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1 ) or can diverge to generate a new function (neofunctionalization).
2 duplication and functional divergence (i.e. neofunctionalization).
3 s through gene duplication and their further neofunctionalization.
4 rom an ancestral LSS by gene duplication and neofunctionalization.
5 iability in protein complex formation drives neofunctionalization.
6 verse functional subdomains that resulted in neofunctionalization.
7 to investigate the times of CBP60 subfamily neofunctionalization.
8 tionary equilibria vs other outcomes such as neofunctionalization.
9 i, emphasizing both subfunctionalization and neofunctionalization.
10 tin molecular function due to redundancy and neofunctionalization.
11 e, suggesting that they may be the result of neofunctionalization.
12 nderappreciated process underpinning protein neofunctionalization.
13 with roles for both subfunctionalization and neofunctionalization.
14 to fully wired pathways upon duplication and neofunctionalization.
15 tion of these genes were preserved following neofunctionalization.
16 m the sterol pathway by gene duplication and neofunctionalization.
17 ying selection, limiting duplication and sub/neofunctionalization.
18 ne duplication event could allow for sub- or neofunctionalization.
19 t duplications that may have facilitated its neofunctionalization.
20 ental gene duplications, likely facilitating neofunctionalization.
21 hich are associated with regulatory sub- and neofunctionalization.
22 ne transfer and gene duplication followed by neofunctionalization.
23 d gene complexity is regained via subsequent neofunctionalization.
24 process of subfunctionalization and possibly neofunctionalization.
25 nalization but decreasing the probability of neofunctionalization.
28 c acceleration of evolution that accompanied neofunctionalization after a duplication of the nonverte
31 ne beta-synthase duplication, cysteine lyase neofunctionalization and cysteic acid decarboxylase co-o
33 Thus, our study highlights the importance of neofunctionalization and positive selection in the reten
34 ific gene duplication, subfunctionalization, neofunctionalization and pseudogenization of duplicated
35 ome, the other GmSHMT members have undergone neofunctionalization and subfunctionalization events.
36 ce occurs only in the presence of regulatory neofunctionalization and that in nonregulatory neofuncti
38 n and loss, by gene subfunctionalization and neofunctionalization, and by changes in protein targetin
39 embled from plant genes by gene duplication, neofunctionalization, and genome reorganization, rather
42 nalization) or emergence of novel functions (neofunctionalization) being the prevalent modes of evolu
43 s, we uncover how whole gene duplication and neofunctionalization can result in pathway bifurcation.
44 has the potential to explore the dynamics of neofunctionalization, characterize viral fitness landsca
45 city evolved in apicomplexan LDHs by classic neofunctionalization characterized by long-range epistas
47 1.7 million years (Myr) ago, followed by its neofunctionalization, created the current S locus assemb
49 cation of spermidine synthase and subsequent neofunctionalization early in the budding yeast Saccharo
50 igin of the betalain synthesis pathway, with neofunctionalization following gene duplications in the
53 on changes suggest that gene duplication and neofunctionalization have significantly shaped S. ciliat
55 porting this notion includes observations of neofunctionalization in bony fishes or crustaceans, and
56 ther vertebrate Crb proteins, representing a neofunctionalization in Crb biology during evolution.SIG
57 eromer formation have the potential to drive neofunctionalization in diverse classes of enzymes, sign
58 duplication of spermidine synthase and then neofunctionalization in lycophytes, coincident with the
61 ne duplication, supporting a common role for neofunctionalization in the long-term maintenance of gen
62 e relative roles of subfunctionalization and neofunctionalization in the retention of duplicate genes
63 hat LacD.1's adaptation represents a form of neofunctionalization in which duplication facilitated th
65 , in the case of the wollamide biosynthesis, neofunctionalization is initiated by intragenomic recomb
69 nvolved organisms by doubling gene dosage or neofunctionalization, it may also result in a simple div
70 men identity, indicating that GLO2 underwent neofunctionalization, likely at the level of the encoded
71 This allowed us to test predictions of the neofunctionalization model for gene duplication and para
72 l events that result in a new gene function (neofunctionalization) necessitates that the other gene c
77 t is derived from duplication and subsequent neofunctionalization of a member of the conserved DBHS f
78 e must have evolved from the duplication and neofunctionalization of a more promiscuous ancestral gen
79 nant mutation, which led to either hyper- or neofunctionalization of a redundant homoeologous gene.
