ライフサイエンスコーパス: nascent polypeptide

1 anisms that degrade the partially translated nascent polypeptide.

2 al sequence by SecYEG, and elongation of the nascent polypeptide.

3 sponds by degrading both the message and the nascent polypeptide.

4 is facilitated by direct ATP binding to the nascent polypeptide.

5 n tmRNA-mediated SsrA-peptide tagging of the nascent polypeptide.

6 of eRF1 and eRF3 in ensuring fast release of nascent polypeptide.

7 ition of a C-terminal degradation tag to the nascent polypeptide.

8 d to the NH2-terminal glycine residue of the nascent polypeptide.

9 tidyl-tRNA bond and release of the completed nascent polypeptide.

10 RF2) from the ribosome after release of the nascent polypeptide.

11 me and adds its aminoacylated alanine to the nascent polypeptide.

12 l that would facilitate the recruitment of a nascent polypeptide.

13 as assayed by tmRNA-mediated tagging of the nascent polypeptide.

14 sequence determinants encoded throughout the nascent polypeptide.

15 (SAD) domain in the carboxy terminus of the nascent polypeptide.

16 codons) may be more biased than the complete nascent polypeptide.

17 tailing enables robust ubiquitination of the nascent polypeptide.

18 e ribosome translates a messenger RNA into a nascent polypeptide.

19 osome activity to structure acquisition by a nascent polypeptide.

20 of Srp1 and Sts1 in degradation of misfolded nascent polypeptides.

21 ore slowly translated, and aggregation-prone nascent polypeptides.

22 osomes, assisting the maturation of emerging nascent polypeptides.

23 ding and post-translational modifications of nascent polypeptides.

24 and prevents misfolding of newly synthesized nascent polypeptides.

25 lly characterized for its role in processing nascent polypeptides.

26 the context of the tag added at the ends of nascent polypeptides.

27 t lacked the ability to add formyl groups to nascent polypeptides.

28 e formation of the Gbetagamma dimer from its nascent polypeptides.

29 ce regulator (CFTR) have distinct effects on nascent polypeptides.

30 rmyl group from the N-terminal methionine of nascent polypeptides.

31 , resulting in N-terminal formylation of all nascent polypeptides.

32 (3)Man(9)GlcNAc(2) to asparagine residues on nascent polypeptides.

33 lecular chaperones to interact directly with nascent polypeptides.

34 charides onto certain asparagine residues of nascent polypeptides.

35 ational processes that determine the fate of nascent polypeptides.

36 rolyl isomerase activity and associates with nascent polypeptides.

37 bstituted for C-terminal signal sequences in nascent polypeptides.

38 und to be the predominant chaperone bound to nascent polypeptides.

39 tes within domain-encoding regions of select nascent polypeptides.

40 downstream pathways that dictate the fate of nascent polypeptides.

41 s with the ribosome to assist the folding of nascent polypeptides.

42 cetylates the N termini of a wide variety of nascent polypeptides.

43 in-biogenesis factors that guide the fate of nascent polypeptides.

44 h glycosylation of acceptor sites (NXT/S) in nascent polypeptides.

45 rate to couple proteasomes to ribosome-bound nascent polypeptides.

46 rst ribosome-associated entities to bind the nascent polypeptide after peptide bond formation.

47 riminately arresting the elongation of every nascent polypeptide after the synthesis of six to eight

48 e affects the early processing events of the nascent polypeptide, altering the efficiency of ER inser

49 f reactions that append a peptide tag to the nascent polypeptide and 'rescue' the ribosome.

50 e and promotes degradation of the incomplete nascent polypeptide and problematic mRNA.

51 Interactions between the nascent polypeptide and the ribosome exit tunnel represe

52 hdrawal, enhanced the expression of arrested nascent polypeptides and caused constitutive protein fol

53 eins while avoiding the misidentification of nascent polypeptides and correctly folded proteins is li

54 release the stalled ribosomes and target the nascent polypeptides and mRNAs for degradation.

55 Protein chaperones promote native folding of nascent polypeptides and refolding of misfolded species,

56 racterize tertiary structural transitions of nascent polypeptides and show that the first nucleotide-

57 of co-translationally active chaperones with nascent polypeptides and the resulting effects on peptid

58 events is tuned by intrinsic features of the nascent polypeptides and timely association of factors w

59 ndoplasmic reticulum (ER) to fold and modify nascent polypeptides and to synthesize phospholipids for

60 ing process by repairing oxidatively damaged nascent polypeptides and unfolded proteins.

