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1 id oxidation (FAO) in the pericardial cells (nephrocytes).
2 s markedly impair filtration function in the nephrocyte.
3 cells, primary patient cells, and Drosophila nephrocytes.
4 tors were silenced using RNA interference in nephrocytes.
5 tissue and is taken up by renal cells called nephrocytes.
6  in early endosomal structures in Drosophila nephrocytes.
7  slit diaphragms in podocyte-like Drosophila nephrocytes.
8 ing to genetic interaction of sns and c3g in nephrocytes.
9 expressed at the lacuna channel membranes of nephrocytes.
10 e invaginated membranes (lacuna channels) of nephrocytes.
11 , the reabsorptive hindgut and the endocytic nephrocytes.
12  reduced filtration function in the affected nephrocytes.
13 podin, was also elevated in Bazooka depleted nephrocytes.
14 s, garland nephrocyte cells, and pericardial nephrocytes.
15 rug screening using podocyte-like Drosophila nephrocytes.
16 like junctions between abnormally aggregated nephrocytes.
17 ene in vitro and in podocyte-like Drosophila nephrocytes.
18  nephrotic syndrome have not been studied in nephrocytes.
19 enotype reminiscent of nephrotic syndrome in nephrocytes.
20 diomyopathy that developed in the absence of nephrocytes.
21 hrin and Neph1, respectively, in pericardial nephrocytes.
22 on of the fluorescent protein in pericardial nephrocytes.
23  rise to cardioblasts, blood progenitors and nephrocytes.
24  in podocytes or the nephrocyte diaphragm in nephrocytes.
25   Expressing the G0 or G1 APOL1 transgene in nephrocytes also impaired the acidification of organelle
26 O-1 (TJP1) and podocin, are expressed in the nephrocyte and form a complex of interacting proteins th
27                                   The insect nephrocyte and the mammalian glomerular podocyte are sim
28 tch that differentiates between the blood or nephrocyte and vascular lineages involves the Notch path
29 he podocyte-like garland cells of Drosophila nephrocytes and a wing precursor tissue.
30    Here, we present a functional analysis of nephrocytes and establish an in vivo system to screen fo
31 n was required for rapid nephrin turnover in nephrocytes and for endocytosis of nephrin induced by ex
32 nd is expressed in cardioblasts, pericardial nephrocytes and hematopoietic progenitors.
33                                   Drosophila nephrocytes and human podocytes share striking similarit
34 important role in the calcium homeostasis of nephrocytes and is required for maintaining nephrocyte f
35 irculatory system: cardioblasts, pericardial nephrocytes and lymph gland hematopoietic progenitors, b
36  complex proteins specifically in Drosophila nephrocytes and studied the effects on protein reabsorpt
37 loss-of-function strategy was used to ablate nephrocytes and then heart function and the hemolymph pr
38 , we conducted genetic studies in Drosophila nephrocytes and validated findings from Drosophila in a
39 imilarities we describe between invertebrate nephrocytes and vertebrate podocytes provide evidence su
40  and Pannier in cardioblasts and pericardial nephrocytes, and by Serpent in hematopoietic progenitors
41 phila impaired function of the podocyte-like nephrocytes, and caused mistrafficking of Sns, the Droso
42 la Vps8 is highly expressed in hemocytes and nephrocytes, and localizes to early endosomes despite th
43 els lacking Rab7 exclusively in podocytes or nephrocytes, and performed histologic and ultrastructura
44                      Drosophila garland cell nephrocytes are podocyte-like cells and thus provide a p
45                             By contrast, the nephrocytes are specialized for uptake of macromolecules
46 rdioblasts) and excretory cells (pericardial nephrocytes), arises from the cardiogenic mesoderm.
47 re evolutionarily related, and establish the nephrocyte as a simple model in which to study podocyte
48 podocytes and an ex vivo model of Drosophila nephrocytes, as well as chemically induced injury models
49 +) upon exposure to a mechanical stimulus in nephrocytes, as well as filtration disturbances.
