ライフサイエンスコーパス: natural ligand

1 mall-molecule agonists that do not mimic the natural ligand.

2 t to the use of protein agonists such as its natural ligand.

3 , as compared with billions of years for the natural ligand.

4 e established primarily because of lack of a natural ligand.

5 xpression of gD in the absence of a cellular natural ligand.

6 a synthetic ligand, and leukotriene B(4), a natural ligand.

7 hat is a 28-fold improvement compared to the natural ligand.

8 ctively blocked CR3 signaling initiated by a natural ligand.

9 veral binding orientations described for the natural ligand.

10 wth factor receptor (EGFR) compared with its natural ligand.

11 e alkyl chain and the glycerol moiety of the natural ligand.

12 ghts into interactions between CXCR4 and its natural ligands.

13 han nuclear receptor with currently no known natural ligands.

14 t gD has on the interaction of HVEM with its natural ligands.

15 est affinity for HVEM compared with the four natural ligands.

16 new insights regarding channel mechanism and natural ligands.

17 ion, then stabilized in each case by unknown natural ligands.

18 gentless biosensors to detect natural or non-natural ligands.

19 anscription in response to both man-made and natural ligands.

20 also to deorphanize GPCRs with unidentified natural ligands.

21 function is limited by a lack of identified natural ligands.

22 needed to positively modify the affinity of natural ligands.

23 iniscent of the interactions of Pvr with its natural ligands.

24 f multivalent binding of both artificial and natural ligands.

25 ted by the regulatory mechanisms that act on natural ligands.

26 ted in the literature for E-selectin and its natural ligand (0.3 A).

27 for binding of these two selectins to their natural ligand (1.7 microm2/s).

28 In absence of their natural ligand, 11-cis-retinal, cone opsin G-protein-cou

29 tion was a decrease in the expression of the natural ligand 15-deoxy-Delta(12,14)-prostaglandin J(2).

30 is study, we demonstrate that the PPAR gamma natural ligand (15-deoxyprostaglandin J(2)) and a synthe

31 parable binding affinities for ERbeta as the natural ligand 17beta-estradiol but are >100-fold select

32 ligand 4,4'-dihydroxybenzil, relative to the natural ligand 17beta-estradiol, by >10(7)-fold.

33 g motifs in the presence of two ligands, the natural ligand 1alpha,25(OH)(2)D(3) and a synthetic, non

34 Upon binding to its natural ligand, 1alpha,25(OH)(2)D(3), the VDR undergoes

35 the vitamin D nuclear receptor (VDR) and its natural ligand, 1alpha,25-dihydroxyvitamin D(3) [1alpha,

36 t RXR in the TR/RXR heterodimer can bind its natural ligand 9-cis-RA in cells.

37 nessing the cellular uptake and transport of natural ligands across the blood-brain barrier (BBB) has

38 of prostate cancer cell surface GRP78 by its natural ligand, activated alpha(2)-macroglobulin (alpha(

39 inflammatory actions on stimulation with its natural ligand alpha-melanocyte-stimulating hormone.

40 between the D3 T-cell receptor (TCR) and its natural ligand, an HIV peptide bound to a HLA-A0201 (HLA

41 ral is the cation-pi interaction between the natural ligand and a tryptophan residue in the aromatic

42 ify a mechanism through which the receptor's natural ligand and GM1 may protect against toxic intrace

43 ive ligand for Sn that is an analogue of the natural ligand and is capable of targeting liposomal nan

44 interaction of Fc epsilon RI alpha with its natural ligand and thus to prevent a primary step in the

45 volved the specificity of BM3h away from its natural ligand and toward dopamine, producing sensors wi

46 uman RNase L in complexes with synthetic and natural ligands and a fragment of an RNA substrate.

47 s, recognize and bind to RGD motifs on their natural ligands and also may be candidate receptors for

48 function in two ways, by competing with the natural ligands and by downregulating HVEM from the cell

49 the current state of the field regarding the natural ligands and molecular factors required for posit

50 Natural ligands and receptors, which inherently modulate

51 d ENMs, leaving open the question of whether natural ligands and seasonal variation will mitigate ENM

52 echnology to measure directly the binding of natural ligands and small molecules to the chemokine rec

53 omprehensive map of all antennal ORNs coding natural ligands and their dose-response functions.