61 NA enters stalled ribosomes, adds Ala to the nascent polypeptide, and serves as a template to encode

62 ribosome rescue, degradation of the stalled nascent polypeptide, and targeting of the mRNA for decay

63 and identified mitotic regulators, misfolded nascent polypeptides, and pathological Huntingtin varian

64 ccomplished, we probe the mechanism by which nascent polypeptides are accurately sorted between the m

65 Nascent polypeptides are degraded by the proteasome conc

66 plasmic reticulum (ER) channel through which nascent polypeptides are imported and from which malfold

67 ational translocation and N-glycosylation of nascent polypeptides are mediated by a ternary supramole

68 s are split into subunits and the 60S-housed nascent polypeptides are poly-ubiquitinated by Listerin.

69 le quality control mechanisms to ensure that nascent polypeptides are properly folded and mature prot

70 complex, whereas the corresponding aberrant nascent polypeptides are ubiquitinated by the E3 ligases

71 template, the translation machinery, or the nascent polypeptide arrest the ribosome during translati

72 le for co-translational glycosylation of the nascent polypeptide as it enters the lumen of the endopl

73 ble for cotranslational glycosylation of the nascent polypeptide as it enters the lumen of the endopl

74 identify the Schizosaccharomyces pombe (Sp) nascent polypeptide associated complex (NAC) as a potent

75 tor (SR) are required for targeting, and the nascent polypeptide associated complex (NAC) prevents in

76 Drosophila homolog of beta NAC, a subunit of Nascent polypeptide Associated Complex (NAC).

77 autoallergen Hom s 2, the alpha-chain of the nascent polypeptide-associated complex (alpha-NAC).

78 ICD-1 is the beta-subunit of the nascent polypeptide-associated complex (betaNAC) and con

79 he signal recognition particle (SRP) and the nascent polypeptide-associated complex (NAC) are release

80 The nascent polypeptide-associated complex (NAC) is a conser

81 Nascent polypeptide-associated complex (NAC) is probably

82 We find that the nascent polypeptide-associated complex (NAC) is required

83 Nascent polypeptide-associated complex (NAC) was initial

84 ing the role of a cotranslational chaperone, nascent polypeptide-associated complex (NAC), in regulat

85 he signal recognition particle (SRP) and the nascent polypeptide-associated complex (NAC), respective

86 es ribosome-associated complex (RAC) but not nascent polypeptide-associated complex (NAC).

87 y spliced isoform of naca, which encodes the nascent polypeptide-associated complex alpha polypeptide

88 ve haematopoiesis due to a deficiency in the nascent polypeptide-associated complex alpha subunit (NA

89 of two genes encoding an archaeal homolog of nascent polypeptide-associated complex alpha subunit and

90 The transcriptional cofactor nascent polypeptide-associated complex and co-regulator

91 rgeting, it has therefore been proposed that nascent polypeptide-associated complex functions as a cy

92 perties of the ribosome bound chaperone NAC (nascent polypeptide-associated complex).

93 presence of all cytosolic factors, including nascent polypeptide-associated complex.

94 alternative signal peptidase cleavage of the nascent polypeptide at a primary site (Cys(-)(1)-Asn(1))

95 the amino acid becomes incorporated into the nascent polypeptide at the site of the PTC.

96 Akt, mTORC2 mediates phosphorylation of the nascent polypeptide at the turn motif (TM) site, Thr450,

97 twork of machineries that transiently engage nascent polypeptides at distinct phases of translation.

98 ing processes facilitates quality control of nascent polypeptides at each stage of their maturation.

99 Nascent polypeptides begin to fold in the constrained sp

100 ard-to-see protein subpopulations, including nascent polypeptides being translated and post-translati

101 n (CTU) is a robust process, with 12%-15% of nascent polypeptides being ubiquitinated in human cells.

102 RP receptor, and rejection of ribosome-bound nascent polypeptides beyond a critical length.

103 the basis of their ability to coprecipitate nascent polypeptides, both before and after chemical cro

104 cond core RQC component, Rqc2p, modifies the nascent polypeptide by adding a carboxyl-terminal alanin

105 properties of the C-terminal residues of the nascent polypeptide can affect the rate of translation t

106 provide a specialized scaffold against which nascent polypeptides can begin to form structure in a hi

107 In E. coli, the SecM nascent polypeptide causes elongation arrest, while inte

108 pathway that targets the associated mRNA and nascent polypeptide chain (NC).

