ライフサイエンスコーパス: negative regulator

1 has been described as both RLR cofactor and negative regulator.

2 y dormant functionally, due to IFN-I-induced negative regulators.

3 We demonstrate that NADP(+) acts as a negative regulator and suppresses ADP-ribosylation both

4 nd lateral organ initiation via positive and negative regulators and network integrators.

5 results present a comprehensive list of NRF2 negative regulators and reveal an intimate link between

6 hat the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the protea

7 how these regulator proteins, especially the negative regulators, are induced by upstream transcripti

8 ectively, can directly recruit TRAF6 and its negative regulator ARRB2 to form a multi-protein complex

9 Pi promoted beclin 1 binding to its negative regulator BCL2, which impairs autophagy flux.

10 ensin-converting enzyme 2 (ACE2) is a potent negative regulator capable of restraining overactivation

11 A number of positive and negative regulators control syp expression and biofilm f

12 Signalling via ERK1/2 and tuning by its negative regulator DUSP4 are critical elements of the VI

13 Endothelial miR-15a/16-1 cluster is a negative regulator for postischemic cerebral angiogenesi

14 we identified a new function of seipin as a negative regulator for sphingolipid production.

15 uncated form of GGA1 behaviors as a dominant-negative regulator for the cell surface export of alpha(

16 tably, our screen revealed both positive and negative regulators for the nuclear speckle localization

17 Here, we present the identification of a negative regulator from rice, which operates downstream

18 We show that ABI1, a negative regulator in abscisic acid (ABA) signaling, dep

19 te receptor, WDR23, as both a positive and a negative regulator in cellular stress responses.

20 teracts with NIM1-INTERACTING1 (CsNIMIN1), a negative regulator in the SA signaling pathway.

21 3 (38%), JAK1 (18%), and STAT5B (3%), and in negative regulators, including SOCS3 (6%), SOCS1 (3%), a

22 ed for innate immunity transcripts and their negative regulators, including those for Toll, melanizat

23 om blocking the interaction of NRF2 with its negative regulator, KEAP1 (Kelch-like ECH-associated pro

24 nical Wnt signalling by interfering with the negative regulator Kremen and increasing cell-surface le

25 Deletion of YAP1's negative regulators LATS1 and LATS2 kinases in NEX-Cre l

26 egulation and marked downregulation of MYC's negative regulator miR-34a, a p53 transcription target.

27 characterised by frequent Wnt/ beta catenin negative regulator mutations, TET2 mutations, mismatch r

28 sponse by controlling the homeostasis of the negative regulator MYB15.

29 e results indicate that CD137 functions as a negative regulator of "browning" in white adipose tissue

30 We hypothesized that ZFP36L1 is a negative regulator of a posttranscriptional hub involved

31 ntified SAB1 (Sensitive to ABA 1) as a novel negative regulator of ABI5 that simultaneously regulates

32 a previous model describing CH2 as a steric negative regulator of actin binding, we find that utroph

33 entify the ubiquitin-editing enzyme A20 as a negative regulator of acute NF-kappaB activation downstr

34 ), indicating that barr2 represents a potent negative regulator of adipocyte beta3-AR activity in viv

35 olipid-binding protein annexin A3 (AnxA3), a negative regulator of adipocyte differentiation, is down

36 anti-inflammatory microRNA, is shown to be a negative regulator of adipocyte inflammation.

37 enes, including Aar, which in turn acts as a negative regulator of AggR itself.

38 hat checkpoint kinase 2 (CHK2) is a critical negative regulator of androgen receptor (AR) transcripti

39 ed mice showed an enhanced expression of the negative regulator of angiogenesis, soluble VEGF recepto

40 ant antiviral immunity, acts as an important negative regulator of antibacterial immunity.

41 Our findings suggest that BIR1 acts as a negative regulator of antiviral defense in plants, and i

42 mycin complex 1 (mTORC1) is a well-conserved negative regulator of autophagy.

43 ase and kinase (STRIPAK) complex as a potent negative regulator of axis length.

