ライフサイエンスコーパス: nearly abolish

1 t S-nitrosylation of the Myr- eNOS mutant is nearly abolished.

2 ion of cortactin with the Arp2/3 complex was nearly abolished.

3 in wild-type cells, and resurgent current is nearly abolished.

4 deleted of both genes, these activities are nearly abolished.

5 ult, the constitutive release of Abeta40 was nearly abolished.

6 In addition, CAT activity in the heart was nearly abolished.

7 fected whereas the intestinal expression was nearly abolished.

8 titatively measure pH while the artifact was nearly abolished.

9 TAT4(-/-) animals, PPT A mRNA expression was nearly abolished.

10 that the silencing of each of these proteins nearly abolished 17beta-estradiol-stimulated SNAT2 promo

11 vitro knockdown of Cav-1 in C6 glioma cells nearly abolished 5-HT(2A) receptor-mediated signal trans

12 esynaptic inhibition, whereas such treatment nearly abolishes adenosine-induced activation of postsyn

13 he second Ig domain deleted both resulted in nearly abolished adhesion.

14 0.7% versus 41.4+/-7.5%; P<0.001), which was nearly abolished after PPVI (3.6+/-5.6%; P<0.001).

15 anatomical cortical maps in these mice were nearly abolished along the nasotemporal (azimuth) axis o

16 ecordings of the chorda tympani nerve reveal nearly abolished ammonium and sour taste responses in Sn

17 T regulatory cells were nearly abolished and antitumor immunity was mediated by

18 ctivation and fos family gene expression was nearly abolished and could be restored by transducing ce

19 ely 37-fold decrease in the binding constant nearly abolishes Argos activity in vivo and in cellular

20 ime spent while hypoglycemic (<70 mg/dL) was nearly abolished as indicated by continuous glucose moni

21 onize over this pH range, ligand binding was nearly abolished at all pH values.

22 of Asp-143 allowed measurable biogenesis but nearly abolished ATP hydrolysis and proton transport.

23 of nox enzymes and found that this treatment nearly abolished bEnd.3 hemangioma growth in vivo.

24 ed lower airway remodeling and fibrosis, and nearly abolished BHR.

25 of 8-oxoguanine, whereas mutation of Arg-109 nearly abolished binding of Fpg to damaged DNA.

26 Mutation within each segment reduced or nearly abolished binding, suggesting that these segments

27 nction-blocking monoclonal antibody Hermes-1 nearly abolishes binding of LS174T CD44 to fibrin, altho

28 the two NF-kappaB sites and of the AP-1 site nearly abolishes both basal and IL-1beta-induced express

29 y decreases after 3 months of age, and it is nearly abolished by 10 to 11 months, whereas outer retin

30 Phasic contractions and tone in the IAS were nearly abolished by ANO1 and CavL antagonists.

31 The current was nearly abolished by apamin and by UCL1684, suggesting me

32 multiple poly-N-acetyllactosamine repeats is nearly abolished by AZT concentrations as low as 2 micro

33 edia, glucose-stimulated IAPP-LI release was nearly abolished by blocking constitutive release with 1

34 This enhancement was nearly abolished by blocking the nuclear translocation o

35 rsistent action potential discharge that was nearly abolished by capsazepine (10 microM) and inhibite

36 he LpL inhibitor tetrahydrolipstatin but was nearly abolished by heparin, monoclonal anti-LpL antibod

37 A7r5 vascular smooth muscle cells, which was nearly abolished by knockdown of TRPC6 using a small int

38 mulated a rapid activation of PLD, which was nearly abolished by pertussis toxin (PTX) treatment, con

39 This inhibition was nearly abolished by PKC-IP, indicating that endothelin r

40 caused bursts of afferent activity that were nearly abolished by retigabine.

