ライフサイエンスコーパス: natural killer T-cell

1 group include the gamma-delta T cell and the Natural Killer T cell.

2 ruitment of tumoricidal immune cells such as natural killer T cells.

3 roduction of alphabeta T cells and invariant natural killer T cells.

4 velopment of alphabeta T cells and invariant natural killer T cells.

5 n loss of conventional T cells and invariant natural killer T cells.

6 CD1d presents lipid antigens to natural killer T cells.

7 dual host T-cell subsets to favor regulatory natural killer T cells.

8 osis were conventional CD4+CD3+ T cells, not natural killer T cells.

9 II MHC-restricted CD4+ T cells but, rather, natural killer T cells.

10 ntified subgroup of T cells, CD1d-restricted natural killer T cells.

11 ds with high affinity to CD1d and stimulates natural killer T cells.

12 ncomitant to increased cytolytic activity of natural killer T cells.

13 velopment of B, alphabetaT, gammadeltaT, and natural killer T cells.

14 in knockout (beta2M-/-) mice lack CD8+ T and natural killer T cells.

15 nd natural killer cells but lack Valpha14(+) natural killer T cells.

16 ies of tumor-infiltrating natural killer and natural killer T cells.

17 l function of CD5L on promoting migration of natural killer T cells.

18 to a specialized subset of T cells known as natural killer T cells.

19 e was independent of CTLs, natural killer or natural killer T cells.

20 he face of normal frequencies of circulating natural killer T cells.

21 with the innate immune system and invariant natural killer T cells.

22 s, which are the major endogenous ligands of natural killer T cells.

23 for mucosa-associated invariant T cells and natural killer T cells.

24 sexual transmission of HIV and stimulator of natural killer T-cells.

25 s and presents IL-15 in trans to neighboring natural killer/T cells.

26 profound microbial depletion and concomitant natural killer/T-cell activation (P < .001).

27 reased apoptosis and elevated natural killer/natural killer T cell and macrophage cell markers.

28 iated innate immune attack by natural killer/natural killer T cell and macrophage cells are instrumen

29 Naive CD8 T cells, natural killer T cells and a subset of memory CD4 T cell

30 cluding regulatory T cells, dendritic cells, natural killer T cells and B cells.

31 nchymal T cells, including a large subset of natural killer T cells and CD69(+) tissue-resident memor

32 nnate T-CD4 T cells, together with invariant natural killer T cells and gammadelta T cells, receive s

33 l killer T cell apoptosis, depleting hepatic natural killer T cells and inducing proinflammatory cyto

34 g food allergy include the role of invariant natural killer T cells and influences of dietary compone

35 al other specialized T-cell lineages such as natural killer T cells and innate mucosal-associated inv

36 As natural killer T cells and liver injury are central in l

37 in numbers of microparticles from invariant natural killer T cells and macrophages/monocytes (CD14(+

38 ells-including gammadelta T cells, invariant natural killer T cells and mucosal-associated invariant

39 In addition to natural killer T cells and mucosal-associated invariant

40 een mostly confined to TCRs from innate-like natural killer T cells and mucosal-associated invariant

41 CD4 and natural killer T cells and neutrophils were markedly red

42 synthesis (P < 0.01), together with reduced natural killer T cells and raised interleukin (IL)-12 an

43 required for development of CD4(+) T cells, natural killer T cells and regulatory T cells.

44 amma response of natural killer cells and of natural killer T cells and the Th1 polarization of antig

45 17 helper T-cell response, characterized by natural killer T-cell and neutrophilic inflammation.

46 ability to effectively stimulate CD8 T cell, natural killer T cell, and natural killer cell immunity.

47 curring CD4+CD25+ Foxp3+ regulatory T cells, natural killer T cells, and approximately 25% of NK cell

48 rtant roles for conventional CD4(+) T cells, natural killer T cells, and CD4(+)CD25(+)FoxP3(+) Tregs

49 dependent on the presence of regulatory host natural killer T cells, and expression of CD1d on donor

50 sident natural killer cells, tissue-resident natural killer T cells, and helper-like innate lymphoid

51 yte populations, including B cells, T cells, natural killer T cells, and innate lymphoid cells.

