ライフサイエンスコーパス: neuregulin-1

1 phrenia (e.g., catechol-O-methyltransferase, neuregulin-1).

2 is dependent on the signaling protein Nrg1 (neuregulin-1).

3 ity receptor, primase 1, erythropoietin, and neuregulin 1.

4 gene encoding the high-affinity HER3 ligand neuregulin 1.

5 genes during nerve repair in animals lacking neuregulin 1.

6 e murine Notch derivative mNDeltaE and human neuregulin-1.

7 acellular polarity maintenance cues, such as neuregulin-1.

8 ence analysis identified the factor as mouse neuregulin-1.

9 ion were specifically blocked by antibody to neuregulin-1.

10 differentiation factor is an isoform of beta-neuregulin-1.

11 NEDD4 and the interaction was independent of neuregulin-1.

12 ds to reduced expression of the ErbB3 ligand neuregulin-1.

13 effects of TGFbeta1 were potentiated by beta-neuregulin-1, a differentiation factor expressed in preg

14 In this report we show that neuregulin-1, a growth and differentiation factor essent

15 responses is the endothelial release of NRG (neuregulin)-1-a paracrine growth factor activating ErbB2

16 ing monoclonal antibody huHER3-8 can inhibit neuregulin-1 activation of ERBB3 and downstream signalin

17 Neuregulin 1 acts as an axonal signal that regulates mul

18 We proposed that neuregulin-1 affects fetal lung maturation through a sim

19 We determined the expression of neuregulin 1 and ErbB4 receptors in AS mice and wild-typ

20 analysis identified key secreted molecules, neuregulin 1 and osteopontin, as pivotal players in regu

21 ors for adult psychiatric illnesses, such as Neuregulin-1 and Disrupted-in-Schizophrenia-1 (DISC1), i

22 Genomic analyses of MPNSTs arising in neuregulin-1 and epidermal growth factor receptor-overex

23 phenotypes are similar to those reported in neuregulin-1 and ErbB mutant mice, and neuregulin effect

24 In cultured cardiomyocytes, combined neuregulin-1 and insulin-like growth factor-I also had a

25 support the concept that the interaction of neuregulin-1 and insulin-like growth factor-I pathways p

26 Combined treatment with neuregulin-1 and insulin-like growth factor-I strongly i

27 In mammals, the growth factor neuregulin-1 and its receptors of the ErbB family play c

28 Although neuregulin-1 and neuregulin-2 are both binding ligands f

29 The effects of neuregulin-1 and of fibroblast-conditioned media on both

30 ulate that neuronally enriched Bace1 cleaves neuregulin-1 and that processed neuregulin-1 regulates m

31 hwann cells to the major axonal mitogen beta-neuregulin-1 and the death response to TGFbeta or serum

32 d in promyelination signaling through axonal neuregulin-1 and the ERBB2 Schwann cell receptor.

33 , we found that expression patterns of NRG1 (neuregulin-1) and its receptor ErbB4, which are essentia

34 wth factor (EGF) family members, Tgf(alpha), Neuregulin 1, and Neuregulin 3, as well as two other sig

35 Cs) express erbB receptors and their ligand, neuregulin-1, and can respond to neuregulin by prolifera

36 role of endothelial-derived growth factors, neuregulin-1, and insulin-like growth factor-I.

37 liary ganglion neurons is an isoform of beta-neuregulin-1, and that this factor acts in concert with

38 These effects of neuregulin-1 appear to involve the activation of focal a

39 th basic fibroblast growth factor (bFGF) and neuregulin-1 beta 1 (NRG1beta1).

40 Thus, neuregulin-1 beta may control fetal lung maturation thro

41 Neuregulin-1 beta was found to be secreted by the fetal

42 Epidermal growth factor (EGF), neuregulin 1-beta (NRG1-beta), betacellulin (BTC), trans

43 metalloproteinase inhibition, inhibition of neuregulin 1-beta binding to HER3, and inhibition of HER

44 rin synthesis, the membrane-bound prohormone neuregulin 1-beta is cleaved and binds to human epiderma

45 e and 6-O-sulfate groups also contributed to neuregulin-1 binding in these two assays.

