ライフサイエンスコーパス: ncRNA

1 ncRNAs are a large family of functionally important RNA

2 ncRNAs have been demonstrated to mediate HCC development

3 These translated to 4 genes/1 ncRNA in hypertrophic obstructive cardiomyopathy, 131 ge

4 We show that the xbp-1 ncRNA acts independently of the protein-coding function

5 sis indicates that the function of the xbp-1 ncRNA depends on a single RNA stem; this stem forms only

6 m; this stem forms only in the cleaved xbp-1 ncRNA fragment.

7 hic obstructive cardiomyopathy, 131 genes/17 ncRNA in dilated cardiomyopathy, and 51 genes/5 ncRNA in

8 NA in dilated cardiomyopathy, and 51 genes/5 ncRNA in ischemic cardiomyopathy.

9 functions in the quality control of the 7SL ncRNA component of the signal recognition particle (SRP)

10 4 713 associations between 142 NSDs and 8593 ncRNAs in 11 species, curated from more than 1300 articl

11 saRNAs recognized target chromatin through a ncRNA stemming from it.

12 Non-coding ribonucleic acids (ncRNA) are functional RNA molecules that are not transla

13 regression coefficients were observed across ncRNA types compared with cardiac troponins and cMyBP-C

14 In addition, ncRNAs are released into the circulation where they are

15 Among the most affected ncRNAs, we found that sorafenib mediated the dysregulati

16 of Eco 6S RNA for Esigma(70) and show how an ncRNA can mimic B-form DNA to directly regulate transcri

17 nt RNA polymerase activity that regulates an ncRNA inhibitor of transcription.

18 zed, revealing novel adaptations to mRNA and ncRNA transcription.

19 iptional activity as well as enriched TF and ncRNA binding across diverse cell types, which may be cr

20 f both high-quality protein coding genes and ncRNAs, we considered the associations between pseudogen

21 ptimal expression dynamics of many mRNAs and ncRNAs.

22 ) non-coding RNAs; (iii) genes, pathways and ncRNAs that are involved in tolerating drugs or induce d

23 et al. show that transcription of antisense ncRNAs induces 'elongation marks' on histones in promote

24 We applied ncRNA profiling to identify rod and cone photoreceptor C

25 As ncRNAs are beginning to be imprecisely classified into f

26 As ncRNAs such as microRNAs (miRNAs), long non-coding RNAs

27 e per se is a poor predictor of function, as ncRNAs dramatically vary in length and structure and oft

28 to define enhancers and enhancer-associated ncRNAs that are involved in a TF-dependent regulatory ne

29 B2 ncRNA induction requires neither host innate immune sign

30 ly been used to uncover many novel bacterial ncRNA classes in recent years.

31 he newest findings in the field of bacterial ncRNAs shows how examples in model pathogens could pave

32 The balance between ncRNA and mRNA production is potentially affected by cot

33 provides insight into the function of brain ncRNAs regulating synaptic transmission, plasticity and

34 insights into the biochemistry performed by ncRNAs.

35 on biological characteristics of circulating ncRNAs and highlight their value as potential biomarker

36 the origin and function of such circulating ncRNAs, these molecules are increasingly recognized as n

37 ion in C. jejuni Inactivation of the CjNC110 ncRNA led to a statistically significant decrease in aut

38 signal for introns and various RNA classes (ncRNA, snRNA, snoRNA) and less variability after degrada

39 on the sequence and function of non-coding (ncRNA) genes is not well understood.

40 strategy favors the discovery of more common ncRNA classes, whereas progressively rarer classes are c

41 e further organized into "phrases" (complete ncRNA structures) with functional meaning (signaling out

42 CjNC110 is a conserved ncRNA in C. jejuni, located downstream of the luxS gene,

43 We constructed TE-containing ncRNA references using bulk RNA-seq data and showed that

44 tation stages and revealed 146 TE-containing ncRNA transcripts with substantial tissue specificity du

45 the Set3 HDAC coordinately suppress cryptic ncRNA transcription initiation internal to mRNA genes.

46 o reveals many previously unreported cryptic ncRNAs induced by specific carbon sources, showing that

47 osis-related EECTG (MEIOB) and its nearby CT-ncRNA have a role in tumorigenesis in lung adenocarcinom

48 lation and close non-coding RNAs (namely, CT-ncRNAs) may be two mechanisms to reactivate EECTG gene e

49 analyses revealed that the targets of the DE ncRNAs and DE mRNAs included several kinds of transcript

50 ein-coding messenger RNAs (mRNAs), degrading ncRNAs that fail to form functional complexes with one o

51 transcription factor (TF) Nrl Nrl-dependent ncRNA expression strongly correlated with epigenetic pro

52 alidated the activity of novel Nrl-dependent ncRNA-defined CREs in developing cones.

