ライフサイエンスコーパス: neural development

1 /TrxG transitions take over key roles during neural development.

2 anching versus extension of dendrites during neural development.

3 enriched for biological pathways involved in neural development.

4 associates with diverse binding partners in neural development.

5 ing proteins involved in pathways related to neural development.

6 training regimens with respect to stages of neural development.

7 early childhood depression on alterations in neural development.

8 ed expression and encode other regulators of neural development.

9 lusive patterns, suggesting a role in normal neural development.

10 uggesting a 'detrimental' maternal effect on neural development.

11 required to explain short-range guidance in neural development.

12 t-right patterning and in cardiovascular and neural development.

13 ell types coincides with critical aspects of neural development.

14 replication in cells at the early stages of neural development.

15 the p53 gene family, plays a crucial role in neural development.

16 the importance of the DNA damage response in neural development.

17 these major brain cell types is required for neural development.

18 recluding in vivo study of Geminin's role in neural development.

19 tination is a core regulatory determinant of neural development.

20 for MeCP2 regulation of gene expression and neural development.

21 dance and neurite outgrowth signaling during neural development.

22 ly 7 divisions before differentiating during neural development.

23 ed protein families not previously linked to neural development.

24 , and Pumilio2, which play critical roles in neural development.

25 nto the cellular and molecular regulation of neural development.

26 f up to 7 months, mimicking endogenous human neural development.

27 lated by differential gene expression during neural development.

28 lity, the regulation of gene expression, and neural development.

29 is an advantageous system for studying early neural development.

30 ays a critical role in tumor suppression and neural development.

31 ential participants in nearly all aspects of neural development.

32 epigenetic regulation of gene expression in neural development.

33 of genes involved in cellular signaling and neural development.

34 sts of the brain and CNS and is required for neural development.

35 sight into this essential protein complex in neural development.

36 on, and the role of endosomal trafficking in neural development.

37 a molecule with critical roles in vertebrate neural development.

38 transmembrane guidance cue signaling during neural development.

39 was controlled post-transcriptionally during neural development.

40 ; and cross-talk in metabolic regulation and neural development.

41 g the general importance of this cytokine in neural development.

42 at uses the Plexin A (PlexA) receptor during neural development.

43 lized and plays a crucial role in regulating neural development.

44 roteins impart functionalities essential for neural development.

45 er specific RDC formation is associated with neural development.

46 thway to control microtubule dynamics during neural development.

47 nalyzing transcriptional networks that guide neural development.

48 l death that is relatively specific to early neural development.

49 ell proliferation and differentiation during neural development.

50 d temporal requirement for Htt expression in neural development.

51 corepressor in the Notch pathway regulating neural development.

52 inked these behavioral changes to underlying neural development.

53 ely understood, despite their importance for neural development.

54 ion that Sall4 regulates both mesodermal and neural development.

55 inous, evolutionarily conserved functions in neural development.

56 d calcium regulation, a critical activity in neural development.

57 d LPAR1, that have previously been linked to neural development.

58 Sox2 and Sox19 appear to play major roles in neural development.

59 romatin remodelling occurs during Drosophila neural development.

60 src in the specification of neurons early in neural development.

61 role of CFI in APA control during Drosophila neural development.

62 of neurodevelopmental disorders and typical neural development.

63 critical pathways regulated by FMR1 in human neural development.

64 er gene (LHX9), which may have a role in the neural development.

65 eport here a critical role for Lsh in murine neural development.

66 crucial role in various aspects of postnatal neural development.

67 rients progenitor cell division and supports neural development.

68 Our data suggest a model in which during neural development, ADR-2 levels overcome ADR-1 repressi

69 osed rats, suggesting a sexual dimorphism in neural development after SSRI exposure.

70 f maternal arachidonic acid and DHA on fetal neural development, although the effects on child IQ by

71 ing evidence for plasticity in cognitive and neural development among children raised in deprived env

72 vestigation, owing to their crucial roles in neural development and adult brain function and because

73 of microglia in utero can profoundly affect neural development and affect behavioral outcomes.

74 ncer), serves as an axon guidance cue during neural development and also contributes to vascular morp

75 onal remodeling through the reprogramming of neural development and assessed the effects on circadian

76 potential chromatin regulator implicated in neural development and autism spectrum disorder (ASD) wi

77 finger proteins with essential functions in neural development and axial skeletal patterning in the

78 alyzed the molecular mechanisms of posterior neural development and axis formation regulated by eve1.