46 ficantly reduced erbB receptor activation by neuregulin-1 but had no effect on the activity of neureg

47 n BACE1-null mice, the abolished cleavage of neuregulin-1 by BACE1 is speculated to cause reduced mye

48 To demonstrate a direct cleavage of neuregulin-1 by BACE1, we have identified a BACE1 cleava

49 ith iris cells or low concentrations of beta-neuregulin-1 by themselves was insufficient to stimulate

50 myelination appears to stem from the loss of neuregulin-1 cleavage by BACE1.

51 hippocampal synaptic dysfunction in a hyper-neuregulin-1 condition and thus provides novel insights

52 tors for schizophrenia, including dysbindin, neuregulin 1, DAOA, COMT, and DISC1, and neurobiological

53 n of muscle spindle differentiation requires neuregulin 1, derived from Ia afferent sensory neurons,

54 Exposure of unloaded cells to neuregulin-1 did not alter neurite density but increased

55 Further, erbB receptor activation by neuregulin-1 enhances cell motility in two-dimensional s

56 his report, we examine the potential for the neuregulin-1/erbB receptor signaling network to contribu

57 ulates prefrontal cortex myelination through neuregulin-1/ErbB3 signaling and that this is essential

58 neocortex, a process apparently mediated by Neuregulin-1/ErbB4 short- and long-range signaling.

59 Low concentrations of beta-neuregulin-1 evoked a robust increase in whole-cell K(Ca

60 wing nerve injury is not dependent on axonal neuregulin 1 expression.

61 Moreover, we show that neuregulin-1 family member neuregulin-3 is also cleavabl

62 One alternatively spliced neuregulin-1 form has a distinct heparin-binding immunog

63 ozyme-based strategy for the perturbation of neuregulin-1 function in developing chick embryos.

64 naling involving dopamine, endocannabinoids, neuregulin-1, GABA, and adenosine, with adenosine being

65 The products of the neuregulin-1 gene constitute a set of polypeptide growth

66 ed cardiomyocytes from mice heterozygous for neuregulin-1 gene deletion (NRG-1+/-) and examined the e

67 neuregulin1-beta (a.k.a. heregulin1-beta), a neuregulin-1 gene isoform that preferentially binds to a

68 mRNA expression profiling revealed that the neuregulin-1 gene, encoding an established endogenous li

69 press human NRG1-IV, an isoform of the NRG1 (Neuregulin 1) gene that is increased in the brains of pa

70 ates the response of endogenous ErbB2 to the neuregulin-1 growth factor.

71 arly administration of a retrovirus carrying neuregulin-1 hammerhead-type ribozymes to blastoderm-sta

72 or, which we have termed Don-1 (divergent of neuregulin 1), has structural similarity with the neureg

73 amined the structural specificity needed for neuregulin-1-heparin interactions using a gel mobility s

74 stitutively active vector or ligand binding (Neuregulin-1), Her4 was able to stabilize the MDMX-MDM2

75 and the MN cell line Ben-Men-1, particularly neuregulin-1/heregulin (NRG1), and confirm increased NRG

76 Furthermore, ARAF inhibited neuregulin 1 (hNRG1)-mediated AKT activation through con

77 Neuronal Neuregulin-1, however, is not involved in this refinemen

78 The loss of neuregulin 1 impaired remyelination after nerve crush, b

79 valuate the role of the N-terminal domain of neuregulin 1 in signaling and turnover of ERBB2/ERBB3.

80 nd repair following nerve injury, we ablated neuregulin 1 in the adult nervous system using a tamoxif

81 hour treatment with either TGFbeta1 or beta-neuregulin-1 in ciliary ganglion neurons developing in v

82 At picomolar concentrations, recombinant neuregulin-1 in combination with GDNF effectively stimul

83 Immunostaining showed neuregulin-1 in fetal lung that increased in fibroblasts

84 sgenic mice overexpressing the growth factor neuregulin-1 in Schwann cells (P(0)-GGFbeta3 mice) devel

85 Neuregulin-1-induced cardiac, neuronal, and mammary diff

86 f a neutralizing antiserum specific for beta-neuregulin-1 inhibited the development of K(Ca) channels

87 tol 3-kinase, blocked the effect of combined neuregulin-1/insulin-like growth factor-I treatment.

