ライフサイエンスコーパス: neural retina

1 f excessive scar tissue found throughout the neural retina.

2 urfaces of vascular endothelial cells of the neural retina.

3 approximately four times more 7kCh than the neural retina.

4 arrays that directly stimulated cells of the neural retina.

5 script is localized to the nuclear layers of neural retina.

6 an additional pathway in Muller cells of the neural retina.

7 tly by controlling development of the distal neural retina.

8 ir immediate neighbors were transformed into neural retina.

9 the retinal pigment epithelium (RPE) and the neural retina.

10 E), a thin layer of cells that underlies the neural retina.

11 u hybridization showed expression across the neural retina.

12 pithelium and surface ectoderm/FGF specifies neural retina.

13 expression found in progenitor cells of the neural retina.

14 g to a dorsal transdifferentiation of RPE to neural retina.

15 liogenesis or angiogenesis take place in the neural retina.

16 both cell division and proliferation in the neural retina.

17 l environment, in this case the degenerating neural retina.

18 s Kir7.1 and Kir4.1 in native bovine RPE and neural retina.

19 orsal retinal pigment epithelium and ventral neural retina.

20 ls, whereas VEGFR-2 was detected only in the neural retina.

21 in the apical membrane of the RPE and in the neural retina.

22 al retina, but Kir4.1 transcript only in the neural retina.

23 on of glial fibrillary acidic protein in the neural retina.

24 lete absence of Raldh1 protein in the dorsal neural retina.

25 generation of the photoreceptor cells of the neural retina.

26 ation of the promoters of genes expressed in neural retina.

27 uption of the RPE monolayer or injury to the neural retina.

28 little is known about prostaglandins in the neural retina.

29 role of FGF9 in defining the boundary of the neural retina.

30 f photoreceptor recruitment in the subjacent neural retina.

31 in cone photoreceptors of the differentiated neural retina.

32 ris and ciliary body in the developing mouse neural retina.

33 pparently promotes vertical divisions in the neural retina.

34 inal pigment epithelium (RPE) to support the neural retina.

35 tion during progenitor cell divisions in the neural retina.

36 encing the plane of division in the adjacent neural retina.

37 E cell layer from the choroidal blood to the neural retina.

38 he domains of the optic vesicle into RPE and neural retina.

39 function of the Reelin signaling pathway in neural retina.

40 e physical location to affect the underlying neural retina.

41 induced with retinal Ags, which targets the neural retina.

42 ium where it regulates lactate levels in the neural retina.

43 o formation of intraretinal circuitry in the neural retina.

44 ransfer of nutrients from choroidal blood to neural retina.

45 A to the mouse RPE cells and to cells of the neural retina.

46 se RPE/choroid and are expressed also in the neural retina.

47 use and rat RPE and in several layers of the neural retina.

48 rt of folate from the choroidal blood to the neural retina.

49 iation of neurons in the embryonic zebrafish neural retina.

50 plate mesoderm, and none was detected in the neural retina.

51 neuroblasts and differentiating cells of the neural retina.

52 n cell axons are found between pigmented and neural retina.

53 ins unclear how EPO functions to support the neural retina.

54 o the complete spectrum of cell types in the neural retina.

55 eptor A but not Endothelin receptor B in the neural retina.

56 yed RPE cells selectively, without damage to neural retina.

57 opment and neuroprotection, including in the neural retina.

58 cone photoreceptors that are present in the neural retina.

59 surements were then extended to human normal neural retina.

60 otoreceptor cells in the macular area of the neural retina.

61 ent epithelium (RPE), a support layer of the neural retina.

62 layer of cells underlying and supporting the neural retina.

63 ap of the transcriptome of the adult, murine neural retina.

64 4) exhibit incomplete vascularization of the neural retina.

65 anced in the retinal vessels, but not in the neural retina.

66 d photoreceptor cells and helps organize the neural retina.

67 f Opa1 and Fis1 were performed on cbs(+)/(-) neural retinas.