79 tanding and interpreting the role of GAGs in neural development and axonal regeneration after CNS inj

80 ulins (NRGs) are protein ligands that impact neural development and circuit function.

81 cellular ribostasis could profoundly affect neural development and contribute to the devastating dev

82 ave other off-target actions that can impact neural development and contribute to therapeutic efficac

83 rturbed expression of many genes involved in neural development and differentiation.

84 at this approach will be useful for studying neural development and disease, and for deriving spheroi

85 portance of these results for modeling human neural development and disease.

86 hPSCs) are powerful tools for studying human neural development and diseases.

87 in a cell type-specific setting relevant to neural development and enables the integration of psychi

88 els has provided unprecedented insights into neural development and evolution.

89 knockout (BERKO) mESCs at defined stages of neural development and examined the effects of an ERbeta

90 o and adult, have important implications for neural development and for learning and memory in the ma

91 lls is a powerful approach both for studying neural development and for modeling human disease.

92 ion of electrically active axons to regulate neural development and function according to environment

93 Corresponding attributes of neural development and function suggest arthropod and ve

94 the CSF-1R and its ligands in microglial and neural development and function, and their relevance to

95 Cs play roles in cellular volume regulation, neural development and function, audition, regulation of

96 ings indicate an essential role for SNX14 in neural development and function, particularly in develop

97 that such extensions might be important for neural development and function.

98 g the importance of GSL expression in normal neural development and function.

99 of poorly understood proteins with roles in neural development and function.

100 alian brain and therefore may participate in neural development and function.

101 in neuronal granules, which are critical in neural development and function.

102 mune cells of the CNS, play crucial roles in neural development and function.

103 e an important and novel role for JAKMIP1 in neural development and further highlight pathways regula

104 8 and Wnt signaling is required for anterior neural development and gastrulation in Xenopus embryos.

105 riched microRNA that plays a crucial role in neural development and has been shown to be down-regulat

106 Due to their well-characterized neural development and high genetic homology to mammals,

107 ontribution of decreased mTORC2 signaling to neural development and homeostasis has not been well stu

108 Microglia have critical roles not only in neural development and homeostasis, but also in neurodeg

109 ight into chromatin regulatory mechanisms in neural development and how alterations to these mechanis

110 es in the regulation of vertebrate embryonic neural development and human cancer cell proliferation.

111 ctor receptor signaling pathways involved in neural development and immune function.

112 and its several members are known to mediate neural development and immune system functioning through

113 oad roles of Rest-mediated repression during neural development and in disease states.

114 articular type V), suggesting roles in early neural development and in the neonatal critical period.

115 The WNT pathway plays multiple roles in neural development and is crucial for establishment of t

116 ating oligodendrocyte precursor cells during neural development and is expressed by myelinating oligo

117 that down-regulation of KLF4 is critical for neural development and its dysregulation may lead to hyd

118 Both proteins play important roles in neural development and may have potential as therapeutic

119 SOX1 plays an important role in neural development and neural progenitor pool maintenanc

120 ay that may also exert critical functions in neural development and neurodegeneration, we asked wheth

121 ific effects on phospholipids linked to both neural development and neurodegeneration.

122 Apoptosis plays an important role in neural development and neurological disorders.

123 lls, and suggest a basis for its function in neural development and neuroprotection.

124 hondrial trafficking, which is essential for neural development and neurotransmission.

125 , these results are consistent with in vitro neural development and physiological progression occurri

126 ich suffer neonatal lethality with defective neural development and pleiotropic phenotypes in multipl

127 us genomic alterations have consequences for neural development and possibly other brain functions.

128 nase in nervous system function, controlling neural development and postsynaptic signal integration.

129 ng how DNA damage signaling pathways promote neural development and preserve homeostasis is essential

130 results identify a novel role for laminin in neural development and provide a possible mechanism for

131 he central nervous system that contribute to neural development and regeneration.

132 papers address the contribution of DISC1 to neural development and schizophrenia risk in this issue

133 OU domain transcription factor implicated in neural development and several cancers.

134 s to assemble protein complexes that promote neural development and signaling, hence tight control of

135 ted proteins that regulate multiple steps of neural development and stem cell differentiation.