54 in occupies the same position as that of the natural ligand, and the hydrogen bonds with histidines 3

55 n our understanding of how GPR56 signals via natural ligands, and a small-molecule agonist may be bro

56 tide embedding is learned by pre-training on natural ligands, and can discriminate between ligands an

57 within human bone marrow, in addition to its natural ligands, and this transactivation is dependent o

58 In contrast to many natural ligands, antibodies are stable, exquisitely spec

59 downstream developability profiles from the natural ligand approach.

60 ansmembrane-spanning receptors for which the natural ligands are large, heterodimeric glycoprotein ho

61 he protein's signaling function and that the natural ligands are probably (polyunsaturated) fatty aci

62 by CD1 molecules, we have characterized the natural ligands associated with mouse CD1d1 as well as h

63 eralgesic effect was mimicked by SFLLRN, the natural ligand at PAR-1 binding sites, but not SLIGRL-am

64 cture of TM1088A, which contains a bound AMP natural ligand at the characteristic GXGXXG nucleotide b

65 Moreover, changing the identity of the natural ligands at the carbohydrate 2-position allows fo

66 n this paper, we show that both P2X4 and its natural ligand, ATP, are enriched in lysosomes of COS1 a

67 study, we show that ligation of CD28 by its natural ligand B7-1/CD80, induces tyrosine phosphorylati

68 Since farnesoid X receptor (FXR) and its natural ligands bile acids (such as chenodeoxycholic aci

69 ner that is quite different from the way the natural ligands bind to the same receptors and direct no

70 a provide support for a common mechanism for natural ligand binding and activation of family B G prot

71 Understanding the molecular basis of natural ligand binding and activation of the glucagon-li

72 s clear insights into the molecular basis of natural ligand binding and supplies testable hypotheses

73 alpha with 9-cis-retinoic acid (9-cis-RA), a natural ligand binding to the classical ligand-binding p

74 Simple insertion of a natural ligand-binding domain into a minimal intein dest

75 e N-terminal extracellular domain, where the natural ligand binds.

76 tightly binding complex between XL35 and its natural ligand but, instead, to create a very stable pro

77 we demonstrated that ligation of CD28 by its natural ligand, but not by Ab, induced polarization of L

78 ptor (hMC4R) with an affinity similar to its natural ligands, but had a markedly reduced ability to a

79 The binding of natural ligands by the birch pollen allergen Bet v 1 or

80 Activation of ANTXR1 by its natural ligand C5A, a fragment of collagen VI alpha3, in

81 ceptor superfamily, by agonist antibodies or natural ligand, can serve as an effective anti-tumor the

82 5000-fold more efficiently to CETP than the natural ligand, cholesteryl ester.

83 d NSP4 peptide 114-135 blocks binding of the natural ligand, collagen I, to integrin alpha2.

84 We show that although DDR1 and its natural ligand, collagen, lack an NLS, DDR1 is present i

85 f galectin-ligand interactions is that their natural ligands comprise a heterogeneous collection of g

86 ands that compete for binding to T3 with its natural ligand could form a novel class of antiviral dru

87 emokine receptor (CXCR) 4 in response to its natural ligands CXC chemokine ligand (CXCL) 12 and macro

88 about the interactions between CXCR4 and its natural ligand CXCL12, and with the HIV-1 glycoprotein g

89 main binds to the C terminus of its proposed natural ligand, CXXC repeat-containing interactor of PDZ

90 cess that can be antagonized by its putative natural ligand, desmosterol (and possibly cholesterol).

91 These selected additives are natural ligands, detergents, salts, buffers, and chemica

92 Binding of the natural ligand dihydrotestosterone by the mutant LBD inv

93 logues were more potent QS agonists than the natural ligand, DPD, in Vibrio harveyi.

94 Stimulation of EGFR by its natural ligand, EGF, induced Ca(2+) release from the end

95 ring in nature is limited to those driven by natural ligands encoded within our genome.

96 de with affinity comparable with that of the natural ligand, ephrin-B2.

97 The activation of EphA2 receptor by its natural ligand EphrinA1 causes blood brain barrier dysfu

98 expressed receptor was phosphorylated by its natural ligand, EphrinB2, and signaled via the protein k

99 we have demonstrated a role for EGFR and its natural ligand, epiregulin (EREG), in pain processing.

100 in vivo the Fas receptor is activated by its natural ligand, Fas-L, whereas anti-Fas antibodies are n

101 epA that are adapted to the transport of the natural ligand, ferric enterobactin.

102 structurally distinct synthetic mimic of the natural ligand, flavin mononucleotide, to repress ribosw

103 as an affinity for 1 similar to that for its natural ligand, folic acid.

