ライフサイエンスコーパス: nestin

1 rential scaffolding of DCX, cdk5, and p35 by nestin.

2 eries that are often positive for the marker nestin.

3 uding expression of synaptopodin, CD2AP, and nestin.

4 n mouse developing cerebellum that expresses Nestin.

5 s glial fibrillary acidic protein (GFAP) and Nestin.

6 of other cdk5 substrates is not affected by nestin.

7 glial- and neuronal cell phenotype (GFAP and Nestin-1 positivity, respectively) in the iERMs, as well

8 expressed Opn1mw, a cone-specific marker and nestin, a marker for neural precursor cells.

9 Colonies were strongly positive for nestin, a marker for neural precursors, and contained Ne

10 ses TLX under the control of the promoter of nestin, a neural precursor marker.

11 s have smaller growth cones, suggesting that nestin affects cytoskeletal dynamics.

12 investigate the molecular mechanism by which nestin affects growth cone morphology and Sema3a sensiti

13 ic lines driven by neural gene promoters for nestin (all neural cells), synapsin (neurons), or P0 (Sc

14 Nestin, an intermediate filament found in neural progeni

15 l subjects is unknown.SIGNIFICANCE STATEMENT Nestin, an intermediate filament protein highly expresse

16 Nestin, an intermediate filament protein widely used as

17 Immunohistochemistry staining of nestin and 5-hmC in 53 clinically annotated primary and

18 ligodendrocyte marker O4), neuronal markers (nestin and B-III-tubulin) and fibroblast-associated mark

19 he dentin, as assessed by immunostaining for nestin and dentin sialoprotein (DSP).

20 1 strongly correlated with that of CD133 and nestin and differentiation status of malignant glioma ce

21 Upon activation, qNSCs upregulate Nestin and EGFR and become highly proliferative.

22 a small subset of CD146(+) cells expressing Nestin and enriched for MSC and HSC niche activities.

23 cell kinetics, resulting in accumulation of nestin and FABP5-expressing transit amplifying cells to

24 ed within myenteric ganglia and express both Nestin and p75NTR, but not the pan-glial marker Sox10.

25 n non-cancerous neural stem cells, including nestin and Sox2.

26 networks with melanoma stem cell-associated nestin and vascular endothelial growth factor receptor-1

27 roblastoma overexpressed gene-3; stem (BMI1, nestin); and chromaffin (chromogranin A, tyrosine hydrox

28 y increasing sex-determining region Y-box 2, nestin, and also enhances synaptic function through upre

29 ers, including Notch pathway members, CD133, Nestin, and c-Myc.

30 ed the expression of the stem cell biomarker nestin, and decreased the expression of reactive astrocy

31 ex, expresses the stem cell markers Sox2 and Nestin, and lacks markers of glial or neuronal different

32 d the expression of stem cell markers CD133, Nestin, and Nanog.

33 with the other GBM stemness markers, CD133, Nestin, and Sox2.

34 on of the neuroectodermal stem cell antigen, nestin, and up-regulating the glial maturation marker, G

35 x1 protein was also expressed in a subset of Nestin- and GFAP-expressing putative neural stem or prog

36 ntin+, CD24+, FoxJ1+, Sox2+, and CD133+, but nestin- and glial fibrillary acidic protein (GFAP)-.

37 n of alpha-smooth muscle (alphaSM)-actin and nestin antigens by pericytes in new vessels, we delivere

38 ressed the nonspecific precursor cell marker Nestin as well as GFAP and Sox2.

39 onance contrast agents (SPION-actin or SPION-nestin at 4 mg Fe/kg) by i.p. injection to C57black6 mic

40 Nestin binding to Gli3 blocked Gli3 phosphorylation and

41 Here, we report that Nestin binds the hedgehog pathway transcription factor G

42 rphology and expressed the progenitor marker Nestin but not Math1, a marker of committed granule neur

43 Therefore, transcriptional repression of Nestin by p53 restricts cellular plasticity and tumorige

44 mia, we observed pericytes (at d 2, using Gd-nestin, by eyedrop solution), significant photoreceptor