136 al an essential role for n1-src in amphibian neural development and suggest that alternative splicing

137 ing, underscoring the importance of ZMIZ1 in neural development and supporting mutations in ZMIZ1 as

138 suggest the participation of EphB2(+) EVs in neural development and synapse physiology.

139 they co-regulate several pathways related to neural development and synaptic function.

140 nvolved in the etiology of SCZ by regulating neural development and synaptic function.

141 aptic structural modification is crucial for neural development and synaptic plasticity, but the mole

142 mbrane protein that plays a critical role in neural development and synaptic plasticity.

143 cific influences of maternal care in shaping neural development and synaptic plasticity.

144 aids in functional specialization throughout neural development and that the loss of this mechanism c

145 CDK5, an important signal transducer in neural development and the closest known functional homo

146 ric, but also neurobiological and can impact neural development and the maintenance of neuronal cell

147 ps we demonstrate here provide insights into neural development and the rise of the metazoan nervous

148 ched for genes in these two modules included neural development and transcriptional regulation.

149 spatiotemporal gene expression in embryonic neural development and uncover a crucial epigenetic mech

150 lucidate the role of calcium fluxes in early neural development and uncover a new factor in the modul

151 unctions influenced by imprinted genes, from neural development and wiring to synaptic function and p

152 Nucleoporins (Nups) are involved in neural development, and alterations in Nup genes are lin

153 Double-strand break repair is required for neural development, and brain cells contain somatic geno

154 y non-homologous end joining is critical for neural development, and brain cells frequently contain s

155 n silenced target gene expression, disrupted neural development, and highly significant larval mortal

156 cell divisions are a fundamental feature of neural development, and misregulation can lead to brain

157 leiotropic signaling molecule that regulates neural development, and mutation of Nrg1 is a risk facto

158 eft-right specification, skeletal formation, neural development, and organogenesis.

159 ish empirical connections among environment, neural development, and perception.

160 r results indicate a novel role for OCRL1 in neural development, and support a model whereby dysregul

161 well as in the cell morphological formation, neural development, and transforming growth factor (TGF)

162 ds and mammals, and although many aspects of neural development are activity-dependent, it has been u

163 However, whether other aspects of neural development are also spared under nutrient restri

164 in the nervous system, although its roles in neural development are only beginning to be understood.

165 roles and mechanisms of action during early neural development are still unclear.

166 athways and cellular processes that regulate neural development are used post-developmentally for pro

167 These profiles are underpinned by atypical neural development at the systems level.

168 osophila melanogaster has led to insights in neural development, axon guidance, ion channel function,

169 During neural development, axonal growth cones depend on rapid

170 tractive system for studying the genetics of neural development because analysis is focused on a sing

171 ke 1 (GRHL1), a gene critical for Drosophila neural development, belonged to the genes most strongly

172 re is a remarkable degree of conservation in neural development both between individual segments in a

173 cific functional relevance of these genes in neural development, brain function, and disease.

174 gans embryo is a powerful model for studying neural development, but conventional imaging methods are

175 tial role in neuronal differentiation during neural development, but it remained unclear whether PS1

176 h in neurodegenerative disease and in normal neural development, but the molecular pathways regulatin

177 Autism is clearly a disorder of neural development, but when, where, and how brain patho

178 stabilizes input and activity levels during neural development, but whether it can restore connectiv

179 et3 plays an essential role in early eye and neural development by directly regulating a set of key d

180 We examined amphioxus neural development by manipulating Hh and downstream gen

181 cal role for SAG in controlling vascular and neural development by modulating RAS activity via promot

182 Astrocytes orchestrate neural development by powerfully coordinating synapse fo

183 e signaling system is a crucial regulator of neural development, cell survival, and plasticity.

184 research and has been central to studies of neural development, circuit computation, and behavior.

185 f the available literature on human prenatal neural development comes from cross-sectional or case st

186 ota and mechanisms by which it can influence neural development, complex behaviours and nociception.

187 t roles of PlexB motifs in distinct steps of neural development contribute to its functional versatil

188 hibitory neurons, and other later aspects of neural development distinct from those regulated by Ascl

189 x8), Wnt signaling (Wnt3, Wnt8a, Wnt7b), and neural development (e.g., Efnb3, Mid1, Nlgn1, Nrxn2).

