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1  (0.66; 0.48-0.92), and suggestion types of "narrow spectrum" (0.65; 0.45-0.94), "change formulation
2 rary of 24 peptide-based antimicrobials with narrow spectrum activity towards veterinary pathogens.
3 ered abaucin, an antibacterial compound with narrow-spectrum activity against A. baumannii.
4 ic florfenicol, which acts as a prodrug with narrow-spectrum activity against M. abscessus-chelonae c
5         Bioactivity assays reveal potent but narrow-spectrum activity against the producing strain an
6                                  It displays narrow-spectrum activity against vancomycin-resistant En
7 ) infections, but the molecular basis of its narrow-spectrum activity in the human gut microbiome rem
8                                        Their narrow-spectrum activity provides opportunities to disco
9 heir clinical use is limited by toxicity and narrow-spectrum activity.
10 ase is a sensitizing element for fidaxomicin narrow-spectrum activity.
11              For initial treatment, the most narrow-spectrum agent active against the likely pathogen
12 ciple of de-escalation: moving from broad to narrow spectrum agents and stopping antibiotics when no
13 easure stewardship efforts to promote use of narrow-spectrum agents and may inadvertently discourage
14 iple of de-escalation: moving from broad- to narrow-spectrum agents and stopping antibiotics when no
15 al products has become increasingly rare and narrow-spectrum agents are typically deemed unsuitable f
16   The comparative effectiveness of different narrow-spectrum agents has not been reported.
17 t bacteria, research is now directed towards narrow-spectrum agents rather than broad-spectrum agents
18                         These inhibitors are narrow-spectrum agents that can cause resistance develop
19                Though Corramycin displayed a narrow spectrum and modest MICs against sensitive bacter
20 from the Planckian blackbody emission with a narrow spectrum and strong directionality.
21  There is an urgent and unmet need for novel narrow-spectrum and microbiome-sparing antibiotics.
22 in (FDX) is a novel antimicrobial agent with narrow-spectrum and potent bactericidal activity against
23 eatment of CDI and herald the development of narrow-spectrum anti-C. difficile agents that relatively
24 2,4-triazolo[1,5-a]pyrimidines that had good narrow-spectrum antibacterial activity against E. faeciu
25 - an extensively modified peptide exhibiting narrow-spectrum antibacterial activity against some symb
26  of antibiotic resistance and development of narrow-spectrum antibacterial drugs, which is an urgent
27 o developing resistance, revealing potential narrow-spectrum antibacterial therapies that could remai
28                               Fidaxomicin, a narrow-spectrum antibiotic approved for Clostridioides (
29 xposure, and 65.0% had at least 1 episode of narrow-spectrum antibiotic exposure at any time before 4
30                                              Narrow-spectrum antibiotic regimens largely conferred si
31 diagnostic tests to allow pathogen-targeted, narrow-spectrum antibiotic therapy, using short rather t
32 pare the effectiveness of broad-spectrum and narrow-spectrum antibiotic treatment for acute respirato
33      The primary outcome was the duration of narrow-spectrum antibiotic treatment.
34 ential to facilitate earlier deescalation to narrow-spectrum antibiotic treatment.
35               LRTS collection did not impact narrow-spectrum antibiotic use but was associated with l
36 ntation of streptomycin mutants and a common narrow-spectrum antibiotic with a strong antibacterial e
37 needs to be treated for 3 days, often with a narrow-spectrum antibiotic, and asymptomatic bacteriuria
38 uate the overall feasibility of switching to narrow spectrum antibiotics during the empiric treatment
39 r increasing the feasibility of switching to narrow spectrum antibiotics in the empiric treatment of
40  manner, allowing for initial treatment with narrow spectrum antibiotics, and helping to reduce the l
41                                              Narrow-spectrum antibiotics and new therapeutic targets
42 ollection did not directly affect the use of narrow-spectrum antibiotics but was associated with exte
43                       The ratio of broad- to narrow-spectrum antibiotics decreased from 1.62 in 2011
44 compared clinical outcomes after (1) empiric narrow-spectrum antibiotics escalated to broad-spectrum
45                These data support the use of narrow-spectrum antibiotics for most children with acute
46  by broad- spectrum antibiotics, the idea of narrow-spectrum antibiotics has been previously proposed
47                                              Narrow-spectrum antibiotics have been found to be equiva
48           Furthermore, we show that pyocins, narrow-spectrum antibiotics made by other P. aeruginosa
49                                 Colicins are narrow-spectrum antibiotics produced by and active again
50                   Neither broad-spectrum nor narrow-spectrum antibiotics were associated with risk of
51                                Extended- and narrow-spectrum antibiotics were found against methicill
52                       The PAP group received narrow-spectrum antibiotics without extension beyond 24
53 ting universal bacterial cellular processes, narrow-spectrum antibiotics work by targeting specific f
54 l or patient-centered outcomes compared with narrow-spectrum antibiotics, and were associated with hi
55  treatment of bacterial skin infections with narrow-spectrum antibiotics, rather than broad-spectrum.