88 suggest that whereas the EGF-like domain of neuregulin 1 is required and sufficient for the formatio

89 Neuregulin-1 is expressed throughout the immature and ad

90 l-cell communication model, where the ligand neuregulin-1 is produced and secreted by one cell type,

91 NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia

92 Glial growth factor (GGF), a neuregulin-1 isoform, significantly inhibited myelinatio

93 Two neuregulin-1 isoforms highly expressed in the nervous sy

94 of a cluster-of-differentiation-44 or of pro-neuregulin-1 monomers represents an essential pre-condit

95 In the neuregulin 1 mutant mice, remyelination was again impair

96 Although studies with neuregulin-1 mutant mice have demonstrated that these gr

97 ing heart, a faithful phenocopy of the mouse neuregulin-1 mutations.

98 zophrenia-related genes, such as NR2A, NR2B, neuregulin 1, NR1 and GABA alpha1 subunit were absent in

99 Neuregulin 1 (NRG)-1, localized in the floor plate as we

100 Neuregulin 1 (NRG-1) and its receptor ErbB4 have emerged

101 r cell motility, we investigated its role in neuregulin 1 (NRG-1)-induced cell scattering.

102 We then tested the neuroprotective effect of neuregulin-1 (NRG-1) against heme treatment in organoids

103 Neuregulin-1 (NRG-1) and its receptors, ErbBs, are conce

104 Neuregulin-1 (Nrg-1) contains an intracellular domain (N

105 Because neuregulin-1 (NRG-1) dramatically increases extracellula

106 Here, we show that neuregulin-1 (NRG-1) exerts a critical role in the estab

107 The neuregulin-1 (NRG-1) family of growth and differentiatio

108 To test the hypothesis that neuregulin-1 (NRG-1) growth factors promote mitogenesis

109 Neuregulin-1 (NRG-1) has been identified genetically as

110 Neuregulin-1 (NRG-1) is a good candidate for the extrace

111 Neuregulin-1 (NRG-1) is a growth factor with potent neur

112 Neuregulin-1 (NRG-1) is a paracrine factor released by m

113 Neuregulin-1 (NRG-1) is genetically linked with schizoph

114 ing axon-derived trophic molecules, although neuregulin-1 (NRG-1) is the only trophic factor shown to

115 We previously showed that neuregulin-1 (NRG-1) protected neurons from death in viv

116 Neuregulin-1 (NRG-1) regulates numerous aspects of neura

117 Neuregulin-1 (NRG-1) signaling has been implicated in in

118 antagonistic interactions between agrin and neuregulin-1 (Nrg-1) signaling in cultured myotubes and

119 tically modified mice have demonstrated that neuregulin-1 (NRG-1), along with the erythroblastic leuk

120 Transmembrane isoforms of neuregulin-1 (Nrg-1), ligands for erbB receptors, includ

121 ene expression to synapses is not known, but Neuregulin-1 (Nrg-1), primarily based on its presence at

122 17 (ADAM17)-dependent shedding of the ligand neuregulin-1 (NRG-1).

123 id peptide, also cleaves type I and type III neuregulin-1 (Nrg-1).

124 Both the neuregulin 1 (Nrg1) and alpha7 nicotinic acetylcholine r

125 Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopment

126 We show that neuregulin 1 (NRG1) and hepatocyte growth factor (HGF) p

127 articipates in the proteolytic processing of neuregulin 1 (NRG1) and influences the myelination of ce

128 As the interaction between neuregulin 1 (Nrg1) and its ErbB receptors has been impl

129 Neuregulin 1 (NRG1) and its interneuron-specific recepto

130 Neuregulin 1 (Nrg1) and its interneuron-specific recepto

131 Genetic variants of Neuregulin 1 (NRG1) and its neuronal tyrosine kinase rec

132 Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathoph

133 Neuregulin 1 (NRG1) and its receptor ErbB4 are both susc

134 Recent genetic evidence indicates that neuregulin 1 (NRG1) and its receptor erbB4 may be suscep

135 We provide evidence that neuregulin 1 (NRG1) and its receptor ErbB4 tyrosine kina

136 Neuregulin 1 (NRG1) and its receptor, erbB4, are genetic

137 , which was rescued by the administration of neuregulin 1 (NRG1) and nerve growth factor (NGF) recomb