190 s by ARID1A to govern both early cardiac and neural development from pluripotent stem cells.

191 on these nonconventional ubiquitin chains in neural development, function, plasticity, and related pa

192 on of cannabinoids during critical stages of neural development has been shown to disrupt the brain's

193 ty of midbrain dopamine (mDA) neurons during neural development have remained rather poorly understoo

194 iginally discovered as axon guidance cues in neural development, have been shown to regulate cell mig

195 Microglia have critical roles in neural development, homeostasis and neuroinflammation an

196 naling plays an important regulatory role in neural development, however, post-developmental function

197 achaete-scute homologs (ash) regulate neural development in all bilaterian model animals indic

198 domain proteins regulate specific aspects of neural development in animals from flies to mammals, and

199 to control the timing of sexually dimorphic neural development in C. elegans.

200 As much of the aberrant neural development in Down syndrome (DS) occurs postnata

201 ehavior and Alters Serotonin and Vasopressin Neural Development in Hamsters".

202 we identify a mechanism required for normal neural development in humans that ensures ordered recrui

203 ation of Purkinje cells, are models to study neural development in part because they establish a reco

204 data support a central role for REST during neural development in promoting NS/P cell self-renewal w

205 revealed that MCT8 is strictly required for neural development in the brain and spinal cord.

206 dder, directly implicating both molecules in neural development in the lower urinary tract.

207 ht into how SMARCB1 loss might interact with neural development in the process of ATRT tumorigenesis.

208 into the mechanisms involved in asymmetrical neural development in these two species.

209 y is prominent among those known to regulate neural development in vertebrates.

210 tent stem cells that accurately recapitulate neural development in vitro and allow for the generation

211 catalytic activity is not required for early neural development in vivo but its overactivation during

212 findings support a novel, two-stage model of neural development, in which networks stabilize prior to

213 encodes N-cadherin, whose essential roles in neural development include neuronal migration and axon p

214 tain long-term viability for later stages of neural development, including axon outgrowth and neurona

215 miR181a are several known to be required for neural development, including Engrailed1 (En1), Engraile

216 mplicated as ligands in different aspects of neural development, including neural crest cell migratio

217 ignaling is required for numerous aspects of neural development, including neural induction, CNS patt

218 oping brain and regulate multiple aspects of neural development, including neurogenesis, dendritogene

219 nervous system (CNS) have essential roles in neural development, inflammation and homeostasis.

220 Cyclin A2 loss early during neural development inhibited hippocampal development thr

221 ated progenitors and neurons can be used for neural-development investigation, drug testing, disease

222 impacted neurogenesis relatively late during neural development involving only certain progenitor pop

223 Neural development is controlled at multiple levels to o

224 Thus, expression of PSD-95 during early neural development is controlled at the RNA level by two

225 A general model of neural development is derived to fit 18 mammalian specie

226 An essential feature of vertebrate neural development is ensheathment of axons with myelin,

227 blishment of precise topographic maps during neural development is facilitated by the presorting of a

228 Using light-sheet microscopy, early neural development is here followed in vivo in real time

229 e site of axon emergence is specified during neural development is not understood.

230 An important question in early neural development is the origin of stochastic nuclear m

231 ncipal function of PKA in the Shh pathway in neural development is to restrain activation of Gli2.

232 The crucial role of NEDD4-1 in neural development is well appreciated; however, its rol

233 Although early neural development is well studied, detailed cellular or

234 to the role of p73 in tumor suppression and neural development, its expression and activity are tigh

235 T) is a neuromodulator that is important for neural development, learning and memory, mood, and perce

236 how can neural circuitry be modified during neural development, learning, and memory?

237 They play important roles in cell migration, neural development, metabolism and cancer cell survival.

238 cells (hPSCs) provide a model to study early neural development, model pathological processes, and de

239 Near the end of neural development, most asymmetric division ends and pr

240 nprecedented insights into the mechanisms of neural development, neurological disease and aging.

241 d have important implications for studies of neural development, neurological disease modelling and r

242 Thus, CUL3 is critical to neural development, neurotransmission, and excitation-in

243 a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plas

244 Amphibian neural development occurs as a two-step process: (1) ind

245 Neural development of echinoderms has always been diffic

246 and anxiety disorders as contributors to the neural development of empathy.

