ライフサイエンスコーパス: neuroectodermal

1 cases supports the hypothesis that a primary neuroectodermal abnormality and a secondary mesenchymal

2 erm-derived cell types as well as cells with neuroectodermal and endodermal characteristics, suggesti

3 gest that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions.

4 scaffold and differentiation of neighboring neuroectodermal and mesodermal cells.

5 tation were capable of differentiation along neuroectodermal and mesodermal lineages, whereas cells i

6 by aberrant expression of genes involved in neuroectodermal and myogenic differentiation, closely si

7 induced pluripotent stem cells (hiPSCs) into neuroectodermal and NC cells using either the MS5 cocult

8 rsistent enhancer repression, despite normal neuroectodermal and neural plate progression.

9 sults show that Wg activity in the precursor neuroectodermal and neuroblast levels specify neuronal m

10 These cells expressed neuroectodermal and progenitor markers such as nestin, d

11 lar adhesion molecule and alpha-fetoprotein, neuroectodermal, and endodermal markers, respectively.

12 rential overexpression of several neural- or neuroectodermal-associated genes in synovial sarcomas re

13 response and were rapidly rejected, whereas neuroectodermal astrocytes demonstrated robust survival

14 so-ventral axis and the repositioning of the neuroectodermal borders.

15 es a subset of medulloblastomas, a malignant neuroectodermal brain cancer, and other cancers.

16 e TRAIL death pathway in childhood primitive neuroectodermal brain tumor (PNET), 8 human PNET cell li

17 e poliovirus receptor, Necl-5, in ectodermal/neuroectodermal cancers.

18 elegans Hox gene, egl-5, in a postembryonic neuroectodermal cell lineage.

19 rosophila CNS develops from three columns of neuroectodermal cells along the dorsoventral (DV) axis:

20 ted transgenic mice that overexpress MYCN in neuroectodermal cells and develop neuroblastoma.

21 ergent-extension movements characteristic of neuroectodermal cells and expressing appropriate genes s

22 nregulated in dysbindin/BLOC-1 deficiency in neuroectodermal cells and iPSC-derived human neurons, am

23 sion in distinct but overlapping clusters of neuroectodermal cells and neuroblasts, whereas the nucle

24 protein first detected in small clusters of neuroectodermal cells and then in a subset of neuroblast

25 differentiate into most mesodermal cells and neuroectodermal cells in vitro and into all embryonic li

26 est that oligodendrocytes are generated from neuroectodermal cells positioned throughout the rostroca

27 It is proposed that single-minded commits neuroectodermal cells to a midline fate, followed by a s

28 ytes can be directly reprogrammed into early neuroectodermal cells via the overexpression of OCT4, th

29 dose of XBF-1 promotes the proliferation of neuroectodermal cells while a low dose inhibits ectoderm

30 s of ENS progenitors with lineally unrelated neuroectodermal cells, the ordered colonization of the s

31 nhances reprogramming of both mesodermal and neuroectodermal cells, while pluripotent cells remain re

32 distinct from the effect of Rb deficiency in neuroectodermal cells.

33 hereas the Wnt(low) hESCs generate primarily neuroectodermal cells.

34 lin (betaT4) and has properties of primitive neuroectodermal cells.

35 ina, brain, and nonretinal tissues with some neuroectodermal components (all P < .01).

36 over-expressed in terminally differentiating neuroectodermal cultures derived from human embryonic st

37 s was strongly upregulated, thus revealing a neuroectodermal default mechanism for differentiation in

38 nti (IP) is an X-linked dominant disorder of neuroectodermal development.

39 S) cells overexpressing mTERT also initiated neuroectodermal differentiation efficiently, acquiring m

40 During onset of neuroectodermal differentiation in P19 embryonal carcino

41 rentiate into neuronal cells when exposed to neuroectodermal differentiation medium.

42 reprogramming process and that CHCHD2 primes neuroectodermal differentiation of hESCs and hiPSCs by b

43 ervous system during mouse embryogenesis and neuroectodermal differentiation of pluripotent P19 embry

44 D2, whose expression seems to correlate with neuroectodermal differentiation potential of pluripotent

45 Here we show that neuroectodermal differentiation stimulated by retinoic a

46 these mutations, we find that OTUD5 controls neuroectodermal differentiation through cleaving K48-lin

47 Neuroectodermal differentiation was triggered on stromal

48 SCs are inferior in their ability to undergo neuroectodermal differentiation.

49 hrough a formative stage prior to undergoing neuroectodermal differentiation.