104 ceptor for a murine PSG as well as the first natural ligand for a member of the tetraspanin superfami

105 ently that MCH has been discovered to be the natural ligand for a previously "orphan" G-protein-coupl

106 The natural ligand for alpha4beta7, mucosal addressin cell a

107 rihexosylceramide (iGb3), is the first known natural ligand for both human and mouse iNKT cells, whos

108 Although the natural ligand for BRS-3 is still unknown, a synthetic p

109 st 2-AG, rather than anandamide, is the true natural ligand for cannabinoid receptors and the key end

110 As a natural ligand for CD4, IL-16 has been shown to preferen

111 n costimulation with hyaluronan, the primary natural ligand for CD44.

112 K10.6), which mimics the binding of CD100 (a natural ligand for CD72) to release the inhibitory funct

113 ction with target cells and identify it as a natural ligand for CD74, which has been implicated previ

114 stridium perfringens enterotoxin (cCPE) is a natural ligand for claudin-4.

115 In addition, chemerin, a natural ligand for CMKLR1, was up-regulated in the CNS o

116 s with stromal-derived factor 1 (SDF-1), the natural ligand for CXCR4, for cellular binding and block

117 c effect of stromal-derived factor-1alpha, a natural ligand for CXCR4, further establishing a correla

118 -SIGN mAb and soluble DC-SIGN, and mannan, a natural ligand for DC-SIGN.

119 ubiquitous component of the diet, may be the natural ligand for dietary aluminum and may prevent its

120 1-phosphate (S1P) is a sphingolipid and the natural ligand for five G protein-coupled receptors (S1P

121 ntly glycosylated in epithelial cancer, is a natural ligand for galectin-3.

122 The natural ligand for IdeR is Fe(II), but Ni(II), Co(II), C

123 t cell types upon exposure to IFN-I and is a natural ligand for ILT7.

124 utively phosphorylated in the absence of the natural ligand for KIT, stem cell factor (SCF).

125 nstruct, together with thymus leukemia Ag (a natural ligand for mCD8alpha), resulted in reduced level

126 cine, and not glutamate, is likely to be the natural ligand for most plant GLR subunits.

127 This is the first analysis of a natural ligand for mouse NKT cells and the first definit

128 However, when fatty acid (the natural ligand for PPARalpha) supply was increased (high

129 Our results suggest that PTN is a natural ligand for RPTP beta/zeta.

130 g the cytoplasmic domain of PECAM-1, another natural ligand for SHP-2.

131 Glucose is a natural ligand for sweet taste receptors (STRs) that are

132 es, except for mammals, use vasotocin as the natural ligand for that receptor.

133 with a diameter of 15-30 nm; asialofetuin, a natural ligand for the asialoglycoprotein receptor, inhi

134 cell-derived factor-1alpha (SDF-1alpha), the natural ligand for the CXCR4 G-coupled receptor, has bee

135 Ghrelin is a novel endogenous natural ligand for the growth hormone (GH) secretagogue

136 edominantly from the stomach, ghrelin is the natural ligand for the growth hormone secretagogue recep

137 ncentrating hormone (hMCH) is a nonselective natural ligand for the human melanin-concentrating hormo

138 ed bilayers of phosphatidylcholine lipids, a natural ligand for the IgM BCR expressed in the CH27 cel

139 the murine hepatitis virus spike protein, a natural ligand for the N-domain of CEACAM1, inhibited th

140 elta(12,14) prostaglandin J2 (15d-PGJ2) is a natural ligand for the peroxisome proliferator-activated

141 nity CD22 glycan ligands and outcompetes the natural ligand for the receptor, resulting in single mol

142 nd controls following incubation with CpG, a natural ligand for TLR9, and determined the basal and st

143 Oxysterols have recently been identified as natural ligands for a G protein-coupled receptor called

144 2 loop that mimics structures present in the natural ligands for alpha4beta7, suggesting that alpha4b

145 This suggests the natural ligands for C8gamma and NGAL are significantly d

146 These results establish cyclophilins as natural ligands for CD147 and suggest an unusual, rotama

147 ts cell activation/differentiation; however, natural ligands for CD33 remain elusive.

