ライフサイエンスコーパス: negative charge

1 tabilization and for neutralization of ATP's negative charge.

2 ite electrostatic repulsion from the growing negative charge.

3 trast to short MWNT-OVA displaying the least negative charge.

4 soluble fraction (CSF), linear, with strong negative charge.

5 ns repelled from each other by their overall negative charge.

6 similar functional effects by introducing a negative charge.

7 llows for the uptake of particles having net negative charge.

8 hr) without compensating for the loss of the negative charge.

9 an enzyme responsible for increasing the LPS negative charge.

10 phosphate leaves, to neutralize the evolving negative charge.

11 atic repulsion from clay surfaces with a net negative charge.

12 ree of conformational entropy and a high net negative charge.

13 complexes within solution due to their high negative charge.

14 separated from the one containing the excess negative charge.

15 hen the buttressing alpha-heteroatom bears a negative charge.

16 of positive topological charge and avoiding negative charges.

17 permutation, shorter CDR3 segments, and less negative charges.

18 ng this repulsion due to its high density of negative charges.

19 ), or short MWNTs-OVA (~122nm) of increasing negative charges (-23.4, -35.8 or -39mV).

20 perbases (DBN and DBU) to help stabilize the negative charge, a family of discrete supertetrahedral c

21 or is tunable through net-charge: increasing negative charge abolishes condensation and speckle incor

22 uctance of the sensor due to accumulation of negative charges added by the immobilized probe DNA and

23 ium substrate, the vermiculite sheets become negative charged again and move away from the substrate

24 Incomplete quenching of negative charges allows stronger oxidants/electrophile (

25 lates at cell tips and defines a gradient of negative charges along the cell surface.

26 h pH plume front, the goethite reversed to a negative charge, along with quartz and kaolinite, then g

27 change in crystal packing originated in the negative charge and 4-5 masculine bend in the reduced is

28 e complementary PNA-beads, the beads acquire negative charge and become electrophoretically mobile.

29 of both substrate and non-substrate lipids, negative charge and curvature activate VPS34 complexes,

30 of the fulvenyl group in stabilizing nearby negative charge and highlight the ability of fulvene spe

31 an HwTx-IV analogue (gHwTx-IV) with reduced negative charge and increased hydrophobic surface profil

32 Negative charge and moderate lipophilicity correlate wit

33 The released eNT, due to its less negative charge and small size, diffuses easily to the n

34 hat stabilizing interaction between a remote negative charge and stable radicals, occurring in gas ph

35 relationship between a plastic sample's net negative charge and the amount of solution metal ions di

36 n its protein environment (modifying the net negative charge and/or substrate accessibility/binding)

37 which transiently interacts with alternating negative charges and hydrophobic stretches of the transl

38 r to be mediated by the increase in nitrogen negative charge (and consequent increase in hydrogen bon

39 h hydrophilic and hydrophobic domains, a net negative charge, and high porosity and pore interconnect

40 y have poor brain penetration because of its negative charge, and is a powerful anticoagulant.

41 ation to physiological pH restores the fixed negative charges, and yields remodeled cartilage that re

42 ClC-5 transport that provides three net negative charges appeared self-inhibitory because of ClC

43 Small molecules with positive, neutral, and negative charge are detected by P-EIM.

44 Moreover, substrates with a net negative charge are disfavored by the channel, probably

45 es the generation of precursors in which the negative charges are masked with biolabile groups.

46 ups, whereas basal surfaces have a permanent negative charge arising from isomorphic substitutions.

47 The oxidized exo residues increase the net negative charge around the active site that should reduc

48 ive charge accelerates the motion, whereas a negative charge arrests it.

49 here proteins were found to carry the lowest negative charge as confirmed by the zeta potential measu

50 double-stranded RNA, which carries the same negative charge as DNA, but assumes a different double h

51 action for physical adsorption resulted from negative charge assisted hydrogen bonding between H atom

52 ution and size of 0.43mum that carried a net negative charge at neutral conditions (pH 7.0).

