ライフサイエンスコーパス: negative regulation

1 6 on NOX4 was critical for this FYN-mediated negative regulation.

2 ated region of SMOX mRNA contributes to this negative regulation.

3 system decreases its activity through strong negative regulation.

4 ion had no additive effects on LGP2-mediated negative regulation.

5 rcadian expression of Tshb independent of TH negative regulation.

6 perfamily lectin receptors (Siglecs) provide negative regulation.

7 aAcos is unusual because it is refractory to negative regulation.

8 which differentially influences positive and negative regulation.

9 d SERK1 mutations likely interfere with this negative regulation.

10 tic pleiotropy through mutations that affect negative regulation.

11 cells are subject to multiple mechanisms of negative regulation.

12 dentifies novel targets of PU.1 positive and negative regulation affecting progenitor cell signaling

13 lity is well characterized, counterbalancing negative regulation and mechanical brakes are less well

14 ction; however, molecular mechanisms for its negative regulation are poorly understood.

15 y responses are subject to complex layers of negative regulation at intestinal mucosal surfaces.

16 more defective for positive regulation than negative regulation at low mRNA expression, but the defe

17 the available evidence that shows reciprocal negative regulation between innate interferons and TH2 m

18 threat sensing through protein detection and negative regulation by a Trip13 ATPase.

19 IFN-I induction is subject to negative regulation by both viral and cellular factors,

20 Here we investigated the possibility of a negative regulation by CB1 receptors of leptin-mediated

21 Regulation at the CBP60 node involves negative regulation by CBP60a as well as positive regula

22 en positive regulation by cytokinin (CK) and negative regulation by CLAVATA (CLV).

23 Importantly, SCI also reduces the negative regulation by Galphai of adenylyl cyclase and i

24 e multiple mechanisms whereby VISTA relieves negative regulation by hematopoietic cells and enhances

25 inactivated by multiple mechanisms; however, negative regulation by insulin is not well understood.

26 The negative regulation by Kil significantly reduces the GTP

27 reduce their host-defense functions, dynamic negative regulation by miR-34a provides one means of fin

28 r data point to multiple mechanisms of PREX1 negative regulation by PAKs within receptor tyrosine kin

29 ilin-p53 pro-apoptotic pathway is subject to negative regulation by PLD1 thorough cofilin inactivatio

30 f ABA binding to receptors, which alleviates negative regulation by protein phosphatases 2C (PP2Cs) o

31 P-triggered immunity (PTI) is under constant negative regulation by protein phosphatases but the unde

32 sitive influence on the immunity, countering negative regulation by regulatory T cells.

33 adation of eRNAs at two enhancers subject to negative regulation by Rev-Erbs resulted in reduced expr

34 in1 receptors- DCC and Unc5C is under direct negative regulation by Satb2 and Ctip2, respectively.

35 ved in starch biosynthesis, suggesting their negative regulation by SlARF4.

36 respectively, leading to either positive or negative regulation by T3.

37 a embryonic salivary gland placode through a negative regulation by the apical polarity protein Crumb

38 its associated proteins (the degradosome) in negative regulation by these sRNAs.

39 en, BMP4 expression was elevated, indicating negative regulation by this hormone.

40 Negative regulation by VEX1 also affected telomeric pol-

41 Negative regulation by yeast extract resulted in signifi

42 We conclude that the dynamics of Smad negative regulation cannot be explained by the negative

43 This negative regulation critically depends on transcriptiona

44 between the cofactor and PAH, explaining the negative regulation exerted by BH(4) BH(4) forms several

45 lopmental competence involves the removal of negative regulation exerted by both NsdD and VosA.

46 Several molecular mechanisms of negative regulation have been published, but the relativ

47 HrpS D32, E200 and K233 are not involved in negative regulation imposed by HrpV.

48 ranscription start site acts as a target for negative regulation imposed on the L4P by cellular TFII-

49 VISTA and examine its function in lymphocyte negative regulation in cancer.

50 Our work identifies novel sites of negative regulation in MYC and thus new sites for its th

51 tronic mRNA isoforms may represent a form of negative regulation in plants, providing a conceptual li

52 internal dynamics leads to poorer allosteric negative regulation in V66A/L68V CzrA.