52 s (natural killer cells, gammadelta T cells, natural killer T cells, and innate-like CD8+ T cells) ar

53 T-cell repertoire, near-to-absent invariant natural killer T cells, and severely diminished mucosal-

54 ion of circulating regulatory T cells, lower natural killer T cells, and stabilization of inflammator

55 ltered residual host T cell subsets favoring natural killer T cells, and the low incidence of GVHD wa

56 lastic large cell; and 1 each had extranodal natural killer/T cell, angioimmunoblastic, and precursor

57 nsufficient norepinephrine increases hepatic natural killer T cell apoptosis, depleting hepatic natur

58 Natural Killer T cells are a distinct lymphocyte lineage

59 Gammadelta T lymphocytes and CD1d-restricted natural killer T cells are classified as innate T lympho

60 Invariant natural killer T cells are found in low numbers in the a

61 Natural killer T cells are immunoregulatory cells, which

62 Natural killer T cells are mediators of important regula

63 ouse models of allergic asthma indicate that natural killer T cells are required for the development

64 for the autoreactive recognition of CD1d by natural killer T cells, are indispensable for the bindin

65 tes, including both natural killer cells and natural killer T cells, are unusually abundant in the li

66 and enhanced interferon-gamma production by natural killer T cells as well as number of viable CD4 T

67 tic cells, T cells, natural killer cells and natural killer T cells, as well as promotion of M2 to M1

68 used CD1d-tetramers, antibodies specific for natural killer T cells, as well as reverse-transcriptase

69 volved in Th2 inflammation such as invariant natural killer T cells, basophils, and interleukin-9 are

70 protein (GFP), revealed CD4+ memory T cells, natural killer T cells, basophils, mast cells, and eosin

71 ghly expressed in activated human CD8(+) and natural killer T cells, both of which have been implicat

72 nal repressor NKAP is required for invariant natural killer T cell but not conventional T cell develo

73 cytotoxic lineage T cells and into invariant natural killer T cells but did not signal the differenti

74 We enumerated invariant natural killer T cells by flow cytometry with the use of

75 nuclear cells before and after activation of natural killer T cells by ligand alpha-galactosylceramid

76 Stimulation of CD1d-restricted semiinvariant natural killer T cells by using the CD1d ligand alpha-ga

77 gammadelta and natural killer T cells can also play a role in protectiv

78 everal immune cells, such as macrophages and natural killer T cells, can have both deleterious and pr

79 t of naturally occurring regulatory T cells, natural killer T cells, CD4(+) and CD8(+) T lymphocytes,

80 -specific Th2 cells did not require B cells, natural killer T cells, CD8(+) T cells, or IFNgamma.

81 are also deficient in natural killer cells, natural killer T cells, CD8+ T lymphocytes, and TCRgamma

82 gulate cytokines expression of dendritic and natural killer T cells co-culture.

83 Microparticles from CD14(+) and invariant natural killer T cells correlated with levels of alanine

84 The frequency of natural killer T cells correlated with the level of anti

85 basal cells, goblet cells, and proliferating natural killer/T cells decrease with age, whereas alveol

86 njected 4 days before partial hepatectomy to natural killer T cells- deficient mice or to anti CD1d1-

87 Natural killer T cells- deficient or mice injected with

88 Alcohol-fed natural killer T cell-deficient Jalpha281(-/-) mice expr

89 Hepatic natural killer T cell depletion leads to Th-1 polarizati

90 re NKAP conditional knockout mice, invariant natural killer T cell development is blocked at the doub

91 due to a role of the SAP-Fyn interaction in natural killer T cell development through the ability of

92 se 3 causes a similar block in the invariant natural killer T cell development, indicating that NKAP

93 mice have defects in natural killer cell and natural killer T cell development, suggesting a role for

94 ensing mature thymocytes for trafficking and natural killer T cell development.

95 ne-1-phosphate receptor S1pr1 as well as for natural killer T cell development.

96 3 functionally interact to control invariant natural killer T cell development.

97 Stimulation of natural killer T cells during alcohol consumption induce

98 Natural killer T cells express a conserved, semi-invaria

99 The natural killer T cells expressed an invariant T-cell rec

100 Natural killer T cells expressing 'invariant' T cell rec

101 Natural killer T cells expressing an invariant T-cell re

102 s, including regulatory T and CD1d-dependent natural killer T cells, fail to develop.

