ライフサイエンスコーパス: neural ectoderm

1 rs originate, at least in part, from the non-neural ectoderm.

2 ing early high levels of Hoxb1 expression in neural ectoderm.

3 eural tube but are down-regulated in the non-neural ectoderm.

4 X1 appears to coincide with the induction of neural ectoderm.

5 ence, in vertebrates, of compartments in non-neural ectoderm.

6 gulation of Foxg1 expression in the anterior neural ectoderm.

7 l cells are derived embryologically from the neural ectoderm.

8 ed apical constriction in the neural and non-neural ectoderm.

9 millimetre-long neural tube covered with non-neural ectoderm.

10 ed via extracellular matrix synthesis by non-neural ectoderm.

11 d epiblast, which is predisposed to form the neural ectoderm.

12 lineages such as endoderm, mesendoderm, and neural ectoderm.

13 tube, and they never loose contact with the neural ectoderm.

14 neurosecretory cells in the anteriormost non-neural ectoderm.

15 etween the neural plate and the adjacent non-neural ectoderm.

16 n establishing and maintaining the embryonic neural ectoderm.

17 e oral ectoderm and a juxtaposed fold in the neural ectoderm.

18 that arises at the border of neural and non-neural ectoderm.

19 in the dorsal mesoderm and in the posterior neural ectoderm.

20 , affecting only convergent extension in the neural ectoderm.

21 s of interactions between the neural and non-neural ectoderm.

22 es are both derived embryologically from the neural ectoderm.

23 nd that early Hh signals comes from adjacent neural ectoderm.

24 l folds at the border between neural and non-neural ectoderm.

25 expanded neural plate abuts Dlx-positive non-neural ectoderm.

26 tending throughout the entire neural and non-neural ectoderm.

27 s generated within the deep layer of the non-neural ectoderm.

28 te that foxD5a maintains an undifferentiated neural ectoderm after neural induction.

29 ional signals from the organizer pattern the neural ectoderm along the anteroposterior axis.

30 s position the border between neural and non-neural ectoderm and are required for the specification o

31 the lateral neural plate is regulated by non-neural ectoderm and bone morphogenetic proteins.

32 yseal cells are exclusively derived from non-neural ectoderm and demonstrate that crosstalk between n

33 enes that maintain a proliferative, immature neural ectoderm and down-regulates genes that promote th

34 a primary function of both N-cadherin in the neural ectoderm and E-cadherin in the non-neural (epider

35 astrula, MAPK activity in both newly induced neural ectoderm and ectoderm overexpressing the anterior

36 ains; tfap2a is expressed in the ventral non-neural ectoderm and foxd3 in the dorsal mesendoderm and

37 terior structures, forebrain and heart, from neural ectoderm and mesoderm, respectively.

38 We show that Fz10 is expressed in the dorsal neural ectoderm and neural folds in the region where pri

39 ting cells and allowed discrimination of non-neural ectoderm and otic lineage cells from off-target p

40 Wnt signals from the neural plate, non-neural ectoderm and paraxial mesoderm have all been sugg

41 sed in mice from embryonic day 7 (E7) in the neural ectoderm and primitive streak and subsequently in

42 es, our results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-to-e

43 The neural ectoderm and surrounding tissues also coordinate

44 first expressed in the presumptive anterior neural ectoderm and the blastoderm margin at the late bl

45 ory neurons form at the boundary between non-neural ectoderm and the neural plate.

46 nscription factors expressed in the anterior neural ectoderm and/or presumptive eye field (otx2, pax6

47 sms drive folding: (1) apical contraction of neural ectoderm, and (2) basal adhesion mediated via ext

48 d TAF1 function in cell-cell adhesion in the neural ectoderm, and disruptions in either NFPC or TAF1

49 d, somitic mesoderm, ventrolateral mesoderm, neural ectoderm, and epidermis, between stages 9 (pregas

50 occurs in the dorsal mesoderm and posterior neural ectoderm, and is mediated by similar molecular pa

51 Signals from the non-neural ectoderm, the neural ectoderm, and the underlying mesoderm have all be

52 tive endoderm, Ihh can respecify prospective neural ectoderm (anterior epiblast) along hematopoietic

53 We find that neural and non-neural ectoderm are necessary and sufficient for folding

54 Cells from the prospective neural ectoderm are the most responsive to notochord-ind

55 c expression is strongest in the presumptive neural ectoderm at gastrula and neural plate stages, but

56 ary development, and deletion of Six3 in the neural ectoderm blocked the development of the pituitary

57 opic neurons that extend to the ventral, non-neural, ectoderm, but show no ectopic or enhanced notoch

58 rkhead transcription factor that expands the neural ectoderm by down-regulating genes that promote th

59 Although induction of posterior neural ectoderm by FGF was accompanied by an elevation o

60 1 is involved in establishing trunk and tail neural ectoderm by two independent mechanisms: First, ev

61 has been suggested that both neural and non-neural ectoderm can contribute to the neural crest.

62 We report that in response to FGF the non-neural ectoderm can ectopically express several early ne

63 These results suggest that the non-neural ectoderm can launch the neural crest program in t

64 is responsive earlier; the retina and other neural ectoderm can respond to RA at any stage.

65 Individual non-neural ectoderm cells on opposing sides of the neural fo

66 We also show that SE cells and neural ectoderm cells possess distinct gene expression p

67 the organizer, can redirect the fate of non-neural ectoderm cells to form a complete, patterned nerv

68 foxD5 is expressed in the nascent neural ectoderm concomitant with several other neural-fa

69 Expression of cfrzb-1 in the neural ectoderm continues up through stage 8.

70 oral ectoderm (Rathke's pouch), whereas the neural ectoderm contributes to the neurohypophysis.