109 hored proteins requires translocation of the nascent polypeptide chain across the endoplasmic reticul

110 Interaction between the nascent polypeptide chain and the ribosomal exit tunnel

111 ating ribosome which interacts with both the nascent polypeptide chain and the ribosome.

112 he SRP pathway: the ongoing synthesis of the nascent polypeptide chain by the ribosome.

113 erated by the cotranslational folding of the nascent polypeptide chain can also enhance PRF.

114 biosynthesis on the ribosome, an elongating nascent polypeptide chain can begin to fold, in a proces

115 , presumably the exit site through which the nascent polypeptide chain emerges from the ribosome.

116 s located close to the tunnel from which the nascent polypeptide chain exits the ribosome.

117 ple in which the conformational state of the nascent polypeptide chain has been linked to PRF.

118 folding constrains the conformations of the nascent polypeptide chain in a manner not experienced by

119 zers and observe simultaneous folding of the nascent polypeptide chain in real time.

120 iation observed is not due to insertion of a nascent polypeptide chain into the membrane.

121 e (LLO) donor to the asparagine residue of a nascent polypeptide chain is catalyzed by an oligosaccha

122 During co-translational folding, the nascent polypeptide chain is extruded sequentially from

123 s indicate that tunnel interactions with the nascent polypeptide chain might be relevant for the regu

124 ribosomal slip site generates a force on the nascent polypeptide chain that scales with observed fram

125 nts that are similar to those imposed on the nascent polypeptide chain.

126 at silencing occurs before completion of the nascent polypeptide chain.

127 UAA, and UGA) and facilitates release of the nascent polypeptide chain.

128 the formyl group from the N terminus of the nascent polypeptide chain.

129 the C-terminus of the partially synthesized nascent polypeptide chain.

130 hesis and processed during elongation of the nascent polypeptide chain.

131 0s which interact with the newly synthesized nascent polypeptide chain.

132 8S ribosomal RNA, and alters the path of the nascent polypeptide chain.

133 the intrinsic dynamic properties of emerging nascent polypeptide chains and guides them toward their

134 n Rmt2 substrates is likely to take place on nascent polypeptide chains and that these substrates exi

135 trigger factor (TF) interacts directly with nascent polypeptide chains as they emerge from the ribos

136 ecruits the multifunctional soluble Hsc70 to nascent polypeptide chains as they exit the ribosome.

137 ar membranes, and ensuring proper folding of nascent polypeptide chains during protein translation.

138 cells, including cotranslational folding of nascent polypeptide chains during their synthesis by the

139 kinase (EF2K), which inhibits elongation of nascent polypeptide chains during translation.

140 longation pausing, roughly at the site where nascent polypeptide chains emerge from the ribosomal exi

141 y the signal recognition particle (SRP) when nascent polypeptide chains emerge from the ribosome.

142 bably the first cytosolic protein to contact nascent polypeptide chains emerging from ribosomes.

143 Signal peptide-bearing nascent polypeptide chains emerging from the ribosome ar

144 itylation and extraction of ribosome-stalled nascent polypeptide chains for proteasomal degradation.

145 s certain aberrant, translationally arrested nascent polypeptide chains for proteasomal degradation.

146 nhance de novo protein folding by protecting nascent polypeptide chains from misfolding and maintain

147 zes stop codons and catalyzes the release of nascent polypeptide chains from ribosomes.

148 ssential role in the folding and assembly of nascent polypeptide chains in the ER.

149 hat both subunits are in direct contact with nascent polypeptide chains on the ribosome and that both

150 ay be confounded by release of puromycylated nascent polypeptide chains prior to fixation.

151 l strategies that would allow domains within nascent polypeptide chains to modulate gene expression.