44 ogether, our data show that Vangl2 acts as a negative regulator of axonal outgrowth by regulating the

45 Our results reveal a role of PHOSPHO1 as a negative regulator of BAT thermogenesis, and inhibition

46 erexpression of SPARC down-regulated RGS4, a negative regulator of beta-cell M3 muscarinic receptors.

47 ation regulatory factor (Smurf)1 is a master negative regulator of BMP signaling, but how its stabili

48 ost mRNA(100-fold) and sclerostin protein, a negative regulator of bone formation(5000-fold), compare

49 IL-33 was a potent negative regulator of both CD8(+) T cell and Th1 respons

50 uggest a novel role for RAB23 as an upstream negative regulator of both FGFR and canonical Hh-GLI1 si

51 we identified E3 ubiquitin ligase IDOL as a negative regulator of brain lipoprotein receptors.

52 ant growth and stress responses by acting as negative regulator of Ca signalling and homeostasis.

53 rotein PDE4B (phosphodiesterase 4B) is a key negative regulator of cardiac beta-adrenergic receptor s

54 Our results identify HSC70 as a negative regulator of caspase-1 activation by the temper

55 results demonstrate that the CTK complex is negative regulator of cat-3 expression by affecting its

56 ooled genetic screen and identify Ptpn2 as a negative regulator of CD8(+) T cell-mediated responses t

57 n for its role in stem-cell renewal and is a negative regulator of cell differentiation.

58 owed that the transcription factor CUC3 is a negative regulator of cell growth and that its expressio

59 The p27 protein is a canonical negative regulator of cell proliferation and acts primar

60 explain this effect, we identify TRIM37 as a negative regulator of centrosomal pericentriolar materia

61 We reveal RNF41 is a negative regulator of Clec9A and the cross-presentation

62 e previously found that the loss of Limk1, a negative regulator of cofilin, accelerates the rate of s

63 homa (c-Cbl) is an E3 ubiquitin ligase and a negative regulator of colorectal cancer (CRC).

64 However, the negative regulator of Ctgf remains unclear.

65 PRKCQ, but not KIT, was a negative regulator of cyclin D1 expression, whereas JUN

66 iacylglycerol (DAG) kinase zeta (DGKzeta), a negative regulator of DAG-mediated cell signaling, prote

67 In accordance with E2F1 being a negative regulator of DC maturation, C/EBPbeta(-/-) bone

68 est and DNA damage-45 alpha (GADD45alpha), a negative regulator of DeltaNp63alpha by interacting with

69 ied the conserved Ste20-like kinase Tao as a negative regulator of dendritic arborization.

70 showed that Rem2 is an experience-dependent negative regulator of dendritic segment number during th

71 positive regulator of dendritic length and a negative regulator of dendritic segments.

72 en together, these findings place PAI-1 as a negative regulator of eNOS and disruptions in eNOS-PAI-1

73 co-regulates genes in ISCs, including Cbl, a negative regulator of Epidermal Growth Factor Receptor (

74 poorly characterized tetraspanin, acts as a negative regulator of exosome release, supporting the ly

75 with robust induction of Homothorax (Hth), a negative regulator of eye fate.

76 nf20, an E3 ubiquitin ligase, can serve as a negative regulator of Foxp3.

77 -AR-driven prostate cancer that centers on a negative regulator of G protein-coupled receptors that i

78 NLRC5 is a negative regulator of gastric inflammation and mucosal l

79 relate of severity in T2D patients, and as a negative regulator of glucose uptake by skeletal muscle,

80 In these cells, DA functions as a negative regulator of glucose-stimulated insulin secreti

81 glycogen synthase kinase 3beta (GSK3beta), a negative regulator of glycogen synthesis.

82 ese experiments revealed that PDE1 is also a negative regulator of growth.

83 PTCH1, a negative regulator of Hh signaling, is an NRF2 target ge

84 sted that the histone acetyltransferase is a negative regulator of Hippo pathway (HP) gene expression

85 IU1 caused degradation of TDP-43, a negative regulator of HIV-1 transcription.

86 insoluble fraction and presumably titrate a negative regulator of Hsf1, the Hsp70 chaperone.