68 in the RPE cells to the membranes facing the neural retina, a location ideally positioned to influenc

69 Diffusible factors secreted by the neural retina acted synergistically with basolateral sti

70 Neural retinas adjacent to the CLIC4-suppressed RPE cell

71 Neonatal neural retinas (aged <24 hours) from C57BL/6 or BALB/c m

72 quence of development found in the mammalian neural retina and a well-established epigenetic aging cl

73 resent in the iris in cases 1, 3, and 4; the neural retina and choroid in case 1; and in the optic ne

74 lar targets and surrounding tissues (such as neural retina and choroid).

75 confluent monolayer, or they may invade the neural retina and disrupt visual function.

76 SD-OCT disclosed undulations of the neural retina and hyperreflectivity of the photoreceptor

77 We confirmed expression of Cnnm4 in the neural retina and in ameloblasts in the developing tooth

78 , we report that miR-24a is expressed in the neural retina and is required for correct eye morphogene

79 ) is specifically expressed in the embryonic neural retina and is required for the genesis of retinal

80 only weakly in undifferentiated, presumptive neural retina and is then up-regulated selectively in pr

81 ciently transduces a variety of cells of the neural retina and of the retinal pigment epithelium (RPE

82 Fz8 expression overlaps with Fz5 in the neural retina and optic fissure/disc.

83 y peripapillary glia, at the junction of the neural retina and optic nerve head and by glia within th

84 express markers characteristic of developing neural retina and photoreceptors.

85 Apposition of the neural retina and pigment epithelium is critical to phot

86 es, at the same developmental stage when the neural retina and pigmented epithelium are specified and

87 the bipotential optic vesicle into specific neural retina and pigmented epithelium domains.

88 for establishing the distinction between the neural retina and pigmented epithelium in the optic vesi

89 rmed eye cups that contained a lens vesicle, neural retina and pigmented epithelium, based on morphol

90 as neuronal and glial migration outside the neural retina and proliferative changes in glial cells,

91 At later stages, Raldh1 expressed in dorsal neural retina and Raldh3 expressed in ventral neural ret

92 unsaturated fatty acid transport between the neural retina and retinal pigment epithelium.

93 retinal primordia (the optic vesicles) into neural retina and retinal pigmented epithelium depends o

94 he retina, which becomes subdivided into the neural retina and retinal pigmented epithelium domains.

95 T-PCR showed expression of PCFT mRNA in both neural retina and RPE eye cup.

96 ta link Chx10 and Mitf to maintenance of the neural retina and RPE fates respectively.

97 analysis were performed in freshly isolated neural retina and RPE/eyecup, primary mouse Muller cells

98 s a T cell-mediated disease that targets the neural retina and serves as a model of human uveitis.

99 the dorsal retinal pigmented epithelium into neural retina and the absence of a defined ganglion cell

100 E is a monolayer of tissue found between the neural retina and the choroid.

101 ilitate the analysis of Crb1 function in the neural retina and the identification of interacting fact

102 The interface between the neural retina and the retinal pigment epithelium (RPE) i

103 used to detect the expression of HFE mRNA in neural retina and the RPE-eyecup.

104 rt of folate from the choroidal blood to the neural retina and uses not only the reduced-folate trans

105 e development of proximo-ventral identities, neural retina and ventral optic stalk is also compromise

106 eflex we showed expression in the developing neural retina and ventricular zone of the optic stalk.

107 While s-actin mRNA was not detected in E7 neural retina and was at variable levels in stage 9-15 n

108 R may initially involve abnormalities of the neural retina and worsen with later development of catar

109 albumin leakage from blood vessels into the neural retina, and electron microscopy demonstrated vasc

110 n) in developing mutant RPE as compared with neural retina, and of Tuba3a, which exhibited dramatical

111 -retinol also accumulated transiently in the neural retina, and the transient increase in all-trans-r

112 ld-type eyes were sectioned and labeled with neural retina- and RPE cell type-specific antibodies.