53 ith a decreased pKa value, to preserve their negative charge at neutral pH, restore the sensitivity t

54 ity experiments also show that addition of a negative charge at Ser-175 favors the autoinhibited conf

55 Placement of negative charge at Ser-175, through phosphorylation or m

56 These effects likely create a small negative charge at the air-water interface, generating a

57 Because of this asymmetry, the net-negative charge at the inner leaflet exceeds that at the

58 Accumulation of negative charge at the NSO3 moiety in the transition sta

59 ectron deficiency in the carbon skeleton and negative charge at the oxygen end that upon reaction wit

60 analysis indicates that the latter builds up negative charge at the substrate C(alpha) and positive c

61 have been observed to acquire a significant negative charge at their surface, which ultimately contr

62 Introducing a negative charge at this position (L118D) increased the t

63 time that M oligomerization, regulated by a negative charge at Thr205, may be critical to production

64 In addition, we show that introduction of negative charge at tyrosine 18 shifts Tau's previously d

65 The ion neutralizes negative charges at the constriction zone, reducing the

66 is achieved by the insertion of positive or negative charges at the interface, and the resultant dip

67 Nucleic acids carry a negative charge, attracting salt ions and water.

68 positive-charged state, hence triggering the negative-charged AuNPs to aggregate by the electrostatic

69 with the MP2/aug-cc-pVQZ model show that the negative charge becomes more dispersed in the anions of

70 or is reactant-like, indicative of a partial negative charge borne by the "in-flight" nucleus being "

71 teraction of these positive charges with the negative charge borne by the initial Fe(0)-CO2 adduct is

72 e four positive charges are replaced by four negative charges borne by sulfonate groups also installe

73 Composed of negative-charged boron-centered tetrahedral linkers, NPF

74 retical calculations provided the pattern of negative charge build-up and distribution over the conto

75 ation by slowing this H(+) transfer, forcing negative charge buildup on the Au and increasing the tra

76 of 2, phosphate residues have just a single negative charge but Asp and Glu are uncharged.

77 sitive not only to lipid composition and net negative charge, but also to the hydrophobic character o

78 single Zn(2+) or Cu(2+) ion reduced the net negative charge by a greater magnitude than predicted (i

79 er hours or days, these OP adducts acquire a negative charge by dealkylation in a process called agin

80 py-driven and unlikely to be affected by the negative charge by K65 acetylation.

81 ic, increasing up to 1.7-fold on addition of negative charges by phosphorylation of grana-hosted prot

82 on by acidic pH, whereas reintroduction of a negative charge (by MTSES modification of Cys) restored

83 cules, with each phosphate carrying a single negative charge, cannot fold into well-defined architect

84 ty (log D = -3.7) and presence of additional negative charges (carboxylates) on the chelator, promoti

85 n, a spin-1/2 excitation, is the fundamental negative charge carrier in pi-conjugated organic materia

86 However, removal of surface negative charges caused low subunit solubility and poor

87 f PA because of its accessibility and higher negative charge compared with the diester phosphates of

88 alpha-synuclein to lipid vesicles with high negative charge content is essentially unaffected by N-t

89 curvature, but binding to vesicles of lower negative charge content is increased, with stronger bind

90 Its negative charge could trigger conformational changes nec

91 The negative charge creates a region, known as the ion atmos

92 tive charges, short MWNT-OVA with the lowest negative charge demonstrated better cellular uptake and

93 acylcarnitines but not a lysolipid without a negative charge, demonstrating the necessity of a negati

94 to varied sulphated polymers with different negative charge densities and resultant structure-proper

95 in the repulsive forces due to their higher negative charge densities.

96 n is promoted by one or more regions of high negative charge density and aromatic/hydrophobic residue

97 helical membrane protein is modulated by the negative charge density around the protein.

98 These models showed that negative charge density associated with tetrahedral site

99 The elevation of negative charge density caused by the presence of the ri

100 ca. 1 cm from the root, has a fairly uniform negative charge density of ca. -15 mC/cm(-2) (in pH 6.8

101 on between the ARMs of the excess CP and the negative charge density of the capsid exterior.