103 tically, PE DHC enhances EAE in mice lacking natural killer T cells, fails to enhance EAE in Toll-lik

104 This report analyzes the role of natural killer T cells, Fas, and TNF-alpha in a model of

105 -galactosyl ceramide (alpha-GalCer) to mouse natural killer T cells, formally demonstrating both the

106 We show here that natural killer T cells from UV-irradiated donor mice fun

107 hat development of colitis involves not only natural killer T-cell functions, but also requires IL-13

108 e subsets of unconventional T cells, namely, natural killer T cells, gammadelta T cells, and mucosal-

109 also regulates the generation or function of natural killer T cells, gammadelta T cells, innate lymph

110 Invariant natural killer T cells have a distinct developmental pat

111 ve and qualitative defects in CD1-restricted natural killer T cells have been reported in several aut

112 as been 10 years since the first workshop on natural killer T cells helped to launch a growth phase f

113 Natural killer T cell hybridomas with identical T cell a

114 articular, little is known about the role of natural killer T cells in alcohol-induced liver injury.

115 cidates the role of vitamin D and CD8(+) and natural killer T cells in asthma exacerbation in a genom

116 ses are generated and the pathogenic role of natural killer T cells in asthma.

117 the current study is to explore the role of natural killer T cells in impaired liver regeneration.

118 association between the number of invariant natural killer T cells in the airway and disease severit

119 We studied the frequency of invariant natural killer T cells in the airways of subjects with m

120 endothelial cells, macrophages, T cells, and natural killer T cells in the CNV.

121 studies in mice indicating a requirement for natural killer T cells in the development of allergen-in

122 Alcohol consumption induces an increase of natural killer T cells in the liver and a high sensitivi

123 nterleukin 4- and interferon gamma-producing natural killer T cells in the liver and spleen and enhan

124 to assess the frequency and distribution of natural killer T cells in the lungs and in the circulati

125 biological activity of ligands for invariant natural killer T cells in the lysosome to shed light on

126 ernatively activated hepatic macrophages and natural killer T cells, in the absence of obesity or ins

127 In alcohol-consuming animals, liver natural killer T cells increase, and further activation

128 Using natural killer T cells (iNKT cell) as a model of a T cel

129 Invariant natural killer T cells (iNKT cells) are a small subset o

130 ylceramide (alphaGC) that activate invariant natural killer T cells (iNKT cells) are being developed

131 Invariant natural killer T cells (iNKT cells) are critical for hos

132 Invariant natural killer T cells (iNKT cells) are innate-like lymp

133 Invariant natural killer T cells (iNKT cells) are innate-like T ce

134 Invariant natural killer T cells (iNKT cells) are innate-like T ce

135 Invariant natural killer T cells (iNKT cells) are innate-like T ly

136 Invariant natural killer T cells (iNKT cells) are involved in the

137 Invariant natural killer T cells (iNKT cells) are lipid-sensing in

138 Glycolipid ligands for invariant natural killer T cells (iNKT cells) are loaded onto CD1d

139 rinsic block in the development of invariant natural killer T cells (iNKT cells) at their earliest pr

140 ortant mechanisms of activation of invariant natural killer T cells (iNKT cells) by microbes: direct

141 Invariant natural killer T cells (iNKT cells) can produce copious

142 Invariant natural killer T cells (iNKT cells) differentiate into t

143 Invariant natural killer T cells (iNKT cells) express a restricted

144 Invariant natural killer T cells (iNKT cells) have a prominent rol

145 Invariant natural killer T cells (iNKT cells) have an innate immun

146 Mouse invariant natural killer T cells (iNKT cells) provide cognate and

147 Invariant natural killer T cells (iNKT cells) rapidly produce effe

148 Invariant natural killer T cells (iNKT cells) respond to CD1d-pres

149 n that interacted with innate-type invariant natural killer T cells (iNKT cells) to regulate B cell r

150 t also promoted the interaction of invariant natural killer T cells (iNKT cells) with those neutrophi

151 -GFP(+) cells, which encompass 70% invariant natural killer T cells (iNKT cells), have been found pri

152 d development and proliferation of invariant natural killer T cells (iNKT cells).

153 presenting glycolipid antigens to invariant natural killer T cells (iNKT cells).

