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1 ly are the neuronal proteins spinophilin and neurabin.
2 sponses by a neural tissue-specific protein, neurabin.
3 GS4 interact with the overlapping regions of neurabin.
4 isoforms contributed to their recognition by neurabins.
5 d suggested that PP1 mediated I-2 binding to neurabins.
6 P1 inhibitor, also attenuated I-2 binding to neurabins.
7 ted RhoGEF), RGS3 and RGS12, spinophilin and neurabin-1, SRC homology 3 domain and multiple ankyrin r
8 es between the canonical PP1-binding motifs (neurabin, (457)KIKF(460); G(M)/R(GL), (65)RVSF(68)).
9 the plasma membrane, a process that requires neurabin (a neural tissue-specific protein).
10 ant peptides representing central regions of neurabins also preferentially bound PP1gamma1 and PP1alp
11 fractionation of rat brain demonstrates that neurabin and p70(S6k) both localize to the soluble fract
12                                  The mRNA of neurabin and p70(S6k) show striking colocalization in br
13 ruitment and catalytic efficiency of the PP1-Neurabin and PP1-Spinophilin fusions is primarily determ
14                                              Neurabin and spinophilin are homologous protein phosphat
15 or subunits suggests that the PDZ domains of neurabin and spinophilin are important for targeting PP1
16                                              Neurabin and spinophilin are neuronal scaffolding protei
17 binding data also allowed us to classify the neurabin and spinophilin PDZ domains as the first identi
18         We report the structures of both the neurabin and spinophilin PDZ domains determined using bi
19   However, thus far, it is still unknown how neurabin and spinophilin themselves are targeted to thes
20 lso outline the required targeting of PP1 by neurabin and spinophilin to achieve substrate specificit
21                                              Neurabins are protein phosphatase-1 (PP1) targeting subu
22 493) proteins identified residues 473-479 of neurabin as containing a crucial PP1gamma1-selectivity d
23                                              Neurabin attenuated adenosine A(1) receptor (A1R) signal
24 n of a conserved PP1-binding motif abolished neurabin binding to both proteins.
25             Next, the adaptor protein NAB-1 (neurabin) binds to F-actin and recruits active zone prot
26                   The central domain of both neurabins bound PP1 and I-2, and mutation of a conserved
27                                 p70(S6k) and neurabin coimmunoprecipitate from transfected HEK293 cel
28                              Spinophilin and neurabin contain a single PDZ domain, a common protein-p
29         Deletion of Pro(464) and Ile(465) in neurabin (deltaPI) to equally space a conserved cluster
30                                 In addition, neurabin domains required for oligomerization are essent
31 1 selectively interacts with spinophilin and neurabin, F-actin-targeting proteins, whereas PP1beta se
32        Immunoprecipitation of spinophilin or neurabin from crude brain extracts selectively coprecipi
33                                              Neurabins from rat brain lysates were sedimented by I-2
34            We expressed wild-type and mutant neurabins fused to green fluorescent protein in Cos7, HE
35                          Inactivation of the neurabin gene enhanced A1R signaling and promoted the pr
36 4 of G(M)/R(GL) fused to residues 457-493 of neurabin (GST-G(M)/Nb) selectively bound to and inhibite
37 sion proteins containing residues 146-493 of neurabin (GST-Nb-(146-493)) or residues 1-240 of G(M)/R(
38 ely interact with one neurabin molecule in a neurabin homo-oligomer to form a ternary complex, repres
39            Filamentous actin binding protein neurabin I (NrbI) targets protein phosphatase-1 (PP1) to
40                       Phosphorylation of GST-neurabin I (residues 318-661) by PKA significantly reduc
41                                              Neurabin I also copurified with both the alpha and gamma
42 vity was confirmed by immunoprecipitation of neurabin I and II from brain extracts from wild type and
43 racts, including the actin-binding proteins, neurabin I and neurabin II.
44                       Immunoprecipitation of neurabin I and neurabin II/spinophilin from rat brain ex
45        Although the F-actin-binding proteins neurabin I and spinophilin (neurabin II) also bind PP1,
46                            Here we show that neurabin I binds protein phosphatase 1 (PP1) and inhibit
47 il and sterile alpha motif domains abolished neurabin I dimerization and induced filopodium extension
48                       Immunoprecipitation of neurabin I established its association with PP1 and I-2
49            A glutathione S-transferase (GST)-neurabin I fusion protein (residues 318-661) containing
50                                              Neurabin I interacted with PP1alpha in an overlay assay,
51                                              Neurabin I is a brain-specific actin-binding protein.
52 n N-terminal F-actin-binding domain dictated neurabin I localization at actin cytoskeleton and promot
53            Immune complex assays showed that neurabin I recruited an active PP1 via a PP1-docking seq
54 tions that attenuated PP1 binding to I-2 and neurabin I suggested distinct and overlapping sites for
55                                              Neurabin I, a neuronal actin-binding protein, binds prot
56 d restored stress fibers in cells expressing neurabin I.
57 d the displacement of PP1 for recruitment to neurabin I.
58 ed protein kinase A (PKA) phosphorylation of neurabin I.