50 Anterior pigmented neuroectodermal disorganization, dysgenesis of angle str

51 These functions separate mesendodermal and neuroectodermal domains by protecting cells against bein

52 e molecular markers that identify particular neuroectodermal domains, all neuroblasts or individual n

53 s composed of epithelial cells with anterior neuroectodermal/ectodermal fates, including retinal cell

54 iver, pancreas, biliary tree, and associated neuroectodermal endocrine cells.

55 iation leads to less accessible chromatin at neuroectodermal enhancers and aberrant gene expression.

56 Here, we interrogated a rich data set of neuroectodermal enhancers in Drosophila, representing ci

57 expressing clusters of genes related to the neuroectodermal epithelial lineage (Epi-iBMEC).

58 in mesoderm and neuroectoderm, with highest neuroectodermal expression in the ventral horn of the sp

59 ical development and reveal a novel role for neuroectodermal expression of Psen1 in development of th

60 ed fashion, reproducing part of the anterior neuroectodermal expression pattern of the endogenous Hox

61 was analyzed to distinguish mesodermal from neuroectodermal expression, we found that N-cadherin is

62 arly somite stage prior to the onset of Fgf8 neuroectodermal expression.

63 se embryo and was shown to promote posterior neuroectodermal fate by enhancing Smad2-activated wnt8 e

64 e embryos has the ability to induce anterior neuroectodermal fate in naive epiblast.

65 Directed differentiation toward a neuroectodermal fate revealed an extended progenitor pha

66 ediated burst in Snail1 expression regulates neuroectodermal fate while playing a required role in ep

67 equired to instruct cells to adopt a ventral neuroectodermal fate.

68 ch generate less ROS, choose the alternative neuroectodermal fate.

69 One of the functions of Snail is to repress neuroectodermal genes and restrict their expressions to

70 The derepression of the neuroectodermal genes into the ventral region in snail m

71 We found that different neuroectodermal genes respond differently in various sna

72 In V2 embryos, neuroectodermal genes, such as single-minded and rhomboi

73 cell fate requires the proper restriction of neuroectodermal genes, while the ventral cell movement i

74 ial cells even before the genesis of retinal neuroectodermal glia.

75 ntly arise in the brain and show features of neuroectodermal-like and glial-like tumors.

76 ese results suggest that Netrin-1 can induce neuroectodermal-like differentiation of human EC cells b

77 tion of RBP-Jkappa and p53 induces primitive neuroectodermal-like tumors in mice.

78 sducer of IL-17 receptor signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocyt

79 trikingly, ectopic expression of Lhx3/4 in a neuroectodermal lineage subject to FGF-dependent specifi

80 with enrichment of variants in cells of the neuroectodermal lineage, pointing to cortical neural pro

81 to affect cell survival primarily within the neuroectodermal lineages during somitogenesis, and secon

82 anted neuroectoderm nuclei overexpressed the neuroectodermal marker gene Sox2 to an excessive level i

83 Instead, we describe the neuroectodermal master modulator SOX10 and the oncogene

84 Melanoma cells, deriving from neuroectodermal melanocytes, may exploit the nervous sys

85 terdependent, sequential genetic programs in neuroectodermal (NE) cells, prior to the formation of ne

86 Ki-ras, an oncogene seldom altered in neuroectodermal neoplasms, is mutated in one third of th

87 and 10 differentiated), and 9 miscellaneous neuroectodermal neoplasms.

88 n, they reflect a primitive undifferentiated neuroectodermal/neural crest phenotype revealing a devel

89 exposed to stress and enhanced in tumors of neuroectodermal origin and in many neurodegenerative dis

90 icate PTPRD in the pathogenesis of tumors of neuroectodermal origin and, when taken together with oth

91 t tissue, small round blue cell neoplasms of neuroectodermal origin defined by the chromosomal aberra

92 he prototype of a family of tumors (ESFT) of neuroectodermal origin formed by small, round cells with

93 potential and induces development of various neuroectodermal origin tumors including medulloblastomas

94 ntly deleted or altered in certain tumors of neuroectodermal origin, it is important to define the sp

95 types as well as in certain neoplasms of non-neuroectodermal origin, such as malignant mesothelioma a

96 ibody scFv-FcC21, which recognized tumors of neuroectodermal origin, various types of carcinomas, mes

97 neural retina is mainly composed of cells of neuroectodermal origin.