152 ponent of the chaperone machinery that binds nascent polypeptide chains upon their exit from the ribo

153 ween the active site of the STT3 protein and nascent polypeptide chains using an in vitro photocrossl

154 e transfected into C2C12 cells, and sites of nascent polypeptide chains were detected using the biars

155 g strategies to label endogenously occurring nascent polypeptide chains within cells using O-propargy

156 Correct folding of nascent polypeptide chains within the ER is critical for

157 During protein synthesis, nascent polypeptide chains within the ribosomal tunnel c

158 plasmic Hsp70 that binds ribosome-associated nascent polypeptide chains, also binds to the TPR domain

159 ce puromycin is covalently incorporated into nascent polypeptide chains, anti-puromycin immunofluores

160 ates, allowing for more efficient folding of nascent polypeptide chains, down-regulation of the UPR,

161 OP-puro forms covalent conjugates with nascent polypeptide chains, which are rapidly turned ove

162 f thioether (lanthionine) cross-links within nascent polypeptide chains, yielding macrocyclic protein

163 from the ribosome through an exit tunnel as nascent polypeptide chains.

164 ocess prevents premature degradation of such nascent polypeptide chains.

165 ribosome, facilitating its interaction with nascent polypeptide chains.

166 s that remove the N-terminal methionine from nascent polypeptide chains.

167 forms the cotranslational N-glycosylation of nascent polypeptide chains.

168 nts addition of N-linked oligosaccharides to nascent polypeptide chains.

169 lar chaperones, which can be cross-linked to nascent polypeptide chains.

170 ptor site of ribosomes and incorporates into nascent polypeptide chains.

171 ing d-amino acids away from the synthesis of nascent polypeptide chains.

172 Here, we generated ribosome-bound nascent polypeptide complexes (RNCs) with different poly

173 re released from the ER membrane as ribosome-nascent polypeptide complexes.

174 on of the individual mRNA, ribosomal, and/or nascent polypeptide components, thereby clearing the cel

175 ted to signal cotranslational degradation of nascent polypeptides, cotranslational ubiquitylation occ

176 puromycin, which purges translocon pores of nascent polypeptides, creating additional empty pores.

177 ar how the changing information in a growing nascent polypeptide dictates the recruitment of function

178 mmunopeptidome derives from rapidly degraded nascent polypeptides (DRiPs).

179 slational transfer of high-mannose sugars to nascent polypeptides during N-linked glycosylation in th

180 cular chaperones interact with and stabilize nascent polypeptides during synthesis and/or translocati

181 through capture onto a solid surface of the nascent polypeptides during translation of synthetic or

182 essential in all cells and initiates when a nascent polypeptide emerges from the ribosome exit tunne

183 Nascent polypeptides emerging from a translating ribosom

184 Nascent polypeptides emerging from the ribosome and not

185 Srp1 binds nascent polypeptides emerging from the ribosome.

186 e translational apparatus and associate with nascent polypeptides emerging from the ribosome.

187 ght to be the first protein to interact with nascent polypeptides emerging from the ribosome.

188 exit, providing a unique environment to the nascent polypeptides emerging from the ribosome.

189 The nascent polypeptide exit site of the ribosome is a crowd

190 The nascent polypeptide exit tunnel (NPET) is a major functi

191 he peptidyl transferase center (PTC) and the nascent polypeptide exit tunnel (NPET), and export of as

192 the mRNA channel, the tRNA passage, and the nascent polypeptide exit tunnel contain Lmr-specific pro

193 cA was found to also bind ribosomes near the nascent polypeptide exit tunnel, but the function of thi

194 position the adjacent ligase domain near the nascent polypeptide exit tunnel.

195 As nascent polypeptides exit ribosomes, they are engaged by

196 large ribosomal subunit near the site where nascent polypeptides exit.

197 nt before the exit site, suggesting a unique nascent-polypeptide exit mechanism.

198 nt conformational changes in MRP mL45 at the nascent polypeptide-exit site within the large mitoribos

199 y, molecular chaperones have evolved to help nascent polypeptides fold correctly and multimeric prote

200 Hsp70 family, Ssb, previously implicated in nascent polypeptide folding and protein turnover, exhibi

201 omes stalled on a truncated mRNA and tag the nascent polypeptide for degradation.

202 selected translation reactions to target the nascent polypeptide for rapid proteolysis.

203 st that TF has a unique ability to sequester nascent polypeptides for a relatively prolonged period.

204 selected translating ribosomes to target the nascent polypeptides for degradation.

205 ts uncover two separate pathways that target nascent polypeptides for Ltn1-Cdc48-mediated degradation

206 (RQC) engages stalled ribosomes and targets nascent polypeptides for proteasomal degradation.