45 -deoxyuridine [BrdU]), (b) neural precursor (nestin), (c) neuronal phenotype (BrdU/beta3-tubulin), an

46 These CD31(-)nestin(+) cells are found in the T and B cell zones or i

47 show that during all stages of development, nestin(+) cells are present within lymph nodes of these

48 Overall our data show that nestin(+) cells contribute to all subsets of the complex

49 Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in dire

50 Here, we show that nestin(+) cells direct inflammatory cell migration durin

51 ared with control mice, there were increased nestin(+) cells in airways and higher levels of active T

52 er, postnatal tamoxifen induced targeting of nestin(+) cells in nes-creER mice showed that most endot

53 d excision of Rac1 in Rac3(-/-) mice reduces Nestin(+) cells in the marrow.

54 The PDGFRalpha(+) CD51 (+)subset of Nestin(+) cells is also enriched in major HSC maintenanc

55 Accordingly, CSF-1 depletion from Nestin(+) cells led to severe depletion and transcriptio

56 Nestin(+) cells localize in the anterior hippocampus, an

57 In contrast, quiescent neural crest-derived nestin(+) cells preserve MSC activity, but do not genera

58 However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic i

59 oE) knockout mice fed with high-fat diet, BM nestin(+) cells regulate the egress of inflammatory mono

60 Fate mapping of nestin(+) cells unambiguously revealed the contribution

61 regions simultaneously with the presence of nestin(+) cells undergoing apoptosis.

62 We hypothesized that deletion of Rac in the Nestin(+) cells would perturb the perivascular space, al

63 omal cells characterizes a large fraction of Nestin(+) cells, containing most fibroblastic CFUs, mese

64 Mcp1 deletion in nestin(+) cells-but not in endothelial cells only- incre

65 portant to find surface markers specific for Nestin(+) cells.

66 altering the survival of neural progenitor (Nestin(+)) cells.

67 We propose that nestin changes growth cone behavior by regulating intrac

68 We propose that nestin changes growth cone behavior by regulating the in

69 hus suggesting a functional role for the DCX-nestin complex in neurons.

70 we demonstrate a functional role for the DCX-nestin complex in neurons.

71 Yap (Yap1) knockout, Yap(nestin) conditional knockout and Yap(GFAP) conditional k

72 ap1 in glial and neuronal precursors using a nestin-conditional approach.

73 mined that the intermediate filament protein nestin correlates with tumorigenic and invasive melanoma

74 Thus, the transient expression of nestin could allow temporal and/or spatial modulation of

75 Unexpectedly, 60% of Nestin(Cre)Bax(fl/fl)Bak(-/-) mice harbored high-grade t

76 Aged Nestin(Cre)Bax(fl/fl)Bak(-/-) mice manifest progressive

77 l activation of the p.Arg1872Trp mutation by Nestin-Cre also resulted in early onset seizures and dea

78 ns and glia in addition to the motor neuron (Nestin-Cre and ChAT-Cre) resulted in the greatest improv

79 rs and neurons in the developing brain using Nestin-cre and Nex-cre lines, respectively.

80 n dopaminergic neurons, in conditional Zeb2 (Nestin-Cre based) knockout mice.

81 l with central nervous system (CNS)-specific Nestin-Cre drivers.

82 Ablation of Hdac1 or Hdac2 by Nestin-Cre had no obvious consequences on brain developm

83 ption factor Lhx2 in cortical progenitors by Nestin-cre leads to a dramatically smaller cortex.

84 ne or after initial lens formation using the Nestin-Cre line.

85 cerebellar development using Wnt5a(-/-) and Nestin-Cre mediated conditional knockout mouse models.

86 control (PC4(+/+) Nestin-Cre) mice, PC4(f/f) Nestin-Cre mice are smaller with decreased nocturnal act

87 Interestingly, PC4(f/f) Nestin-Cre mice exhibit a severe deficit in spatial memo

88 alysis of the dorsal hippocampus of PC4(f/f) Nestin-Cre mice revealed dysregulated expression of seve

89 C9orf72(fl/fl) mice were crossed with Nestin-Cre mice to selectively remove C9orf72 from neuro

90 Nestin-Cre mice were crossed with ERalpha(flox) mice to

91 rain GLUT4 (BG4KO) was generated by crossing Nestin-Cre mice with GLUT4-floxed mice.