41 T activation capacity of apoA-I in vitro was nearly abolished by the helix 6 point (helix 6P-apoA-I[R

42 vasodilative reactions to both agonists was nearly abolished by the K(ATP) channel inhibitor glibenc

43 Inactivation of macroscopic Na+ currents was nearly abolished by the N1662A mutation and the combinat

44 mitochondria was markedly reduced by GTP and nearly abolished by the non-hydrolyzable GTP analogue, g

45 Ca(2+) from the SR through RyR2s, but it did nearly abolish Ca(2+) spark-activated, large-conductance

46 Inhibition of TRPV4 nearly abolished Ca(2+) signaling at initial stages of c

47 M markedly decreased SR Ca(2+) leak rate and nearly abolished Ca(2+) sparks.

48 Heterologous expression of Rem2 nearly abolished calcium currents arising from preexisti

49 h a His-tagged, Tat-filamin-A fusion protein nearly abolished CaR-mediated activation of ERK1/2 MAPK

50 NA delivery using lipid nanoparticles (LNPs) nearly abolished cell death and ameliorated cell growth,

51 antly reduced the number of EBV genomes, and nearly abolished cell proliferation in low serum.

52 ction of glutamate receptor antagonists that nearly abolished cough evoked from the trachea and laryn

53 ckdown of TxnRd1 in both HeLa and FaDu cells nearly abolished curcumin-mediated radiosensitization.

54 The G100V/C103V mutation nearly abolishes depolarization-evoked exocytosis (measu

55 esponses to electrical field stimulation are nearly abolished despite persistent nNOS expression, whe

56 Nitric oxide (NO) synthase inhibitor L-NAME nearly abolished dilations to bradykinin and flow and at

57 ment with antimurine IL-1alpha antibody (Ab) nearly abolished DMBA-induced IL-1alpha mRNA (P = 0.0001

58 the EC50 for dzp, and the Y159S substitution nearly abolished dzp-mediated potentiation.

59 ith the corresponding cyanobacterial protein nearly abolished electron transfer at low ionic strength

60 missense amino acid polymorphism in WRN that nearly abolishes enzymatic activity while leaving expres

61 Mutation of Lys48, Lys106, or His108 nearly abolishes EST activity, indicating that they play

62 ingly, Mn(2+)-ATPase in the Q783A mutant was nearly abolished, even at concentrations of up to 10 mic

63 ion of key genes of lens differentiation and nearly abolished expression of gamma-crystallin.

64 of these residues reduced (R388H; R388A) or nearly abolished (F391G; Y406A) the S3969-mediated ENaC

65 easures of viability, while deletion of tolC nearly abolished FFA production.

66 This effect is nearly abolished following selective genetic disruption

67 incorporation of a tRNA upstream of the UTR nearly abolishes gfp mRNA (and GFP protein), presumably

68 We found that CTK1 deletion nearly abolished H3K4 monomethylation yet caused a signi

69 by adherent cells; 2) depleting CD14+ cells nearly abolished HIV-1-induced IFN-alpha production; and

70 id showed that the complete deletion of hypB nearly abolished hup promoter activity, whereas the hist

71 A specific CaMK inhibitory peptide nearly abolished I(Ca) facilitation, but the facilitatio

72 ensities by 2-fold in HEK/Na(v)1.5 cells and nearly abolished I(Na) in mouse cardiomyocytes.

73 lism or signaling were fed KD, seizures were nearly abolished if mice had intact A1Rs, were reduced i

74 steines involved in covalent binding to heme nearly abolished immunodetectable protein.

75 Binding was nearly abolished in a cell line expressing the ldlA (Q40

76 ity to replicate the modified vector DNA was nearly abolished in a pol IV-deficient strain.

77 f an overlapping long noncoding RNA was also nearly abolished in aorta and bladder.

78 d beta-arrestin-2 (betaarr-2) because it was nearly abolished in betaarr-2-knockout (ko) mice.

79 e element-binding protein, at serine 133, is nearly abolished in CC2D1A mutant cells.

80 specificity binding to macrophages that was nearly abolished in competitive inhibition experiments.