56 es not necessarily mean more frequent use of narrow-spectrum antibiotics.
57                Broad-spectrum antibiotics vs narrow-spectrum antibiotics.
58 % for broad-spectrum antibiotics vs 3.1% for narrow-spectrum antibiotics; risk difference for full ma
59 % for broad-spectrum antibiotics vs 2.7% for narrow-spectrum antibiotics; risk difference for full ma
60  for broad-spectrum antibiotics vs 25.1% for narrow-spectrum antibiotics; risk difference for full ma
61 2 for broad-spectrum antibiotics vs 91.5 for narrow-spectrum antibiotics; score difference for full m
62 ted the development of FabI inhibitor 4 with narrow spectrum antimicrobial activity and in vivo effic
63                                              Narrow spectrum antimicrobial activity has been designed
64 nfections there is a pressing need for novel narrow-spectrum antimicrobial agents in veterinary medic
65 solates of S. lugdunensis are susceptible to narrow-spectrum antimicrobial agents.
66 mimetic strategy may aid the design of other narrow-spectrum antimicrobial peptides.
67 function compared with subtherapeutic PK and narrow spectrum antimicrobials.
68 d potentially extend the lifespan of current narrow-spectrum antimicrobials.
69 s to nudge clinicians toward the use of more narrow-spectrum antimicrobials.
70 selective ribosomal inhibition and excellent narrow-spectrum antitubercular activity.
71 ne SAAR models and the addition of SAARs for narrow-spectrum B-lactam agents, antifungals predominant
72 um antibacterials (0.61; .54-.70) and higher narrow-spectrum B-lactam use (1.43; 1.22-1.67).
73 nditions, the low-intensity irradiation, the narrow spectrum band (<4 nm) of the laser and comparably
74 s, rmPCR/AS 45 hours; P = .01) and increased narrow-spectrum beta-lactam (control 42 hours, rmPCR 71
75             Sulbactam is a first-generation, narrow-spectrum beta-lactamase inhibitor that also has i
76 confidence interval [CI], 1.45-5.42), as was narrow-spectrum beta-lactams (aOR, 3.54; 95% CI, 1.98-6.
77 ased (PRE 655.2 vs POST 585.8; P = .043) and narrow-spectrum beta-lactams increased (69.1 vs 141.7; P
78   Antibiotics were ranked into 4 categories: narrow spectrum, broad spectrum, extended spectrum, and
79   Antibiotics were ranked into 4 categories: narrow-spectrum, broad-spectrum, extended-spectrum, and
80 eplacement of broad-spectrum insecticides by narrow-spectrum Bt crops does not reduce control of pest
81            Selective drugs with a relatively narrow spectrum can reduce the side effects of treatment
82                          In order to achieve narrow-spectrum coverage of clinically most relevant str
83 fluenzae, thus implicating them as potential narrow-spectrum drug targets.
84 ons provide valuable insights into designing narrow-spectrum drugs that selectively cause system-wide
85 95% CI, 1.04-1.14 at 6-11 months of age) but narrow-spectrum drugs were not at any age or frequency.
86  negative predictive value of three types of narrowed spectrum endoscopy (narrow-band imaging [NBI],
87 le pathogen-derived molecular pattern, these narrow-spectrum genes are usually readily overcome.
88 piric receipt of broad-spectrum, compared to narrow-spectrum, gram-negative antibiotics.
89 itor valproic acid (VPA) and enhanced by the narrow-spectrum HDAC inhibitor entinostat.
90                                  2CA acts as narrow-spectrum immunosuppressant that selectively targe
91 m two different proton energy/LET spectra (a narrow spectrum in group 1 and a widespread heterogeneou
92     Subsequent development has brought forth narrow-spectrum inhibitors with potent in-vivo activity
93 ctivate Cas9 in lytic growth using variable, narrow-spectrum inhibitors, while the broad-spectrum Acr
94                                  Compared to narrow spectrum lamps, broad spectrum technologies enabl
95                                      Using 8 narrow spectrum light sources in the visible range, we d
96     Promysalin was previously described as a narrow spectrum molecule with a unique species-specific
97 phenotypic tests, mycolic acid analysis, and narrow-spectrum nucleic acid probes.