92 y postnatal development was also impaired in Nestin-Cre p75(NTR) floxed mice, indicating a novel role

93 0) in neural progenitors using a conditional Nestin-Cre p75(NTR) floxed mouse causes increased apopto

94 dm16 deletion during fetal development using Nestin-Cre prevented the formation of ependymal cells, d

95 nestin-Cre Tor1a(flox/DeltaE) compared with nestin-Cre Tor1a(flox/-) animals.

96 at conditional deletion of Tor1a in the CNS (nestin-Cre Tor1a(flox/-)) or isolated CNS expression of

97 egeneration that was substantially milder in nestin-Cre Tor1a(flox/DeltaE) compared with nestin-Cre T

98 lated CNS expression of DYT1 mutant torsinA (nestin-Cre Tor1a(flox/DeltaE)) causes striking abnormal

99 brain-wide deletion of ADK by introducing a Nestin-Cre transgene into a line of conditional ADK defi

100 We show that a Nestin-Cre transgene targets perivascular cells (adventi

101 ned with conditional PC4 knock-out (PC4(f/f) Nestin-Cre) mice where PC4 is knocked out specifically i

102 Compared with the control (PC4(+/+) Nestin-Cre) mice, PC4(f/f) Nestin-Cre mice are smaller w

103 Analysis of Crb2F/F/Nestin-Cre+/- mice, and targeted reduction of Crb2/CRB2S

104 eted from haematopoietic cells, osteoblasts, nestin-cre- or nestin-creER-expressing cells.

105 Nestin-Cre-directed excision of Rac1 in Rac3(-/-) mice r

106 Nestin-Cre-driven deletion of podoplanin on neural proge

107 Mice with Nestin-Cre-driven deletions of Trp53 and Pten alleles we

108 d with tamoxifen inducible CAG-CRE-ER(T2) or nestin-CRE-ER(T2) mice.

109 etion of Cxcl12 from haematopoietic cells or nestin-cre-expressing cells had little or no effect on H

110 tailed behavioural analysis of the resulting Nestin-Cre-Lpd knockout mouse line revealed a specific b

111 ycan anchor biosynthesis, class A (Piga) and Nestin-Cre.

112 n-deficient mouse lines using CaMKII-Cre and Nestin-Cre.

113 l complexes (AJCs) was responsible for PH in Nestin-Cre/Llgl1(fl/fl) brains.

114 neural stem-cell-specific deletion of Llgl1 (Nestin-Cre/Llgl1(fl/fl)), a mammalian ortholog of the Dr

115 lso highly enriched CFU-Fs, but negative for Nestin-CreER and NG2-CreER, markers which were unlikely

116 Nestin-CreER(T2) and Pdgfra-CreER(T2) transgenic mice we

117 Postnatal Prdm16 deletion using Nestin-CreER(T2) did not cause hydrocephalus or prevent

118 Our findings suggest that each nestin-CreER(T2) line may best serve different experimen

119 Reporter expression in the third nestin-CreER(T2) line was considerably more specific, bu

120 Here we compare three such nestin-CreER(T2) lines to evaluate specificity of expres

121 We found that all three nestin-CreER(T2) strains induced reporter expression wit

122 Using an inducible nestin-CreER(T2)/R26R-yellow fluorescent protein (YFP) m

123 We generated nestin-CreER(T2)/R26R-YFP/Hif1a(fl/fl) triple transgenic

124 ato-expressing cells in the adult cochlea of nestin-CreER(T2)/tdTomato mice remains unclear; however,

125 We used nestin-CreER(T2)/tdTomato-reporter mice to trace the lin

126 Cells were isolated from colonic LMMP of Nestin-creER(T2):tdTomato mice and incubated with agonis

127 ith conventional C57/BL6, germ-free C57/BL6, Nestin-creER(T2):tdTomato, Nestin-GFP, and ChAT-cre:tdTo

128 Tamoxifen-inducible nestin-creER(tm)4 lineage tracing demonstrated that it i

129 topoietic cells, osteoblasts, nestin-cre- or nestin-creER-expressing cells.