81 y IFN-independent inhibition of IL-12p40 was nearly abolished in DCs deficient in IFN regulatory fact

82 ned gamma frequency oscillations, which were nearly abolished in deprived columns.

83 Expression of Shh and Fgf10 is nearly abolished in double mutant limb buds.

84 of hippocampal IL-6 after pilocarpine SE was nearly abolished in EP2 conditional KO mice.

85 significantly attenuated in GalphaoGS/GS and nearly abolished in Galphai2GS/GS cells because of enhan

86 ient-induced EEC mitochondrial activation is nearly abolished in GF zebrafish.

87 The sag and rebound were nearly abolished in Hcn1-deficient hair cells.

88 afish mutant cloche (clo), SCL expression is nearly abolished in hematopoietic and vascular tissues.

89 re decreased in orthotopic (14+/-0.9 mV) and nearly abolished in heterotopic allografts (2+/-1.2 mV).

90 pha or tumor necrosis factor (TNF)-alpha was nearly abolished in homozygous mutant (Shp-2(-/)-) fibro

91 BVE(Cyp24a1-null)-derived tumor cells to be nearly abolished in immunocompromised nude mice.

92 Last, BRL-37344-imparted benefits were nearly abolished in isolated I/R injured myoBDNF KO hear

93 t for adenylyl cyclase activation [which was nearly abolished in lpa(1)((-/-)) fibroblasts], these re

94 is innate type 2 response to the allergen is nearly abolished in mice deficient in IL-33R (i.e., ST2)

95 whose expression is controlled by leptin and nearly abolished in ob/ob mice, inhibits bone resorption

96 he ATP-induced increases in [Ca(2+)](i) were nearly abolished in P2X(7)(-/-) submandibular acinar and

97 hat T. cruzi-induced IFN-beta production was nearly abolished in primary murine cGAS-/- or stimulator

98 knockout mice, GABAA-mediated inhibition was nearly abolished in reticular nucleus, but was unaffecte

99 uring ischemia, whereas this interaction was nearly abolished in Sestrin2 KO hearts.

100 The CVC response to whole-body heating was nearly abolished in sites pretreated with substance P co

101 Myogenin expression and myogenesis were nearly abolished in the absence of both AMPKalpha1 and A

102 Looping was nearly abolished in the absence of transcription activat

103 e single mutants was greatly reduced and was nearly abolished in the double mutants in both in vivo a

104 steoblasts and encoding bone ECM proteins is nearly abolished in transgenic mice, and ex vivo assays

105 cells with attenuated Foxp3 expression were nearly abolished in vitro and in vivo, whereas their ane

106 - and alpha(2)-mediated vasoconstriction was nearly abolished in young and older adults (DeltaFVC app

107 enetic knockdown of AXL in a glial cell line nearly abolished infection.

108 letion of ARHI's unique N-terminal extension nearly abolished its inhibitory effect on cell growth, s

109 rocarbonate (DEPC) modification of isoform E nearly abolishes its cytoplasmic membrane binding capaci

110 in the B6.Sle1.Sle3 multigenic model of SLE nearly abolished key disease manifestations including an

111 and ATP-sensitive potassium (KATP) channels nearly abolished lactate-induced vasodilation.

112 Mutation of SLiM4 nearly abolished liprin-alpha1 interaction with PP2A hol

113 c acid (5 microM) or thapsigargin (5 microM) nearly abolished (<20% control) the increase in [Ca2+]i

114 Mertk elimination nearly abolished macrophage apoptotic cell phagocytosis;

115 d (KMV), a site-specific inhibitor for KGDH, nearly abolished mH(2)O(2) generation in both male and f

116 ural analysis to interact with E960-NKA also nearly abolished NKA-PLM FRET.

117 Increased LAP2B expression nearly abolished NM ruptures in cells subjected to mecha

118 RNA interference knockdown of C/EBPalpha nearly abolished OHT-ERalpha-induced apoptosis.

119 or of inosine and guanosine metabolism) were nearly abolished (P < 0.0001).