53 Tbx5-dependent ncRNA transcription provided a quantitative metric of Tb

54 Tbx5-dependent ncRNAs emanated from regions that are enriched for TBX5-

55 Tbx5-dependent ncRNAs were enriched for tissue-specific marks of active

56 atria, identifying 2600 novel Tbx5-dependent ncRNAs.

57 tRNA-derived ncRNAs show differential expression profiles and play ro

58 pecific expression profiles for tRNA-derived ncRNAs.

59 ch alone may not be sufficient for detecting ncRNAs in a single sequence.

60 This work supports differential ncRNA profiling as a platform for the identification of

61 marker potential and the recently discovered ncRNA-derived micropeptides.

62 factors, including many recently discovered ncRNAs.

63 Increasing evidence shows that diverse ncRNAs play a critical role in various NSDs.

64 Despite their conformational diversity, ncRNAs mostly preserve their secondary structure through

65 echniques, we assessed the potential of EBOV ncRNAs to function as viral miRNAs.

66 ch regarding the nature and function of EBOV ncRNAs.

67 gical role of computationally predicted EBOV ncRNAs.

68 As from both viruses, we identified two EBOV ncRNAs in our sequencing data that were near-matches to

69 Currently, the most effective ncRNA detection methods combine structure-based techniqu

70 Here, we compare emerging ncRNA biomarkers in the cardiovascular field with protei

71 Because aberrant and excess ncRNAs are largely degraded by exoribonucleases, a key c

72 verse biological roles for virally expressed ncRNAs have been described, including regulation of vira

73 e systematically profiled the levels of five ncRNA classes (microRNA [miRNA], small nucleolar RNA [sn

74 se interactions bears crucial importance for ncRNA functional studies.

75 Moreover, we will discuss new roles for ncRNAs, as well as a novel Pol II RNA-dependent RNA poly

76 accurately detect the presence of functional ncRNAs by incorporating novel predictive features based

77 Subsequent gene/ncRNA expression analysis was assessed using quantitativ

78 However, unlike coding genes, ncRNAs often lack distinctive sequence features that cou

79 ation-sensitive and disease-associated genes/ncRNA identified from this study represent a unique coho

80 the free-living nematode C. elegans, it has ncRNA families that are enriched in parasites, and expre

81 We discuss how ncRNAs inhibit spurious recombination among repetitive D

82 erspective, we will discuss newly identified ncRNAs that facilitate DNA looping, regulate transcripti

83 The abundance of other recently identified ncRNAs and new insights regarding ncRNAs as dietary bioa

84 Thus, a computational method for identifying ncRNAs under positive selection is needed.

85 VISs and virus-host interactions involved in ncRNA.

86 hts into structure-function relationships in ncRNAs and can aid in the development of functional hypo

87 emerged as promising candidates to integrate ncRNAs with protein biomarkers.

88 fy Neat1 as a p53-regulated large intergenic ncRNA (lincRNA) with a key role in suppressing transform

89 e focused on the long intergenic/intervening ncRNAs (lincRNAs), hidden within the large amount of inf

90 An explosion of studies into ncRNA biology has since shown that they represent a dive

91 of cancer-focused clinical trials involving ncRNAs as novel biomarkers or therapies have begun and t

92 fectively capture sequence homology to known ncRNA families.

93 We suggest that spectrums of "letters" (ncRNA elements) are assembled into "words" (ncRNA domain

94 sm orchestrated by the two alleles of a long ncRNA.

95 cterize LINC00261 as a tumor suppressor long ncRNA epigenetically silenced in lung cancer.

96 Here, we show that the long ncRNA CCAT2, located at the 8q24 amplicon on cancer risk

97 ing 17,743 protein-coding genes, 11,053 long ncRNAs, and 551 microRNAs.

98 as enhancer-derived RNAs (eRNAs) and as long ncRNAs (lncRNAs) have received much attention, but their

99 reads mapping to protein-coding genes, long ncRNAs, and antisense RNAs were due to DNA contamination

100 ated ncRNAs, including short microRNAs, long ncRNAs and circular RNAs, across various heart diseases

101 Of the long ncRNAs unique to bacteria, the OLE (ornate, large, extre

102 in understanding the function of viral long ncRNAs and circular RNAs.

