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1 atively long-term nature of gene deletion or natural mutation.
2 nd functional avidities for both SL9 and its natural mutations.
3 t stress, and is plastic to tolerate various natural mutations.
4                       By contrast, the Y447C natural mutation abolished the transport of organic cati
5 to intended hosts are necessary to cope with natural mutation accumulation and pervasive lateral gene
6 base substitutions tested, which include six natural mutations and 14 artificially introduced ones, h
7 e, conformational changes induced by keratin natural mutations and extensive tissue injury result in
8                            We have used this natural mutation, and the cGMP phosphodiesterase inhibit
9 ent to predict the CD40-binding site, to map natural mutations, and to rationalize their effects.
10 ntrolled by CTRC in a manner that individual natural mutations are unlikely to increase stability eno
11                                            A natural mutation at codon 151 (Gln --> Met; Q151M) of HI
12                         We have identified a natural mutation at the -30 amino acid position of the a
13                                          Two natural mutations, causing P167S and D240G substitutions
14                                            A natural mutation D351YERalpha enhances 4-OHT agonist act
15 is was performed to create 7 TM mutants with natural mutations either previously identified (Ala25Thr
16 sly suspected and illustrates the utility of natural mutations for defining functional domains in pro
17                               The only known natural mutation found in mature human IAPP is a Ser20-t
18                              The majority of natural mutations identified in this and other Na(+)/sol
19                                        These natural mutations identify tyrosine residues possibly in
20              The E452K mutation is the first natural mutation in a mammalian cotransporter affecting
21 4 must be functionally important because its natural mutation in cone photoreceptor CNG channels is a
22 in-like CTRC variant highlights how the same natural mutation in homologous pancreatic serine proteas
23                                            A natural mutation in Ppd-H1 prevalent in spring barley de
24 erent from humans in that human cells have a natural mutation in the alpha1,3 galactosyltransferase (
25  Kinetic studies have demonstrated that this natural mutation in the coenzyme-binding site decreases
26 tcher mice, both male and female, carrying a natural mutation in the galc gene were given fingolimod
27                        C3H/HeJ mice harbor a natural mutation in the gene that encodes Toll-like rece
28               Infected db/db mice, bearing a natural mutation in the leptin receptor, have a markedly
29 entity of three such residues that underwent natural mutations in a transgenic mouse line.
30 find that NG-ABEmax-KR efficiently introduce natural mutations in gamma globin gene promoters with mo
31 veals that G186D and D190N, along with other natural mutations in recent H3N2 strains, alter the comp
32 activity and correlating with the absence of natural mutations in regions bordering the third cluster
33 ues in airway smooth muscle, suggesting that natural mutations in the PDE4D gene have profound effect
34 chemical evidence that certain (but not all) natural mutations in the TM gene reduce expression and i
35    This study illustrates the power of using natural mutations in transgenes as guides for studying s
36                                          The natural mutation increased the concentration of sodium r
37 nts regulate alpha globin expression and how natural mutations interfere with this mechanism to cause
38 e expression in pancreatic beta-cells due to natural mutation is responsible for susceptibility to vi
39       In this study, we investigated whether natural mutations occurring in this locus in FQ-resistan
40 a molecular basis for the observation that a natural mutation of Arg-57 in humans is associated with
41 drophobic pocket that binds Val-6(beta), the natural mutation of HbS, and the latter site is a promin
42                                   Further, a natural mutation of the gene encoding NIK in alymphoplas
43   We found that asebia mice homozygous for a natural mutation of the gene for SCD1 (SCD-/-) are defic
44                                         This natural mutation of the TSH-beta subunit confirms the im
45 y, and immunodeficiency represents the first natural mutation of this transcription factor in a human
46                                              Natural mutations of CCR5 that impair surface expression
47                                              Natural mutations of S412-homologous residues in brain a
48                                      Various natural mutations of the CCR5 gene have been reported to
49 emoval of the palmitate or site-directed and natural mutations of the modified cysteine result in los
50                                 We show that natural mutations of these residues in maple syrup urine
51         Loss of function of VRN2, whether by natural mutations or deletions, resulted in spring lines
52 s, but abnormal conditions, such as specific natural mutations or oxidation, produce an altered state
53  S237 and D299 as well as at the site of the natural mutation R274L.
54 c neofunction(s) through the accumulation of natural mutation(s).
55               Methylated CpG sites provide a natural mutation saturation experiment for fitness effec
56                                              Natural mutations such as lysine 255 to glutamic acid (K
57  differences in C. albicans and delineates a natural mutation that alters the balance between commens
58 d, as an RNA virus, is highly susceptible to natural mutation that may impact its properties.
59                                  Moreover, a natural mutation that resulted in longer Sda1 and SdaD a
60                  Here, we show that among 70 natural mutations that are present in the NA of a recent
61  affect the nervous system provide a host of natural mutations that can be deployed in the quest to u
62 cts of gene regulation have been revealed by natural mutations that downregulate globin gene expressi
63                                              Natural mutations that impair either defense activation
64  framework for exploring the introduction of natural mutations that may enable the derepression of si
65 nvestigate the heterogeneity in the types of natural mutations that occur in covR and covS and the ph
66 , we show that ABE8e can efficiently install natural mutations that upregulate fetal hemoglobin expre
67 luding the furin cleavage site and the D614G natural mutation, that modulate viral cytopathic effects
68     We used alanine scanning mutagenesis and natural mutations to map the subregion of the MH1 domain
69 scape of antigenic site B can be reshaped by natural mutations via modulation of the receptor-binding
70 actor IX (residues 403-415) contains several natural mutations which result in mild to severe forms o
71 c stem/progenitor (CD34+) cells to emulate a natural mutation, which deletes the MCS-R2 alpha-globin
72 tural frameworks can be derived by using non-natural mutations, which differ from those found in came
73         We aim to characterize the impact of natural mutations within the RBDs of civet-CoVs on viral