50 STAT signaling pathway in the adipose tissue-nephrocyte axis and its contribution to HFD-associated n
51              We conclude that the Drosophila nephrocyte can be used to elucidate clinically relevant
52 ial relevance to humans using the Drosophila nephrocyte-cardiomyocyte system.
53 on of APOL1 risk variants in D. melanogaster nephrocytes caused cell-autonomous accumulation of the e
54 podocyte function in mice and the equivalent nephrocyte cell in Drosophila.
55 regionally specific principal cells, garland nephrocyte cells, and pericardial nephrocytes.
56 factor Klf15 (Klf15(NN)) are viable but lack nephrocytes-cells structurally and functionally homologo
57                    In conclusion, the insect nephrocyte combines filtration with protein reabsorption
58 late the structure and function of the SD in nephrocytes, connecting the SD protein complex to the ac
59          This innate immune response-induced nephrocyte damage is a major contributor to reduced long
60                                In Drosophila nephrocytes, deficiency of the Pals1 ortholog caused alt
61 ucing albuminuric kidney disease in mice and nephrocyte depletion in Drosophila.
62 rivation or antibiotic treatment ameliorates nephrocyte deterioration and extends the lifespan of tum
63 ph by uptake of molecules through an SD-like nephrocyte diaphragm (ND) into labyrinthine channels tha
64 structure revealed that the formation of the nephrocyte diaphragm and lacunar structure, which is ess
65 ermore, gene silencing of c3g partly rescued nephrocyte diaphragm defects of an sns overexpression ph
66 compromised nephrocyte filtration and caused nephrocyte diaphragm defects.
67 wn as the slit diaphragm in podocytes or the nephrocyte diaphragm in nephrocytes.
68                Furthermore, we find that the nephrocyte diaphragm is completely lost in flies lacking
69  function declined, cell size increased, and nephrocytes died prematurely.
70          RNAi-mediated knockdown of dKank in nephrocytes disrupted slit diaphragm filtration structur
71                Piezo loss of function caused nephrocyte dysfunction, including disrupted slit diaphra
72                              Rendering adult nephrocytes dysfunctional by disrupting their endocytic
73                                We found that nephrocytes efficiently take up secreted fluorescent pro
74                                              Nephrocyte endo-lysosomal function and slit diaphragm ar
75 eath and direct ER stress induction enhanced nephrocyte endocytic function similar to expression of A
76                  Expression of Rab11 RNAi in nephrocytes entailed defective delivery of slit diaphrag
77                         Strikingly, boosting nephrocyte expression of the lipid droplet resident enzy
78 g SD components and their trafficking to the nephrocyte external membrane, where SDs assemble.
79                                   Drosophila nephrocytes feature a special basement membrane that may
80                               The Drosophila nephrocyte features a molecularly conserved filtration b
81 fic gene silencing of sns or c3g compromised nephrocyte filtration and caused nephrocyte diaphragm de
82 nd knockdown) to study the roles of Piezo in nephrocyte filtration and function.
83  basement membrane defines properties of the nephrocyte filtration barrier.
84               We used Drosophila pericardial nephrocytes, filtration kidney cells with striking struc
85 sed to drugs in liquid food before recording nephrocyte fluorescence intensity.
86 xpression of the APOL1 G0 or G1 transgene in nephrocytes, fly cells homologous to mammalian podocytes
87                                   Drosophila nephrocytes form a slit diaphragm-like filtration barrie
88                                           In nephrocytes from Drosophila melanogaster , a well-establ
89           We screened for genes required for nephrocyte function and identified two Drosophila genes
90  nephrocytes and is required for maintaining nephrocyte function and the slit diaphragm filtration st
91 ed a faster but reliable screening assay for nephrocyte function compared with the established approa
92 As transgenic flies with either allele aged, nephrocyte function declined, cell size increased, and n
93     We identified significant improvement of nephrocyte function for zacopride, a respective agonist
94                                        Since nephrocyte function was further decreased as detected by
95 ion of an APOL1 transgene initially enhances nephrocyte function, causing hypertrophy and subsequent
96 We developed a fast assay testing Drosophila nephrocyte function, suitable for whole-animal drug scre
97 tically encoded tracer for rapid analysis of nephrocyte function.