87 s role as a component of IL-27, can act as a negative regulator of humoral and cellular responses dur

88 tioning as an antiviral effector, ISG15 is a negative regulator of IFN signaling, and inherited ISG15

89 IL-21 was a critical negative regulator of IgE responses, whereas IFN-gamma,

90 s in the gene encoding IL-36RA, an important negative regulator of IL-36 signaling.

91 ressor of cytokine signaling 3 (SOCS3)-a key negative regulator of IL-6 signaling.

92 indicate that endogenous CGRP is a critical negative regulator of ILC2 responses in vivo.

93 In this study, we identify miR-146a as a negative regulator of immune activation, comparable to i

94 PN6) gene, also known as SHP-1, an important negative regulator of immune processes.

95 a-induced-protein 8-like 2), identified as a negative regulator of immune response, has been found to

96 olic pathogen sensor NLRP12 has emerged as a negative regulator of inflammation, but its role in HCC

97 al domain 2 (CITED2) as a critical intrinsic negative regulator of inflammation, which broadly attenu

98 maintenance of oral tissue homeostasis as a negative regulator of inflammation.

99 redicted target is Pellino3 (PELI3), a known negative regulator of inflammation.

100 lated by itchy E3 ubiquitin ligase (ITCH), a negative regulator of inflammation.

101 ss III NAD-sirtuin 1 (SIRT1) is an important negative regulator of inflammation; however, SIRT1 activ

102 estigated miR-147-3p (now termed miR-147), a negative regulator of inflammatory cytokines (e.g., inte

103 an intracellular member of NLR family, is a negative regulator of inflammatory signaling pathways in

104 results identify IFN-I-inducible TRIM21 as a negative regulator of innate immune responses to S Typhi

105 itin ligase TRIM21 plays a crucial role as a negative regulator of innate immune responses.

106 hosphatase and tensin homologue 10 (PTEN), a negative regulator of insulin signalling, in the KA mous

107 hese results identify Basigin as a potential negative regulator of integrin in the glia, supporting p

108 ein (CIS; encoded by the gene CISH) is a key negative regulator of interleukin-15 (IL-15) signaling i

109 gical analyses indicated that EHB1 acts as a negative regulator of iron acquisition.

110 s and their substrates, confirming PstP as a negative regulator of kinase activity and global serine

111 erol, or downstream derivatives, acting as a negative regulator of lateral root emergence.

112 onstrate here that LACCASE2 (LAC2) acts as a negative regulator of lignin deposition in root vascular

113 an X-linked E3 ubiquitin ligase acting as a negative regulator of LIM-domain containing transcriptio

114 ponse to adipogenic treatment and may act as negative regulator of lipid storage in ccRCC cells.

115 rnalized, AimP reduces the expression of the negative regulator of lysogeny, AimX, by binding to the

116 ggest an important role of mutant LRRK2 as a negative regulator of lysosomal GCase activity.

117 of human signal regulatory protein alpha, a negative regulator of macrophage phagocytosis allowing r

118 Here, we identify p31(comet), a negative regulator of MAD2 and the spindle assembly chec

119 l candidate molecules, including Inhibin A-a negative regulator of Matrilin-2.

120 Here, we show that in HEMs, OPN3 acts as a negative regulator of melanin production by modulating t

121 other codependently secreted factors) is the negative regulator of miR-147.

122 SNPH), a molecule originally identified as a negative regulator of mitochondrial dynamics in neurons,

123 hosphatase and tensin homolog (PTEN) gene, a negative regulator of mTOR signaling, are prone to devel

124 G, whereas several genes associated with the negative regulator of mTOR, AMP-activated protein kinase

125 lopment of DNA damage responses 1 (REDD1), a negative regulator of mTOR/protein kinase B, is poorly u

126 Here, we identify c-Maf as a crucial negative regulator of murine T-bet(+) CCR6(-) ILC3s.

127 Myostatin is a negative regulator of muscle growth, and its inhibition

128 Inhibition of myostatin, a negative regulator of muscle mass, offers a promising ap

129 usly identified LYN tyrosine kinase as a key negative regulator of myeloid cell biology; however, LYN

130 xpression revealed that PA200 functions as a negative regulator of myofibroblast differentiation of h

131 report that the E3 ligase MARCH2 is a novel negative regulator of NEMO-mediated signaling upon bacte

132 Unexpectedly, one top hit was Traf3, a negative regulator of NF-kappaB signaling that has never

133 vated by targeted deletion of A20/Tnfaip3, a negative regulator of NF-kappaB signaling.