102 ochlorite, which leads to an increase in the negative charge density of the membrane due to the forma

103 on BOD-GO composite having the same moderate negative charge density, but the highest kS of (79.4+/-4

104 Owing to their high negative charge density, PP-InsP(y) will not cross the c

105 osomes containing acidic lipids depending on negative charge density.

106 bserved on BOD-GO composite having different negative charge density.

107 f pneumococcus may assume various degrees of negative charge depending on the polysaccharide capsule,

108 uch as a transition from net-positive to net-negative charge depending on the solution pH.

109 ll-length Lon with residues conferring a net negative charge disrupted binding of Lon to DNA.

110 analysis of Arn revealed that its shape and negative charge distribution are similar to dsDNA, sugge

111 ce of Xyn30D-CBM35 shows a unique stretch of negative charge distribution extending from its binding

112 Treating AN69 dialysis membrane, which bears negative charge due to incorporated sulfonate groups, wi

113 specially effective at helping to delocalize negative charge due to some cyclopentadienide character

114 iciently stabilize the resulting build-up of negative charge during Meisenheimer complex formation, l

115 A negative-charge-enriched hairpin loop connecting S5 and

116 and positrons in the geomagnetic field and a negative charge excess in the shower front.

117 beta-pyrrolic position confirmed the largest negative charge for the C12 carbon atom in antipodal pos

118 A variant with negative charges forms 1:2 host/guest complexes with ami

119 ing neutral bilayers, which do not mimic the negative charge found in the plasma membrane of cancer c

120 Negative charge "freezing" at the boron atom is indeed a

121 pproximately pH 5 to 5.5 and reduced its net negative charge from -30.8 to -27.0 mV.

122 lcholine, and with the same overall membrane negative charge, Gag strongly preferred lipids with both

123 taurine-driven E-ring opening and increasing negative charge generally enhanced ROS photogeneration i

124 At elevated temperatures, a negative charge generated on the surface by a vigorous H

125 ffect of the modified chemical bonding, this negative charge gives rise to an additional barrier for

126 attraction toward substrates of concentrated negative charge governs substrate discrimination, which

127 ound 80 kJ mol(-1) in the gas phase, while a negative charge has a smaller opposite effect.

128 enhances the efficacy of the prodrugs; (ii) negative charges, high steric hindrance in the side chai

129 Loss of the negative charge in one of these residues, D39, causes a

130 -state distributions for proteins with a net negative charge in solution do not depend on tip size.

131 onalized by considering the stabilization of negative charge in the C-Si and C-B bond breaking transi

132 surface hydrophobicity, positive charge and negative charge in the CDRs, and asymmetry in the net he

133 effect was found, alleviating the excess of negative charge in the guest toward the outer surface of

134 Its negative charge in the open state is decisive for proton

135 esentation of the C terminus, an increase in negative charge in the proline-rich region (PRR), and a

136 and inter-species chimaeras have shown that negative charge in the RACK1 loop dictates ribosome sele

137 first order reaction in hydroxide and a full negative charge in the rate-determining step.

138 mic acid substitution (G84E), resulting in a negative charge in the SUP-1 TMD.

139 Increased negative charge in this C-terminal tail balances positiv

140 enerate charge and to transport positive and negative charges in spatially separated phases.

141 Enrichment of negative charges in TCR binding loops, particularly the

142 or E2 is explained via the redistribution of negative charges in the electrode double-layer region wh

143 d, low-pH gradients within the tissue: fixed negative charges in the proteoglycan matrix are protonat

144 etaines, are polymers with both positive and negative charges incorporated into their structure.

145 The negative charge increased during these experiments due t

146 tage dependence, and the neutralization of a negative charge increased it.

147 itive charge but not for proteins with a net negative charge indicates that the unfolding occurs prio

148 nate complexes that-owing to their increased negative charge-induce the swelling of the polymeric mat

149 ive charges facilitating oligomerization and negative charges inhibiting it.

150 For this, the negative charge, initially located on position 1, circum

151 midation, like phosphorylation, introduces a negative charge into proteins.

152 olding mutant FiP35 Pin1, which introduces a negative charge into the first turn.