148 ditionally, ANP and BNP were found to be the natural ligands for cell membrane-bound guanylyl cyclase

149 Natural ligands for CR2 are C3 breakdown products deposi

150 controls neutrophil chemotactic responses to natural ligands for CXCR2 and regulates the magnitude of

151 The natural ligands for family B G protein-coupled receptors

152 f Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell fun

153 tabolites, predominantly the oxysterols, the natural ligands for liver X receptor (LXR), induced thes

154 cells,T cells and activated macrophages.The natural ligands for murine NKG2D are distant major histo

155 Natural ligands for nuclear receptors are believed to ac

156 nnabinoids are lipid molecules that serve as natural ligands for the cannabinoid receptors CB1 and CB

157 Natural ligands for the co-receptors and C-terminal GP41

158 While searching for natural ligands for the peroxisome proliferator-activate

159 cids and eicosanoids have been identified as natural ligands for the PPARs.

160 CCL3 and CCL4 are natural ligands for the primary human immunodeficiency v

161 nflammatory response in these cells, but the natural ligands for the receptor are not known.

162 As it is likely that the natural ligands for this receptor may include fatty acid

163 tus contains unmethylated CpG sequences, the natural ligands for TLR9.

164 g motif, which we have defined by elution of natural ligands from Mamu-A*02.

165 agement of CD66b, but not CD66a, by mAb or a natural ligand, galectin-3, activated a Src kinase famil

166 ers, understanding of the molecular basis of natural ligand GLP1 binding to its intact receptor remai

167 rently with responsiveness to the endogenous natural ligand, gonadotropin releasing hormone, and an a

168 For PecS, the natural ligand has not been identified.

169 ence (arginine-glycine-aspartic acid) of the natural ligands; however, the RGD-mimetic antagonists fo

170 ysis suggested that TWEAK mimicked the CD163 natural ligand (Hp-Hb).

171 stressin2-B, the agonists stressin1, and the natural ligands human Ucn1, Ucn2, and Ucn3) were determi

172 4 through Ab cross-linking or binding to its natural ligands hyaluronan and osteopontin induced NKT c

173 Engagement of CD44 by its natural ligands, hyaluronic acid or chondroitin sulfate,

174 tion of complement receptor 2 (CR2) with its natural ligands iC3b and C3d are still not well understo

175 PTN is the first natural ligand identified for any of the RPTP family; it

176 , anti-CD123 Ab may be acting similar to the natural ligand, IL-3.

177 ogen receptor phosphorylation induced by the natural ligand in estrogen receptor's cellular distribut

178 e fraction <3 kDaA reflect the importance of natural ligands in controlling the concentrations of Ag

179 Overall, YKL-40 likely binds many natural ligands in vivo, but its concurrence with physic

180 r with recombinant human CD100 (rCD100), its natural ligand, induced the phosphorylation of CD72 with

181 On the other hand, natural ligands influence the use of HVEM by HSV.

182 Compared with the natural ligand intercellular adhesion molecule-1, AL-57

183 ability to similarly identify the receptor's natural ligand is not possible by these methods.

184 ntrol, and reporter assays indicate that its natural ligand is present even when cells are grown in d

185 ceptor is a G-protein-coupled receptor whose natural ligand is the NOP/orphanin FQ (N/OFQ) peptide.

186 entire alphavbeta8 ectodomain and its intact natural ligand, L-TGF-beta, as well as two different inh

187 SMM-chemokines, unlike neuroprotective CCR5 natural ligands, leads to neurotoxicity by activating a

188 ice with agonistic anti-LTbR antibody or the natural ligand lymphotoxin-alpha1beta2, increased Ccl5 m

189 mokine receptors observed in response to two natural ligands, macrophage-inflammatory protein-1alpha

190 AG binds small hydrophobic ligands, that the natural ligand may be a polyunsaturated fatty acid, and

191 ific Ca(2+)-dependent binding to immobilized natural ligands, no specific binding of either factor H

192 resumably substituting for a higher affinity natural ligand, occupying an apolar groove between its a

193 ein-coupled receptor whose activation by its natural ligand octopamine leads to rapid and transient i

194 recently reported that cellular Beclin1 is a natural ligand of 2C and that it is involved in the auto

195 Addition of a natural ligand of AhR, FICZ, induces AhR translocation t

196 ocytes to the gut is mediated by MAdCAM, the natural ligand of alpha(4)beta(7) that is expressed on g

197 analogs of C-C chemokine ligand 5 (CCL5), a natural ligand of CCR5, are highly potent CCR5 inhibitor

198 gh-affinity Fc receptor (CD64) and CD86, the natural ligand of CD28 (KT64/86).

199 y engagement with either anti-CD28 mAbs or a natural ligand of CD28, B7.2 (CD86).

200 ite that overlaps with that of chemerin, the natural ligand of ChemR23.

