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1  phenylamidines were investigated along with netropsin.
2  be blocked by the minor groove binding drug netropsin.
3 pin of sequence 5'-CGAATTCGTCTCCGAATTCG) and netropsin.
4 duplex DNA are unaffected by the addition of netropsin.
5 ercoiled form by ligation in the presence of netropsin.
6  DNA upon binding of the minor groove binder netropsin.
7 d cytotoxicity can be inhibited in vivo with netropsin, a potent competitive inhibitor of binding of
8                                     However, netropsin affects neither the level of N3-methyladenine
9 ferential duplex affinity exhibited by 5PTB, netropsin and 4',6-diamidino-2-phenylindole (DAPI), two
10  between two minor groove binding compounds, netropsin and 4,6-diamidino-2-phenylindole (DAPI), and a
11  binding ligands (Hoechst 33258, distamycin, netropsin and berenil) with DNA fragments which have bee
12                                              Netropsin and chromomycin promote the release of DNA fro
13      Two members of this class of molecules, netropsin and chromomycin, are shown here to displace DN
14 ructures of the two duplexes, in contrast to netropsin and DAPI, which bind with similar affinities t
15 a series of bis-linked lexitropsins based on netropsin and distamycin have been screened for their ef
16                     The minor groove binders netropsin and distamycin inhibited oxopropenylation, but
17 :1 recognition beyond the initial studies on netropsin and distamycin.
18 data have shown cooperativity of binding for netropsin and Hoechst 33258 and have provided ligand:DNA
19 eir association to the (AATT)2 binding site, netropsin and pentamidine acquire 26+/-3 and 34+/-2 addi
20 gineered a crystal designed to position both netropsin and the polyamide at two distinct locations wi
21 ss of compounds is related to the linked bis-netropsins and bis-distamycins, but here, only one amino
22 y, a representative DNA minor-groove binder (netropsin) and ligands binding DNA base-pairing defects
23 d that minor groove-binding ligands berenil, netropsin, and distamycin and the intercalating ligand a
24  groove binding ligands, such as distamycin, netropsin, and GLX, an indole-linked dimer of netropsin,
25        4',6-diamidino-2-phenylindole (DAPI), netropsin, and pentamidine are minor groove binders that
26 GCAAATTTGCGC)2 also forms two complexes with netropsin, and the complex with weaker affinity is again
27                        Both cationic ends of netropsin are bridged by water molecules in one of the i
28                                          The netropsins are held by hydrogen bonding interactions to
29 ook 2 (HMGA2) as the protein of interest and netropsin as the inhibitor of HMGA2-DNA interactions.
30  immobilize the molecules DAPI, Hoechst, and netropsin at defined positions in the lattice, allowing
31 eveloped: (i) two different bound species of netropsin at single binding sites and (ii) a netropsin i
32                            In one mechanism, netropsin binding induces a hairpin-to-duplex DNA transi
33                             Cooperativity of netropsin binding to a 12mer with two potential sites ha
34                    The guanidinium moiety of netropsin binds in a narrow part of the minor groove, wh
35                               Alternatively, netropsin binds in two thermodynamically different modes
36                       The mechanism by which netropsin binds to hairpin DNA remains controversial wit
37         Furthermore, the minor groove ligand netropsin binds to the minor groove and to the hydrophob
38 momycin A(3) (GC-specific), distamycin A and netropsin (both AT-specific), have been chosen.
39  the first example of a crystal structure of netropsin bound to decamer DNA.
40                     The crystal structure of netropsin bound to the decamer d(CGCAATTGCG) has been de
41 elty of the structures is that there are two netropsins bound end-to-end in the minor groove of each
42 S) with nanoscale ion emitters indicate that netropsin can simultaneously and sequentially bind to bo
43 etropsin, and GLX, an indole-linked dimer of netropsin, can effectively disrupt the UL9-DNA complex o
44 , although an orientational disorder for the netropsins cannot be excluded.