130 omide treatment or using a genetic approach (Nestin-CreERT2/NSE-DTA mice) impeded the forgetting of o

131 and their progeny by giving transgenic mice (nestin-CreERT2/R26R-YFP/CDK5(flox/flox) [iCdk5] and nest

132 CreERT2/R26R-YFP/CDK5(flox/flox) [iCdk5] and nestin-CreERT2/R26R-YFP/CDK5(wt/wt) [WT]) tamoxifen duri

133 Crossing with Nestin-cyclization recombinase (Cre) eliminated EAAT2 fr

134 A nestin-DeltaTK-IRES-GFP (Nes-DeltaTK-GFP) transgene that

135 ence-activated cell sorting, only Prominin-1/Nestin double-positive cells fulfilled the defining stem

136 uroectodermal and progenitor markers such as nestin, doublecortin, GFAP, neurofilament, and vimentin.

137 Conversely, loss of Nestin dramatically inhibited proliferation and promoted

138 Our findings show how Nestin drives hedgehog pathway-driven cancers and uncove

139 and Cre drivers that are activated at early [Nestin; embryonic day 10.5 (E10.5)] and late [human glia

140 amoxifen-inducible cre recombinase driven by nestin enhancer (Nes-creER) in developing bone marrow we

141 trabecular and cortical bone compartments in nestin-ERalpha(-/-) mice compared with controls.

142 We propose that the increased bone mass in nestin-ERalpha(-/-) mice is mediated via decreased centr

143 The high bone mass phenotype in nestin-ERalpha(-/-) mice was mainly caused by increased

144 Femoral bone strength was increased in nestin-ERalpha(-/-) mice, as demonstrated by increased s

145 WAT) and slightly increased amount of WAT in nestin-ERalpha(-/-) mice.

146 a expression specifically in nervous tissue (nestin-ERalpha(-/-)).

147 lar zone (SVZ) of the lateral ventricles and nestin expressing NeuN positive neurons and adenomatous

148 hese data indicate that Sildenafil amplifies nestin expressing neural stem cells and their neuronal a

149 middle-aged mouse with Sildenafil increased nestin expressing neural stem cells, mature neurons, and

150 Nestin-expressing (Nestin(+)) mesenchymal stromal cells

151 R) cells, stem cell factor-expressing cells, nestin-expressing cells and platelet-derived growth fact

152 Therefore, we selectively removed Cdk5 from nestin-expressing cells and their progeny by giving tran

153 When Cdk5 gene deletion was induced in nestin-expressing cells and their progeny during the wav

154 porter mice to trace the lineage of putative nestin-expressing cells and their progeny in the cochlea

155 Thus, glial cells that originate from nestin-expressing cells and their progeny require Cdk5 f

156 Cell-specific loss of Tsc1 within nestin-expressing cells in adult mice leads to the forma

157 In addition, two populations of vimentin/nestin-expressing cells were identified: a dorsal group

158 ream AKT, and in human pancreatic epithelial nestin-expressing cells, activates both the AKT and MAPK

159 maintained a significantly greater number of nestin-expressing neural progenitor cells compared with

160 We found that nestin-expressing neurons have smaller growth cones, sug

161 Therefore, we tested whether nestin-expressing neurons showed altered responses to Se

162 We find that nestin-expressing newborn neurons are more sensitive to

163 moxifen-inducible Hif1a gene inactivation in nestin-expressing NSCs within the adult SVZ.

164 zed that Mef2a, -c, and -d deletion in adult nestin-expressing NSPCs and their progeny would result i

165 , -c, and -d were inducibly deleted in adult nestin-expressing NSPCs and their progeny.

166 estin was colocalized in alphaSM- actin- and nestin-expressing pericytes in BCAO-treated C57black6 or

167 nic NSCs led to an increase in the number of Nestin-expressing precursors; mutational analysis of SC1

168 Moreover, Hedgehog signaling in two Nestin-expressing progenitor populations is crucial not

169 d a marker for multipotent stem cells, these Nestin-expressing progenitors (NEPs) are committed to th

170 tnatal ablation of granule cell progenitors, Nestin-expressing progenitors, specified during mid-embr

171 e show that, in the adult mouse hippocampus, nestin-expressing radial glia-like quiescent neural stem

172 We examined nestin expression (a marker for MSCs) and TGF-beta1 sign

173 Nestin expression is thus not restricted to neural proge

174 Therefore, nestin expression marks cells that regulate inflammatory

175 further define the interplay between 5-hmC, nestin expression, and melanoma virulence.