98 eveloping new antimicrobials; however, their narrow spectrum of action is limiting.
99 ibitors, PTC-847 and PTC-672, that exhibit a narrow spectrum of activity against Ng including MDR iso
100 st human immunodeficiency virus (HIV) have a narrow spectrum of activity and, more often, have associ
101                                          The narrow spectrum of activity exhibited by 57 should avoid
102 hat Cry1B.3, Cry1Da_7, and Vip3Cb1 exhibit a narrow spectrum of activity limited to the lepidopteran
103 ell surface receptor and therefore display a narrow spectrum of activity, we find that ABPs act in a
104                             We report that a narrow spectrum of amino-acid substitutions within the t
105                       Capuramycin displays a narrow spectrum of antibacterial activity by targeting b
106 s (Traf6DeltaTEC mice) showed a surprisingly narrow spectrum of autoimmunity affecting the liver.
107            We report that in contrast to the narrow spectrum of benign tumors in human NF2 patients,
108             These R. bromii strains encode a narrow spectrum of carbohydrate active enzymes (CAZymes)
109       In this systematic review, there was a narrow spectrum of ClinROMs and PROMs with limited valid
110 teins encoded by a single virus, providing a narrow spectrum of coverage.
111 e the emergence of drug-resistance and their narrow spectrum of coverage.
112 HMCES is specialized in protecting against a narrow spectrum of DNA damaging agents in addition to A3
113 ficacy of prototypic PGs was restricted to a narrow spectrum of IAV strains.
114  most commonly detected in patients within a narrow spectrum of isolated conotruncal heart defects (m
115                         Here, we harness the narrow spectrum of Raman spectroscopy and introduce Rama
116                                          The narrow spectrum of tissues containing RII mutations illu
117                                  Compared to narrow spectrum-only antibiotic use, broad spectrum-only
118 acterial agents that could enable conduct of narrow-spectrum, organism-specific clinical trials and u
119 /mL values for 101 C. difficile strains) and narrow-spectrum oxadiazole (3-(4-(cyclopentyloxy)phenyl)
120  formation as a nonlethal method, as well as narrow-spectrum pathogen-specific antibiotics, which are
121 labeled patients, we observed an increase in narrow-spectrum penicillin usage (adjusted odds ratio [O
122 al antimicrobial dosing strategies including narrow spectrum penicillins, such as penicillin-V.
123 ity score analysis, there was an increase in narrow-spectrum penicillins (OR, 10.89 [95% CI, 5.09-23.
124 microbial modification led to an increase in narrow-spectrum penicillins (p=0.0322).
125                     Post-AAT, prescribing of narrow-spectrum penicillins was more likely (adjusted od
126 behaviors are mediated by the compound eye's narrow-spectrum photoreceptors R7 and R8 and their downs
127 ividing broad-spectrum prescription rates by narrow-spectrum prescription rates.
128         We calculated the ratio of broad- to narrow-spectrum prescriptions by dividing broad-spectrum
129 .4, and the ratio between broad-spectrum and narrow-spectrum prescriptions ranged from 0.7 to 1.8 acr
130 erized in a kinome-wide screen demonstrating narrow spectrum profiles.
131 patients without comorbidities, 52% received narrow-spectrum regimens (44% macrolide, 8% doxycycline)
132     Some countries should increase access to narrow-spectrum, safe, and affordable (Access) antibioti
133                                              Narrow-spectrum SSI prophylaxis with ceftriaxone or cefa
134 he enzyme active sites resemble those of the narrow-spectrum TEM-1 and SHV-1, and not the enlarged si
135                         Sarecycline is a new narrow-spectrum tetracycline-class antibiotic approved f
136  Moreover, we show that microcins can act as narrow-spectrum therapeutics to inhibit enteric pathogen
137  providers, than to change to appropriate or narrow-spectrum therapy, respectively.
138 a rationale for why bacteria commonly evolve narrow-spectrum toxins such as bacteriocins and suggests
139              However, many bacteria also use narrow-spectrum toxins, such as bacteriocins, that princ
140 this toxin loss reveals a major advantage to narrow-spectrum toxins: They target the strongest ecolog
141 termined, the cerastecins may open a path to narrow-spectrum treatment modalities for important nosoc
142 ociated with improved outcomes compared with narrow-spectrum treatment.
143 reflection spectrum of the device exhibits a narrow spectrum whose height and position in wavelength
144 se data demonstrate the therapeutic value of narrow-spectrum Wnt signaling inhibitor in treating brea
145 e side effect, but the therapeutic effect of narrow-spectrum Wnt-FZD inhibitors remains to be establi

 
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