201 The natural ligand of CXCR4 is stromal cell-derived factor 1

202 cell-derived factor-1alpha (SDF-1alpha) is a natural ligand of CXCR4.

203 l cell-derived factor (SDF)-1alpha, the only natural ligand of CXCR4.

204 a variety of tumor cells, and EGF is a known natural ligand of EGFR.

205 ther IgE, a high-affinity, non-cross-linking natural ligand of FcepsilonRI, could be used to target A

206 ng the transport of ferric enterobactin, the natural ligand of FepA.

207 It has been shown that the binding of C1q, a natural ligand of gC1qR, on T cells inhibits their proli

208 and was highly homologous to a self-derived natural ligand of HLA-B27.

209 how abnormal distribution of E-cadherin, the natural ligand of KLRG1, in the intestinal mucosa; and h

210 binding RIFINs mimic the binding mode of the natural ligand of LILRB1 and suppress the function of NK

211 25-Hydroxycholesterol is a natural ligand of LXRs that is produced by the enzyme ch

212 tructural changes in LCA, and so it may be a natural ligand of MDM2 and MDM4, raising the possibility

213 hat inhibiting the release of glutamate (the natural ligand of mGlu1 receptors), results in a decreas

214 mpetes with a catechol iron-siderophore, the natural ligand of mLcn2.

215 tal muscles have the capacity to produce the natural ligand of MR, aldosterone, which in excess is kn

216 emarkable success of retinoic acid (RA), the natural ligand of RARalpha, in the treatment of APL, has

217 dogenous compounds, like 20-hydroxyecdysone (natural ligand of the ecdysone receptor, EcR), methyl fa

218 of the epidermal growth factor (EGF) gene, a natural ligand of the EGFR, may play a role in the genes

219 Ghrelin, the natural ligand of the growth hormone secretagogue recept

220 , and we recently cloned the gene encoding a natural ligand of the human CD19 receptor (CD19L).

221 d the effect of 22-(R)-hydroxycholesterol, a natural ligand of the liver X receptor (LXR), and the LX

222 Although progesterone, the natural ligand of the progesterone receptor (PR), has a

223 20-HE, the natural ligand of this complex, controls major aspects o

224 otif that mimics structures presented by the natural ligands of alpha4beta7.

225 splays limited expression in normal tissues, natural ligands of CCK2R were recently explored for use

226 1alpha, MIP-1beta, and RANTES chemokines are natural ligands of CCR5 and are known to interfere with

227 The natural ligands of CCR5, the beta-chemokines macrophage

228 We show that the natural ligands of CD300c, phosphatidylserine and phosph

229 y, soluble anti-CD36 antibodies, but not the natural ligands of CD36, inhibit release of virions from

230 We show that inherently neurotoxic natural ligands of CXCR4, such as stromal cell-derived f

231 portance of residence time are presented for natural ligands of different receptor types.

232 be as tools to identify and characterize the natural ligands of gammadelta T cells.

233 To identify natural ligands of human HAVCR1/TIM1, we used an express

234 Natural ligands of mouse CD1d1 included cellular phospha

235 Compared to fatty acids as known natural ligands of PPARgamma and RXR, TETRAC differs mar

236 cidate a novel mechanism of the signaling by natural ligands of PPARs, which involves modulating the

237 olites of linoleic and arachidonic acids are natural ligands of PPARs.

238 compounds are structurally unrelated to the natural ligands of the enzyme.

239 n-1alpha (MIP-1alpha), and MIP-1beta are the natural ligands of the HIV-1 coreceptor CCR5 and compete

240 Furthermore, siIL-32 reduced the natural ligands of the HIV-1 coreceptors CCR5 (MIP-1alph

241 ghly specific toward organotin compounds and natural ligands of the RXR.

242 results suggest that fatty acids may be the natural ligands of these regulatory proteins.

243 1 (HIV-1) can be profoundly inhibited by the natural ligands of two major HIV-1 coreceptors, CXCR4 an

244 PSGL-Ig), as a competitive inhibitor for the natural ligand on leukocytes.

245 lastic cells expressing KIT activated by its natural ligand or by RT activating mutations such as gas

246 ge gap is partially due to the lack of known natural ligands or selective agonists of RPTPs.

247 between truncated P- and L-selectin to their natural ligand, P-selectin glycoprotein ligand-1 (PSGL-1

248 y fully orthogonal to the wild-type receptor-natural ligand pair.