138 Neuregulin 1 (NRG1) and the gamma-secretase subunit APH1

139 Here, we identified neuregulin 1 (NRG1) as a key EGF family ligand that driv

140 Our studies revealed that the ErbB3-neuregulin 1 (NRG1) axis is a dominant pathway responsib

141 Some studies suggest that neuregulin 1 (NRG1) could be involved in the regulation

142 We identify neuregulin 1 (NRG1) in CAF supernatant, which promotes r

143 B4, which is the only autonomous receptor of neuregulin 1 (NRG1) in the basolateral amygdala (BLA), w

144 nduces expression of ephrin b2a (efnb2a) and neuregulin 1 (nrg1) in the endocardium to promote trabec

145 Neuregulin 1 (NRG1) is a multifunctional neurotrophin th

146 Neuregulin 1 (NRG1) is a secreted trophic factor that ac

147 Neuregulin 1 (Nrg1) is a susceptibility gene of schizoph

148 Neuregulin 1 (NRG1) is a trophic factor that has been im

149 Neuregulin 1 (NRG1) is a trophic factor thought to play

150 Neuregulin 1 (NRG1) is an axon-derived factor that is cr

151 Genetic variation in neuregulin 1 (NRG1) is associated with schizophrenia.

152 Neuregulin 1 (NRG1) is essential for the development and

153 effects of a protective missense variant in neuregulin 1 (NRG1) linked to schizophrenia by meta-anal

154 factors have been identified, high levels of neuregulin 1 (NRG1) mRNA and protein expression in the C

155 Neuregulin 1 (NRG1) plays a critical role in myelination

156 ewal and survival, we obtained evidence that neuregulin 1 (NRG1) produced by TICs promotes their prol

157 The neuregulin 1 (NRG1) receptor, ErbB4, has been identified

158 Moreover, neuregulin 1 (NRG1) secreted from adipocyte precursors w

159 Neuregulin 1 (NRG1) signaling is critical to various asp

160 Several lines of evidence suggest that neuregulin 1 (NRG1) signaling may influence cognitive fu

161 ate myelination in the absence of functional Neuregulin 1 (Nrg1) signaling.

162 Neuregulin 1 (NRG1) type III is involved in myelination

163 m, extrinsic signals from the axonal protein neuregulin 1 (NRG1) type III regulate Schwann cell fate

164 We demonstrate that zebrafish Neuregulin 1 (Nrg1) type III, which signals through ErbB

165 Neuregulin 1 (NRG1), a critical developmental neurotroph

166 in cell culture and in animals suggest that neuregulin 1 (NRG1), a probable schizophrenia susceptibi

167 udies suggest that the signalling pathway of neuregulin 1 (NRG1), a protein involved in the regulatio

168 both male and female mice were suppressed by neuregulin 1 (NRG1), an epidermal growth factor whose ex

169 Neuregulin 1 (Nrg1), an ERBB3/ERBB4 ligand that is abund

170 Neuregulin 1 (NRG1), previously known to be increased in

171 ressed in sensory neurons regulates neuronal Neuregulin 1 (Nrg1), protein involved in cell-cell commu

172 ation in cultured Schwann cells and identify neuregulin 1 (NRG1), specifically the membrane-bound typ

173 However, the source of neuregulin 1 (NRG1), the ligand for ErbB3, is unknown.

174 g is regulated by laminin211- and, possibly, neuregulin 1 (Nrg1)-derived signals.

175 Neuregulin 1 (NRG1)-ErbB signaling mediates, therefore,

176 silencing the expression of the ErbB3 ligand neuregulin 1 (NRG1).

177 as Disrupted-in-schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1).

178 ng are those encoding dysbindin (DTNBP1) and neuregulin 1 (NRG1).

179 post-MI day 7 showed increased expression of neuregulin 1 (Nrg1).

180 r/tyrosine kinase B receptor (BDNF/TrkB) and neuregulin 1 (NRG1)/ErbB2.