134 In this study, we identify Abin-1, a negative regulator of NF-kappaB, as an interaction partn

135 Our previous studies suggested that NRARP, a negative regulator of Notch signaling, could have a supp

136 d WD40 repeat domain containing-7 (FBXW7), a negative regulator of NOTCH1, is mutated in 2% to 6% of

137 rs (NSCLC) harboring mutations in KEAP1, the negative regulator of NRF2.

138 Our identification of EGLN3, a known negative regulator of nuclear factor kappaB (NF-kappaB),

139 f human skin cancer given that it is a major negative regulator of oncogenic signaling.

140 lular auxin carrier PIN-LIKES 6 (PILS6) is a negative regulator of organ growth and that its abundanc

141 Together, these findings identify BCL6 as a negative regulator of oxidative metabolism and reveal th

142 ly mitigated by MUSASHI-1 (MSI1) acting as a negative regulator of p21(Waf1/Cip1) mRNA translation, w

143 clib alters the pre-mRNA splicing of MDM4, a negative regulator of p53, leading to decreased MDM4 pro

144 The negative regulator of p53, MDM2, is frequently overexpre

145 ctively, these findings identify Sema3d as a negative regulator of parathyroid growth.

146 fied CD22, a canonical B cell receptor, as a negative regulator of phagocytosis that is upregulated o

147 mutants of BBX31 indicate that it acts as a negative regulator of photomorphogenesis under white lig

148 r results identify a novel role for tec-1 as negative regulator of planarian adult neurogenesis.

149 ify the conserved tyrosine kinase tec-1 as a negative regulator of planarian neuronal regeneration.

150 Hence, we propose that PLDgamma1 acts as a negative regulator of plant immune responses in complex

151 n vitro assays, and StMKK1 was shown to be a negative regulator of plant immunity, as determined by o

152 StMKK1 is a negative regulator of plant PTI, and the kinase activiti

153 cyte domain is a key feature, and Fgf10 is a negative regulator of postnatal hypothalamic neurogenesi

154 thalamic patterning, identifying Nkx2.1 as a negative regulator of prethalamic identity.

155 findings collectively show that Sema3E is a negative regulator of protective CD4(+) Th1 immunity in

156 NORAD acts as a negative regulator of PUMILIO (PUM) proteins in the cyto

157 RADX is also a negative regulator of RAD51-mediated homologous recombin

158 2 substrate preference for Sprouty1, a known negative regulator of Ras signaling and a potential tumo

159 In conclusion, RASA1 functions as a negative regulator of Ras signaling in EC that is necess

160 RASA1, a negative regulator of Ras-MAPK signaling, is essential f

161 Negative regulator of reactive oxygen species (NRROS) is

162 Here, we identify the TRIP13 ATPase as a negative regulator of REV7.

163 TPases) SPV-1 was previously identified as a negative regulator of RHO-1/Rho and spermathecal contrac

164 The negative regulator of RNA polymerase (pol) III mafr-1 ha

165 We report that PNUTS-PP1 phosphatase is a negative regulator of RNA polymerase II (Pol II) elongat

166 MAF1 homolog, negative regulator of RNA polymerase III (MAF1) is a key

167 mediates the transcriptional repression of a negative regulator of root branching, IAA27, and promote

168 ACTING RECEPTOR-LIKE KINASE1 (BIR1), a known negative regulator of SERK-SOBIR1 signaling.

169 binding partner of mTOR that functions as a negative regulator of signaling responses.

