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1 cellular maturation in planarian stem cells (neoblasts).
2 out adulthood, mediated by their stem cells (neoblasts).
3  arise from a proliferative cell population (neoblasts).
4  in adult proliferating, regenerative cells (neoblasts).
5 quiring a population of proliferating cells (neoblasts).
6 sults in a dramatic reduction/elimination of neoblasts.
7 nstrate the migration and differentiation of neoblasts.
8  require a population of stem cells known as neoblasts.
9 ic principles of clonal growth of individual neoblasts.
10 ions, in response to BMP signaling, required neoblasts.
11 rate without memory or communication between neoblasts.
12 ion of pluripotent somatic stem cells called neoblasts.
13 regeneration is enabled by stem cells called neoblasts.
14 arts using a population of stem cells called neoblasts.
15 n abundant somatic stem cell population, the neoblasts.
16  cells, is extended during the cell cycle of neoblasts.
17  lineage capacity, and can give rise to zeta-neoblasts.
18 tion, which requires adult stem cells termed neoblasts.
19  specific cell type regeneration programs in neoblasts.
20 cause of the action of dividing cells called neoblasts.
21              Planarian regeneration requires neoblasts, a population of dividing cells that has been
22                 This capacity is mediated by neoblasts, a proliferative cell population that contains
23 nduced by Smed-histone-2B RNAi, resulting in neoblast ablation.
24 gene expression that are not associated with neoblast ablation.
25 stone-2B RNAi over a time course as means of neoblast ablation.
26 abilities of flatworms are closely linked to neoblasts - adult pluripotent stem cells that are the on
27 cent studies indicate that survival of a few neoblasts after sublethal irradiation results in the clo
28 egeneration requires adult stem cells called neoblasts and amputation triggers two peaks in neoblast
29 ly and gene expression signatures of somatic neoblasts and germline cells will be a valuable resource
30 sesses collectively pluripotent aPSCs called neoblasts and produces manipulable embryos.
31 ke (bruli) mRNA and protein are expressed in neoblasts and the central nervous system.
32 s response that induces the proliferation of neoblasts and the concomitant expansion of not only epid
33 ) and cell-cycle markers to label subsets of neoblasts and their progeny.
34           The molecular similarities between neoblasts and undifferentiated cells of other organisms
35 om the intestine to target tissues including neoblasts, and are required for tissue homeostasis and r
36 o, represented by somatic stem cells, called neoblasts, and germline cells.
37 symmetrically on the cytoplasmic membrane of neoblasts, and the ratio of asymmetric to symmetric cell
38                                              Neoblasts are adult stem cells (ASCs) in planarians that
39                                              Neoblasts are also heterogeneous, with subpopulations of
40                                              Neoblasts are an abundant, heterogeneous population of a
41                                At least some neoblasts are individually pluripotent.
42 hich indicate that at least some specialized neoblasts are likely clonogenic.
43  results challenge the notion that canonical neoblasts are necessary for flatworm regeneration and op
44                                    Planarian neoblasts are pluripotent, adult somatic stem cells and
45 of smedwi-2 blocks regeneration, even though neoblasts are present, irradiation-sensitive, and capabl
46 ding, or during the course of cell turnover, neoblasts are signaled to divide and/or differentiate, t
47                                              Neoblasts are stem cells in the planarian Schmidtea medi
48                                              Neoblasts are traditionally described by their morpholog
49 tudies confirm that the aPSCs, also known as neoblasts, are the source of differentiated cells and re
50  mediterranea embryogenesis, and report that neoblasts arise from an anarchic, cycling piwi-1+ popula
51 As and examine the roles of PIWI proteins in neoblast biology.
52                                     A single neoblast can rescue an entire animal depleted from stem
53                        Fate specification in neoblasts can be regulated through expression of fate-sp
54                     We find that specialized neoblasts can divide to produce progeny with asymmetric
55 e a model for neoblast pluripotency in which neoblasts can undergo specialization during the cell cyc
56 nscriptome profiling across development with neoblast cell-lineage tracing and identified a molecular
57  interference (RNAi) for genetic ablation of neoblast cells in Schmidtea mediterranea as an alternati
58 we analyze the overall expression profile of neoblast cells.
59 one-2B RNAi and validate their expression in neoblast cells.
60  population-based studies have revealed many neoblast characteristics, whether functionally distinct
61                        Furthermore, no known neoblast class was present in all neoblast colonies, sug
62                  We identified two prominent neoblast classes that we named zeta (zeta) and sigma (si
63 ikely functions as an essential regulator of neoblast clonal expansion.