53 One mechanism of negative regulation involves phosphorylation of the link

54 This negative regulation is achieved by the formation of Ure2

55 virus (HCV) core and NS5A proteins, and this negative regulation is apparent in chronically HCV-infec

56 Negative regulation is lost by effector binding to the c

57 This negative regulation is mediated by the induction of the

58 Infants in whom this negative regulation is strongest manifest increased risk

59 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important roles in m

60 Pyrin is held in an inactive conformation by negative regulation mechanisms to avoid premature inflam

61 e events to changes in neuronal activity via negative regulation of a newly identified mitogen-associ

62 humans and mice, where it is involved in the negative regulation of Ab production and cellular activa

63 These results also reveal that negative regulation of ACLY and lipid synthesis is a nov

64 Through negative regulation of ACLY, CUL3 inhibits lipid synthes

65 ess whereas cellular component organization, negative regulation of actin filament depolymerization a

66 uations in these binding modes are linked to negative regulation of actin polymerization.

67 6a exerts a kidney protective effect through negative regulation of acute inflammatory response by su

68 ings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis un

69 ch may at least partially contributed to the negative regulation of AIM2 by RGFP966.

70 Fpk1-mediated negative regulation of Akl1 enhances endocytosis, becaus

71 eveals a novel nonenzymatic role of Aldob in negative regulation of Akt activation, suggesting that d

72 ied as being associated with positive and/or negative regulation of alternative splicing in a positio

73 ion of AMPKalpha at Ser-485, blocks cAMP-PKA negative regulation of AMPK, and improves metformin resi

74 reviously unrecognized role for USP21 in the negative regulation of antiviral response through deubiq

75 ever, the molecular mechanism underlying the negative regulation of aPKCs remains largely unknown.

76 wn-regulation of genes strongly enriched for negative regulation of apoptosis, angiogenesis, and meta

77 uency of autophagosome formation through its negative regulation of ATG9.

78 herefore, the data strongly suggest that the negative regulation of autophagy by sulfide is mediated

79 play vital roles in auxin signaling via the negative regulation of auxin response factors (ARFs).

80 development processes were up-regulated and negative regulation of axon extension processes were dow

81 The lack of negative regulation of BA synthesis may be accountable f

82 embryo myogenesis and uncover the concerted negative regulation of BAF60a and BAF60b by the muscle-s

83 rogram of gene expression exemplified by its negative regulation of Bcl6.

84 Our results reveal a new mechanism for the negative regulation of BCR signaling and broadly suggest

85 These results reveal a role of CD23 in the negative regulation of BCR signaling in the absence of I

86 ribution of C5aR and C5L2 indicates that the negative regulation of BDNF secretion by C5L2 correlates

87 APP limits venous thromboembolism through a negative regulation of both fibrin formation and neutrop

88 bioactive state is inhibited by LXR through negative regulation of both pro-caspase 1 expression and

89 enhanced in bp mutants, suggesting a direct, negative regulation of BP over SOBIR1/EVR expression.

90 of host gene myosin effects with evidence of negative regulation of cAMP-specific 3',5'-cyclic phosph

91 otein phosphatase (PP1), likely resulting in negative regulation of cAMP/calcium response element-bin

92 These data indicate that the negative regulation of cap-dependent translation by mTOR

93 cid signaling cross talk, is involved in the negative regulation of caterpillar resistance and in the

94 We demonstrated that negative regulation of CCL2 production by GPBAR1 agonism

95 CD4+ Th1 differentiation is associated with negative regulation of CD4+ Th2 and Th17 differentiation

96 ypoxia, activation of NF-kappaB pathway, and negative regulation of cell cycle, a gene signature also

97 ocess, regulation of peptidase activity, and negative regulation of cell death.

98 ctions induced by CHK2 variants impairs CHK2 negative regulation of cell growth.

99 ed in cellular amino acid metabolic process, negative regulation of cell proliferation and cell redox

100 ults reveal a novel function of KDM2B in the negative regulation of cell proliferation by assembling

101 ET5 and TET6 in leaf and root growth through negative regulation of cell proliferation.

102 Ghr-induced FOXO1 nuclear translocation and negative regulation of cell proliferation.

103 Negative regulation of cells in the mediastinal lymph no

104 the Tcf7 gene recapitulated Foxp3-dependent negative regulation of chromatin accessibility.