170 thdrawal by virally overexpressing SRCIN1, a negative regulator of SRC activity known to interact wit

171 r, our findings demonstrate that TRIC-A is a negative regulator of STIM1/Orai1 function.

172 The results suggest that OsCADT1 acts as a negative regulator of sulphate/selenate uptake and assim

173 Here, we show that Stromalin functions as a negative regulator of synaptic vesicle (SV) pool size in

174 Blimp-1 is a pivotal negative regulator of T(H)9 differentiation and controls

175 s identify ZAP-70-associated Rasal1 as a new negative regulator of T-cell activation and tumor immuni

176 onses in the tumor microenvironment and as a negative regulator of T-cell tumor infiltration and pati

177 and mice with a knockout of CD59, which is a negative regulator of TCC formation, were used in this s

178 These data identify Trib1 as a negative regulator of TCR signaling and downstream funct

179 C-terminal Src kinase (CSK), a negative regulator of TCR signaling, was identified as a

180 d GABARAPs countered the action of mTOR as a negative regulator of TFEB.

181 the transcription factor Bach2 as a central negative regulator of Tfh cells.

182 a meningitidis virulence factor that binds a negative regulator of the alternative complement pathway

183 ypanosome receptor for mammalian factor H, a negative regulator of the alternative pathway.

184 asymmetry during gravitropism by acting as a negative regulator of the cell-surface signaling mediate

185 me in the NAD salvage pathway, which acts as negative regulator of the CXCR4 retention axis of hemato

186 ing protein (GAP) activity toward Rags-1), a negative regulator of the cytosolic branch of the nutrie

187 vide direct evidence that C5L2 constitutes a negative regulator of the dentinogenic marker DMP1 (dent

188 ole for ST2(+) T(reg) cells in the lung as a negative regulator of the early innate gammadelta T cell

189 mic reticulum (ER), is a recently identified negative regulator of the ER-associated retinal pigment

190 ro studies implicated PLP2/DUB activity as a negative regulator of the host interferon (IFN) response

191 Programmed cell death protein 1 (PD-1) is a negative regulator of the immune response that may contr

192 These results imply that CD73 is a negative regulator of the inflammatory microenvironment,

193 r the circadian clock, driven by BMAL1, as a negative regulator of the ISG response, and highlight th

194 ecreased expression of Pten, which encodes a negative regulator of the kinase AKT.

195 Here, we reveal that IRGM/Irgm1 is a negative regulator of the NLRP3 inflammasome activation.

196 clerostin, encoded by Sost gene, is the main negative regulator of the proformative and antiresorptiv

197 mutations of the RASA1 gene, which encodes a negative regulator of the Ras signaling pathway, cause b

198 ested to selectively bind KRAS4b to act as a negative regulator of the RAS/mitogen-activated protein

199 We identified the Notch ligand Dll4 as a negative regulator of the recruitment phase of IAHC.

200 ed Ang converting enzyme 2 (ACE2), the major negative regulator of the renin-Ang system (RAS), as an

201 MCJ is an endogenous negative regulator of the respiratory chain Complex I th

202 tase that is traditionally perceived to be a negative regulator of the same processes.

203 Therefore, XVP functions as a negative regulator of the TDIF-PXY module and fine-tunes

204 Our results thus identify p73 as a negative regulator of the Th1 immune response, suggestin

205 e mice exhibited elevated levels of Smad7, a negative regulator of the transforming growth factor-bet

206 is a key oncogenic protein that serves as a negative regulator of the tumor suppressor p53.

207 ubiquitin ligase RING domain, is a critical negative regulator of the type I IFN response in Mus mus

208 Carboxylesterase Notum is a negative regulator of the Wnt signaling pathway.

209 nary conserved serine/threonine kinase and a negative regulator of the Wnt signaling pathway.

210 poiesis and lymphoid activation, acting as a negative regulator of the Wnt/beta-catenin pathway.