207 minate these transcripts and target arrested nascent polypeptides for proteasomal degradation.

208 es stop codons and promotes the release of a nascent polypeptide from tRNA on the ribosome.

209 reatment with puromycin (0.1-1 mm) to remove nascent polypeptides from ribosomes increases Ca(2+) lea

210 Its nascent polypeptide has a putative amino-terminal endopl

211 is achieved through a tiered system wherein nascent polypeptides have a chance to fold before becomi

212 We demonstrate and caution that nascent polypeptides have a propensity for binding many

213 itment, tRNA interaction, and exiting of the nascent polypeptide in Lmr must differ markedly from the

214 nd P/E hybrid-state tRNAs, and analysis of a nascent polypeptide in the exit tunnel.

215 Correct folding of a nascent polypeptide in the lumen of the endoplasmic reti

216 lity control (RQC) purges aberrant mRNAs and nascent polypeptides in a multi-step molecular process i

217 rotein that interacts with a wide variety of nascent polypeptides in Escherichia coli.

218 removal of the N-terminal formyl group from nascent polypeptides in eubacteria.

219 the anti-puromycin staining of puromycylated nascent polypeptides in fixed cells accurately reports o

220 biochemical assays and live cell imaging of nascent polypeptides in mammalian cells, that puromycyla

221 ed the direct interaction of chaperones with nascent polypeptides in the cytosol of mammalian cells b

222 llowed by the transfer of the core glycan to nascent polypeptides in the endoplasmic reticulum (ER).

223 lyzes the cotranslational N-glycosylation of nascent polypeptides in the endoplasmic reticulum in all

224 in cytoplasmic loops caused retention of the nascent polypeptides in the endoplasmic reticulum, all t

225 of dolichol-linked oligosaccharide chains to nascent polypeptides in the endoplasmic reticulum, consi

226 yme that catalyzes N-linked glycosylation of nascent polypeptides in the lumen of the endoplasmic ret

227 on motif found at the C terminus of abnormal nascent polypeptides in vivo.

228 Glc(3), 1a) to an asparagine side chain of a nascent polypeptide inside the lumen of the endoplasmic

229 ng of transmembrane domains begins after the nascent polypeptide integrates into the lipid bilayer or

230 Nascent polypeptides interact cotranslationally with a f

231 to the tunnel exit guaranteeing an efficient nascent polypeptide interaction.

232 ng UAG at these two positions may divert the nascent polypeptide into an alternative folding pathway

233 ex is important for efficient insertion of a nascent polypeptide into the translocation pore.

234 is essential for productive insertion of the nascent polypeptide into the translocation site, channel

235 ins may play a critical role in transforming nascent polypeptides into 3-dimensional configurations t

236 sp70s, which assist in the proper folding of nascent polypeptides into higher ordered structures.

237 Timely and accurate selection of nascent polypeptides into the correct pathway is essenti

238 n topology by cotranslationally partitioning nascent polypeptides into the cytosol, ER lumen, and lip

239 nel that translocates signal peptide-bearing nascent polypeptides into the endoplasmic reticulum (ER)

240 global protein synthesis, lowering influx of nascent polypeptides into the stressed ER, coincident wi

241 that sequestration of misfolded proteins and nascent polypeptides into two distinct compartments, str

242 In this process, the nascent polypeptide is modified by the addition of a sho

243 rmylated methionine, the formyl group of the nascent polypeptide is removed by peptide deformylase.

244 o-translationally when the N-terminus of the nascent polypeptide is still attached to the ribosome.

245 , and EF-TucGTP binds stalled ribosomes, the nascent polypeptide is transferred to the alanine on tmR

246 eria) that recognizes the signal sequence of nascent polypeptides is a GTPase, as is the SR-alpha sub

247 inefficient, and a substantial proportion of nascent polypeptides is rejected by an ER quality contro

248 t ribosome-translocon junction; synthesis of nascent polypeptides lacking a signal sequence resulted

249 The biosynthetic processing of the nascent polypeptide leading to channel assembly involves

250 ring by default in the absence of productive nascent polypeptide-membrane interactions.