154 strate that the cross-talk between invariant natural killer T cells (iNKT) and CD8(+) T cells in the

155 riant T (iT) cell subsets, such as invariant natural killer T cells (iNKT) and mucosal-associated inv

156 V alpha14 invariant natural killer T cells (iNKT) are localized in periphera

157 but markedly decreased numbers of invariant natural killer T cells (iNKT) as defined by staining wit

158 Invariant natural killer T cells (iNKT) cells are T lymphocytes di

159 requirements for invariant Valpha14-bearing natural killer T cells (iNKT) in the thymus are poorly u

160 (GVHD) are regulated via recipient invariant natural killer T-cell (iNKT) interleukin-4-driven expans

161 Invariant Natural Killer T-cells (iNKT-cells) are an attractive ta

162 CD1d-restricted Valpha24-invariant natural killer T cells (iNKTs) are important in immunore

163 way, we have previously found that invariant natural killer T cells (iNKTs) are involved in CM allerg

164 CD1d-restricted Valpha24-Jalpha18-invariant natural killer T cells (iNKTs) are potentially important

165 Invariant natural killer T cells (iNKTs), a small population chara

166 sets, B cells, regulatory T cells, invariant natural killer T cells [iNKTs], NK cells, and dendritic

167 ltiple innate lymphocyte lineages, including natural killer T cell, innate lymphoid cell, mucosal-ass

168 ecently identified CD1d-restricted invariant natural killer T cells is a matter of controversy.

169 It has been shown that the proportion of natural killer T cells is markedly elevated during liver

170 uing member of the innate immune system, the natural killer T cell, is activated during bacterial inf

171 TIM-1, expressed in T cells, B cells, and natural killer T cells, is essential for cell activation

172 sed on a subset of CD4+ T helper 1 cells and natural killer T cells, is involved in lymphocyte homing

173 sis including the Hut 78 T-cell leukemia, JY natural killer T-cell leukemia, Daudi B-cell lymphoma, H

174 ncy were enhanced by coadministration of the natural killer T-cell ligand 7DW8-5, which heightened th

175 ole for NKAP in selection into the invariant natural killer T cell lineage.

176 urvival of 55%, 95% CI 46-65) and extranodal natural killer T-cell lymphoma (108 deaths and 3-year ov

177 The clinical outcome of extranodal natural killer T-cell lymphoma (ENKTL) has improved subs

178 Extranodal natural killer T-cell lymphoma (NKTCL), nasal type, is a

179 Extranodal natural killer T-cell lymphoma (NKTCL; nasal type) is an

180 .011), whereas the percentage for extranodal natural killer T-cell lymphoma was higher in Central Ame

181 T-cell leukaemia or lymphoma and extranodal natural killer T-cell lymphoma.

182 T-cell leukaemia or lymphoma and extranodal natural killer T-cell lymphoma.

183 Extranodal natural killer-T-cell lymphoma (NKTCL) of nasal type is

184 Natural killer/T cell lymphoma (NKTCL) is a rare and agg

185 the genomic and transcriptional landscape of natural killer/T cell lymphoma (NKTCL), a rare form of n

186 Extranodal natural killer/T-cell lymphoma (ENKTL), nasal type, gene

187 large-cell lymphoma (n = 2), and extranodal natural killer/T-cell lymphoma (n = 2).

188 Peripheral T-cell lymphoma (PTCL) and natural killer/T-cell lymphoma (NKTCL) are rare and hete

189 Natural killer/T-cell lymphoma (NKTCL) is a rare, aggres

190 Extranodal natural killer/T-cell lymphoma (NKTCL) is an aggressive

191 In the current study, using natural killer/T-cell lymphoma (NKTL) as a disease model

192 aberrantly overexpressed in the majority of natural killer/T-cell lymphoma (NKTL), an aggressive lym

193 gy of different cancers including extranodal natural killer/T-cell lymphoma (NKTL).

194 IR, 16.2; 95% CI, 14.5-18.1), and extranodal natural killer/T-cell lymphoma (SIR, 44.3; 95% CI, 5.37-

195 her incidence of AITL, extranodal nasal-type natural killer/T-cell lymphoma and NK-cell leukemia (ENK

196 Extranodal natural killer/T-cell lymphoma rarely presents as intrao

197 ies, including acute lymphoblastic leukemia, natural killer/T-cell lymphoma, and acute myeloid leukem

198 nagement of mycosis fungoides and extranodal natural killer/T-cell lymphoma.