247 enues for using fMRI adaptation to study the neural development of high-level visual and cognitive fu

248 , an ASD gene whose expression is related to neural development of the cortex and the hippocampus, sh

249 Parenting in turn shapes the neural development of the infant social brain.

250 However, it is unknown how neural development of these regions relates to the devel

251 d their physiological roles in germ cell and neural development, oncogenic functions in cancer, and p

252 ion of the anteroposterior axis and anterior neural development, or endoderm specification and axial

253 le expression of Dkk1 is required for proper neural development, overexpression of Dkk1 is characteri

254 habitat in both species: cell proliferation, neural development, oxygen responses and muscle capacity

255 ate genes within the GABAergic signaling and neural development pathways.

256 t human microRNA cluster, activating a fetal neural development program.

257 By comparison to earlier steps in neural development, progress has been slow in identifyin

258 d early environments influence cognitive and neural development provides a complementary perspective

259 e SETDB1 solo peaks, particularly those near neural development-related genes, was found to be associ

260 herens junctions, its physiological roles in neural development remain uncertain due to the lack of s

261 hin a cell type-specific setting relevant to neural development remain unclear.

262 Its role in neural development remains unknown.

263 Neural development requires both synapse elaboration and

264 Neural development requires N-glycosylation regulation o

265 involved in promoting muscle development and neural development, respectively.

266 idic protein (hGFAP); E13.5] stages of mouse neural development resulted in no apparent developmental

267 lanogaster embryonic mesoderm development or neural development scored by the Lever motif analysis al

268 During neural development, semaphorin-plexin signalling instruc

269 According to the prevailing view of neural development, sensory pathways develop sequentiall

270 e statistically rich, large-scale studies of neural development, sexual dimorphism, degree of stereot

271 During this early period of neural development, SST(+) cells play critical roles in

272 rofiles included many genes/terms related to neural development, such as cell proliferation, neuronal

273 ach can be used to assess various aspects of neural development, such as developmental waves of diffe

274 conserved transcription factors in mammalian neural development suggest that a similar cascade may al

275 n understanding the significance of DISC1 at neural development, the mechanisms underlying DISC1 regu

276 uncovers a new role of mechanical tension in neural development: the regulation of axon fasciculation

277 stone acetylation and gene expression during neural development, thereby providing a likely explanati

278 in, are essential for processes ranging from neural development through potassium homeostasis to syna

279 ytokine/growth factor with multiple roles in neural development, tissue repair, and disease.

280 However, during early neural development, transcription of most essential neur

281 The timing of notochord, somite, and neural development was analyzed in the embryos of six di

282 e functional role of alternative splicing in neural development, we analyzed purified neural progenit

283 l the functional significance of RBPs during neural development, we carried out an in vivo RNAi scree

284 vidence for Ars2 as a chromatin regulator in neural development, we generated Ars2 ChIP-seq data.

285 o investigate the role of these Pax genes in neural development, we have generated an allelic series

286 understand the genes involved in controlling neural development, we have performed a forward genetic

287 To study neural development, we infected three-dimensional cortic

288 ions between SMARCB1 loss and the process of neural development, we introduced an inducible SMARCB1 l

289 Exploiting this sensitive period of neural development, we modified existing behavioural int

290 ore the relationship between impulsivity and neural development, we studied functional connectivity i

291 pon recent advances in activity-driven early neural development, we suggest a sequence of three devel

292 To study the role of Copb2 in neural development, we utilized genome-editing technolog

293 n factors that are typically associated with neural development were modulated across all three speci

294 Although early phases of neural development were unaltered, Slc7a5 knockdown effe

295 mors were enriched for those associated with neural development where H3K27me3 loss released the pois

296 signaling elicits repulsion of axons during neural development, whereas in endothelial cells this pa

297 l block-face scanning electron microscopy to neural development with fine temporal resolution and the

298 nal FA status in pregnancy may improve fetal neural development with lasting consequences for child d

299 r of the SHH pathway in normal and oncogenic neural development, with direct diagnostic and/or therap

300 se included semaphorin 3a, a guidance cue in neural development without known functions in the pancre