64                             These clonogenic neoblasts (cNeoblasts) produce cells that differentiate
65                              Our analysis of neoblast colonies is consistent with a cell-intrinsic de
66 , no known neoblast class was present in all neoblast colonies, suggesting that pluripotency is not t
67                                       If the neoblasts comprise a uniform population of cells during
68       These findings indicate that planarian neoblasts comprise two major and functionally distinct c
69                        Dividing cells called neoblasts contain pluripotent stem cells and drive plana
70 anching flatworm lineage, lacks conventional neoblasts despite being capable of whole-body regenerati
71                                          How neoblast differentiation and clonal expansion are govern
72          A long-standing question is whether neoblasts directly sense and respond to the identity of
73 tology, expression of key polarity genes, or neoblast distribution.
74 lthough adult pluripotent stem cells, called neoblasts, drive long-term homeostatic tissue maintenanc
75                     Planarian stem cells, or neoblasts, drive the almost unlimited regeneration capac
76 rucial role for the functionality of somatic neoblasts during homeostasis and regeneration.
77            We investigated the provenance of neoblasts during Schmidtea mediterranea embryogenesis, a
78                                         Zeta-neoblasts encompass specified cells that give rise to an
79 growth factor (EGF) signaling during in vivo neoblast expansion mediated by Smed-egfr-3 (egfr-3) and
80  By contrast, recent data indicate that some neoblasts express lineage-specific transcription factors
81                                              Neoblasts express the conserved RNA regulatory PIWI prot
82 tion, reduced animal size, reduced number of neoblasts, fewer chromatoid bodies and increased levels
83 ng and identified a molecular trajectory for neoblast formation that includes transcription factors H
84 highly intermingled manner, with neighboring neoblasts frequently making divergent fate choices for t
85 es show that Smed-histone-2B RNAi eliminates neoblast gene expression with high specificity and discr
86                                  Our list of neoblast genes parallels their morphological features an
87               Knockdown of a selected set of neoblast genes, including Mlig-ddx39, Mlig-rrm1, Mlig-rp
88 otype revealed a striking anterior-posterior neoblast gradient.
89 ogeneous, with subpopulations of specialized neoblasts having different specified fates.
90 ched transcripts and behave differently than neoblasts in cell transplantation assays.
91 lastomeres gives rise to cells that resemble neoblasts in distribution, behavior, and gene expression
92 d BrdU labeling to study the distribution of neoblasts in the intact animal, as well as to directly d
93 e is not a large, slow-cycling population of neoblasts in the intact animal.
94 neoblasts to wounds, even in areas that lack neoblasts in the intact animal.
95  binding proteins is critical for regulating neoblasts in the planarian Schmidtea mediterranea.
96 ion uses a population of regenerative cells (neoblasts), including pluripotent stem cells.
97             Wound-induced gene expression in neoblasts, including that of runt-1, required SRF (serum
98 -induced genes was activated directly within neoblasts, including the Runx transcription factor-encod
99  have examined the proposal that a subset of neoblasts is arrested in the G2 phase of the cell cycle
100                        Fate specification in neoblasts is regulated by fate-specific transcription fa
101                  A characteristic feature of neoblasts is the presence of chromatoid bodies, large cy
102                  A characteristic feature of neoblasts is the presence of large cytoplasmic ribonucle
103 arge population of proliferative stem cells (neoblasts) is required for physiological tissue homeosta
104                   Our analyses indicate that neoblasts lacking Bruli can respond to wound stimuli and
105                     Although the presence of neoblast-like cells and whole-body regeneration in other
106 on profiling, we find that these schistosome neoblast-like cells express a fibroblast growth factor r
107 ing flatworms (for example, planarians), and neoblast-like cells have been described in some parasiti
108             Here we describe a population of neoblast-like cells in the trematode Schistosoma mansoni
109 egeneration and open up the possibility that neoblast-like cells may have evolved convergently in dif
110 re studies deciphering the function of these neoblast-like cells will have important implications for
111 ene is required for the maintenance of these neoblast-like cells.
112                                              Neoblast lineages arise as organogenesis begins and are
113 reatment inhibits regeneration and abrogates neoblast maintenance.
114 otency genes, which are considered canonical neoblast markers, are not expressed in dividing cells, b
115 oblasts and amputation triggers two peaks in neoblast mitoses early in regeneration.
116               These cells resemble planarian neoblasts morphologically and share their ability to pro
117 ose piRNAs for potentially critical roles in neoblast mRNA turnover.