113 ed cortical vitreous near or adherent to the neural retina, appeared clearly in most peripheral findi

114 he diencephalon-derived optic stalk (OS) and neural retina are also patterned in response to Hh signa

115 How and when positional identities in the neural retina are established have been addressed primar

116 Pigmented epithelium and neural retina are established through interactions with

117 ven major classes of cells of the vertebrate neural retina are generated from a pool of multipotent p

118 tion to differential EphA3 expression in the neural retina, are required for retinal ganglion axons t

119 e seven major cell classes of the vertebrate neural retina arise from a pool of multipotent progenito

120 the retinal pigment epithelium (RPE) and the neural retina arise from a single layer of neuroectoderm

121 barely detectable in calvaria, notochord, or neural retina at select stages of development, suggestin

122 Diabetes leads to dysfunction of the neural retina before and independent of classical microv

123 ized to an appropriately sized-transcript in neural retina but not in RPE.

124 ognized a monomer of approximately 60 kDa in neural retina but not in RPE.

125 MCT4 was detected in the neural retina but not in the RPE.

126 /SPARC in both the macula and the peripheral neural retina but only in trace amounts in the RPE/choro

127 PE)CAV1(-/-) mice developed a normal RPE and neural retina but showed reduced rod photoreceptor light

128 s revealed Kir7.1 transcript in both RPE and neural retina, but Kir4.1 transcript only in the neural

129 ecifically repressed EphA3 expression in the neural retina, but not in other parts of the central ner

130 in the normal development of the underlying neural retina, but the mechanisms by which this regulati

131 ript of approximately 1.5 kb in both RPE and neural retina, but with greater expression in RPE.

132 ics have been designed to interface with the neural retina by electrically stimulating the remaining

133 PE regulates proliferation in the underlying neural retina by the release of a soluble factor and ide

134 pressed in developing B-cells, forebrain and neural retina, by analyzing embryos deficient in functio

135 anophthalmia, or a change of cell fate into neural retina called transdifferentiation.

136 in several neural structures, including the neural retina, cerebellum, cortex, striatum, and hippoca

137 The vertebrate neural retina comprises six classes of neurons and one c

138 ressive appearance of pigmented cells in the neural retina, concomitant with loss of expression of re

139 ng raises the possibility that damage to the neural retina contributes to capillary degeneration.

140 The seven principal cell types of the neural retina derive from a population of multipotent pr

141 opment, Sey/Sey cells that contribute to the neural retina die, even when wild-type cells are availab

142 embryonic origin, the pigment epithelium and neural retina differentiate into two very distinct tissu

143 ated us to test whether FGF is necessary for neural retina differentiation during the initial stages

144 FGF-induced neural retina differentiation in the absence of the pre-

145 n in controlling RPE apicobasal polarity and neural retina differentiation.

146 If ectopic BMP is added, a neural retina does not develop and optic cup morphogenes

147 The neural retina domains were always close to a source of F

148 is predominantly expressed in the peripheral neural retina during early eye development, but not in t

149 c protective mechanisms are activated in the neural retina during early stages of retinal detachment.

150 ocular vascular endothelial cells and mouse neural retina during normal and ROP development, and alt

151 munication via gap junctions between RPE and neural retina during RGC neurogenesis.

152 and Delta were found to be expressed in the neural retina during the period of cell fate determinati

153 To evaluate the function of the neural retina, electroretinographic (ERG) responses to f

154 We show that the adult mammalian neural retina exhibits a surprising degree of plasticity

155 The neural retina expresses multiple monocarboxylate transpo

156 etinal pigmented epithelium cells to adopt a neural retina fate and abnormal differentiation of the d

157 ich the retinal pigment epithelium (RPE) and neural retina fates segregate during ocular morphogenesi

158 A (all-trans-retinol (all-trans-ROL)) in the neural retina following a photobleach and 5-fold lower r

159 that Sey/Sey cells contribute poorly to the neural retina forming small clumps of cells restricted t

160 x6(-/-) cells contributed only poorly to the neural retina, forming small clumps of cells that were n

161 s of eye-cups that included RPE and isolated neural retina from Abcr-/- mice and RPE isolated from hu

162 protocols have been described for producing neural retina from human pluripotent stem cells (hPSCs),

163 in the retinal pigment epithelium (RPE) and neural retina from individual donors were compared.