251 ane-derived complexes, we determined how the nascent polypeptide modulates translocon component assoc

252 hese results indicate that ubiquitination of nascent polypeptides occurs in two contexts and define C

253 initiator Met in good Kozak context, a large nascent polypeptide of 3576 amino acids is predicted, in

254 As translation proceeds, nascent polypeptides pass through an exit tunnel that tr

255 tides in mammalian cells, that puromycylated nascent polypeptides rapidly dissociate from ribosomes e

256 role of the C-terminal tail (CTT) of SecA in nascent polypeptide recognition.

257 Nascent/newly synthesized proteins, nascent polypeptides released from the ribosome by purom

258 eam of the RodZ transmembrane domain dictate nascent polypeptide selection by SecA instead of the SRP

259 Analysis of the nascent polypeptides showed that the modifications at th

260 ultivalent fluorescence amplification of the nascent polypeptide signal, we develop a method to image

261 w much interactions between the ribosome and nascent polypeptide skew folding pathways.

262 eveal that S-palmitoylation is important for nascent polypeptide stability of both proteins.

263 res composed of a dense core inaccessible to nascent polypeptides surrounded by a surface that stably

264 d with ribosomes and is required for optimal nascent polypeptide synthesis.

265 showed that while the hybrid tmRNA supported nascent polypeptide tagging and ribosome rescue, it suff

266 control (RQC) pathway for the degradation of nascent polypeptides that are encoded by defective messe

267 ) transfers high mannose-type glycans to the nascent polypeptides that are translated by the membrane

268 ds to 60S ribosomal subunits to ubiquitylate nascent polypeptides that become stalled during synthesi

269 Nascent polypeptides that emerge vectorially from the ri

270 alyses demonstrated that translocon-targeted nascent polypeptides that subsequently stall are polyubi

271 th rates and defects in the translocation of nascent polypeptides that use the cotranslational transl

272 erplay between biophysical properties of the nascent polypeptide, the vectorial nature and rate of tr

273 of elongating mitoribosomes bound to tRNAs, nascent polypeptides, the guanosine triphosphatase elong

274 ed by the post-translational modification of nascent polypeptides, the use of modified ribosomes to p

275 by a specificity factor that recognizes the nascent polypeptides they encode.

276 Since molecular chaperones often fold nascent polypeptides through a bind-and-release interact

277 in biogenesis factors (RPBs) compete for the nascent polypeptide to influence their localization, fol

278 tein and the envelope protein E1 targets the nascent polypeptide to the endoplasmic reticulum (ER) me

279 0 chaperone Ssb interacts with ribosomes and nascent polypeptides to assist protein folding.

280 d environment where numerous factors contact nascent polypeptides to influence their folding, localiz

281 es to detect the proximity of ribosome-bound nascent polypeptides to Sec61alpha.

282 omes stalled on truncated mRNAs and tags the nascent polypeptides to target them for proteolysis.

283 t signal peptides act primarily in targeting nascent polypeptides to the endoplasmic reticulum, we su

284 ence of an alternative route for delivery of nascent polypeptides to the proteasome.

285 challenged to efficiently and properly fold nascent polypeptides, traffic them to their appropriate

286 ing translation are split into subunits, and nascent polypeptides trapped in the 60S subunit are ubiq

287 the early stage of a protein's life, as the nascent polypeptide traverses and emerges from the ribos

288 ar basis of how hydrophobic signals within a nascent polypeptide trigger channel opening is not under

289 ER quality control" prevent the transport of nascent polypeptides until they properly fold.

290 uggests that the E3 ligase listerin accesses nascent polypeptides via a gap in the ribosome-transloco

291 ing ribosome docking on the ER membrane, the nascent polypeptide was shielded from the cytosol as it

292 tagged with biotin or BODIPY; although most nascent polypeptides were cytoplasmic, some were found i

293 iggers release of 60S subunits with attached nascent polypeptides, which undergo ubiquitination by th

294 We find that SSB binds to a subset of nascent polypeptides whose intrinsic properties and slow

295 oration of the coumarin derivative generated nascent polypeptides with a hydrophobic residue at their

296 to tag and capture a population of truncated nascent polypeptides with no bias as to the identity of

297 the folding of single ribosome-bound stalled nascent polypeptides with optical tweezers.

298 hat the cargo for SRP--ribosomes translating nascent polypeptides with signal sequences--accelerates

299 rimary and likely secondary structure of the nascent polypeptide within the ribosome exit tunnel can

300 eta cells beyond the capacity for folding of nascent polypeptides within the endoplasmic reticulum (E