153 The negative charge introduced by phosphorylation of the sub

154 Thus, negative charges introduced by copper-dependent phosphor

155 ing to sensing membrane curvature when lipid negative charge is decreased.

156 While the source of this negative charge is disputed to this day, its presence is

157 Thus, a continuous phosphodiester backbone negative charge is not essential for sliding over nonspe

158 the Poisson-Boltzmann equation indicate that negative charge is transferred across the membrane when

159 In completely encapsulated films, negative charging is enhanced leading to uniform optical

160 N-terminus, coupled with its high content of negative charges, is likely important for dissociation a

161 moiety is not a good electrophile due to the negative charge it carries.

162 Despite its negative charge, it remains Lewis acidic and permits the

163 contrast, at pH 10.0, where PE lipids bear a negative charge, K(DApp) decreases with increasing PE co

164 d confirmed that the addition of positive or negatives charges led to a greater dependence on YidC-Se

165 binding equilibria involving anions of high negative charge, like SO(4)(2-), SeO(4)(2-), S(2)O(3)(2-

166 The negative charge localization at the central core has bee

167 cations and we suggest that the formation of negative charges might create a surface on the helicase

168 For negative charge migration, this class of bifunctional li

169 The mechanistically novel negative-charge migration that comprises the Brook rearr

170 SICM was also able to detect regions of high negative charge near B. subtilis, not detected in the to

171 se results suggest that DNA and consequently negative charge near the electrode possess a larger impa

172 We conclude that a concentrated region of negative charge, not steric properties, resulting from m

173 y are of negative polarity, transporting net negative charge of 17-23 C to the lower ionosphere.

174 n this paper we show that removing the fixed negative charge of a single acidic amino acid (Glu(51))

175 The net negative charge of apo-SOD1 was similar to predicted val

176 The negative charge of aspartic acid is believed to be able

177 ere used to screen efficiently the intrinsic negative charge of biogenic Se suspensions at circumneut

178 The negative charge of capsular polysaccharides has been pro

179 For alpha-chlorofatty acid, the negative charge of carboxylic acids is exploited to dete

180 estraints, can be introduced by reducing the negative charge of DNA nanotubes using counter ions and

181 The negative charge of NLC was reduced from -17.54 to -8.47

182 arges of heparin, they do not neutralize the negative charge of OSCS.

183 inder actin association, while the increased negative charge of oxidized C147 would lead to electrost

184 The negative charge of phosphatidylserine in lipid bilayers

185 singly, aspartate replacements mimicking the negative charge of phosphorylated serines or threonines

186 of the skin combined with the large size and negative charge of siRNAs make epidermal delivery of the

187 e third metal is positioned to stabilise the negative charge of the 5'-phosphate, and thus three meta

188 demonstrated that the respective positive or negative charge of the 8 aforementioned residues is requ

189 In addition, we provide evidence that the negative charge of the A2662 phosphate group must be ret

190 ivity was brought on scale by offsetting the negative charge of the anchoring carboxylate group.

191 n was correlated with smaller size and lower negative charge of the attached metal chelates.

192 ly through the partial neutralization of the negative charge of the backbone.

193 eaction, thereby potentially dissipating the negative charge of the catalytically active enolate form

194 e concluded that an increase in the internal negative charge of the cell triggers a signaling cascade

195 Importantly, increasing or decreasing the negative charge of the complexin-I accessory helix inhib

196 gly affected by charge repulsion, due to the negative charge of the hydroxyl functionalized nanoparti

197 ids spontaneously 'overcharge'; that is, the negative charge of the NA exceeds the positive charge on

198 A into cells is achieved by neutralizing the negative charge of the phosphate backbone in a reversibl

199 uggesting that the effect was related to the negative charge of the phospholipid head.

200 of Ca2+ binding to C2A is to neutralize the negative charge of the pocket, thereby unleashing the fu

201 utase (SOD1) by increasing the intrinsic net negative charge of the polypeptide, i.e., by acetylation

202 The hydrophilicity and negative charge of the pore surface gradually increase a

203 the O-antigen causing an increase in overall negative charge of the remaining LPS inner section.