105 fear memory formation, suggesting that this negative regulation of contextual fear memory by AMPK in

106 Taken together, these studies establish negative regulation of CREB activity by endogenous CaMKI

107 D1 promoter, resulted in abolishment of the negative regulation of cyclin D1 by HIF-1alpha, which pr

108 cotine N-demethylation and suggests that the negative regulation of CYP82E4 expression may serve to r

109 Namely, TAM-mediated efferocytosis, negative regulation of dendritic cell activity, and dysr

110 ng that p180C and/or p70 are involved in the negative regulation of DNA pol activity.

111 The loss of negative regulation of Dnmt3a by miR-29a is a major cont

112 cal for maintaining HSC function through its negative regulation of Dnmt3a.

113 h signaling to control cell-cell adhesion by negative regulation of E-cadherin expression.

114 ndent tumor suppressor, mediates coordinated negative regulation of efferocytosis by resident murine

115 Finding a role for RpS6 in the negative regulation of efferocytosis provides the opport

116 LDH2 and Glu4Gly of BRAP are involved in the negative regulation of excessive alcohol consumption.

117 brate-specific protein unveil key aspects of negative regulation of exocytosis.

118 g Wnt and TGFbeta during early regrowth, and negative regulation of extracellular proteases in late s

119 he modification and its correlation with the negative regulation of FadD32 activity.

120 e that Gal3 is involved in both positive and negative regulation of FcepsilonRI-mediated signaling ev

121 the BBX19-CO interaction and eliminates the negative regulation of flowering time, while the analogo

122 nd human pre-B B-ALL cells that involves the negative regulation of FOXO1 by nuclear factor kappaB (N

123 sly described systems mostly on the basis of negative regulation of FtsZ assembly.

124 Negative regulation of gene expression by transcriptiona

125 Biological functions involved in negative regulation of gene expression were enriched in

126 e a novel transcriptional repressor-mediated negative regulation of glycolysis.

127 Together, the data suggest non-canonical, negative regulation of growth and reproduction by DPY-21

128 Furthermore, the dynamics and function of negative regulation of GTP-loaded K-Ras have not been fu

129 We identify negative regulation of GvHD-related neovascularization b

130 stimulated upon overproduction of DsrA, via negative regulation of H-NS, or of GadY, likely by titra

131 -regulated genes that could be involved in a negative regulation of heart morphogenesis.

132 both unique and overlapping functions in the negative regulation of heat tolerance, and their loss of

133 esults suggest that in contrast to the known negative regulation of HIF-2alpha in most cell types, hi

134 trating that EGLN1 dependency was related to negative regulation of HIF1A.

135 Negative regulation of HIF1alpha by AMPK1 is bypassed in

136 In this study, we explore the reciprocal negative regulation of HNF4alpha and cyclin D1, a key ce

137 t follicle rupture and ovulation through its negative regulation of Hnt and promotion of Ttk69 expres

138 programming revealed a significant degree of negative regulation of IFN-gamma-induced Ag presentation

139 rstood, and potential mechanisms involved in negative regulation of IL-31Ralpha signaling have so far

140 eventing multiorgan autoimmunity through its negative regulation of Il-6 gene expression in Fo B cell

141 ic effector cells and has been implicated in negative regulation of immediate hypersensitivity respon

142 Negative regulation of immune responses in cancer can be

143 that complement C5a directly participates in negative regulation of immune responses to bacteria-indu

144 firmed an important role for B-cell-mediated negative regulation of immunity.

145 L-35-producing B cells as key players in the negative regulation of immunity.

146 Thus, AnxA2 directly exerted negative regulation of inflammatory responses through TL

147 ncreased bacterial burden, inflammation, and negative regulation of innate immune cell recruitment to

148 Negative regulation of innate immunity is essential to a

149 protein tyrosine phosphatase involved in the negative regulation of insulin and leptin signaling.

150 cular disease have been described, including negative regulation of insulin signaling, a role in myoc

151 ance, cell-intrinsic molecular mechanisms of negative regulation of integrin adhesiveness and neutrop

152 stored integrin beta1 expression, suggesting negative regulation of integrin beta1 by FAK.