98 netic screen identified c3g as necessary for nephrocyte function.
99 ophila KANK homolog (dKank) is essential for nephrocyte function.
100 ing the identification of genes required for nephrocyte function.
101  cells and oenocytes (also called Drosophila nephrocytes) function in taking up waste material from t
102                                 We performed nephrocyte functional assays, carried out super-resoluti
103 o loss-of-function mutant showed significant nephrocyte functional decline.
104 lencing Cindr in nephrocytes led to dramatic nephrocyte functional impairment and shortened life span
105 und that 85% of these genes are required for nephrocyte functions, suggesting that a majority of huma
106  co-expressed within binucleate garland cell nephrocytes (GCNs) that contribute to detoxification of
107   Mature genetic or pharmacological podocyte/nephrocyte GSK3 inhibition is also detrimental; producin
108            Here, we show that the Drosophila nephrocyte has molecular, structural, and functional sim
109                 Here we show that the insect nephrocyte has remarkable anatomical, molecular and func
110                          Larval garland cell nephrocytes have also been included.
111 rmacological inhibition of JAK-STAT restored nephrocyte HFD-associated dysfunction.
112 nephrin colocalized at the slit diaphragm in nephrocytes in a mutually dependent manner, interacting
113                            The podocyte-like nephrocytes in Drosophila harbor both a slit diaphragm a
114 data suggest that the Drosophila pericardial nephrocyte is a useful in vivo model to help identify ge
115                 Similarly, silencing GSK3 in nephrocytes is developmentally lethal for this cell.
116                                              Nephrocyte knockdown of diglyceride acyltransferase 1 (D
117  shortened life span, as well as collapse of nephrocyte lacunar channels and effacement of nephrocyte
118                                  Ablation of nephrocytes led to a severe cardiomyopathy characterized
119                           Silencing Cindr in nephrocytes led to dramatic nephrocyte functional impair
120                   Silencing exocyst genes in nephrocytes led to profound changes in structure and fun
121 on microscopy showed that silencing Piezo in nephrocytes led to reduced slit diaphragm density and ab
122                                        These nephrocyte lipid droplets correlate with endoplasmic ret
123                                 A HFD drives nephrocyte lipid uptake via the multiligand receptor Cub
124 -red fluorescent protein at early stages and nephrocyte loss at later stages.
125 te, but the lack of a functional readout for nephrocytes makes it challenging to study this model of
126 eads to disruption of the slit diaphragm and nephrocyte malfunction.
127 perimentally in vitro and using a Drosophila nephrocyte model.
128 tly regulated to maintain normal pericardial nephrocyte morphology and function.
129 , we study nephrin dynamics in podocyte-like nephrocytes of Drosophila and show that selective endocy
130                         We used garland cell nephrocytes of Drosophila melanogaster to monitor the ro
131  hosts, as blocking the NF-kB/Imd pathway in nephrocytes or removing gut bacteria via germ-free deriv
132 n GsMTx4 reverses the phenotypes observed in nephrocytes overexpressing Piezo.
133                                           In nephrocytes, overexpression of Rac1 resulted in mislocal
134                 The latter contribute to the nephrocyte phenotype observed upon loss of Bazooka.
135 hannel activity, does not result in a severe nephrocyte phenotype, suggesting the observed changes in
136 zo expression levels also result in a severe nephrocyte phenotype.
137       In conclusion, Drosophila garland cell nephrocytes provide a model with which to study the path
138                                In Drosophila nephrocytes, Rab7 knockdown resulted in the accumulation
139 own of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis.