204 yr(187) are responsible for neutralizing the negative charge of the substrate, and Lys(143) acts as b

205 Given the large size and the negative charge of these macromolecules, their delivery

206 The negative charge of two aspartate residues within this st

207 ile Ca(2+) ions can efficiently suppress the negative charges of heparin, they do not neutralize the

208 Using the negative charges of nucleic acid tags, we develop a vers

209 Ca(2+) neutralizes the negative charges of the Ca(2+)-binding sites, resulting

210 f nucleosome survival correlate with the net negative charges of the histone-interacting surfaces.

211 cal function of FH because by binding to the negative charges of the modified target, FH could preven

212 nding of CL, whose specific features combine negative charges of the two phosphate groups with four h

213 function of the dualism between positive and negative charged off-stoichiometric sites (i.e., N-vacan

214 We suggest the adenosine neutralizes the negative charge on a nonbridging phosphate oxygen atom a

215 Anionic phospholipids can confer a net negative charge on biological membranes.

216 glycans was to quantitatively neutralize the negative charge on both alpha2,3- and alpha2,6-linked si

217 imulations (AIMD) show that highly localized negative charge on Cl(-) allows the chloride anion to mo

218 resent on both C2 epitopes and complementary negative charge on each antibody.

219 a(2+) and Mg(2+), known to interact with the negative charge on phospholipids, facilitates G(i3) coup

220 tom and that the successive depletion of the negative charge on Pt drives the CO(2) insertion into th

221 on and electrostatic potential analyses, the negative charge on Pz(-) is diluted due to the XB.

222 ive charge on the pyridine and destabilizing negative charge on the anthracene will favor the LEPT pa

223 iO2 and to supported Au particles produces a negative charge on the Au, whereas the transfer from the

224 sting of the stabilization of the developing negative charge on the beta-phosphate by the hydrogen of

225 llenge, likely due to the rapidly increasing negative charge on the cluster as the size goes up.

226 s 3 nm and show that cations that screen the negative charge on the DNA backbone more effectively cau

227 has been proposed to stabilize a developing negative charge on the ether oxygen in the migration of

228 ith positive charge on the beta-nitrogen and negative charge on the gamma-nitrogen.

229 A binding, which is due to the effect of its negative charge on the iron-sulfur bonds.

230 to PS, Cu(2+) binding does not alter the net negative charge on the membrane as the Cu(PS)2 complex f

231 Here, we exploit the single negative charge on the monosialoganglioside GM1, commonl

232 zes the transition state by neutralizing the negative charge on the nonbridging phosphoryl oxygens.

233 d to an appreciable increase in the size and negative charge on the particles in the system.

234 It is seen forming a salt bridge with the negative charge on the phosphate headgroup.

235 organophosphide ligands (PR2(-)) bearing one negative charge on the phosphorus atom; (2) the dianioni

236 ations predict that substituents stabilizing negative charge on the pyridine and destabilizing negati

237 Partially reversing the negative charge on the RS surface impaired motility in C

238 and two lysines (K215 and K217) mitigate the negative charge on the siroheme macrocycle.

239 the terminal sialic acid residues creating a negative charge on the surface of prion particles.

240 hilicity exclusively attributed to localized negative charges on carboxylate or amide group of deprot

241 Due to a high density of negative charges on its surface, DNA condenses cations a

242 ellular Cl(-) and the concentration of fixed negative charges on macromolecules.

243 d chromatin leading to neutralization of the negative charges on polyanionic DNA and modification of

244 t both peptides accumulate at and neutralize negative charges on the bacterial surface.

245 We thus suggest that the two negative charges on the C-terminus of the obliquely tilt

246 Increasingly negative charges on the complexes lowered the activation

247 lt of the repulsive interactions between the negative charges on the DNA helices.

248 Negative charges on the HBc VLP surface were then reduce

249 protein with enhanced sweetness by removing negative charges on the interacting side of thaumatin wi

250 Together, these results indicate that negative charges on the modified proteins dominate the i

251 ulfonate) (PSS) layer onto the AuNRs imposed negative charges on the nanorod surface, and the interac

252 In Cx46, neutralization of negative charges or addition of a positive charge in the

253 a pH higher than 5, phosphopeptides have two negative charges per residue and are well-retained in AE

254 minantly acidic, provide evidence that a net negative charge plays a significant role in driving the

255 We conclude that the P-domain undergoes negative charge polarization due to dephosphorylation of

256 by layer-by-layer deposition of positive or negative charged polyelectrolytes.