103 Here, we review the main ncRNA classes and how they influence cardiac biology.

104 Many ncRNA genes are narrowly distributed to only a few organ

105 Although many ncRNAs are known to have a well conserved secondary stru

106 KEY MESSAGE: ncRNA PN_LNC_N13 shows contrasting expression in reprodu

107 es to be revealed, we believe that many more ncRNA species and functions will be discovered.

108 Moreover, ncRNAs hold promise as clinical biomarkers, but further

109 cis-regulatory elements uncover a core mRNA-ncRNA transcriptional signature shared by IgG(+) and IgA

110 We present a new global factor, called mRNA:ncRNA avoidance, and provide evidence that avoidance inc

111 GFP) mRNAs with different potential for mRNA:ncRNA interactions, we demonstrate that GFP levels corre

112 lection for the avoidance of stochastic mRNA:ncRNA interactions across prokaryotes, and that these ha

113 Therefore, taking stochastic mRNA:ncRNA interactions into account enables precise modulati

114 ll nuclear (sn)RNA (U1) is a multifunctional ncRNA, known for its pivotal role in pre-mRNA splicing a

115 These results demonstrate that multiple ncRNA genes respond to HS, some as direct HSF-1 targets,

116 time, to our knowledge, in human and murine ncRNAs, determining that most have motif use consistent

117 ne proteins that transiently protect nascent ncRNA ends from exoribonucleases, with partner proteins

118 nting these methods, we discovered 224 novel ncRNA classes, which include ROOL RNA, an RNA class aver

119 ect can accurately and reliably detect novel ncRNAs, outperforming the current state-of-the-art metho

120 to efficiently scan genomes to detect novel ncRNAs.

121 In addition to identifying several novel ncRNAs from both viruses, we identified two EBOV ncRNAs

122 ion page for researchers to submit novel NSD-ncRNA associations.

123 Mining and summarizing NSD-ncRNA association data can help researchers discover use

124 w focuses on the mechanisms by which nuclear ncRNAs directly contribute to the maintenance of genome

125 Here, we review each major class of ncRNA that is currently annotated in the human genome an

126 specialist advisors for different classes of ncRNA to ensure that ncRNA nomenclature is accurate and

127 the transcription-factor-(TF)-dependence of ncRNA expression to define enhancers and enhancer-associ

128 Accordingly, deregulation of ncRNA expression has been associated with multiple disea

129 The flexibility of ncRNA provides a challenge for probing their complex 3D

130 ng (CLIP-seq) to validate the interaction of ncRNA with lamin B1 and EXOSC2.

131 nd the functions and molecular mechanisms of ncRNA involved in NSDs.

132 e has been a rapid increase in the number of ncRNA sequences deposited in various databases over the

133 es, the method produces all major species of ncRNA in high yield and with high integrity, enabling di

134 Suppression of ncRNA transcription by strand-specific CRISPR/dCas9 resu

135 Experimental results on tens of thousands of ncRNA sequences available from the Rfam database indicat

136 d significantly advance our understanding of ncRNA roles in shaping tissue functions.

137 In a comparative assessment of ncRNAs and protein biomarkers for myocardial injury, cMy

138 any challenges associated with assessment of ncRNAs that are not well addressed by conventional phylo

139 , we discuss the functions and biogenesis of ncRNAs produced by animal viruses.

140 B2 RNAs, a class of ncRNAs of the B2 family of SINE repeats, mediate through

141 e charge in the RNA revolution is a class of ncRNAs that are synthesized at active enhancers, called

142 ing novel features for accurate detection of ncRNAs in combination with comparative genome analysis.

143 ization of NGMs can enhance the detection of ncRNAs that have sparse folding structures with many unp

144 miotic analogy can guide the exploitation of ncRNAs as new therapeutic targets through the developmen

145 a resource for the further identification of ncRNAs involved in tissue function in health and dysfunc

146 In this review, we describe the impact of ncRNAs on telomere function and discuss their implicatio

147 Intermolecular interactions of ncRNAs are at the core of gene regulation events, and id

148 As the multifaceted nature of ncRNAs continues to be revealed, we believe that many mo

149 Based on accumulation profiles, a network of ncRNAs and mRNAs associated with bell pepper fruit ripen

150 g RNA (ncRNA) field: an increasing number of ncRNAs in fact codify for short peptides that have biolo

151 Of note, the number of ncRNAs within a cell increases progressively, with the c

152 o modulate the expression of a wide range of ncRNAs and specifically, GAS5 and miR-126-3p were involv

153 addition we provide insight into the role of ncRNAs in chemotherapy-induced cardiac dysfunction.