164 g eye development, namely the demarcation of neural retina from pigmented epithelium.

165 Freshly harvested intact sheets of RPE with neural retina from pigmented normal rat fetuses were gel

166 ter blood-retina barrier (BRB) separates the neural retina from the choroidal vasculature, which is r

167 Detachment of the neural retina from the retinal pigment epithelium induce

168 ous opacities, and shallow separation of the neural retina from the RPE.

169 and chelation (using kainic acid, KA) on the neural retina from wildtype and Ca(v)2.3-deficient mice.

170 Neural retinas from 5-day-old chick embryos were dissoci

171 , the expression of PEDF receptors in native neural retinas from adult steers was examined.

172 The neural retinas from both diabetic and nondiabetic subjec

173 The early patterning events that shape the neural retina guide the genesis and distribution of post

174 expression increased in Muller cells in the neural retina in association with RPE changes and photor

175 a supply of new photoreceptors, because the neural retina in human eyes lacks regeneration capabilit

176 effects on adjacent RPE, creating an ectopic neural retina in place of the RPE.

177 factor NeuroD were studied in the developing neural retina in rodent.

178 s aus embryos, there is ectopic outgrowth of neural retina in the temporal half of the eyes, whereas

179 pigment epithelium, resulting in a duplicate neural retina in transgenic mice.

180 fate, resulting in formation of a duplicated neural retina in transgenic mice.

181 nown to be present in many cell types of the neural retina, in situ hybridization analysis in the pre

182 The accumulation of all-trans-retinol in neural retina, in the absence of CRBPI and the reduced a

183 etraction was also present in full-thickness neural retina incubated at 37 degrees C.

184 ment epithelium extends into the presumptive neural retina, indicating a role of FGF9 in defining the

185 autoimmune uveitis (EAU) is a disease of the neural retina induced by immunization with retinal antig

186 taraldehyde) are substantially different for neural retina interactions than for liver or heart inter

187 vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hedgehog (Hh) sig

188 The neural retina is a complex sensory structure designed to

189 In addition, the embryonic zebrafish neural retina is characterized by the presence of amoebo

190 Transgene expression in the neural retina is limited exclusively to rod photorecepto

191 The vertebrate neural retina is mainly composed of cells of neuroectode

192 The neural retina is organized along central-peripheral, dor

193 Despite the high metabolic demands of the neural retina, its detachment from the retinal pigment e

194 Although Pcdh15 is present in neural retina, its role remains unclear.

195 und in association with blood vessels in the neural retina itself, as well as with choroidal blood ve

196 outer pigment epithelium layer and an inner neural retina layer.

197 r sequence (-8 to +33 bp) of Frmpd1 binds to neural retina leucine zipper (NRL) and cone-rod homeobox

198 phototransduction genes synergistically with neural retina leucine zipper (NRL) and cone-rod homeobox

199 The protein neural retina leucine zipper (Nrl) is a basic motif-leuc

200 The transcription factor neural retina leucine zipper (Nrl) is a critical determi

201 Neural retina leucine zipper (NRL) is an essential trans

202 Using the "pure-cone" retinas of the neural retina leucine zipper (Nrl) knock-out (KO, -/-) m

203 ns are significantly higher in cone-dominant neural retina leucine zipper (Nrl) knock-out mouse retin

204 nscription factors-cone--rod homeobox (CRX), neural retina leucine zipper (NRL), and nuclear receptor

205 Maf and the closely related family members Neural retina leucine zipper (Nrl), L-Maf, and Krml1/Maf

206 ic motif leucine zipper transcription factor neural retina leucine zipper (NRL).