98 is of several neoplasms, including tumors of neuroectodermal origin.

99 FF is very effective against tumor cells of neuroectodermal origin.

100 sing the CasBrE envelope protein in cells of neuroectodermal origin.

101 wth of a variety of cells of mesenchymal and neuroectodermal origin.

102 f a small blue cell-like tumor of epithelial/neuroectodermal origin.

103 r phenotype involving RPE and CE, tissues of neuroectodermal origin.

104 tivity typically are cells of mesodermal and neuroectodermal origin; in addition, expression of FGF-1

105 in mesenchymal cells of both mesodermal and neuroectodermal origins undergoing chondrogenesis, sugge

106 inputs is required to establish the precise neuroectodermal pattern of huckebein, which is subsequen

107 specific morpholino oligonucleotides altered neuroectodermal patterning, which could be rescued by ex

108 expression is responsible for the primitive neuroectodermal phenotype of EFT, we established a tetra

109 as the cells differentiate to endodermal or neuroectodermal phenotypes.

110 ic stem cells (hESCs) were differentiated to neuroectodermal precursors (NEP), but not to epidermal (

111 and the cytoskeleton, regulates polarity of neuroectodermal precursors and neurons, helping specify

112 ein that is abundantly expressed in eggs and neuroectodermal precursors during early development.

113 nd hCPe descend from the same pool of dorsal neuroectodermal progenitor cells of the rhombic lip.

114 ogenitor marker Gata4 and a strongly reduced neuroectodermal progenitor compartment.

115 during early gastrulation in the prospective neuroectodermal region of the epiblast and later in deve

116 Neuroectodermal signalling centres induce and pattern ma

117 ., flies and grasshoppers) revealed that the neuroectodermal size is conserved and originates similar

118 AF to CNCC-lineage specific enhancers at the neuroectodermal stage, specifically when neural crest ge

119 erentiation decreasing the expression of the neuroectodermal stem cell antigen, nestin, and up-regula

120 ssion of the intermediate filament nestin, a neuroectodermal stem cell marker, is linked to increased

121 In addition to expressing nestin, the neuroectodermal stem cell marker, retinal progenitors ar

122 os of this class show a reduction of ventral neuroectodermal structures and variable fusion of the ey

123 gotic inactivating mutations of RHOA cause a neuroectodermal syndrome combining linear hypopigmentati

124 , gut TF (CDX2), pluripotent TF (NANOG), and neuroectodermal TF (PAX6) (p < .05), all consistent with

125 s, Porcn is required in both extraocular and neuroectodermal tissues to regulate distinct Wnt-depende

126 rmation, but they lack the ability to induce neuroectodermal tissues, a characteristic common to chor

127 s of patients with Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) metastatic to bone/bone

128 foci of yolk sac tumor (n = 21) or primitive neuroectodermal tumor (n = 2), whereas 50 had pure immat

129 pendymoma (n = 8), medulloblastoma/primitive neuroectodermal tumor (n = 4), glioblastoma multiforme (

130 m glioma (n = 7), medulloblastoma/peripheral neuroectodermal tumor (n = 6), ependymoma (n = 3), and p

131 ren treated for medulloblastoma or primitive neuroectodermal tumor (PNET) and document the associated

132 of Ewing's Sarcoma and peripheral Primitive Neuroectodermal Tumor (PNET) are associated with aberran

133 Medulloblastoma (MB) and primitive neuroectodermal tumor (PNET) are histologically similar

134 imaging of brain involvement with primitive neuroectodermal tumor (PNET) demonstrated mild hypometab

135 the Ewing sarcoma (ES)/peripheral primitive neuroectodermal tumor (PNET) family are pediatric cancer

136 with metastatic Ewing's sarcoma or primitive neuroectodermal tumor (PNET) of bone were entered onto a

137 loblastoma, central nervous system primitive neuroectodermal tumor (PNET), and astrocytoma before 6 y

138 medulloblastoma or supratentorial primitive neuroectodermal tumor (PNET).

139 c patients with medulloblastoma or primitive neuroectodermal tumor (PNET).