181 The Neuregulin 1 (NRG1)/ErbB4 signaling pathway has been gen

182 Neuregulin-1 (NRG1) and Disrupted-in-Schizophrenia-1 (DI

183 Accumulating evidence suggests that neuregulin-1 (NRG1) and disrupted-in-schizophrenia-1 (DI

184 Neuregulin-1 (NRG1) and its ErbB2/B4 receptors are encod

185 and functional studies implicate variants of Neuregulin-1 (NRG1) and its neuronal receptor ErbB4 in s

186 Neuregulin-1 (NRG1) and its receptor ErbB4 influence sev

187 further identified the ERBB receptor ligand Neuregulin-1 (NRG1) as a key transcriptional target and

188 lin thickness is related to the abundance of neuregulin-1 (NRG1) expressed on the axon surface.

189 amine specifically induces downregulation of neuregulin-1 (NRG1) expression in parvalbumin-expressing

190 we show that the neuronally secreted protein Neuregulin-1 (NRG1) fulfills all these criteria in the a

191 Members of the neuregulin-1 (Nrg1) growth factor family play important

192 Recently, the gene that encodes neuregulin-1 (NRG1) has been identified as a potential s

193 on the surface of Schwann cells and neuronal Neuregulin-1 (NRG1) has emerged as the pivotal signal th

194 In vitro assays revealed that neuregulin-1 (NRG1) induces expression of myelin protein

195 Neuregulin-1 (Nrg1) is a pleiotropic signaling molecule

196 Neuregulin-1 (NRG1) is both a candidate oncogene and a c

197 Neuregulin-1 (Nrg1) is encoded by a single gene and exis

198 Neuregulin-1 (NRG1) is one of susceptibility genes for s

199 Neuregulin-1 (NRG1) is the main physiological ligand to

200 Neuregulin-1 (NRG1) signaling participates in numerous n

201 phenotype caused by disruption of BMP10 and Neuregulin-1 (NRG1) signaling pathways, two central medi

202 Neuregulin-1 (NRG1) signaling through its tyrosine kinas

203 hat treatment of cells with the ErbB3 ligand neuregulin-1 (NRG1) stabilizes the deubiquitinating enzy

204 In the developing PNS, axonal neuregulin-1 (NRG1) type III is the key determinant for

205 We now report that threshold levels of neuregulin-1 (NRG1) type III on axons determine their en

206 Neuregulin-1 (Nrg1), a member of the neuregulin family o

207 Neuregulin-1 (NRG1), a regulator of neural development,

208 Neuregulins (i.e. neuregulin-1 (NRG1), also called neu differentiation fac

209 We discovered that neuregulin-1 (NRG1), either as an isolated EGF-like doma

210 supported schizophrenia susceptibility gene, neuregulin-1 (NRG1).

211 ibroblast growth factor receptor (FGFR), and neuregulin-1 (NRG1).

212 elevated neurotrophic response, specifically neuregulin-1 (NRG1).

213 ith autocrine production of the ErbB3 ligand neuregulin-1 (NRG1).

214 Neuregulin-1 (Nrg1)/erbB signaling regulates neuronal de

215 The growth factor neuregulin-1 (Nrg1, encoded by NRG1) is a key signalling

216 anges that enhance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-growth-factor) or CD44 (re

217 ion during the critical period downregulates neuregulin-1(NRG1)/ErbB4 signaling in PV neurons, causin

218 Accordingly, we have examined the effects of neuregulin-1 on myelination in neuron-Schwann cell cocul

219 ns that overexpress the Schwann cell mitogen neuregulin-1 or overexpress the epidermal growth factor

220 Neuregulin 1 (or NRG1, hereafter referred to as hereguli

221 ndothelial markers von Willebrand factor and neuregulin-1, or phosphorylation of the signal mediators

222 ite that turns out be highly conserved among neuregulin-1 paralogues.

223 Injection of beta-neuregulin-1 peptide into the brains of developing embry

224 BACE1-cleaved extracellular domain of axonal neuregulin-1, perhaps neuregulin-3 as well, binds to Sch

225 Taken together these data suggest that neuregulin-1 plays an important modulatory role in gliom

226 blocked the promyelinating effect driven by neuregulin-1, prion protein and inactivated RAC1/CDC42.