80 ic anhydrase orthologous group reflected the neofunctionalization of ancient paralogs that have been
82 suggested that change in gene expression and neofunctionalization of capsaicin synthase have shaped c
83 ite on EPCOT3 has potentiated the regulatory neofunctionalization of CYP82C2 and the evolution of ind
84 Polyploidization and subsequent sub- and neofunctionalization of duplicated genes represent a maj
85 cies-specific genes and characterized by the neofunctionalization of expression patterns of members o
86 aspects related to the CYP79 gene losses and neofunctionalization of FMO-catalyzed biosynthesis of ox
87 biosynthesis evolved through recruitment and neofunctionalization of genes from gibberellin and abiet
88 reduction in Cyanidiophyceae and enabled the neofunctionalization of genes in multi-enzyme pathways.
89 t regulation or function, duplication and/or neofunctionalization of genes that maintain plant homeos
90 ssion, and potential subfunctionalization or neofunctionalization of HYDIN2 early in the evolution of
93 and Lal2/SCRL likely occurred, together with neofunctionalization of Lal2/SCRL, and both haplotype gr
94 an ancestor of vascular plants, followed by neofunctionalization of one of the paralogous CPs, poten
95 athways in C3 plants, through the regulatory neofunctionalization of preexisting genes and not throug
96 ing novel immunoglobulin-like receptors, and neofunctionalization of recently duplicated paralogs.
97 y, we explore the possible mechanism for the neofunctionalization of SUMO proteases through the fusio
98 date of the underlying gene duplication and neofunctionalization of the ancestral diterpene synthase
99 gence of neural crest cells (NCCs), in which neofunctionalization of the duplicated genes are thought
100 e evolution of the stony corals involved the neofunctionalization of the newly arisen SLC4gamma for a
101 n mammalian reproduction originated from the neofunctionalization of the vitamin B9-binding pocket of
103 cations followed by divergence may result in neofunctionalizations of co-expressed WRKY genes that fi
104 ars, through duplication and specialization (neofunctionalization) of aminoacyl-tRNA synthetases and
105 at selection pressures can determine whether neofunctionalization or SUBF is the more likely evolutio
106 provide an experimental system for studying neofunctionalization or subfunctionalization of talin fo
109 y fates: one copy acquires a novel function (neofunctionalization), or each copy adopts part of the t
110 version and subsequent combinations may be a neofunctionalization process in modular PKS assembly-lin
111 uggest that vitellogenins may have undergone neofunctionalization, reflecting their potential for fun
112 went multiple rounds of gene duplication and neofunctionalization, resulting in the development of AT
113 ven in large populations, the probability of neofunctionalization scales only with the square of the
115 ecies to quantify the roles of conservation, neofunctionalization, subfunctionalization, and speciali
116 trajectories that resolve their redundancy: neofunctionalization, subfunctionalization, or pseudogen
117 ce that the Ohno's Duplication-Retention-Non/Neofunctionalization, subfunctionalization/duplication-d
119 ntial for male fertility in B. napus through neofunctionalization that has likely occurred since the
120 t are not silenced may evolve new functions (neofunctionalization) that will alter the developmental
121 of ancestral functions among duplicates) or neofunctionalization (the acquisition of novel function)
122 of young duplicates in Drosophila shows that neofunctionalization, the gain of a novel function in on
124 e classical Ohno's Duplication-Retention-Non/Neofunctionalization theory, and the recently proposed a
126 s, favoring retention of gene duplicates and neofunctionalization, thus seeding acquisition of new fu
127 underwent subsequent domain duplication and neofunctionalization to give rise to vertebrate IRBP.
128 in M. sexta lineage via gene duplication and neofunctionalization, whereas MsexD5 representing an alt
129 explain duplicate retention invokes sub- or neofunctionalization, whereas others focus on sharing of
130 SbCYP82D1.1 via gene duplication followed by neofunctionalization, whereby the ancestral F6H activity
131 , suggesting that the adaptation is owing to neofunctionalization, which we find to be explicable by
132 e transfers, gene duplication and subsequent neofunctionalization) will cause some genes to exhibit a
133 tic trafficking in plants was accompanied by neofunctionalization within the GBF family, whereas in o