45   The asymmetric unit of the RT fragment-DNA-netropsin crystals contains one protein molecule and one
46 y for several agents including distamycin A, netropsin, DAPI, Hoechst 33258, and berenil is described
47                                     Although netropsin, distamycin, and all other monomeric DNA binde
48 tries, AT sequence specific ligands, such as netropsin, distamycin, and GLX, prefer uniform, narrow m
49   We compare this structure to other Class I netropsin-DNA structures and find that the asymmetry of
50           In contrast to previously reported netropsin-DNA structures, our oligonucleotide contains t
51 ridging water molecule in the lower affinity netropsin/DNA complex.
52 es were in excellent agreement; for example, netropsin/DNA formation constants were determined to be
53                                              Netropsin, ethidium, daunorubicin and actinomycin, ligan
54  side-by-side binding mode of the distamycin/netropsin family of drugs.
55                                              Netropsin, for example, has two DNA binding enthalpies i
56                                   In buffer, netropsin forms two complexes with a net stoichiometry o
57  of the DNAs investigated clearly shows that netropsin forms two different complexes at AATT sites, a
58                      With (CGCGCAATTGCGCG)2, netropsin has one binding mode in buffer, and complex fo
59 ts with minor groove binding agents, such as netropsin, have provided detailed, atomic level views of
60  andactinomycin D) and minor groove binders (netropsin, Hoechst 33258 and distamycin) has shown the s
61 netropsin at single binding sites and (ii) a netropsin induced DNA hairpin to duplex transition.
62                                          DNA/netropsin interactions are investigated as a function of
63 halpy and heat capacity changes suggest that netropsin interacts similarly with these two oligonucleo
64                                              Netropsin is a well-characterized DNA minor groove bindi
65                                              Netropsin is bound to the DNA decamer d(CCCCCIIIII)2, th
66                                              Netropsin is one of the first ligands to be discovered t
67 elated minor groove binders distamycin A and netropsin (K(i) </=1 microM).
68 inding reactions involving the ligands DAPI, netropsin, lexitropsin, and the lambda repressor binding
69  molecule and one-half of the 16mer with one netropsin molecule bound.
70                                          The netropsin molecule fits within a five base pair long min
71                                          The netropsin molecule lies within the minor groove of the o
72                                         Each netropsin molecule spans approximately 5 bp.
73 By contrast, the binding to either duplex of netropsin or DAPI induces little or no change in the ele
74                                          The netropsins refined with their guanidinium heads facing e
75 groove binding agents (DAPI, distamycin, and netropsin) showed a strong preference for AT-rich duplex
76 ded by this screening excise, we showed that netropsin, the specific inhibitor of HMGA2-DNA interacti
77 dynamically distinct complexes on binding of netropsin to a number of hairpin-forming DNA sequences c
78               Studies done on the binding of netropsin to similar constructs, a 24-mer and a 28-mer,
79 ng interactions from the amide groups of the netropsin to the A x T base pairs of the minor groove.
80     However, and relative to ATT, binding of netropsin to the hydrophobic groove has a decreased bind
81                                   Binding of netropsin to the minor groove yielded thermodynamic prof
82   The well-characterized minor groove binder netropsin was used to develop and test the assay.
83            Similar effects are observed with netropsin, which competes with H-NS and StpA for AT-rich
84                      The antibiotic compound netropsin, which undergoes electrostatic and sequence-sp
85 s binding mechanism" for the interactions of netropsin with DNA.
86 nucleotide contains two AATT sites that bind netropsin with flanking 5' and 3' sequences that are not
87                      We have co-crystallized netropsin with the RT fragment bound to the symmetric 16
88                     Thus, the interaction of netropsin with these A/T binding sites is influenced bot
89 lutes and DNA sequence on the interaction of netropsin with three duplexes has been studied by isothe
90  AATT site contributes to the orientation of netropsin within the groove while hydrogen bonding patte