249 two out of around 100,000 per cell, by their natural ligands (peptide-MHC complexes or epitopes on an

250 fin unsaturation required for potency in the natural ligand PGF(2)(alpha) yet retain binding affinity

251 )2D3 and 1,25(OH)2D3 similar to those of the natural ligands, predicting good binding to the receptor

252 LPA and potentially other natural ligands primarily utilize a PKC-dependent pathwa

253 in the expression of both PPAR-gamma and its natural ligand-producing enzyme 12/15-lipoxygenase (12/1

254 athway through which the recently identified natural ligand, prosaposin, promotes plasma membrane ass

255 rugs of the thiazolidinedione class, and the natural ligand prostaglandin J2 act as agonists for PPAR

256 stigated whether stimulation of NKG2D by the natural ligand RAE1epsilon was able to costimulate effec

257 The importance of CLEC-2, a natural ligand/receptor for Gp38/Podoplanin, in the form

258 The natural ligands recognized by gammadelta TCRs are still

259 evel of CD22 expression following binding of natural ligand(s) may affect its ability to modulate the

260 ficantly impact receptor activity, hence the natural ligands(s) of HM74a/PUMA-G remain to be elucidat

261 we found that the activation of S1P1 by its natural ligand S1P, acting as a paracrine signal, contri

262 However, in contrast to the natural ligand S1P, FTY720-P appears to act as a functio

263 t contraction similar to that induced by the natural ligand S1P.

264 more, activation of S1P receptors with their natural ligand, S1P, as well as pharmacological ligands

265 CXCR4-PMPLs specifically bound the natural ligand, SDF-1alpha, and the gp120s from CXCR4-us

266 Riboswitches are natural ligand-sensing RNAs typically that are found in

267 While the first structure contains the natural ligand, sialic acid, the second structure contai

268 These constructs bound their natural ligands specifically and saturably, with these a

269 ibitors, pathway-selective cAMP analogs, and natural ligands stimulating PKA activity in SCs, such as

270 functionality mimics the 3-keto group of the natural ligand testosterone and is involved in H-bonding

271 Other mice received annexin V, a natural ligand that binds to anionic phospholipids.

272 Natural ligands that activate LXRs include oxysterol der

273 actor (TNF) receptor family member with four natural ligands that either stimulate (LIGHT and LTalpha

274 In the presence of their natural ligand, the nucleotide adenosine 5'-phosphosulfa

275 lain AL-57's antagonistic mimicry of LFA-1's natural ligands, the ICAM molecules.

276 ction of gD with HVEM affects the binding of natural ligands, thereby modulating the immune response

277 D47, an integrin-associated protein, and its natural ligand thrombospondin 1 (TSP-1).

278 s that this heme utilizes plastoquinone as a natural ligand, thus defining an electron transfer compl

279 Binding of the natural ligand thyroxine was clearly observed, and a ran

280 which creates the two binding sites for the natural ligand thyroxine.

281 Binding of the natural ligands thyroxine or retinol-binding protein (RB

282 Factor VII is the natural ligand to TF.

283 Factor VII (FVII) is the natural ligand to TF.

284 We postulate that binding natural ligands to this domain results in a conformation

285 TRAIL DRs with affinities comparable to the natural ligand TRAIL.

286 onises Nrp1 interaction with one of its main natural ligands, vascular endothelial growth factor-A (V

287 2 (VEGFR2) in a region overlapping with its natural ligand VEGFA, and VEGFR2 was required for decori

288 r sites mediating different functions of the natural ligand versus the viral or synthetic ligands has

289 sed as targets to identify and isolate their natural ligands via the application of the "orphan recep

290 Its natural ligand was recently identified as 26RFa, a novel

291 The mutant cannot bind to its natural ligand WBP11, which regulates mRNA processing.

292 Glutamine and ATP, two of the natural ligands, were found to be extremely complementar

293 actor activated by a variety of man-made and natural ligands, which has recently emerged as a critica

294 Characterization of TREM-1 natural ligands will further illuminate the mechanisms r

295 ess TIM-3 and that blocking signals from its natural ligand with a mAb results in more severe lesions

296 icity of CTLA-4 inhibition of MAPKs by using natural ligand with ex vivo-purified CD4(+) T cells defi

297 receptor must be selective for and bind its natural ligand with high affinity.

298 ng CTLA-4 has been limited by sharing of its natural ligands with the costimulatory protein CD28.

299 rg-Gly-Asp integrin recognition motif of the natural ligand within the third complementarity-determin

300 response higher than that obtained with the natural ligand Wnt3a.