176 Many human HCCs and CCs show elevated nestin expression, which correlates with p53 loss of fun

177 ulting in increased 5-hmC levels and reduced nestin expression.

178 mors within the testis, a peripheral site of Nestin expression.

179 grammed senescence, characterized by loss of nestin expression.

180 tion, and stem cell marker (BMI1, Nanog, and Nestin) expression, and these effects could be rescued b

181 Nestin fate-mapped astrocytes also flow anteriorly from

182 These nestin fate-mapped corpus callosum astrocytes are unifor

183 We propose that nestin functions in immature neurons to modulate cdk5 do

184 TET2 and TET2-mutated constructs, decreased nestin gene and protein expression in vitro.

185 Moreover, knockdown of nestin gene expression impaired laminin expression and n

186 binding in the 3' untranslated region of the nestin gene in melanoma compared to nevi, and 5-hmC bind

187 lized by a specific neural enhancer from the Nestin gene that is strongly induced in developing arter

188 binding at the 3' untranslated region of the nestin gene, providing one potential pathway for underst

189 senchymal stem cells are labeled with GFP in nestin-GFP mice, and we show that during all stages of d

190 l cells and pericyte-like cells) in WAT, and Nestin-GFP specifically labels pericyte-like cells.

191 icroscopy and electron microscopy to examine Nestin-GFP transgenic mice and provide a detailed ultras

192 Isolated Nestin-GFP(+) cells differentiate into adipocytes ex viv

193 Expression of niche factors by Nestin-GFP(+) mesenchymal-derived stromal cells (MSCs) i

194 ved BM stroma, which have characteristics of Nestin-GFP(+) MSPCs.

195 The neonatal Nestin-GFP(+) Pdgfralpha(-) cell population also contain

196 share a common signature (Pax7(+), Ki67(-), Nestin-GFP(+), Myf5(nLacZ+), MyoD-positive lineage origi

197 We show that within the Hes5-GFP(+)/Nestin-GFP(+)/EGFR(+) cell population, which comprises t

198 ia through proliferation, are recruited to a Nestin-GFP(high) perivascular population, and contribute

199 lls were Scf-GFP(+), Cxcl12-DsRed(high), and Nestin-GFP(low), markers which also highly enriched CFU-

200 erm-free C57/BL6, Nestin-creER(T2):tdTomato, Nestin-GFP, and ChAT-cre:tdTomato.

201 negative for the skeletal stem cell markers Nestin-GFP, Leptin receptor and Gremlin1.

202 MSPCs can be labeled in the adult BM by Nestin-GFP, whereas committed osteoblast progenitors are

203 d ultrastructural reconstruction analysis of Nestin-GFP-positive RGL cells of the dentate gyrus.

204 leptin-receptor-positive stromal cells, and nestin-green fluorescent protein (GFP)-positive mesenchy

205 say to show that CGRP-sensitized transgenic (nestin/hRAMP1), but not control, mice exhibited light av

206 P receptor hRAMP1 subunit in nervous tissue (nestin/hRAMP1).

207 There was an inner part with vimentin- and nestin-immunopositive glia whereas GFAP and the water-ch

208 alysis revealed high levels of microvascular nestin immunoreactivity in the same region.

209 Nestin-immunoreactivity delineated a potential macroscop

210 stem and progenitor-cell-associated protein nestin in an Sp1/3 transcription-factor-dependent manner

211 ic cortical neurons that transiently express nestin in their axons.

212 , along with two stem cell markers CD133 and nestin, in multiple glioma patient specimens, glioma pri

213 Nestin is an atypical intermediate filament expressed st

214 anscription-factor-dependent manner and that Nestin is required for tumor initiation in vivo.