140 Ten of 20 (50%) patients (primitive neuroectodermal tumor (PNET)/medulloblastoma, three pati

141 genic (OS) and Ewing's (ES) and/or primitive neuroectodermal tumor (PNET)] sarcoma, treated with chem

142 mice to the human medulloblastoma/primitive neuroectodermal tumor (PNETs) in location, histologic ap

143 PR) in one patient with peripheral primitive neuroectodermal tumor (PPNET), and a minimal response (M

144 rentiated sarcoma, and soft tissue primitive neuroectodermal tumor at all sites except paratesticular

145 y SCLC cultures as well as in some primitive neuroectodermal tumor biopsies.

146 Using a human peripheral primitive neuroectodermal tumor cell line, SK-N-MC, we demonstrate

147 Neuroectodermal tumor cell lines derived from other site

148 The GD2 ganglioside expressed on neuroectodermal tumor cells has been used as a target fo

149 TF4 mediates ER stress-induced cell death of neuroectodermal tumor cells in response to fenretinide o

150 eipt of AC, or if pure teratoma or primitive neuroectodermal tumor elements were found in the retrope

151 allmark of the Ewing's sarcoma and primitive neuroectodermal tumor family, encodes a fusion protein w

152 ntaining tumors, brain lymphoma or primitive neuroectodermal tumor make use of systemic administratio

153 ithout a bone sarcoma (ie, neither primitive neuroectodermal tumor nor osteosarcoma) (HR for PFS, 0.3

154 Ewing's sarcoma and primitive neuroectodermal tumor of bone are closely related, highl

155 n patients with Ewing's sarcoma or primitive neuroectodermal tumor of bone who had a relapse after st

156 ith nonmetastatic Ewing's sarcoma, primitive neuroectodermal tumor of bone, or primitive sarcoma of b

157 d or younger with Ewing's sarcoma, primitive neuroectodermal tumor of bone, or primitive sarcoma of b

158 or = 30 years with Ewing sarcoma, primitive neuroectodermal tumor or primitive sarcoma of bone were

159 We have analyzed a primitive neuroectodermal tumor sample exhibiting loss of heterozy

160 and Type II) are differentially expressed in neuroectodermal tumor tissue relative to differentiated

161 al teratoid/rhabdoid tumor and CNS primitive neuroectodermal tumor).

162 Among sarcomas, 21 of 21 Ewing's/primitive neuroectodermal tumor, 28 of 29 rhabdomyosarcomas, 28 of

163 eosarcomas, one Ewing sarcoma, one primitive neuroectodermal tumor, and one desmoplastic small round

164 hed GEM models of medulloblastoma, primitive neuroectodermal tumor, astrocytoma, oligodendroglioma, m

165 or medulloblastoma, supratentorial primitive neuroectodermal tumor, ependymoma, and rhabdoid tumors,

166 uld raise the suspicion of a renal primitive neuroectodermal tumor, in a young adult.

167 gene found in Ewing's sarcoma and primitive neuroectodermal tumor, is able to transform certain cell

168 lly Ewing's sarcoma and peripheral primitive neuroectodermal tumor, share a common class of tumor-spe

169 of the chest wall, and peripheral primitive neuroectodermal tumor.

170 stoma, choroid plexus carcinoma, and primary neuroectodermal tumor.

171 ade glioma, 32 had medulloblastoma/primitive neuroectodermal tumor/embryonal tumor, 17 had malignant

172 Primary renal primitive neuroectodermal tumor/extraskeletal Ewing's sarcoma (PNE

173 lastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly

174 Ewings sarcoma and primitive neuroectodermal tumors (ES/PNET) are characterized by th

175 ma and 158 children diagnosed with primitive neuroectodermal tumors (PNET) in the United States and C

176 loped bilateral retinoblastoma and primitive neuroectodermal tumors (PNET) of the midbrain.

177 such as Ewing's sarcoma (EWS) and primitive neuroectodermal tumors (PNET), are highly aggressive mal

178 Primitive neuroectodermal tumors (PNETs) are a family of primary m

179 Primitive neuroectodermal tumors (PNETs) of the central nervous sy

180 Primitive neuroectodermal tumors (PNETs) of the central nervous sy

181 ions in medulloblastomas and other primitive neuroectodermal tumors (PNETs) of the childhood CNS we p

182 (HASH1) in cerebellar and cerebral primitive neuroectodermal tumors (PNETs), gliomas, and cell lines

183 neuroblastoma, pineoblastoma, and primitive neuroectodermal tumors (PNETs).

