient site of abscission [6-8].

132 The linked haplotype at 2p13 was narrowed down to <806 kb.

133 376 studies were originally identified, then narrowed down to 1,312 for title/abstract screening.

134 1.3% and negative for 3 islet autoantibodies narrowed down to 4% of the cohort, and detected 96% of M

135 The Gbeta-gamma-binding region was further narrowed down to 62 amino acids (residues Leu-580 to Val

136 itial search produced 844 entries, which was narrowed down to 68 trials.

137 survivin promoter responding to Bcr-abl was narrowed down to a 116 bp fragment between nucleotides -

138 the commonly deleted region could be further narrowed down to a 2 cM (based on the Whitehead genetic

139 n 65% of the 26 lung tumors examined and was narrowed down to a 2.2-Mb region.

140 de, the calmodulin binding domain is further narrowed down to a 23-amino acid stretch.

141 genesis, the PA binding site within RafC was narrowed down to a 35-amino acid segment between residue

142 n axial spin-triplet state, which is further narrowed down to a chiral spin-triplet state with eviden

143 The critical region was narrowed down to a cluster of five amino acids by expres

144 lar gene is located can relatively easily be narrowed down to a comparatively small area contained wi

145 tral linewidths of plasmon resonances can be narrowed down to a few nanometers by optimizing the morp

146 ite within the effector domain of MARCKS was narrowed down to a heptapeptide that binds to LPS in an

147 The position of m(6)A in IME2 was narrowed down to a region in the 3'-end.

148 al signaling associated with this region was narrowed down to a sequence of eight amino acids, the L4

149 d library, and 20% more structures correctly narrowed down to a set of five possible candidates.

150 The NDEL1 binding site of DISC1 was narrowed down to a small portion of exon 13, correspondi

151 remaining unidentified nucleophile has been narrowed down to be one of the residues between 150 and

152 We then narrowed down to five metabolites [p-cresol sulfate, lin

153 gh LDLR type A (LA) binding domain, which we narrowed down to LA domains 1 and 2 through functional e

154 d from the databases, the pool of papers was narrowed down to studies published until March 20th, 202

155 d from the databases, the pool of papers was narrowed down to studies published until May 2024.

156 53% non-professional) and one workshop, were narrowed down to the final top ten uncertainties of prio

157 e ubiquitin monomer coding sequence has been narrowed down to the first 9 nt coding for the first thr

158 peptides, the binding site for fibulin-2 was narrowed down to the N terminus of fibrillin-1 (amino ac

159 tructs were made, and the minimal region was narrowed down to the proximal 130 bp of the Satb2 promot

160 This effect was further narrowed down to the secreted cytolysin ShlA and the bio

161 The binding pocket was narrowed down to the upper part of transmembrane helices

162 e mDia2-interacting interface on drebrin was narrowed down to three highly conserved 9-16 residue seq

163 n can be determined, and its location can be narrowed down to two or three positions, leading to a si

164 earch for intellectual turning points can be narrowed down to visually salient nodes in the visualize

165 b QTL genomic region, which was subsequently narrowed-down to a functional candidate gene CaHSFA5 and

166 cribing the chemical shift vector trajectory narrows down to (i) mathematically describing the FID in

167 llows for high-precision formula assignments narrowing down tremendously the chemical space of unknow

168 ic compositions at the species/strain level, narrowing down which species/strains need more attention

169 Positive genomic regions were rescreened and narrowed down with smaller overlapping deficiencies from

170 uarius (a marine amphipod) population can be narrowed down without excluding samples, and that redund