153 We hypothesized that negative regulation of IRS-2 activity after IL-4 stimula

154 del where BRD4 coordinates both positive and negative regulation of ISG elongation.

155 Ypk1, among other actions, alleviates negative regulation of L-serine:palmitoyl-CoA acyltransf

156 The negative regulation of leaf senescence by AtPAT14 in Ara

157 By contrast, BiP's negative regulation of leaf senescence may be linked to

158 binding protein exerting diverse effects via negative regulation of let-7 miRNAs and other RNA target

159 /b as a novel atheroprotective mechanism via negative regulation of LOX-1 signaling.

160 n, suggesting that Fie1 could be involved in negative regulation of MADS78 and MADS 79 Misregulation

161 rocess, which becomes the major mechanism of negative regulation of mature proliferating hematopoieti

162 LGP2's negative regulation of MDA5 and RIG-I remains intact irr

163 and palmitoylated protein kinase involved in negative regulation of membrane fusion at the lysosomal

164 pho-deficient Env7 mutants were defective in negative regulation of membrane fusion, increasing the n

165 Hypermethylation of the miR-137 promoter and negative regulation of miR-137 by CAR contribute in part

166 lded, leading to removal of the ECD-mediated negative regulation of MprB and subsequent activation of

167 t and an accumulation of RNA nucleotides and negative regulation of mRNA.

168 In contrast, negative regulation of mTORC1 signaling by DNA damage is

169 ution of endogenous TGF-beta proteins to the negative regulation of muscle mass via their activation

170 zero, was decreased, genes associated with a negative regulation of myelination, including c-Jun, Sox

171 disrupts the N-UBR7 interaction and relieves negative regulation of N.

172 for R-Ras in promoting autoimmunity through negative regulation of natural regulatory T cell numbers

173 Negative regulation of NCX1- mediated renal Ca(2+) absor

174 reviously unrecognized role for USP18 in the negative regulation of NF-kappaB activation by inhibitin

175 EF24 induced cell apoptosis along with negative regulation of NF-kappaB- X-linked inhibitor of

176 trophy/fibrosis through mechanisms involving negative regulation of NFAT activity in cardiomyocytes a

177 of Mfn2 deletion in HSCs, demonstrating that negative regulation of Nfat is the prime downstream mech

178 s unveil lipin-2 as a critical player in the negative regulation of NLRP3 inflammasome.

179 y, both LjEin2a and LjEin2b are required for negative regulation of nodulation and Ljein2a Ljein2b do

180 We further confirmed this negative regulation of Nrf2 by Hrd1 using Hrd1 condition

181 strates a novel signaling action for RGS6 in negative regulation of oncogene-induced transformation a

182 Our results show that negative regulation of OsARF18 expression by OsmiR160 is

183 in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.

184 erestingly, the PLS is also required for the negative regulation of p190A RhoGAP activity.

185 ta emphasize dual functions for Ptpn6 in the negative regulation of p38 mitogen-activated protein kin

186 gical signals and the mechanisms involved in negative regulation of P450s.

187 he p53 pathway and impede full-length MDM2's negative regulation of p53.

188 We propose that negative regulation of Par protein expression by miR-219

189 lanoma and uncover a novel mechanism for the negative regulation of PARK2 via the ERK1/2-ELK1 axis.

190 ulatory subunit PP2A-B'gamma is required for negative regulation of pathogenesis responses and for ma

191 ld be directly or indirectly involved in the negative regulation of PCD.

192 lex 1 (mTORC1)/p70 S6 kinase (p70S6K) in the negative regulation of PD-L1 on cancer cells and tissues

193 scriptional changes were consistent with the negative regulation of peroxisome proliferator-activated

194 A model where H2O2 mediates the negative regulation of plant responses to prolonged stre

195 pendent gene expression, indicating that the negative regulation of plasmid-dependent genes is a comm

196 Thus, negative regulation of postinitiation mRNA biogenesis ca

197 sustain glutamate release at TC synapses via negative regulation of presynaptic adenosine signaling t

198 of PD-1 and CTLA-4 that were associated with negative regulation of proliferation in all patients, ir

199 ation of actin filament depolymerization and negative regulation of protein complex disassembly are i

200 ciates with polysomes and contributes to the negative regulation of protein synthesis.