118 ycle, it is also guided to another subset of neoblast mRNAs by antisense piRNAs and binds these witho
119             While SMEDWI-3 degrades numerous neoblast mRNAs in a homotypic ping-pong cycle, it is als
120 ing regeneration, promoting heterogeneity in neoblasts near wounds.
121                                              Neoblasts normally increase eye progenitor production fo
122 n of Smed-CHD4 with RNA interference (RNAi), neoblast numbers were initially normal, despite an inabi
123  cells from diverse organisms, in particular neoblasts of planarians (free-living relatives of schist
124 nnel gene expressed in the adult stem cells (neoblasts) of the planarian Schmidtea mediterranea.
125  expressed in the dividing adult stem cells (neoblasts) of the planarian Schmidtea mediterranea.
126                                              Neoblasts, originally defined as undifferentiated cells
127  peripheral localization of cells, including neoblasts, outside of the muscle layer.
128 is of these findings, we propose a model for neoblast pluripotency in which neoblasts can undergo spe
129 erous studies have examined genes underlying neoblast pluripotency, molecular pathways driving postmi
130                          We characterize the neoblast population by using antibodies recognizing SMED
131 on using pluripotent adult stem cells of the neoblast population, can reversibly scale body size over
132 pansion of the population of differentiating neoblast progeny and dysregulates expression of genes en
133 dramatic reduction in the numbers of certain neoblast progeny cells.
134 es should occur in multipotent, non-dividing neoblast progeny cells.
135 CHD4 was required for the formation of these neoblast progeny cells.
136 erve as a source of metabolites required for neoblast progeny differentiation.
137                                              Neoblast progeny generate new cells of blastemas, which
138 ting in response to wounding; smedwi-2(RNAi) neoblast progeny migrate to sites of cell turnover but,
139                           By contrast, sigma-neoblasts proliferate in response to injury, possess bro
140 homeostasis in intact animals and stem cell (neoblast) proliferation in amputated animals identifying
141 ferentiation into specific lineages disrupts neoblast proliferative capacity without inducing compens
142                                              Neoblasts provide an excellent system for in vivo study
143                             Subclustering of neoblasts recovers transcriptionally distinct subpopulat
144 anisms regulating the population dynamics of neoblasts remain largely unknown.
145 onse to any injury and that a second, local, neoblast response is induced only when injury results in
146 viously found that loss of SMEDWI-1 from the neoblasts results in accumulation of non-coding and aber
147 e, we find that FSTF expression is common in neoblast S/G2/M cell-cycle phases but less common in G1.
148                    Our findings suggest that neoblasts select their progenitor lineage based on a cel
149                   We characterize the rapid, neoblast-specific phenotype induced by Smed-histone-2B R
150                                              Neoblast stem cells and progenitor cells were mislocaliz
151 sion changes occurred even in the absence of neoblast stem cells, which are required for regeneration
152 lities of freshwater planarians are based on neoblasts, stem cells maintained throughout the animal's
153                                          One neoblast subset, showing enriched expression of the hist
154 rians, pluripotent somatic stem cells called neoblasts supply new cells for growth, replenish tissues
155  and single-cell transplantation to identify neoblasts that can form large descendant-cell colonies i
156 d to a population of adult stem cells called neoblasts that proliferate and differentiate to produce
157 ms contain a population of adult stem cells (neoblasts) that proliferate and generate cells of all ti
158     In addition to requiring new cells (from neoblasts), these feats require mechanisms that specify
159 e molecularly and functionally distinct from neoblasts: they express unique cohorts of early embryo e
160 ed in adult planarians by stem cells, called neoblasts, through their fate specification to eye proge
161       However, the proliferative response of neoblasts to amputation or growth stimulation in Smed-CH
162  analogue bromodeoxyuridine (BrdU), allowing neoblasts to be labeled specifically during the S phase
163 al profiling from over a thousand individual neoblasts to directly compare gene expression fingerprin
164 val was neither sufficient nor necessary for neoblasts to increase eye progenitor production.
165 flatworms, use pluripotent stem cells called neoblasts to maintain and regrow organs.
166 ults indicate that Smed-CHD4 is required for neoblasts to produce progeny cells committed to differen
167 narian regeneration is the specialization of neoblasts to produce specified rather than naive blastem
168 gest that SMEDWI-2 functions within dividing neoblasts to support the generation of cells that promot
169 response was characterized by recruitment of neoblasts to wounds, even in areas that lack neoblasts i
170   It is unknown how the collective output of neoblasts transit through differentiation pathways to pr
171                          Subsequently, these neoblasts were induced to divide and differentiate near
172 ies as early in the lineage as the epidermal neoblasts, with further pre-patterning occurring in thei

 
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