154 To provide a better understanding of ncRNAs in cardiovascular biology we present an outlook o

155 abundance of the traditional linear mRNA or ncRNA transcript.

156 More recently, other ncRNA classes have been identified, including long nonco

157 In the most extreme case, pathogenic ncRNAs alone (such as viroids) can infect eukaryotic org

158 While a few pathogenic ncRNAs have been implicated in regulating gene expressio

159 expression, the functions of most pathogenic ncRNAs in host-pathogen interactions remain unclear.

160 ant immune systems can respond to pathogenic ncRNAs, which has broad implications for providing new o

161 to dissect host interactions with pathogenic ncRNAs, using comprehensive transcriptome analyses.

162 on the observation that active CREs produce ncRNAs.

163 eases function with cofactors that recognize ncRNAs with accessible 5' or 3' ends and/or increase the

164 identified ncRNAs and new insights regarding ncRNAs as dietary bioactive compounds could remodel our

165 ccumulating evidence on aberrantly regulated ncRNAs, including short microRNAs, long ncRNAs and circu

166 and an imbalance in the levels of regulatory ncRNAs such as small nuclear and nucleolar RNAs (snRNAs

167 tic strategies targeting telomere-regulatory ncRNAs in aging pathology.

168 age is a biologically active non-coding RNA (ncRNA) essential for axon regeneration in Caenorhabditis

169 w concept is emerging in the non-coding RNA (ncRNA) field: an increasing number of ncRNAs in fact cod

170 n cytoplasmic (BC1) RNA is a non-coding RNA (ncRNA) involved in neuronal translational control.

171 Research on non-coding RNA (ncRNA) is a rapidly expanding field.

172 RNA biology including small non-coding RNA (ncRNA) mediated gene silencing.

173 entified by context-specific non-coding RNA (ncRNA) profiling, based on the observation that active C

174 HSUR2 is a viral non-coding RNA (ncRNA) that functions as a microRNA (miRNA) adaptor.

175 e class of molecules, termed non-coding RNA (ncRNA), plays key regulatory roles in shaping cellular a

176 ost interactions involved in non-coding RNA (ncRNA), target gene and microRNA expression in five canc

177 ion alterations in coding and noncoding RNA (ncRNA) across different etiological subtypes of HF.

178 iptomes and identification of noncoding RNA (ncRNA) classes has been greatly facilitated by the adven

179 We identify Neat1, a noncoding RNA (ncRNA) constituent of paraspeckles, as a p53 target gene

180 ranscribed, retrotransposable noncoding RNA (ncRNA) elements ubiquitously spread throughout mammalian

181 ex to both protein-coding and noncoding RNA (ncRNA) genes via a SUMO-interacting motif in the HDAC Cp

182 uding microRNAs (miRNAs), are noncoding RNA (ncRNA) molecules involved in gene regulation.

183 nd influence Ro's function in noncoding RNA (ncRNA) quality control and processing.

184 , thus generating exclusively noncoding RNA (ncRNA) that must hijack the machinery required for their

185 The transition from noncoding RNA (ncRNA) to mRNA production accompanies transcriptional ac

186 ral classes of long and small noncoding RNA (ncRNA).

187 dentified several classes of noncoding RNAs (ncRNA) also associated with aging-related senescence and

188 m only ~1.5% of the genome), noncoding RNAs (ncRNA) are emerging as versatile key regulators of gene

189 NAs are shaped by regulatory noncoding RNAs (ncRNA).

190 hese RNA molecules are named noncoding RNAs (ncRNA).

191 at interact with coding and non-coding RNAs (ncRNAs) and to identify hundreds of protein-RNA interfac

192 , tRNA, and other conserved non-coding RNAs (ncRNAs) are excluded from these bodies.

193 Non-coding RNAs (ncRNAs) are known to play crucial roles in various biolo

194 Non-coding RNAs (ncRNAs) are known to regulate gene expression at practic

195 Small non-coding RNAs (ncRNAs) are short non-coding sequences involved in gene

196 tl2 locus produces multiple non-coding RNAs (ncRNAs) from the maternally inherited allele, including

197 nctional importance of many non-coding RNAs (ncRNAs) generated by repetitive elements and their conne

198 stress on the expression of non-coding RNAs (ncRNAs) has not been systematically examined.