71 s arise at the border of the neural- and non-neural ectoderm during anamniote vertebrate development.

72 at the BMP pathway is active in the anterior neural ectoderm during late blastula to early gastrula s

73 rulation and the proper specification of the neural ectoderm during neural induction.

74 ation signal acting from the extraocular non-neural ectoderm during optic vesicle evagination.

75 Cells of the overlying posterior neural ectoderm engage in similar morphogenetic cell mov

76 ozygous for Otx2 deficiency in the pituitary neural ectoderm exhibited altered patterning of gene exp

77 Upon neural induction(5,6), neural ectoderm folds into a millimetre-long neural tube

78 an initially synchronous guidance toward non-neural ectoderm, followed by comparatively asynchronous

79 nstrate that Dlx activity is required in non-neural ectoderm for the production of signals needed for

80 eural crest cells require BMP expressing non-neural ectoderm for their induction.

81 rder region between the neural plate and non-neural ectoderm from which multiple cell types, includin

82 ddress the molecular mechanisms by which non-neural ectoderm generates neural crest.

83 derm contributing the anterior lobe, and the neural ectoderm generating the posterior lobe.

84 along the anterior-posterior axis depends on neural ectoderm geometry in addition to molecular gradie

85 ding to neural crest development via the non-neural ectoderm in amniotes and present a distinct respo

86 al crest (NC), cranial placode (CP), and non-neural ectoderm in multiple hPSC lines, on different sub

87 ssion of cfrzb-1 is in cells fated to become neural ectoderm in streak-stage embryos.

88 RA signals to regulate AP patterning of the neural ectoderm in the late blastula to gastrula embryo

89 ation were first recruited to the dorsal non-neural ectoderm in the tunicate-vertebrate ancestor but

90 anism underlying convergent extension of the neural ectoderm in the Xenopus laevis late gastrula and

91 s a major role in shaping and patterning the neural ectoderm in vertebrate embryos.

92 Neural ectoderm in X. laevis consists of two components,

93 ion homologously to define neural versus non-neural ectoderm in Xenopus.

94 ing AP-2 gamma (Tfap2c), is expressed in non-neural ectoderm including transiently in neural crest.

95 ectoderm, via meso-ectodermal, or neural-non-neural ectoderm interactions.

96 Neurogenesis in Xenopus neural ectoderm involves multiple gene families, includi

97 Expression in non-neural ectoderm is a conserved feature in amphioxus and

98 conclude that contact between neural and non-neural ectoderm is capable of inducing RBs, that BMP4 ca

99 udy demonstrates that Otx2 expression in the neural ectoderm is important intrinsically for the devel

100 ry gland, and suggest that Hh signaling from neural ectoderm is necessary for induction and functiona

101 late and its inhibition in the most anterior neural ectoderm is required for normal forebrain develop

102 rainyhead-like 2 (GRHL2) is expressed in non-neural ectoderm (NNE) and Grhl2 loss results in fully pe

103 BMP receptor, was transplanted into the non-neural ectoderm of un-manipulated hosts.

104 , inhibition of beta-catenin activity in the neural ectoderm of whole embryos by a truncated TCF resu

105 Cells in the presumptive neural ectoderm of Xenopus are committed to neural fate

106 actions at the border between neural and non-neural ectoderm or mesoderm, and defined factors such as

107 helia that represent the mouse embryonic non-neural ectoderm, preplacodal ectoderm and otic vesicle e

108 onological expression of marker genes of non-neural ectoderm, preplacodal ectoderm, and early otic li

109 ulation to pattern both the mesoderm and the neural ectoderm properly.

110 on and reciprocal expansion in nonneural and neural ectoderm, respectively, in snailhouse, somitabun,

111 genes, BMP2/4 and chordin, in nonneural and neural ectoderm, respectively, of chordates and Drosophi

112 Furthermore, the non-neural ectoderm responds to FGF by expressing the prospe

113 nd cellular morphologies as the cells in the neural ectoderm shape and form the neural folds and neur

114 Also, the cohesiveness of differentiating neural ectoderm should increase after induction, causing

115 erentiating cultures first expressed the non-neural ectoderm specific transcriptional factors TFAP2A,

116 across the interface between neural and non-neural ectoderm that is critical for inducing and patter

117 Signals from the non-neural ectoderm, the neural ectoderm, and the underlying

118 on protein expands the neural plate into non-neural ectoderm tissue whereas ectopic activation of Dlx

119 we reveal that Tcf3 is essential within the neural ectoderm to maintain anterior character and that

120 hat Cdx factors function directly within the neural ectoderm to specify spinal cord.

121 patially restrict mesoderm, endoderm and non-neural ectoderm to their proper locations in the Xenopus

122 signals can respecify anterior (prospective neural) ectoderm to a posterior mesodermal fate, resulti

123 ation of these neural crest markers, the non-neural ectoderm upregulates both BMP and Wnt molecules i

124 endent mechanisms: First, eve1 posteriorizes neural ectoderm via induction of aldh1a2, which encodes

125 The lack of FGF signaling from the neural ectoderm was sufficient to impair anterior lobe g

126 luence the differentiation of neural and non-neural ectoderm, we show here that members of the Dlx fa

127 ry lobe and stalk, which normally arise from neural ectoderm, were extremely hypoplastic.

128 s in the inner or sensorial layer of the non-neural ectoderm where a subset of cells are chosen to di

129 brate embryos is comprised of neural and non-neural ectoderm, with the border territory at their inte