207 (Rho-/-, lacking rod OS), Rom-1 (Rom-1-/-), neural retina leucine zipper (Nrl-/-, cone-dominant), an

208 thyroid hormone receptor beta2 (TRbeta2) and neural retina leucine zipper factor (NRL) lack M cones a

209 The neural retina leucine zipper factor (NRL) transcription

210 les that described for Nrl(-/-) mice lacking neural retina leucine zipper factor.

211 in situ hybridization analyses of the mouse Neural retina leucine zipper gene (Nrl) mutant, which sh

212 vival were compared between mouse retinas of neural retina leucine zipper knockout (Nrl(-/-)) mice an

213 th that of the cone-only retina of Nrl(-/-) (Neural retina leucine zipper knockout) mouse.

214 both, including the rod-determining factors neural retina leucine zipper protein (Nrl) and the orpha

215 The rod photoreceptor-specific neural retina leucine zipper protein Nrl is essential fo

216 The neural retina leucine zipper transcription factor-knocko

217 NRL (neural retina leucine zipper) and CRX (cone rod homeobox

218 NRL (neural retina leucine zipper) is a basic motif leucine z

219 NRL (neural retina leucine zipper) is a key basic motif-leuci

220 The bZIP transcription factor NRL (neural retina leucine zipper) is critical for rod versus

221 egion of the human retina, we used Nrl(-/-) (neural retina leucine zipper) mice, to generate Rpgr(ko)

222 ors expressing the transcription factor Nrl (neural retina leucine zipper) to show that successfully

223 KLF15, Crx (cone rod homeobox), and/or Nrl (neural retina leucine zipper).

224 tif-leucine zipper transcription factor NRL (neural retina leucine zipper).

225 els than the MFAO-1s while achieving similar neural retina levels.

226 methyl-d-aspartate-induced cell death in the neural retina, levels of the nuclear isoform of CaMKIIal

227 tors that give rise to some iRGCs in ventral neural retina (Marcucci et al., 2016), cell cycle exit i

228 The neural retina metabolizes glucose through aerobic glycol

229 ght junctions, but secretory products of the neural retina must induce the expression of additional p

230 In the developing chick, neural retina neurocan is present in the inner plexiform

231 vestigate how tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE

232 ment, retinal pigmented epithelium (RPE) and neural retina (NR) arise from a common origin, the optic

233 pigmented epithelial cells and self-forming neural retina (NR)-like structures containing retinal pr

234 buted on the surface of cells from the adult neural retina of bovine eyes.

235 ced reduction of GLUT1 expression in retina, neural retina of diabetic rats still possessed more GLUT

236 ) in the RPE and, to a lesser extent, in the neural retinas of AAV.GFP-treated eyes.

237 Neonatal neural retinas of C57BL/6 mice or ovalbumin were injecte

238 al donor cells (1 ~ 2 x 10(4)) isolated from neural retinas of neonatal eGFP transgenic mice were inj

239 t epithelium (RPE) possessed more GLUT1 than neural retina or its microvessels, and expression of the

240 m, serum-free medium that was conditioned by neural retinas, or serum-free medium that was supplement

241 achment induces neurochemical changes in the neural retina over a span of days to weeks.

242 eural retina and Raldh3 expressed in ventral neural retina (plus weaker expression of each in lens/co

243 tion of retinal pigment epithelium (RPE) and neural retina progenitor cells (NRPCs), to investigate t

244 ound that the Muller cells in the salamander neural retina promote cone-specific pigment regeneration

245 Here, we show that mouse, primate, and human neural retinas promote pigment regeneration and dark ada

246 In developing neural retina, radial glia-like Muller cells are generat

247 hic factors normally provided by the healthy neural retina rather than by a direct effect of the gene

248 We examined how the neural retina regulates the assembly of tight junctions

249 RA that delivers an essential signal to the neural retina required for morphogenetic movements that

250 together, these observations imply that the neural retina responds to Edn2 by synthesizing one or mo

251 RT-PCR of whole neural retina resulted in the amplification of mRNA tran

252 its loss, or separation from the underlying neural retina results in severe photoreceptor degenerati

253 ovements coordinated between the prospective neural retina, retinal pigmented epithelium (RPE) and le

254 In neural retina, rod sprouting was significantly increased

255 ith concomitant disruption of the developing neural retina, RPE and lens.