199 Non-coding RNAs (ncRNAs) have been reported to control function and signa

200 The discovery of structured non-coding RNAs (ncRNAs) in bacteria can reveal new facets of biology and

201 illance pathway for certain non-coding RNAs (ncRNAs) including ribosomal RNAs (rRNAs), transfer RNAs

202 ate vast numbers of non-protein-coding RNAs (ncRNAs) that can inhibit mRNA synthesis through transcri

203 cally finds both coding and non-coding RNAs (ncRNAs) that interact with tissue-specific promoters and

204 Small non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and piwi-interact

205 he regulatory complexity of non-coding RNAs (ncRNAs), which occupy the bulk of the genome.

206 th protein coding genes and non-coding RNAs (ncRNAs).

207 serves as a source of short non-coding RNAs (ncRNAs).

208 overy of several classes of non-coding RNAs (ncRNAs).

209 ps in the biogenesis of both noncoding RNAs (ncRNAs) and protein-coding messenger RNAs (mRNAs), degra

210 Small noncoding RNAs (ncRNAs) are involved in many important physiological fun

211 Among a subset of noncoding RNAs (ncRNAs) cosedimenting with the ubiquitin-proteasome syst

212 ncer and promoter associated noncoding RNAs (ncRNAs) could stabilize deleterious secondary DNA struct

213 deep sequencing, of numerous noncoding RNAs (ncRNAs) derived from both EBOV and MARV during infection

214 Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions

215 Many pathogens express noncoding RNAs (ncRNAs) during infection processes.

216 RNAs (tRNAs) and other small noncoding RNAs (ncRNAs) encapsulated within vesicles.

217 Noncoding RNAs (ncRNAs) generated from enhancers have been proposed as a

218 he discovery of thousands of noncoding RNAs (ncRNAs) has expanded our view on mammalian genomes and t

219 Noncoding RNAs (ncRNAs) have been assessed as biomarkers, and miRNAs hav

220 l analyses of new classes of noncoding RNAs (ncRNAs) have revealed their widespread use in many pathw

221 matin-modifying factors, and noncoding RNAs (ncRNAs) in ~4,300 single cells, encompassing more than 6

222 The world of noncoding RNAs (ncRNAs) is composed of an enormous and growing number of

223 Noncoding RNAs (ncRNAs) longer than 200 nucleotides are rare in bacteria

224 Small noncoding RNAs (ncRNAs) play a vital role in a broad range of biological

225 nt transcription of a set of noncoding RNAs (ncRNAs) preferentially within tumors as opposed to norma

226 Noncoding RNAs (ncRNAs) regulate gene expression in all organisms.

227 Noncoding RNAs (ncRNAs) regulating virulence have been identified in mos

228 TE-containing noncoding RNAs (ncRNAs) show considerable tissue specificity and play im

229 RNAs are small (~ 22nt long) noncoding RNAs (ncRNAs) that regulate gene expression at the post-transc

230 ed to produce mRNAs and some noncoding RNAs (ncRNAs) within mammalian cells.

231 e one of many types of small noncoding RNAs (ncRNAs), but their specific function is not known.

232 ntially every mRNA, and some noncoding RNAs (ncRNAs), can be targeted to stress granules, the targeti

233 ta support the importance of noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and lncRNAs, which

234 Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), circular RNAs (ci

235 ell pepper fruit ripening by noncoding RNAs (ncRNAs), we examined their expression profiles; 43 micro

236 cells, many viruses express noncoding RNAs (ncRNAs).

237 ranslated regions (UTRs) and noncoding RNAs (ncRNAs).

238 ive, and potentially harmful noncoding RNAs (ncRNAs).

239 s system diseases (NSDs) and noncoding RNAs (ncRNAs).

240 Short ncRNAs underlie a programmable system of chromatin modif

241 signaling events that are modulated by SINE ncRNAs, particularly during gammaherpesvirus infection.

242 chanisms underlying MHV68 activation of SINE ncRNAs.

243 Here, we review the biology of these SINE ncRNAs, explore how DNA virus infection may lead to thei

244 A new study identifies a small ncRNA from Trypanosome brucei as a vault RNA (vtRNA) bas

245 role in the sorting of highly abundant small ncRNA species, including tRNAs, Y RNAs, and Vault RNAs.