201 trols actin and microtubule dynamics through negative regulation of Rac.

202 effector Stat5, providing a link between the negative regulation of Rag transcription by IL-7 and a n

203 NF1 is essential for negative regulation of RAS activity and is altered in ab

204 depend on G-coupled receptor kinase-mediated negative regulation of receptor signaling and contrasted

205 Negative regulation of receptor signaling is essential f

206 At present, the knowledge on the negative regulation of reprogramming process is indeed p

207 ented here suggest a novel role for IFI35 in negative regulation of RIG-I-mediated antiviral signalin

208 complex, but it was involved in positive and negative regulation of RNA granule assembly by being pho

209 These data reveal a newly defined negative regulation of RUNX1/CBFbeta by MLL fusion prote

210 the transcriptional program associated with negative regulation of Schwann cell maturation.

211 t is unable to do so in trans Therefore, the negative regulation of seed dormancy by asDOG1 in cis re

212 for Cdc42 in membrane remodeling through the negative regulation of selected endocytic pathways.

213 these results reveal a role for WFS1 in the negative regulation of SERCA and provide further insight

214 dependent under all conditions tested, while negative regulation of sigma(70) is DksA- but not (p)ppG

215 ily of adaptors is generally involved in the negative regulation of signaling pathways.

216 cells; however, the mechanism underlying the negative regulation of signaling remains elusive.

217 of the signaling molecules Jak1 and Jak3 and negative regulation of signaling via Jak and the transcr

218 in yeast seipin mutants, suggesting that the negative regulation of sphingolipid synthesis by seipin

219 onosiga brevicollis Our results suggest that negative regulation of Src by Csk is more ancient than p

220 emically-induced skin carcinogenesis via the negative regulation of STAT3 and AKT signaling.

221 To date, the negative regulation of STAT3 is poorly understood.

222 Our studies implicate myeloid PTP1B in negative regulation of STAT3/IL-10-mediated signaling, h

223 Our data provide a unique mechanism for the negative regulation of STING-mediated DNA sensing.

224 tes this developmental stage by positive and negative regulation of superenhancers with distinct line

225 the paradigm of NCR function to include the negative regulation of symbiotic persistence in host-str

226 Thus, we have defined a novel mechanism of negative regulation of T cell function by endogenous bra

227 ratinocyte proliferation, wound healing, and negative regulation of T-cell activation showed a signif

228 downregulation of IFN receptor (IFNAR)-2 and negative regulation of T-cell receptor signaling.

229 These findings unveil the negative regulation of TBK1 via tyrosine phosphorylation

230 These data reveal cooperation of negative regulation of TBP with specific chromatin regul

231 These findings therefore show that negative regulation of TCR signaling during NKT developm

232 ultiple influences on T-cell fate, including negative regulation of Tfh cell differentiation.

233 The negative regulation of TG2 by GPR56 associates with the

234 ppressor function of alphaE-catenin involves negative regulation of the beta4 integrin-SRC signaling

235 ffeine decreases miR-301b expression through negative regulation of the cAMP/PKA/NF-kappaB axis.

236 GC-binding interface on RD3 required for the negative regulation of the cyclase localizes to the Lys(

237 ene containing the miR-15a/16-1 loci, and by negative regulation of the Dleu2 promoter, results in re

238 N, consistent with the CEN/SN's hypothesized negative regulation of the DMN.

239 poptosis, and differentiation, primarily via negative regulation of the downstream effectors, Yes-ass

240 This negative regulation of the Hippo pathway by fibronectin

241 or collectively, to immune homeostasis: the negative regulation of the innate immune response, the p

242 We also explore further the negative regulation of the L4P by its products and show

243 inflammatory signaling, with emphasis on the negative regulation of the NF-kappaB pathway and the NLR

244 is a well known tumor suppressor through the negative regulation of the PI3K signaling pathway.