215 Although Nestin is widely considered a marker for multipotent ste

216 In this study, the first nestin isoform, Nes-S, was identified in neurons of dors

217 a in a roscovitine-sensitive manner, whereas nestin knockdown results in lowered sensitivity to Sema3

218 The intermediate filament protein Nestin labels populations of stem/progenitor cells, incl

219 gene (UL123) specifically increased Sox2 and Nestin levels in the IE1-positive tumors, upregulating s

220 In a mouse model system, Nestin levels increased progressively during medulloblas

221 hosphodiesterase type 5 (PDE5) inhibitor, on nestin lineage neural stem cells and their progeny in th

222 showed that focal cerebral ischemia induced nestin lineage neural stem cells in the subventricular z

223 itional ablation of the miR-17-92 cluster in nestin lineage NSCs, we tested the hypothesis that the m

224 The presence of nestin may indicate stem cell-capabilities whereas aquap

225 ntly higher expression of Nestin, suggesting Nestin may serve as a biomarker for diagnosing cHCC-ICC.

226 ncreased density in the interstitial area of Nestin(+) mesenchymal cells expressing CXCL12 and myeloi

227 -1 secretion from BM stromal cells including Nestin(+) mesenchymal stem cells via reactive oxygen spe

228 Nestin-expressing (Nestin(+)) mesenchymal stromal cells (MSCs) are importan

229 ate-modified micro-DNA that targets actin or nestin mRNA.

230 Proliferative mesoderm-derived nestin(-) MSCs participate in fetal skeletogenesis and l

231 wherein CD19+ cells closely associated with nestin+ MSCs after AraC, but not in the other conditions

232 ct LGs, MECs expressed the stem cell markers nestin, Musashi 1, ABCG2, Pax6, Chx 10, DeltaN p63, and

233 Moreover, qNSCs are Nestin negative, a marker widely used for neural stem ce

234 Strikingly, deletion of Cxcl12 from nestin-negative mesenchymal progenitors using Prx1-cre (

235 lls identified by either their expression of nestin (Nes) or osterix (Osx) have previously been shown

236 eminate, we overexpressed candidate genes in Nestin(+) neural progenitors in the cerebella of mice by

237 notype, associated with a loss of periportal Nestin(+)NG2(+) cells and emigration of HSCs away from p

238 Nestin(+)NG2(+) cells and HSCs scale during development

239 We show that Nestin(+)NG2(+) pericytes associate with portal vessels,

240 ML disrupts SNS nerves and the quiescence of Nestin(+) niche cells, leading to an expansion of phenot

241 Production of new astrocytes from nestin(+) NPCs is absent in the normal adult cortex, str

242 of early neural markers - OTX2, PAX6, Sox1, Nestin, NR2F1, NR2F2, and IRX2 - in the onset of rosette

243 from Dcx KO mice to show that the effects of nestin on growth cone morphology and on Sema3a sensitivi

244 Nestin-positive (Nes(+)) cells are important hematopoies

245 ce in which Snf5 was ablated specifically in nestin-positive and/or glial fibrillary acid protein (GF

246 Snf5 ablation in nestin-positive cells resulted in early lethality that c

247 hout the CNS occurs through proliferation of nestin-positive cells that then differentiate into micro

248 /-) mice with conditional deletion of Bax in Nestin-positive cells.

249 Nestin-positive enteric neural precursor cells expressed

250 entrations of TGF-beta1 induced formation of nestin-positive mesenchymal stem cell (MSC) clusters, le

251 the TGF-beta type II receptor (TbetaRII) in nestin-positive MSCs led to less development of osteoart

252 transgenic elevated expression of miR-155 in nestin-positive neural and hematopoietic stem cells, inc

253 tes genome wide, and decreases the number of nestin-positive neural progenitors in the subventricular

254 or the CSF-1R, ablation of the Csf1r gene in Nestin-positive neural progenitors led to a smaller brai

255 e role of BAX/BAK in long-term regulation of Nestin-positive progenitor cell pools, with loss of func

256 e role of BAX/BAK in long-term regulation of Nestin-positive progenitor cell pools, with loss of func

257 dedifferentiation of mature hepatocytes into nestin-positive progenitor-like cells, which are poised

258 rdings and Patch-seq on neurons derived from Nestin-positive progenitors labeled by tamoxifen inducti

259 show that the proliferative effect of NPY on nestin(+) precursor cells is NO-dependent.