257 exist to the idea that a higher magnitude of negative charge predicts higher prevalence.

258 Similarly, neutralization of the negative charges present in the cell microenvironment le

259 ics simulations suggest that this additional negative charge prevents the C-terminal tail from intera

260 -SO(2)R derivatives with variable amounts of negative charges provide high mobilities of glycoconjuga

261 MB bears an additional carboxylic group, the negative charge provided by this group prevents intimate

262 essential role, in addition to serving as a negative-charge provider, as a critical determinant of t

263 iboeletricity being a mosaic of positive and negative charges rather than a homogeneous ensemble and

264 linked mutations to SOD1 will reduce its net negative charge regardless of subcellular localization.

265 some alkylammonium-based systems the excess negative charge resided on anions and not on the positiv

266 uential blocks having positive, neutral, and negative charges, respectively.

267 that certain configurations of positive and negative charges result in enhanced uptake into a mucin

268 The negative charge results in the generation of C-type glyc

269 to provide a fluorescent label and a triple-negative charge, separated by microchip electrophoresis,

270 Compared to the short MWNTs-OVA bearing high negative charges, short MWNT-OVA with the lowest negativ

271 at is inserted, in which case a compensating negative charge should be distributed over the carbon ca

272 Probes containing a fluorophore with negative charge showed high M(2)R affinities (pK(i) (rad

273 esulting HCR products with a large number of negative charges significantly enhanced the stability of

274 tudied primarily in their highest accessible negative charge states (3-, 4-, and 5-, respectively), a

275 quest for stable gas-phase anions in highly negative charge states has been a great challenge.

276 oxide (GO), such as the high hydrophilicity, negative charge, strong adsorption capability, and large

277 ichannels and Vj gate polarity reversal by a negative charge substitution (N2E) in the amino terminal

278 Conversely, negative charge substitution at these serines (3S>D) ant

279 rotein underwent smaller fluctuations in net negative charge than predicted (i.e., ~3 units, instead

280 constitutively active in the absence of the negative charge that is associated with the common V600E

281 The Q875E mutation introduces a negative charge that may modify the local electrical fie

282 mical protecting group, thus eliminating the negative charges that have been shown to have a negative

283 Due to its negative charge, the protein conjugate readily electrost

284 An increase in headgroup negative charge through the addition of phosphatidylglyc

285 By shielding the negative charge, thus increasing the interaction of DNA

286 This modification adds a negative charge to residues of the histone tails that in

287 By imparting additional negative charge to these Asp/Glu clusters, such Ser/Thr

288 arge-transfer picture, but instead exhibit a negative charge-transfer energy in line with recent mode

289 o 19 km vs. 6 to 16 km for CIDs transporting negative charge upward and (b) had considerably higher N

290 A total of 1096 CIDs transporting negative charge upward and 8 CIDs transporting positive

291 he percentages of isolated CIDs transporting negative charge upward decreased from 92% for 5 km searc

292 ergy barrier in gas phase increases with the negative charge, varying from 16 kJ mol(-1) for [EDTAH4.

293 the twisted helicene frame to delocalize the negative charge was probed as a perturbation of aromatic

294 mitochondria (i.e. mitochondria with greater negative charge) which partly explains greater cellular

295 tal (NBO) charges show that Cgamma carries a negative charge, while Lu, Hgamma, and Sibeta carry posi

296 phosphatidylinositol 4,5-bisphosphate (PIP2)-negative charges with poly-l-lysine and prevented by int

297 es were negative polarity, supportive of net negative charge within the plume.

298 between the average centres of positive and negative charge within the unit cell.

299 One mutation, D51/E52/E55A, targeted negative charges within region II of the primary interfa

300 The ability to incorporate negative charge without sacrificing binding affinity is