199 Extranodal natural-killer/T-cell lymphoma (ENKTL) is a rare and agg

200 s, as well as non-Hodgkin, Hodgkin and nasal natural killer/T-cell lymphomas, although all three TET

201 t commonly caused by Wegener granulomatosis, natural killer/T-cell lymphomas, cocaine abuse, or infec

202 s have provided evidence that T lymphocytes, natural killer T cells, mast cells, and B cells also ent

203 IL-9 is produced by T cells, natural killer T cells, mast cells, eosinophils, and inn

204 romoting the activation of T lymphocytes and natural killer T cells, maturation of DCs, secretion of

205 colitis remains slow, but IL-13 produced by natural killer T cells may be involved.

206 -like and T helper type 2-like properties of natural killer T cells may originate largely from differ

207 Natural killer T cell-mediated apoptosis proceeds by the

208 ive immunity and compromised the function of natural killer T-cell-mediated innate immunity.

209 ource for CD5L, and blocking CD5L attenuated natural killer T cell migration induced by liver macroph

210 Hepatic natural killer T cells modulate liver injury by balancin

211 innate lymphoid cells, natural killer cells, natural killer T cells, mucosal-associated invariant T c

212 o differences in the percentages of T cells, natural killer T cells, natural killer (NK) cells, macro

213 Depletion of natural killer-T cells, natural killer cells, plasma cel

214 ge infiltration, while natural killer cells, natural killer T cells, neutrophils and dendritic cells

215 F, which is essential for the development of natural killer T cell (NKT cell) effector functions.

216 ation of a type of white blood cell known as natural killer T cell (NKT cell).

217 family receptors can affect innate immunity [natural killer T cell (NKT) and gamma-delta T-cell recep

218 g in reduced expression of genes critical to natural killer T cell (NKT) and gammadelta T-cell differ

219 b(+)Ly6C(hi)Ly6G(-) cells also enhance liver natural killer T cell (NKT) death in an Fas-dependent ma

220 This glycolipid activates innate Valpha14(+) natural killer T cell (NKT) lymphocytes, which drive DC

221 to an impaired thymic selection of Valpha14 natural killer T cells (NKT cells) and a subsequent redu

222 e T cell antigen receptor (TCR) expressed by natural killer T cells (NKT cells) and the antigen-prese

223 (MHC) class I homolog CD1d are recognized by natural killer T cells (NKT cells) characterized by eith

224 (+) T cells (T regulatory cells [Tregs]) and natural killer T cells (NKT cells) each protect against

225 Natural killer T cells (NKT cells) expressing a semi-inv

226 glycosphingolipids (GSLs) to activate type I natural killer T cells (NKT cells) has been known for 2

227 Natural killer T cells (NKT cells) have stimulatory or i

228 Loss of natural killer T cells (NKT cells) in CD1 knockout mice

229 rpose of this study is to identify invariant natural killer T cells (NKT cells) in cellular infiltrat

230 CD1d-restricted natural killer T cells (NKT cells) possess a wide range

231 Natural killer T cells (NKT cells) recognize glycolipid

232 Natural killer T cells (NKT cells) restricted by the ant

233 ggestive of a niche shared by MAIT cells and natural killer T cells (NKT cells).

234 ession and thereby the effector functions of natural killer T cells (NKT cells).

235 The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted m

236 While type I natural killer T cells (NKT) display exquisite specifici

237 e the spectrum of cellular self-antigens for natural killer T cells (NKT), we developed a sensitive l

238 relation with an IL-15-mediated increase of natural killer T-cells (NKT) and the up-regulation in li

239 f antigen-presenting cell CD1d with distinct natural killer T-cell ("NKT") populations can induce rap

240 However, after exclusion of natural killer T cells (NKTs) and gammadelta T cells by

241 Human natural killer T cells (NKTs) are innate-like T lymphocy

242 Unlike T cells, Valpha24-invariant natural killer T cells (NKTs) are not alloreactive and c

243 Valpha24-invariant natural killer T cells (NKTs) have anti-tumor properties

244 Valpha24-invariant natural killer T cells (NKTs) localize to tumors and hav

245 phoid cells, macrophages, natural killer and natural killer T cells, nonclassical T cells, and memory

246 IL-9 production from CD4(+) T cells, but not natural killer T cells or innate lymphoid cells, suggest

247 ediated by heat shock proteins, glycolipids, natural killer T cells, or dendritic cells in disease pa

248 vity, our results strongly suggest that CD4+ natural killer T cells play a prominent pathogenic role

249 Natural killer T cells play a role in the pathogenesis o

250 airway hyperreactivity, we hypothesized that natural killer T cells play an important role in human a

251 Natural killer T cells play an important role in liver r

252 ed indirectly in the expansion of protective natural killer T-cell populations.