140                     Proteomics revealed that nephrocytes regulate the circulating levels of many secr
141 these known NS genes play conserved roles in nephrocytes remains unknown.
142                        Tracer endocytosis by nephrocytes required Cubilin and reflected size selectiv
143 uggest that the slit diaphragm of Drosophila nephrocytes requires balanced endocytosis and recycling
144 ull allele of Drosophila TBC1D8B exhibited a nephrocyte-restricted phenotype of nephrin mislocalizati
145  Loss of function analysis in Piezo depleted nephrocytes reveal a severe morphological and functional
146             Rescue experiments in Drosophila nephrocytes revealed atypical protein kinase C (aPKC)-Pa
147 erular basement membrane model in Drosophila nephrocytes reveals that matrix receptor-mediated cues e
148 he study identified four novel regulators of nephrocyte SDs: Dlg, Lgl, Scrib, and Par-1.
149                           Because Drosophila nephrocytes share molecular and structural features with
150                               The Drosophila nephrocyte shares remarkable similarities to the glomeru
151                Moreover, the Piezo-deficient nephrocytes showed internalized slit diaphragm component
152 es reduced the density of slit diaphragms in nephrocytes, showing a direct effect of the matrix.
153                Rac1 overexpression disrupted nephrocyte slit diaphragm architecture, providing a scre
154 ephrocyte lacunar channels and effacement of nephrocyte slit diaphragms.
155 d fluorescent protein and combined it with a nephrocyte-specific driver for targeted gene knockdown,
156                                     In vivo, nephrocyte-specific gene silencing of sns or c3g comprom
157 ice and Drosophila with podocyte-specific or nephrocyte-specific loss of Rab7, and a human podocyte c
158                                              Nephrocyte-specific silencing of Piezo showed disruption
159 ulation was found at garland and pericardial nephrocytes supporting its role in organismal defence an
160 ch are pairs of highly endocytic pericardial nephrocytes that modulate cardiac function by uncharacte
161 o elevate endocytic function of garland cell nephrocytes that simultaneously showed early signs of ce
162                                           In nephrocytes, the Ajuba homolog Djub recruited Warts (LAT
163 s the slit diaphragm filtration structure in nephrocytes, the fly functional equivalent of mammalian
164  in a mechanosensation pathway in Drosophila nephrocytes, the podocyte homologue in the fly.
165                          Vps34 deficiency in nephrocytes, the podocyte-like cells of Drosophila melan
166 can was removed from systemic circulation by nephrocytes through endocytosis and subsequent lysosomal
167 tion in primary patient cells and Drosophila nephrocytes to systematically characterize a large panel
168 bsorption is required for the maintenance of nephrocyte ultrastructure and fly survival under conditi
169 stic syndrome model, wherein the pericardial nephrocytes undergo severe damage due to an elevated imm
170 rgeted expression of human AMN in Drosophila nephrocytes was sufficient to rescue defective protein u
171    Using RNAi and conditional CRISPR/Cas9 in nephrocytes, we found this pattern depends on the expres
172 pression of dCubilin and dAMN is specific to nephrocytes, where they function as co-receptors for pro
173 ctional genetic screen of Drosophila cardiac nephrocytes, which are equivalents of mammalian podocyte
174  Drosophila melanogaster, SDs are present in nephrocytes, which filter the fly's hemolymph.
175 e that HFD activates the JAK-STAT pathway in nephrocytes, which has previously been linked to diabeti
176 g apicobasal polarity proteins in Drosophila nephrocytes, which have SDs similar to those of mammalia
177 system, consisting of Malpighian tubules and nephrocytes, which shares similarities with the mammalia
178                                              Nephrocytes with impaired Sns or C3G expression displaye
179                               In Drosophila, nephrocytes with reduced filamin homolog Cher displayed

 
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