227 These results suggest that neuregulin-1 promotes both muscle cell differentiation i

228 During development, neuregulin-1 promotes Schwann cell proliferation and sur

229 caused by the conditional elimination of the neuregulin 1 receptor ErbB2 from muscle precursors.

230 toskeleton-associated protein (ARC), and the neuregulin 1 receptor ERBB4.

231 nome-scale shRNA screens that implicated the neuregulin-1 receptor erb-B2 receptor tyrosine kinase 3

232 bB2, an integral member of the heterodimeric neuregulin-1 receptor, has been shown to be overexpresse

233 interaction prevents phosphorylation of beta-neuregulin-1 receptors and results in decreased cell pro

234 ace1 cleaves neuregulin-1 and that processed neuregulin-1 regulates myelination by means of phosphory

235 3 heterodimers and metalloprotease-dependent neuregulin 1 release, resulting in the activation of bot

236 Optimal binding to neuregulin-1 required eight or more heparin disaccharide

237 e turnover, but stimulation with full-length neuregulin 1 resulted in receptor degradation at rates t

238 nic mouse heart and show that treatment with neuregulin-1 results in electrophysiological changes in

239 utants precludes an analysis of hypothesized neuregulin-1 roles in later aspects of development.

240 Neuregulin-1 signaling molecules have various roles in t

241 te both the localization and potentiation of neuregulin-1 signaling.

242 s role as an important mediator of the NRG1 (Neuregulin 1) signaling pathway and activator of rapid c

243 Neuregulin 1 signalling is therefore an important factor

244 fetal lung fibroblast-conditioned media and neuregulin-1 stimulated erbB2 receptor phosphorylation i

245 PC3 prostate tumor cells suppresses EGF- and neuregulin-1-stimulated cell cycle progression.

246 gulin-1 but had no effect on the activity of neuregulin-1 that lacks the heparin-binding domain.

247 on is impaired by the prolonged elevation of neuregulin-1, the abnormality of which is a hallmark in

248 ocampal slices were chronically treated with neuregulin-1, the degradation of 2-arachidonoylglycerol

249 In the early phase following injury, axonal neuregulin 1 therefore promotes nerve repair, but at lat

250 Expression of type III neuregulin-1 (TIIINRG1) in induced pluripotent stem cell

251 elates with an enhanced ability of full-size neuregulin 1 to disrupt higher order oligomers of the ER

252 as two disaccharides were still able to bind neuregulin-1 to a lesser extent.

253 Addition of neuregulin-1 to cultures on MSC-1 feeder layers resulted

254 beta-Neuregulin-1 transcripts are expressed in the midbrain p

255 e found to express 100-fold higher levels of neuregulin-1 transcripts than MSC-1 cells.

256 Neuregulin 1 type III (NRG1 type III) is a major physiol

257 Neuregulin 1 type III (Nrg1III) and laminin alpha2beta1g

258 Axonal neuregulin 1 type III (Nrg1TIII) drives peripheral nerve

259 In the peripheral nervous system, axonal neuregulin 1 type III promotes myelination by activating

260 In addition, BACE1 cleaves neuregulin 1 type III, a protein critical for myelinatio

261 ociates with the BRG1 complex in response to neuregulin 1 type III.

262 toward local inhibition by overexpression of neuregulin-1 type 1 results in an absence of early L5b G

263 Neuregulin-1 Type III has been proposed to activate calc

264 h length, as well as reports that PNS axonal neuregulin-1 type III regulates the initiation and prope

265 Axonal factors, such as Neuregulin-1 Type III, trigger promyelinating signals th

266 se cerebellar granule neurons the effects of neuregulin-1 (type I) are mediated by a homo-dimeric Erb

267 Full-length neuregulin-1 was increased and its cleavage product was

268 This inductive effect of neuregulin-1 was restricted to a window of sensitivity b

269 diffusible factors into the cardiac chamber, neuregulin-1 was shown to promote trabeculation of the v

270 Using the whole mouse embryo culture system, neuregulin-1 was shown to regulate lacZ expression withi

271 wever, by 3 months post-injury axons lacking neuregulin 1 were effectively remyelinated and virtually

272 ypomyelination to the impaired processing of Neuregulin-1 when BACE1 is absent.

273 ves production and release of the cardiokine neuregulin-1, which facilitates paracrine communication