120 ntaining 285 base pairs of upstream sequence nearly abolished promoter activity, and co-transfection

121 However, mutation of the AP-1 site alone nearly abolished promoter activity.

122 ction in chondrogenesis, as blockage of ECM1 nearly abolishes PTHrP regulation of chondrocyte hypertr

123 PKC inhibitor GF109203X nearly abolished PTP in both control and cKO.

124 , whereas chronic synaptic activity blockade nearly abolished receptor recycling.

125 nges the phasing of a subset of rhythms, and nearly abolishes resetting of phase by a pulse of darkne

126 e eye during a critical period in early life nearly abolishes responses to that eye in visual cortex.

127 ffect was enhanced when combined (-87+/-4%), nearly abolishing RH.

128 pon adrenergic isoproterenol stimulation and nearly abolished ryanodine receptor type 2 (RyR2)-depend

129 wever, the K(V) 7 channel agonist retigabine nearly abolished sensory nerve outflow from the urinary

130 LMP1 aggregation in the plasma membrane and nearly abolished signaling from LMP1 or the LMPCD40 chim

131 K in the first intracellular loop of TMEM16B nearly abolished slow gating, but, mutating 448 AVK451 t

132 in spinal expiratory (pectoralis) nerves and nearly abolished spinal inspiratory activity (serratus n

133 Global blockade of nAChRs similarly nearly abolished stage 1 waves.

134 2Q decreased protein stability/synthesis and nearly abolished steady-state cell surface density of Ca

135 mg) and 300,000 IU of porcine lipase (18 g) nearly abolished steatorrhea.

136 synaptotagmin I's C(2)B Ca(2+)-binding motif nearly abolish synaptic transmission and decrease the ap

137 iol (E2; an estrogen receptor alpha agonist) nearly abolished TDCIPP-induced epiboly defects.

138 TSA nearly abolishes TF-kappaB binding without affecting NF-

139 ue 1 mouse-IgG2aFc (B7-H1-Ig) fusion protein nearly abolish TH17, but not TH1 and TH2, differentiatio

140 plastid-targeted BVR expression was found to nearly abolish the qualitative inhibition of flowering b

141 Deletion of residues 24-53 nearly abolished the ability of CaD to inhibit actin fil

142 t many mutations in the FIMAC and SP domains nearly abolished the ability of FI to degrade C4b and C3

143 TP to aspartate (M159D) or glutamate (M159E) nearly abolished the ability of PLTP to remove cellular

144 u-478, on the C-terminal domain to glutamine nearly abolished the activity of the enzyme.

145 ulfate (2 mg/kg, i.v.) or bilateral vagotomy nearly abolished the bradycardia and attenuated the hypo

146 The P2X receptor antagonist, PPADS, nearly abolished the contractions.

147 e p47phox promoter) reduced PU.1 binding and nearly abolished the contribution of this element to pro

148 deno-associated virus serotype 9 TnT-MEK1-CA nearly abolished the detrimental phenotype of knockout m

149 y adiposity; however, controlling for IP fat nearly abolished the differences in HTGC, indicating a c

150 PP2 (but not PP3) nearly abolished the effect of FN on channel activity, s

151 ites of the apoA-I promoter/apoCIII enhancer nearly abolished the expression of apoA-I and the report

152 TTX nearly abolished the expression of maternal retrieval of

153 studies demonstrated that NALCN alterations nearly abolished the expression of wild-type NALCN, sugg

154 ead mutants for each of these 3 TRP isoforms nearly abolished the flow-induced cation currents and Ca

155 ens to mouse skin before each UV irradiation nearly abolished the frequency of p53 mutations.