59 sights into the assembly and regulation of a neurabin I/PP1 complex that controls actin rearrangement
60            Finally, p70S6K was excluded from neurabin I/PP1 complexes and required the displacement o
61                                              Neurabin-I actin-binding domain bundled F-actin, promote
62             Furthermore, the expression of a neurabin-I polypeptide unable to bind PP1 delayed the ma
63 ociation of protein phosphatase-1 (PP1) with neurabin-I through a canonical KIXF motif inhibited filo
64                 In contrast, dimerization of neurabin-I via C-terminal coiled-coil domains and associ
65 ted by a fragment of the PP1-binding protein neurabin-I, Nb-(146-493), because of the selective inhib
66 - and protein phosphatase-1-binding protein, neurabin-I, promotes filopodia in neurons and nonneurona
67 on, they impaired the ability of PP1 to bind neurabin-I, the neuronal regulatory subunit, and G(M), t
68 d hippocampal neurons showed that endogenous neurabin II and I-2 colocalized at actin-rich structures
69 n phosphatase 1 catalytic subunit (PP1) with neurabin II and inactivate PP1 and block mitosis during
70 on of the phosphorylated DCX and spinophilin/neurabin II from DCX-synthesizing glioma cells indicated
71 o a block of anchorage-independent growth as neurabin II is a synergistic inhibitor of anchorage-inde
72   Interaction between phosphorylated DCX and neurabin II may induce the association of the protein ph
73 binding proteins neurabin I and spinophilin (neurabin II) also bind PP1, their role in PP1 isoform se
74 g the actin-binding proteins, neurabin I and neurabin II.
75        Immunoprecipitation of neurabin I and neurabin II/spinophilin from rat brain extracts sediment
76                 Site-directed mutagenesis of neurabin implicates its PDZ domain in the interaction wi
77                            Cotransfection of neurabin in HEK293 cells activates p70(S6k) kinase activ
78 lective targeting of PP1gamma1 to F-actin by neurabins in intact cells requires both the canonical PP
79 erely attenuated PP1gamma1 interactions with neurabins in vitro and in cells and disrupted PP1gamma1
80                  Recombinant spinophilin and neurabin interacted with endogenous PP1 and also with ea
81                      Reduction of endogenous neurabin levels by interference RNA (RNAi)-mediated knoc
82 way of its PDZ domain, the neuronal-specific neurabin may target p70(S6k) to nerve terminals.
83                  Our mechanistic analysis of neurabin-mediated regulation of A1R signaling in this st
84 , A1R and RGS4 each likely interact with one neurabin molecule in a neurabin homo-oligomer to form a
85        Here, we report the identification of neurabin (neural tissue-specific F-actin binding protein
86                        Spinophilin (SPL) and neurabin (NRB) are structurally similar scaffolding prot
87  death in wild-type (WT) mice did not affect neurabin-null mice or WT mice cotreated with an RGS4 inh
88                              Coexpression of neurabin or spinophilin with Lfc resulted in their clust
89 ed in brain, where it interacted with either neurabin or spinophilin.
90                           We demonstrate the neurabin-p70(S6k) interaction by yeast two-hybrid analys
91 ctly and differentially bind spinophilin and neurabin PDZ domains.
92 t disrupting the functions of a cytoskeletal neurabin/PP1 complex enhanced filopodia and impaired sur
93  Spinophilin residues 427-470, or homologous neurabin residues 436-479, were sufficient to bind PP1 i
94 zed F-actin-binding proteins spinophilin and neurabin, respectively.
95 rid analysis using the coiled-coil domain of neurabin revealed an interaction with Lfc, a Rho GEF.
96                          These data identify neurabin-RGS4 as a novel tissue-selective regulatory mec
97   Moreover, these findings implicate the A1R/neurabin/RGS4 complex as a valid therapeutic target for
98 ive effect achieved by disruption of the A1R/neurabin/RGS4 complex is elicited by the on-site and on-
99 ation are essential for formation of the A1R/neurabin/RGS4 ternary complex, as well as for stable loc
100            In the absence of PP1gamma1, both neurabins showed enhanced association with PP1alpha but
101 anslational regulators as substrates for the Neurabin/Spinophilin PIPs, implicated in neuronal plasti
102            Thus, interaction between Lfc and neurabin/spinophilin selectively regulates Rho-dependent
103          Analysis of PP1 binding to chimeric neurabins suggested that sequences flanking a conserved
104 A) holoenzymes containing spinophilin and/or neurabin target specific neuronal PP1 isoforms, facilita
105 el PP1gamma1-selective interaction domain in neurabin that may allow for selective regulation and/or
106 me of the structural determinants in PP1 and neurabins that together contribute to preferential targe
107 M)/R(GL) severely compromised the ability of neurabin to bind and inhibit both isoforms but did not a
108 d the rank order of PP1 isoform selection by neurabins to be PP1gamma1 > PP1alpha > PP1beta.
109 h structures, consistent with the ability of neurabins to target the PP1.I-2 complex to actin cytoske
110 pinophilin: conserved as residues 473-479 in neurabin) to VKDYDTW severely attenuated PP1gamma1 inter
111 argeting proteins DARPP-32, spinophilin, and neurabin were also unchanged.
112 s efficiently coprecipitated spinophilin and neurabin, whereas PP1beta immunoprecipitation did not.
113  PP1 binding, facilitated PP1 recruitment by neurabins, which also targeted I-2 to polymerized F-acti
114 PP1-binding motif attenuated interactions of neurabins with both isoforms.
115 s not involved in the weaker interactions of neurabins with PP1beta.

 
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