246 and hybridization probe for different small ncRNA detection methods, can be designed and searched us

247 A recent study of small ncRNA expression in A. limnaeus embryos in response to a

248 omprehensive quantitative reference of small ncRNA expression would significantly advance our underst

249 contains the largest number of unique small ncRNA transcripts, some of which were previously annotat

250 le platform that can be used to detect small ncRNAs.

251 er designing and query web service for small ncRNAs.

252 How small ncRNAs utilise phase separated environments for their fu

253 exRNA is enriched in small ncRNAs, such as miRNAs in exosomes, and precisely proces

254 MitosRNAs, small ncRNAs derived from the mitochondrial genome, emerged as

255 both sexes, we identified that ~30% of small ncRNAs are distributed across the body in a tissue-speci

256 e design for the expression profile of small ncRNAs.

257 including full-length tRNAs and other small ncRNAs.

258 o anoxia and aerobic recovery revealed small ncRNAs with expression patterns that suggest a role in s

259 th reads of tRNAs and other structured small ncRNAs; high-throughput mapping of post-transcriptional

260 Moreover, some ncRNA genes appear to be direct targets of the HSR, as t

261 ation pathways that protect the ends of some ncRNAs from nucleases.

262 ming to functionally characterize a specific ncRNA.

263 ion, whereas CRX alone favored cone-specific ncRNA expression, providing quantitative evidence that h

264 retinal TF CRX correlated with rod-specific ncRNA expression, whereas CRX alone favored cone-specifi

265 re able to connect identified brain-specific ncRNAs with their cell types of origin.

266 S induces up- and downregulation of specific ncRNAs from multiple classes, including miRNA, piRNA, li

267 re depleted in genes with overlapping stable ncRNAs (SUTs), presumably to avoid degrading the non-cod

268 for a set of sequences including structured ncRNA, mRNA and randomized sequences.

269 Riboswitches are structured ncRNAs that directly interact with small molecules to re

270 ibility that novel noncoding RNA structures (ncRNAs) are embedded within intronic sequences and are c

271 or different classes of ncRNA to ensure that ncRNA nomenclature is accurate and informative, where po

272 e premise of this review is the concept that ncRNAs, like many large proteins, have a multidomain arc

273 t functions, it is now well established that ncRNAs identify a class of regulatory molecules that fin

274 n 17 hematopoietic cell types, we found that ncRNAs expressed from the Dlk1-Gtl2 locus are predominan

275 across various heart diseases indicates that ncRNAs are critical contributors to cardiovascular patho

276 While in the past it was thought that ncRNAs would be redundant without relevant functions, it

277 e observed a marked cohesiveness in both the ncRNA and mRNA layers and the associations between them.

278 NA-10 was first described in a survey of the ncRNA repertoire in this organism.

279 direct chemical and sequence analysis of the ncRNA species.

280 evidence that silencing depends, not on the ncRNA, but on the promoter sequence.

281 ing output) through complex "sentences" (the ncRNA interactor networks).

282 tive splicing inhibitory sequences using the ncRNA-a2 as a model.

283 In another two cases we showed that the ncRNAs were further processed from their introns.

284 ts" (SEs) directing their wiring within the "ncRNA interactor networks" through the emergence of seco

285 Knocking down these ncRNAs significantly inhibited proliferation and invasio

286 Here, we describe how these ncRNAs influence key regulatory steps of the transcripti

287 st decade, the biological functions of these ncRNAs are largely not well understood.

288 Defining the sequences of these ncRNAs is essential for future studies aiming to functio

289 latory and immune-related functions of these ncRNAs may impact the viral life cycle.

290 fy p50 and p52 as primary regulators of this ncRNA.

291 roviding an official gene symbol and name to ncRNA genes brings order to otherwise potential chaos as

292 technical challenge of ascribing function to ncRNAs, diverse biological roles for virally expressed n

293 l transcribed regions (including unconserved ncRNAs), without requiring assembly of the full-length t

294 equencies in genes with overlapping unstable ncRNAs (CUTs), so limiting the availability of non-funct

295 tin-proteasome system, our approach unveiled ncRNA MaIL1 as a critical structural component of the To

296 ts into conserved interactions between viral ncRNAs and host cell machinery frequently lead to novel

297 g-related senescence and cancer, but whether ncRNAs are also involved in short-telomere-induced senes

298 unexpected repertoire of mechanisms by which ncRNAs contribute to genome stability and even potential

299 yla, several highly conserved and widespread ncRNA classes with properties that suggest sophisticated

300 (ncRNA elements) are assembled into "words" (ncRNA domains) that are further organized into "phrases"