211 Our findings demonstrate that EphA4 is a negative regulator of Tie2 receptor signaling, which lim

212 highly expressed in inflamed joints and is a negative regulator of tissue damage in a mouse model of

213 ne how IL-1R-associated kinase-M (IRAK-M), a negative regulator of TLR signaling, modulates monocyte

214 rase reporter assay indicates that POGZ is a negative regulator of transcription.

215 tion factor 4E-binding protein 1 (4E-BP1), a negative regulator of translation.

216 ge-upregulated phosphatase ALPL, a predicted negative regulator of transport, enhances brain uptake o

217 SOCS1 is an essential negative regulator of type I and type II IFN signaling.

218 ties of the human deubiquitinase A (DUBA), a negative regulator of type I interferon.

219 Negative regulator of ubiquitin-like protein 1 (NUB1) an

220 Our discovery of PTPRK as a negative regulator of Wnt receptor turnover provides a r

221 carboxylesterase Notum was shown to act as a negative regulator of Wnt signaling by mediating the rem

222 e transmembrane E3 ubiquitin ligase ZNRF3, a negative regulator of Wnt signaling promoting Wnt recept

223 Here, we identify USP7 as a potent negative regulator of Wnt/beta-catenin signaling through

224 Under basal conditions, DYRK1A is a negative regulator of Wnt/beta-catenin.

225 a WW domain-containing protein, STXBP4, as a negative regulator of YAP.

226 We also identified the microRNA miR-30e as a negative regulator of Zdhhc21 expression.

227 und revealed that, in planta, both forms are negative regulators of abscisic acid-induced SnRK2 activ

228 Negative regulators of adult neurogenesis are of particu

229 diate proteasomal degradation of one or more negative regulators of AdV infection.

230 F-1) and c-Myc, yet the impact of hypoxia on negative regulators of angiogenesis is unknown.

231 Further, pharmacological inhibition of two negative regulators of antigen presentation, EZH2 and th

232 est that these same checkpoints are critical negative regulators of atherosclerosis.

233 ally targeted CSK, SHP-1 and HPK1, which are negative regulators of BCR signaling.

234 of mitotic entry due to overaccumulation of negative regulators of cell cycle such as Wee1-like prot

235 found that mammalian cryptochromes are also negative regulators of CRL4(Cop1), and through this mech

236 type-A response regulators (type-A ARR) are negative regulators of cytokinin signaling that are tran

237 ated to axillary bud dormancy in the SAM and negative regulators of cytokinin signaling.

238 ell-cell adhesion, whereas the expression of negative regulators of E-cadherin was decreased.

239 Several positive and negative regulators of FLS2-signaling play similar roles

240 ors, Polycomb group (PcG) proteins are major negative regulators of gene expression in mammals.

241 Our work reveals GPRASP proteins as negative regulators of HSCT and CXCR4 activity.

242 iated sorting proteins (GPRASPs) function as negative regulators of HSCT.

243 3A mRNAs as well as IFN-lambda receptors and negative regulators of IFN signaling.

244 suppressor cells (MDSC) are one of the major negative regulators of immune responses during many path

245 zed HOS15 and its associated protein HDA9 as negative regulators of immunity and NLR gene expression.

246 ission transcriptomic signatures enriched in negative regulators of inflammation.

247 xpression through increased transcription of negative regulators of innate immune activity and change

248 (ATF3), and tribbles pseudokinase 3 (TRIB3), negative regulators of innate immune signaling, in HT-29

249 irus infection by directly targeting several negative regulators of IRF3 and STAT1 activities, includ

250 Here, we identify two negative regulators of light-induced PCD that modulate O

251 -LIKE KINASE3 (BIR3) receptor pseudokinases, negative regulators of LRR-RK signaling.

252 IC-DUX4 transcriptionally up-regulates these negative regulators of MAPK to dampen ERK activity, lead

253 A genetic screen for negative regulators of Mis4 yielded a CDK called Pef1, w

254 hus, we identified a network of positive and negative regulators of MYO18B mRNA expression which refl

255 Here, we show that tropomyosins act as negative regulators of myosin stack formation.

256 on promoter-proximal and -distal elements of negative regulators of neurogenesis.