256 Eya2 is expressed in neural retina, sclera and optic nerve sheath.

257 ate optic cup: pigmented epithelium, sensory neural retina, secretory ciliary body and muscular iris.

258 eneration and accumulation of albumin in the neural retina, significantly reducing diabetes-induced r

259 is used to target the Nrl gene, encoding for Neural retina-specific leucine zipper protein, a rod fat

260 c genes and downregulating expression of the neural retina-specific markers.

261 ar mesenchyme inhibits the expression of the neural retina-specific transcription factor Chx10 and do

262 Hemorrhage under the neural retina (subretinal hemorrhage) can occur in the c

263 optic vesicle that is destined to become the neural retina, suggesting a role in neural patterning in

264 RMD7 in human embryonic brain and developing neural retina, suggesting a specific role in the control

265 to convert the retinal pigment epithelium to neural retina, suggesting that Ras-mediated signaling ma

266 concomitant reduction in MCT1 and -4 in the neural retina supporting a role for 5A11/basigin in the

267 isomers, and the total levels were higher in neural retina than in retinal pigment epithelium (RPE).

268 terations in the glutamatergic system of the neural retina that are consistent with a massive efflux

269 mical mechanism in Muller glial cells of the neural retina that can contribute to sustained cone func

270 the retinal vasculature and function of the neural retina that were most marked at age 18 days.

271 In the adult neural retina, the administration of 1.99.25 induced PLV

272 Within the neural retina, the ganglion cells showed axonal projecti

273 mally fated to become the anterior brain and neural retina, the induced aggregates contribute to ante

274 formation of four different structures: the neural retina, the retinal pigment epithelium (RPE), the

275 ing neuroepithelial cells of the presumptive neural retina, then it is down-regulated as differentiat

276 al lamina protein that is synthesized by the neural retina throughout development is agrin with gangl

277 ight-dependent processes in both the RPE and neural retina to ensure adequate 11-cis-retinal producti

278 in shaping the precise connections from the neural retina to the brain.

279 opose that MG act like springs that hold the neural retina together, finally confirming an active mec

280 sicle explant cultures or in the presumptive neural retina using in ovo-electroporation.

281 lectrical stimulation of intact cells of the neural retina using this prosthetic device reliably elic

282 of dissection, the authors found that in the neural retina, vitamin E displayed a minimum near the fo

283 acquisition and retention of flavins in the neural retina, warranting future investigation into retb

284 The neural retina was dissected from normal pigmented mice a

285 RT-PCR from the RPE/choroid complex and the neural retina was functional as assessed by the binding

286 Neural retina was removed by exposure of the eyecup to i

287 ung (postnatal day 11/12) Muller glia of the neural retina, we isolated the Muller glia from Rlbp-Cre

288 The only remaining Sey/Sey cells in the neural retina were associated with blood vessels, includ

289 l capillaries and accumulation of albumin in neural retina were significantly increased in mice diabe

290 the retinal vasculature and function of the neural retina were studied longitudinally.

291 s of isolated photoreceptor cells and intact neural retina were used.

292 Opa1 and Fis1 protein levels in cbs(+)/(-) neural retinas were elevated to 191.00% +/- 26.40% and 2

293 extracellular adenosine is regulated, rabbit neural retinas were maintained by superfusion at differe

294 Cat and rabbit neural retinas were separated from the RPE in vivo for 5

295 The eyes were enucleated, and the neural retinas were separated from the RPE/choroid/scler

296 witch their phenotype and differentiate into neural retina when treated with fibroblast growth factor

297 Whether damage to the neural retina will damage the vasculature, however, is l

298 xpressed asymmetrically across the embryonic neural retina with highest levels of mRNA within dorsal

299 SMCT2 mRNA and protein were detected only in neural retina, with a pattern of protein localization co

300 ed neural differentiation in the presumptive neural retina, without affecting pigmented epithelial ce