245 n various non-ribosomal functions, including negative regulation of the pro-apoptotic transcription f

246 Here, we showed the synergistic negative regulation of the pro-inflammatory cytokine int

247 inhibits Rac/STAT-1 activation, leading to a negative regulation of the production of TNF-alpha and N

248 Our findings implicate USP44 in negative regulation of the RNF8/RNF168 pathway and illus

249 d translation/host cell cytotoxicity through negative regulation of the Ser/Arg (SR)-rich protein kin

250 Inappropriate stimulation or defective negative regulation of the type I interferon response ca

251 BR1, suggesting that DydA is involved in the negative regulation of these pathways.

252 These data suggest the existence of a negative regulation of this cross talk between OCN and i

253 f increased Wnt/beta-catenin signalling, and negative regulation of this pathway results in restorati

254 rabidopsis thaliana, where it contributes to negative regulation of this process.

255 ever, inappropriate stimulation or defective negative regulation of this system can lead to inflammat

256 pathways demonstrate distinct mechanisms of negative regulation of TLR responses, and all impact aut

257 ect dimerization of BCAP TIR is required for negative regulation of TLR signaling.

258 cumulation in rafts, thereby determining the negative regulation of TLR4 signaling.

259 l module, which is required for positive and negative regulation of transcription, correct preinitiat

260 We previously established a mechanism of negative regulation of transforming growth factor beta s

261 In accord with its negative regulation of translation, dTau loss specifical

262 h OX40L and TSLP have been implicated in the negative regulation of Treg.

263 role of the DNA damage response (DDR) in the negative regulation of tumorigenesis.

264 s on the emerging mechanisms involved in the negative regulation of type 2 immunity.

265 ting host resistance to tuberculosis through negative regulation of type I IFN production.

266 enetic events linked to a novel mechanism of negative regulation of VDR-mediated transcription.

267 hile PTP1B siRNA increased both, implicating negative regulation of VEGFR2 by PTP1B.

268 in E. amylovora virulence and suggested that negative regulation of virulence by GacS/GacA acts throu

269 o understand the molecular mechanism for the negative regulation of Wg signaling by Sulf1, we studied

270 tructural and functional differentiation via negative regulation of Wg trans-synaptic signaling in th

271 ic map of gene function revealed TRAF2/c-REL negative regulation of YAP1/WWTR1-responsive pathways.

272 iquitin-dependent protein catabolic process, negative regulations of cellular catabolic process, and

273 The positive and negative regulations of some chromosomal genes by pGP4 a

274 angl2 (Vang-like 2) exerts dual positive and negative regulation on Dvl during CE in both the mouse a

275 Leptin is also known to exert a negative regulation on hypothalamic endocannabinoid leve

276 Our data suggest that IL-21 exerts negative regulation on IRF4 and Treg activity, developin

277 responses are more persistent due to lack of negative regulation on pro-IL-1beta expression.

278 at the dCas9 effectors can exert positive or negative regulation on the expression of developmentally

279 Ca(2+) also exerts negative regulation on the olfactory transduction cascad

280 urthermore, let-7-Fam miRNAs appear to exert negative regulation on the worm's resistance to P. aerug

281 miR-200b exerted a negative regulation on tumor-induced angiogenesis.

282 This negative regulation, on grooved topography, was reversed

283 ctively, our data indicate that CD151 exerts negative regulation over IgE-induced late phase response

284 ontelomeric pol-I-transcribed genes, whereas negative regulation primarily affected VSGs.

285 This novel negative regulation principle might balance TNF-induced

286 r signaling components of efferocytosis, its negative regulation remains incompletely understood and

287 pressed or depleted, indicating positive and negative regulation, respectively.

288 However, the mechanisms of negative regulation that differentiate between TLR7 and

289 pansion and the action of various sources of negative regulation that hold it in check.

290 ion proceeds firstly via pathways subject to negative regulation, then via promoter mutations and gen

291 Neurogenesis requires negative regulation through differentiation of progenito

292 kinases and its correlation with the enzyme-negative regulation, thus shedding a new horizon on the

293 How plants overcome this negative regulation to mount an effective defense respon

294 nalling is subject to stringent positive and negative regulation to promote proper development and ho

295 Loss of this negative regulation under ER stress increases capacity f

296 more, the model suggests that impairing this negative regulation will drive a bifurcation which may r

297 Such collective negative regulation will help to ensure that recombinati

298 trosome-associated SYS-1 degradation couples negative regulation with cell-division timing to facilit

299 igen/integrin receptor pathway and increased negative regulation within the Akt1 pathway in CD4(+) T

300 , downregulation of MRTF-A/B alleviates this negative regulation without further translocation of NF-