257 results suggest that family members serve as negative regulators of neurotransmission, acting directl

258 g activates cAMP pathway and upregulates the negative regulators of NF-kappaB but does not influence

259 nd inactivate specific substrates, including negative regulators of NF-kappaB.

260 both CD160 and BTLA serve as non-overlapping negative regulators of NKT cells.

261 Additionally, they are negative regulators of nuclear RNAi triggered from exoge

262 High expression of X-linked negative regulators of p53 in wild-type TP53 cancers cor

263 We discovered MDM2 and MDM4, the canonical negative regulators of p53, as significant vulnerabiliti

264 Mechanistically, SGs may sequester negative regulators of paraspeckle formation, such as UB

265 -LIKE KINASES BIR2 and BIR3, which are known negative regulators of pattern-triggered immunity.

266 ur results reveal CAD7 subfamily proteins as negative regulators of plant immunity that are exploited

267 elta, suggesting that the Gbeta proteins are negative regulators of pPLAIIIdelta.

268 ns within GTPase-activating proteins (GAPs), negative regulators of RAS family members.

269 ely catalytically inactive, similar to known negative regulators of RNA editing.

270 (ORM) proteins, which have been known to be negative regulators of sphingolipid biosynthesis, act as

271 Negative regulators of stress signaling, such as ENHANCE

272 mmune homeostasis is partially maintained by negative regulators of T-cell activation, cytotoxic T-ly

273 lear accumulation of transcripts that encode negative regulators of the circadian clock, which are re

274 ignaling (SOCS) proteins that are well-known negative regulators of the JAK/STAT pathway.

275 ting mutations in the genes encoding TSC1/2, negative regulators of the mammalian target of rapamycin

276 d by mutations in TSC1 or TSC2, which encode negative regulators of the mTOR signaling pathway.

277 TGF-beta pathway were up-regulated, whereas negative regulators of the pathway were down-regulated u

278 Sproutys are negative regulators of the Ras/Raf/MAPK signaling pathwa

279 and Ang 1-7 (angiotensin 1-7) are endogenous negative regulators of the renin-angiotensin system exer

280 Both Rsu1 and RhoGAP18B are negative regulators of the small Rho-family GTPase, Rac1

281 r these proteins act directly as positive or negative regulators of the synthase has been unclear.

282 MDM2 and MDMX, negative regulators of the tumor suppressor p53, can wor

283 for genes that were previously identified as negative regulators of the type-II interferon response (

284 s of DNA-binding transcription factors or as negative regulators of transcription by interacting with

285 rminal (BET) BRD proteins, BRD2 and BRD4, as negative regulators of transcription-associated RNA-DNA

286 mplicated BC200 and the rodent analog BC1 as negative regulators of translation in both cell-based an

287 MELESS1 (TCL1) and TCL2, the two established negative regulators of trichome initiation, and reduce t

288 l negative feedback loop (TTFL) in which the negative regulators Per and Cry suppress their own expre

289 of PI3Kalpha and PI3Kbeta isoforms and their negative regulator phosphate and tensin homolog deleted

290 This network includes negative regulator RBP-J and positive regulators, NFATc1

291 th increased Gli3 repressor activity, a Hoxd negative regulator, resulting from increased Gli3 transc

292 ity to increase E2F signaling by binding E2F negative regulator Retinoblastoma-1 (RB).

293 Acc1 (acc1(S/A) ) or a deletion of the Acc1 negative regulator, Snf1 (yeast AMPK), shows elevated au

294 ositive regulators such as PBS3 and EDS1 and negative regulators such as NPR3 and NPR4.

295 By contrast, in individuals lacking these negative regulators, such as ISG15 or USP18, this siloed

296 NLRC3 is a negative regulator that attenuates type I interferon (IF

297 their target genes, we identify miR760 as a negative regulator that binds to a conserved site in ATX

298 t expression of tyrosine phosphatase SHP1, a negative regulator that normally limits the activation a

299 ng phenotype of lon-2, a gene that encodes a negative regulator that sequesters DBL-1.

300 n aar is more highly expressed, it acts as a negative regulator via AggR.