184 s to the development of cerebellar primitive neuroectodermal tumors (PNETs).

185 rade glioma and in two of six with primitive neuroectodermal tumors (PNETs)/ medulloblastoma.

186 hereas experimental supratentorial primitive neuroectodermal tumors (sPNET) correspond to atypical te

187 of a panel of human supratentorial primitive neuroectodermal tumors (sPNET) showed low activity of th

188 Ganglioside GD2 is highly expressed on neuroectodermal tumors and an attractive therapeutic tar

189 as found to be overexpressed in a variety of neuroectodermal tumors and described as an essential ang

190 involved in Ewing sarcoma, related primitive neuroectodermal tumors and desmoplastic small round cell

191 se (PR) in two patients with Ewing/primitive neuroectodermal tumors and included one PR and one minor

192 multilayered rosettes (ETMRs) are primitive neuroectodermal tumors arising in infants.

193 as, and cell lines derived from a variety of neuroectodermal tumors by Northern analysis and in situ

194 strates, in contrast to cells from primitive neuroectodermal tumors cells (n=6), which only migrated

195 with pathology consistent with grade III-IV neuroectodermal tumors in mice.

196 evidence for the development of inheritable neuroectodermal tumors induced by the human polyomavirus

197 One hallmark of Ewing's sarcoma/peripheral neuroectodermal tumors is the presence of the Ews/Fli-1

198 The neuroectodermal tumors neuroblastoma and melanoma repres

199 Primitive neuroectodermal tumors of the central nervous system (CN

200 a new approach to the treatment of primitive neuroectodermal tumors we evaluated the effect of the HM

201 ic animals that develop cerebellar primitive neuroectodermal tumors which model human medulloblastoma

202 ansformed with N-Myc, we generated primitive neuroectodermal tumors with divergent differentiation in

203 g of treatment: medulloblastoma or primitive neuroectodermal tumors, 57.8; germ cell tumors, 63.5; ep

204 of gliomas, central nervous system primitive neuroectodermal tumors, and atypical teratoid/rhabdoid-l

205 blastomas (MBs) and supratentorial primitive neuroectodermal tumors, and we report the outcome in the

206 ise Ewing's sarcoma and peripheral primitive neuroectodermal tumors, are highly aggressive and mostly

207 ingle cell type (two patients with primitive neuroectodermal tumors, five with undifferentiated RMS,

208 onal renal cell carcinoma, 100% of primitive neuroectodermal tumors, renal malignant masenchymomas an

209 tem NSCs generated medulloblastoma/primitive neuroectodermal tumors, whereas forebrain NSCs developed

210 neuroblastomas to Ewing's sarcoma/peripheral neuroectodermal tumors.

211 nificantly, CD155 is aberrantly expressed in neuroectodermal tumors.

212 g development and the expression of CD155 in neuroectodermal tumors.

213 nt of Ewing's sarcoma and related peripheral neuroectodermal tumors.

214 also thought to be etiological in primitive neuroectodermal tumors.

215 anslocation in Ewing's sarcoma and primitive neuroectodermal tumors.

216 creaticoblastomas and 1 of 10 with primitive neuroectodermal tumors.

217 eleted in neuroblastoma, melanoma, and other neuroectodermal tumors.

218 mmon mechanism in the causation of primitive neuroectodermal tumors.

219 the neuroblastic rosettes in human primitive neuroectodermal tumors.

220 Since primitive neuroectodermal tumors/medulloblastomas (PNETs/medullobl

221 a) or malignant (rhabdomyosarcoma, melanotic neuroectodermal tumour of infancy).

222 of Rb/p53 or Rb/p53/PTEN generated primitive neuroectodermal tumours (PNET), indicating an important

223 from other brain tumours including primitive neuroectodermal tumours (PNETs), atypical teratoid/rhabd

224 motherapy, while in supratentorial primitive neuroectodermal tumours future treatment will be aimed a

225 In primitive neuroectodermal tumours prognostic biological markers ha

226 ing sarcoma and related peripheral primitive neuroectodermal tumours share recurrent translocations t

227 l phaeochromocytoma with a family history of neuroectodermal tumours.

228 l phaeochromocytoma with a family history of neuroectodermal tumours.