156 conserved GTP-binding motif of HypB (Lys59) nearly abolished the GTPase activity of the mutant prote

157 Ingestion of Skippy, however, nearly abolished the increase in peanut-specific IgE and

158 98059 for postoperative days 1-4 reduced and nearly abolished the initial GT upregulation in CCI rats

159 reas the combined application of both toxins nearly abolished the modulation.

160 Blockade of AMPA receptors nearly abolished the orthodromic component of the respon

161 tors of NLRP3 (CY-09) or S100A9 (paquinimod) nearly abolished the ponatinib-induced cardiac dysfuncti

162 Further addition of L-NA nearly abolished the relaxation response in the LM, but

163 BMS-200150 at 40 microm nearly abolished the secretion of endogenous apoB100-con

164 On the other hand, increasing the [Mg2+]i nearly abolished the stimulatory pressure effect.

165 ibition (10 micromol/L Y27632), in contrast, nearly abolished the sustained force but had a lesser ef

166 , a blocker of store-operated Ca2+ channels, nearly abolished the thapsigargin-induced rise in [Ca2+]

167 contrast, moderate activating mutation A456V nearly abolishes the GKRP inhibition (76-fold increase i

168 of the Ang II substrate in this brain region nearly abolishes the pressor and bradycardic effects of

169 s1, a member of the Ste20 family of kinases, nearly abolishes the sporulation-associated H4 S1ph modi

170 of a construct containing a PIP2 phosphatase nearly abolished them.

171 ced the frequency and size of stage 1 waves, nearly abolishing them.

172 Acinar cells are nearly abolished through apoptosis by 100 hpf, though ne

173 odeling, while deletion of the TATA box that nearly abolishes transcription is permissive to 5'-end r

174 base pairs in the center of the dT-dA tract nearly abolishes transcription of snr6-Delta42, yet inve

175 siRNA knockdown (in BJ fibroblasts) of iNOS nearly abolished transdifferentiation, an effect that co

176 beta-subunit-encoding gene of A. oligospora nearly abolished trap formation.

177 A disease-related TSC2 mutation (Y1571H) nearly abolished tuberin phosphorylation when stimulated

178 ckpoint blockade), and combination treatment nearly abolished tumor outgrowth.

179 Also, the allosteric activity was nearly abolished upon coapplication with the AA site-sel

180 -O-tetradecanoylphorbol-13-acetate treatment nearly abolished UVA-induced ERK and Ras activation.

181 the HLA-B27 anchor residue, R(2937) , which nearly abolished viral replication.

182 elongation is what matters, reinitiation was nearly abolished when a pseudoknot that causes a pause i

183 F(CFP)) by 21.5 +/- 4.1% (n = 13), an effect nearly abolished when co-expressing excess phospholemman

184 gonist AP-7, glutamate-dependent current was nearly abolished when high Ca2+ was substituted for high

185 , hVAChT expression on synaptic vesicles was nearly abolished when the hVMAT2 cytoplasmic tail was pr

186 inhibition of ENaC by hNedd4; inhibition was nearly abolished when WW domain 3 was mutated.

187 ols is blocked, norepinephrine secretion was nearly abolished whereas glutamate and GABA release was

188 Hepatic portal ascorbate accumulation was nearly abolished, whereas intestinal absorption was marg

189 (hypercapnia), postinspiratory discharge was nearly abolished, whereas laryngeal inspiratory discharg

190 of the DnaK T199A and DnaK K70A proteins are nearly abolished, while the ATPase activity of the DnaK

191 with F956A or F967A, reduced with L964A, and nearly abolished with E960A.

192 This effect was nearly abolished with fmgBC DNA fragments having a mutat

193 NAME (24 +/- 2%; P = 0.002 from l-NAME), and nearly abolished with l-NAME + TEA (13 +/- 2%; P = 0.001

194 e normalized protein density of Ca(V)2.3 was nearly abolished with the quadruple Ca(V)beta3 Leu mutan

195 Synaptic transmission is nearly abolished, with residual transmission delayed, hi

196 Of interest, Rga7 localization is nearly abolished without Rng10.