260 s unambiguously revealed the contribution of nestin(+) precursor cells to the mesenchymal as well as

261 However, the intracellular location of Nestin prevents its use for prospective live cell isolat

262 ution from nonmicroglial lineages, including Nestin+ progenitors and the circulating myeloid populati

263 e line expressing Cre under the CNS specific Nestin promoter to restrict the genetic ablation of Lpd

264 Upon activation of the nestin promoter, tdTomato was observed just below and me

265 g mice expressing GFP under the direction of nestin promoter/enhancer (Nes-GFP) revealed distinct end

266 ransgenic lines have been designed using the nestin promoter; however, only a subset are capable of e

267 layer (dVL) cells adjacent to dorsal midline Nestin(+) radial glia (dmNes+RG) down-regulate apical po

268 In young cortical cultures, nestin regulates axonal growth cone morphology.

269 ur findings provide evidence suggesting that nestin regulation is negatively controlled epigeneticall

270 regulates the transcriptional activation of Nestin's enhancer in developing coronary vessels while i

271 We now report that nestin selectively facilitates phosphorylation of the li

272 We find that nestin selectively facilitates the phosphorylation of th

273 The intermediate filament protein Nestin serves as a biomarker for stem cells and has been

274 ency significantly reduced the generation of NESTIN(+)SOX1(+) neuroectoderm cells from 70% in wild-ty

275 participants with a mean age of 90.6 years, Nestin(+)Sox2(+) neural progenitor cells (NPCs) and DCX(

276 xpression of genes associated with stemness (Nestin, Sox2) was regulated, and thrombin-induced cell d

277 roliferative and pro-neurogenic genes (KI67, Nestin, Sox2, and PAX6), reduction of the pro-inflammato

278 /precursor cell markers, including vimentin, nestin, Sox2, Sox9, and GLAST, but not others such as CD

279 ted, while group 3 medulloblastoma resembles Nestin(+) stem cells, group 4 medulloblastoma resembles

280 In the aorta, nestin(+) stromal cells increase approximately 30 times

281 se populations, including the LeptinR(+) and Nestin(+) subsets.

282 m astrocytes are continuously generated from nestin(+) subventricular zone (SVZ) neural progenitor ce

283 Cs showed significantly higher expression of Nestin, suggesting Nestin may serve as a biomarker for d

284 panded stromal cells, including perivascular Nestin(+) supportive stromal cells, which may facilitate

285 03 knockdown reduced mRNA levels of Sox1 and Nestin, the markers of neural progenitor cells, and decr

286 Nestin thus creates a selective scaffold for DCX with ac

287 However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood.

288 trate selectivity is based on the ability of nestin to interact with DCX, but not with other cdk5 sub

289 c-E4G10 radioimmunoconstruct in a transgenic Nestin-tumor virus A (Ntva) mouse model of high-grade gl

290 examined this hypothesis in the RCAS-PDGF-HA/nestin-TvA proneural glioma mouse model, in which p21 fa

291 Nestin, unlike other intermediate filament subtypes, reg

292 re stained positive for Cytokeratin 7, SOX2, Nestin, Vimentin, and CD44.

293 We also found that SPION-nestin was colocalized in alphaSM- actin- and nestin-exp

294 cells expressing the progenitor cell marker nestin was increased at 1 and 3 days following capsaicin

295 mentin, glial fibrillary acidic protein, and nestin, we show that the distribution of cytoplasmic IFs

296 revealed that the tumor-promoting effects of Nestin were mediated by binding to Gli3, a zinc finger t

297 (fMRI), and neuronal precursor cells (BrdU+/Nestin+) were detected by immunofluorescence.

298 ial fibrillary acidic protein, vimentin, and nestin, which are essential for migration.

299 e cancer stem cell markers c-Myc, CD133, and nestin, which could contribute to the efficacy of the tr

300 In addition, nestin, which is known to bind the neuronal cdk5/p35 kin