253 ines, dendritic cells, and type 1 T cells or natural killer T cells potentially drives pathogenic inf

254 is paramount, which results in expansion of natural killer T cells producing IL-13 (and perhaps IL-5

255 suppressed expression of interferon gamma by natural killer T cells, promoting hepatocyte proliferati

256 ide and antibodies specific to the invariant natural killer T-cell receptor in samples of bronchoalve

257 evidence of gene expression of the invariant natural killer T-cell receptor.

258 xpression of messenger RNA for the invariant natural killer T-cell-receptor domains Valpha24 and Vbet

259 Mouse type I natural killer T cell receptors (iNKT TCRs) use a single

260 secreted following the ligation of invariant natural killer T cell receptors to sphingolipids (SLs).

261 How viruses evade natural killer T cell recognition remains unclear.

262 Tolerance required host natural killer T-cell recognition of CD1d on donor marro

263 Natural killer and natural killer T cells remove virus-infected hepatocytes

264 TIM-1-expressing, but not TIM-1-deficient, natural killer T cells responded to apoptotic airway epi

265 suppression of protective CD4(+) T cells and natural killer T-cell responses against ehrlichiae.

266 on of oral type I/III interferon and blunted natural killer-/T-cell responses, reflecting a potential

267 in Apoe(-/-)Rag2(-/-) mice lacking T, B and natural killer T cells, ruling out the role of the adapt

268 ng indicates a role for TCR beta in defining natural killer T cell specificity, despite the more rest

269 Identification of a natural killer T-cell subtype associated with cell-media

270 ers effector properties resembling invariant natural killer T cells, such as copious production of cy

271 igen-presenting cell-mediated stimulation of natural killer T cells, supporting the idea that this me

272 reducing the activity of natural killer and natural killer T cells that normally contribute to tumor

273 dual host T cell subsets to favor regulatory natural killer T cells that suppress GVHD and prevent or

274 wing host T-cell subsets to favor regulatory natural killer T cells that suppress GvHD by polarizing

275 these mediators in proliferating T cells and natural killer T cells, that also expressed the antimicr

276 pattern-recognition receptor, conferring on natural killer T cells the ability to sense and respond

277 The hepatic natural killer T cells themselves are regulated by Kupff

278 ceptors promote the progression of invariant natural killer T cells through the thymic maturation pro

279 irecting the innate-like effector program of natural killer T-cell thymocytes, is prominently associa

280 analysis of the invariant T-cell receptor of natural killer T cells to assess the frequency and distr

281 naive, wild-type CD4(+) Th cells depleted of natural killer T cells to Lck(cre)IL-4Ralpha(-/lox) mice

282 gonist that recruits T cell help from type I natural killer T cells under mRNA-vaccination conditions

283 V(alpha)14 invariant natural killer T cells (V(alpha)14iNKT cells) are thymus

284 hich liver gamma-delta T cells and invariant natural killer T cells were found to be involved in IL-1

285 ts, naive conventional T cells and invariant natural killer T cells were reduced in the spleen.

286 oduced IFN-alpha, whereas natural killer and natural killer T cells were the main source of IFN-gamma

287 Natural killer T cells, which are stimulated by lipids p

288 ages (ie, Kupffer cells), natural killer and natural killer T cells, which constitute the innate immu

289 Glycolipid reactive natural killer T cells with an invariant TCR alpha-chain

290 Two populations of natural killer T cells with invariant TCR alpha-chains (

291 LC3), and innate-like lymphocytes, including natural killer T cells, with an emphasis on the known re

292 ses mediated by IFN-gamma and CD4(+) Th1 and natural killer T cells, with lower IL-10 secretion by T

293 lavage, and sputum induction were invariant natural killer T cells, with no significant differences